Publications

2026

【Original papers】

1. Nakao, S., Liao, J., Ino, Y., Oura, K., Ito, S., Kageyama, K., Sato, M., Murakami, Y., Ishida, S., Hirota, T., Endo, S., Uchida, M., Iguchi, K., Nakamura, M., Evaluation of the association of pseudoaldosteronism with licorice-containing herbal medicine using the Japanese adverse drug event report (JADER) database., J. Ethnopharmacol., 360, 121202 (2026) PMID: 41534754  10.1016/j.jep.2026.121202

2. Morikawa, Y., Azuma, N., Sakai, Y., Tsuchimura, S., Miyazono, H., Suenami, K., Yanase, E., Endo, S., Ikari, A., Matsunaga, T., Mechanistic insights into the structure-toxicity relationship of α-aminononanophenone derivatives: role of CYP3A4 and oxidative stress. Toxicology, 519, 154333 (2026) PMID: 41242374  10.1016/j.tox.2025.154333

3. Endo, S., Hayashi, R., Nakada, Y., Kudo, Y., Morikawa, Y., Sakai, Y., Suenami, K., Abe, N., Matsunaga, T., Hara, A., Ueda, H., Canine aldo-keto reductase 1C3 (AKR1C3/PGFS) exhibits 17β/20α-hydroxysteroid dehydrogenase activity and is inhibited by trilostane., J. Steroid Biochem. Mol. Biol., 255, 106874 (2026) PMID: 41061770 10.1016/j.jsbmb.2025.106874                   

【Review articles and book chapters】

2025

【Original papers】

1. Tanio, M.#, Miyamoto, Y.#, (#Equal first author contribution), Saka, T., Kudo, Y., Hayashi, R., Kawano, S., Yoshino, Y., Abe, N., Yamaguchi, E., Arai, Y., Kashiwagi, H., Oyama, M., Itoh, A., Ikari, A., Endo, S., Kobochromone A, a polyphenol in Carex kobomugi, suppresses androgen signaling induced by 11-oxygenated androgens and enhances the efficacy of AKT inhibitors in triple-negative breast cancer cells. Steroids, 223, 109692 (2025) PMID: 41015102 10.1016/j.steroids.2025.109692 

2. Miyamoto, C., Yoshino, Y., Tanaka, H., Hara, H., Endo, S. and Ikari. A., Plasma-activated medium disrupts intercellular barrier function in HaCaT cells by suppressing claudin-1 expression via clathrin-dependent endocytosis. Biochim. Biophys. Acta – General Subjects, 1869, 130826 (2025) PMID: 40441538 10.1016/j.bbagen.2025.130826

3. Kawai, M.#, Saka, T.# (#Equal first author contribution), Kawano, S., Kudo, Y., Nomura, T.K., Honda, R., Yoshino, Y., Kashiwagi, H., Abe, N., Oyama, M., Ikari, A. and Endo, S.*, Gnetin C sensitizes darolutamide-resistant prostate cancer cells by targeting NAD+ and energy metabolism. Biochem. Biophys. Res. Commun., 770, 152009 (2025) PMID: 40393106 10.1016/j.bbrc.2025.152009

4. Kudo, Y., Hirota, K., Tsuzuki, H., Kawano, S., Saka, T., Hayashi, R., Yoshino, Y., Ikari, A. and Endo, S.*, Inhibition of autophagy by Atg7 knockdown enhances chemosensitivity in gemcitabine/paclitaxel-resistant pancreatic cancer MIAPaCa2 cells. J. Biochem., 178, 11-24 (2025) PMID: 40329484  10.1093/jb/mvaf022

5. Fujimoto, A., Koutake, Y., Tsutsui, Y., Nakahara, M., Matsuo, K., Yabuuchi, Y., Amimura, G., Kawamata, Y., Uehara, T., Ikari, A., Endo, S. and Oyamada, J., Effect of antiemetic corticosteroids on the development of immune-related adverse events caused by chemoimmunotherapy: a multi-center retrospective study. Support. Care Cancer, 33, 204 (2025) PMID: 39971819 10.1007/s00520-025-09268-1

【Review articles and book chapters】

1. 「BOOKS紹介　新薬に出会うまで　私の履歴書」、MEDCHEM NEWS、Vol.35 No.1 (2025)

2024

【Original papers】

1.  Kudo, Y., Nakamura, K., Tsuzuki, H., Hirota, K., Takaya, D., Fukuzawa, K., Honma, T., Yoshino, Y., Nakamura, M., Shiota, M., Fujimoto, N., Ikari, A. and Endo, S.*, Docosahexaenoic acid enhances the treatment efficacy for castration-resistant prostate cancer by inhibiting autophagy through Atg4B inhibition. Arch. Biochem. Biophys., 760, 110135 (2024) PMID: 39181384 doi: 10.1016/j.abb.2024.110135 

2. Kimura, R., Ito, A., Hashimoto, S., Eguchi, H., Nasako, H., Takashina, Y., Morikawa, Y., Suenami, K., Yoshino, Y., Endo, S., Matsunaga, T. and Ikari, A., Enhancement of chemoresistance by claudin-1-mediated formation of amino acid barriers in human lung adenocarcinoma A549 cells. Arch. Biochem. Biophys., 759, 110106 (2024) PMID: 39067558 doi: 10.1016/j.abb.2024.110106 　

3. Endo, S.*, Morikawa, Y., Suenami,　K., Sakai,　Y., Abe, N., Matsunaga, T., Hara, A. and Takasu, M., Involvement of porcine and human carbonyl reductases in the metabolism of epiandrosterone, 11-oxygenated steroids, neurosteroids, and corticosteroids. J. Steroid Biochem. Mol. Biol., 243, 106574 (2024) PMID: 38945307 doi: 10.1016/j.jsbmb.2024.106574 

4. Yoshino, Y., Teruya, T., Miyamoto, C., Hirose, M., Endo, S., Ikari, A., Unraveling the Mechanisms Involved in the Beneficial Effects of Magnesium Treatment on Skin Wound Healing. Int. J. Mol. Sci., 25, 4994 (2024) PMID: 38732212 doi: 10.3390/ijms25094994 

5. Yamamoto, K., Matsumaru, D., Ishida, K., Endo, S., Hiromori, Y., Nakanishi, T., Binding profiles of human and mouse complement component 8γ to trisubstituted organometallic compounds. Chem. Biol. Interact., 395, 110998 (2024) PMID: 38614317  doi: 10.1016/j.cbi.2024.110998 

6. Himura, R.#, Kawano, S.# (#Equal first author contribution), Nagata, Y., Kawai, M., Ota, A., Kudo, Y., Yoshino, Y., Fujimoto, N., Miyamoto, H., Endo, S.*, Ikari, A., Inhibition of aldo-keto reductase 1C3 overcomes gemcitabine/cisplatin resistance in bladder cancer cells. Chem. Biol. Interact., 388, 110840 (2024) PMID: 38122923 doi: 10.1016/j.cbi.2023.110840 

7. Nagaoka, U., Oshiro, K., Yoshino, Y., Matsunaga, T., Endo, S.* and Ikari, A., Activation of the TGF-β1/EMT signaling pathway by claudin-1 overexpression reduces doxorubicin sensitivity in small cell lung cancer SBC-3 cells. Arch. Biochem. Biophys., 751, 109824 (2024) PMID:7984759 doi: 10.1016/j.abb.2023.109824 

【Review articles and book chapters】

1. Shiota, M., Endo, S., Tsukahara, S., Tanageshima, T., Kobayashi, S., Matsumoto, T., Eto, M., Importance of 3β-hydroxysteroid dehydrogenases and their clinical use in prostate cancer. Endocr. Relat. Cancer, 31, e240023 (2024) PMID: 38688318 doi: 10.1530/ERC-24-0023 

2. 「うちの子紹介します　第70回砂浜に広がるモコモコ　コウボウムギ」、someone、vol.69 (2024年冬)、リバネス出版

【Patents】

1. 特願2024-044128、化合物、アジュバント組成物および医薬組成物、遠藤智史、2024.03.19

2023

【Original papers】

1. Nomura, T., Endo, S., Kuwano, T., Fukasawa, K., Takashima, S., Todo, T., Furuta, K., Yamamoto, T., Hinoi, E., Koyama, H. and Honda, R., ARL-17477 is a dual inhibitor of NOS1 and the autophagic-lysosomal system that prevents tumor growth in vitro and in vivo. Sci. Rep., 13, 10757 (2023) PMID: 37402770 doi: 10.1038/s41598-023-37797-4 

2. Endo, S.*, Morikawa, Y., Matsunaga, T., Hara, A. and Takasu, M., Characterization of a novel porcine carbonyl reductase activated by glutathione: Relationship to carbonyl reductase 1, 3α/β-hydroxysteroid dehydrogenase and prostaglandin 9-ketoreductase. Chem. Biol. Interact., 381, 110572 (2023) PMID: 37247810 doi: 10.1016/j.cbi.2023.110572 

3. Fujimoto, A., Koutake, Y., Hisamatsu, D., Ookubo, N., Yabuuchi, Y., Kamimura, G., Kai, T., Kozono, A., Ootsu, T., Suzuki, H., Matsuo, K., Kuwahara, K., Oiwane, Y., Nagata, Y., Tanimoto, K., Sato, E., Suenaga, M., Uehara, T., Ikari, A., Endo, S., Hiraki, Y. and Kawamata, Y., Risk factors indicating immune‑related adverse events with combination chemotherapy with immune checkpoint inhibitors and platinum agents in patients with non‑small cell lung cancer: a multicenter retrospective study. Cancer Immunol., Immunother., 72, 2169-2178 (2023) PMID: 36849845 doi: 10.1007/s00262-023-03408-4 

4. Matsunaga, T., Horinouchi, M., Saito, H., Hisamatsu, A., Iguchi, K., Yoshino, Y., Endo, S. and Ikari, A., Availability of aldo-keto reductase 1C3 and ATP-binding cassette B1 as therapeutic targets for alleviating paclitaxel resistance in breast cancer MCF7 cells. J. Biochem., 173, 167-175 (2023) PMID: 36413758 doi: 10.1093/jb/mvac098 

5. Ota, A.#, Kawai, M.# (#Equal first author contribution), Kudo, Y., Segawa, J., Hoshi, M., Kawano, S., Yoshino, Y., Ichihara, K., Shiota, M., Fujimoto, N., Matsunaga, T., Endo, S.* and Ikari, A., Artepillin C overcomes apalutamide resistance through blocking androgen signaling in prostate cancer cells. Arch. Biochem. Biophys., 735, 109519 (2023) PMID: 36642262 doi: 10.1016/j.abb.2023.109519 

6. Yamamoto, K. and Endo, S., Bombyx mori-derived aldo-keto reductase AKR2E8 detoxifies aldehydes present in mulberry leaves. Arch. Insect Biochem. Physiol., 112, e21979 (2023) PMID: 36430833 doi: 10.3390/ijms232214356 

【Review articles and book chapters】

1.  Shiota, M., Endo, S., Blas, L., Fujimoto, N., Eto, M., Steroidogenesis in castration-resistant prostate cancer. Urol. Oncol., 41, 240-251 (2023) PMID: 36376200 doi: 10.1016/j.urolonc.2022.10.018 

【Patents】

1. 特願2023-027556、アスパラギン酸プロテアーゼDDI2阻害剤およびその利用、遠藤智史、2023.02.24

2. 特許第7644471号、オートファジー阻害剤、遠藤智史、五十里彰、豊岡尚樹、岡田卓哉、藤本直浩、2023.09.07

2022

【Original papers】

1. Eguchi, H., Kimura, R., Ito, A., Yu, Y., Yoshino, Y., Matsunaga, T., Endo, S. and Ikari, A., Elevation of anticancer drug toxicity by caffeine in spheroid model of human lung adenocarcinoma A549 cells mediated by reduction of claudin-2 and Nrf2 expression. Int. J. Mol. Sci., 23, 15447 (2022) PMID: 36555089 doi: 10.3390/ijms232415447 

2. Kudo, Y., Endo, S.*, Tanio, M., Saka, T., Himura, R., Abe, N., Takeda, M., Yamaguchi, E., Yoshino, Y., Arai, Y., Kashiwagi, H., Oyama, M., Itoh, A., Shiota, M., Fujimoto, N. and Ikari, A. Antiandrogenic effects of a polyphenol in Carex kobomugi through inhibition of androgen synthetic pathway and down-regulation of androgen receptor in prostate cancer cell lines. Int. J. Mol. Sci., 23, 14356 (2022) PMID: 36430833 doi: 10.3390/ijms232214356 

3. Yamamoto, K., Yamada, N., Endo, S., Kurogi, K., Sakakibara, Y., Suiko, M., Novel silkworm (Bombyx mori) sulfotransferase swSULT ST3 is involved in metabolism of polyphenols from mulberry leaves. PLos One, 17, e0270804 (2022) PMID: 35925958 doi: 10.1371/journal.pone.0270804 

4. Eguchi, H., Kimura, R., Matsunaga, H., Matsunaga, T., Yoshino, Y., Endo, S. and Ikari, A., Increase in anticancer drug-induced toxicity by fisetin in lung adenocarcinoma A549 spheroid cells mediated by the reduction of claudin-2 expression. Int. J. Mol. Sci., 23, 7536 (2022) PMID: 35886884 doi: 10.3390/ijms23147536 

5. Endo, S.*, Morikawa, Y., Matsunaga, T., Hara, A. and Nishinaka, T., Porcine aldo-keto reductase 1C subfamily members AKR1C1 and AKR1C4: Substrate specificity, inhibitor sensitivity and activators. J. Steroid Biochem. Mol. Biol., 221, 106113 (2022) PMID: 35398259 doi: 10.1016/j.jsbmb.2022.106113 

6. Kudo, Y., Endo, S.*, Fujita, M., Ota, A., Kamatari, Y.O., Tanaka, Y., Ishikawa, T., Ikeda, H., Okada, T., Toyooka, N., Fujimoto, N., Matsunaga, T. and Ikari, A., Discovery and structure-based optimization of novel Atg4B inhibitors for the treatment of castration-resistant prostate cancer. J. Med. Chem., 65, 4878-4892 (2022) PMID: 35244402 doi: 10.1021/acs.jmedchem.1c02113 

7. Kobayashi, M., Yonezawa, A., Takasawa, H., Nagao, Y., Iguchi, K., Endo, S., Ikari, A. and Matsunaga, T., Development of cisplatin resistance in breast cancer MCF7 cells by up-regulating aldo-keto reductase 1C3 expression, glutathione synthesis, and proteasomal proteolysis. J. Biochem., 171, 97-108 (2022) PMID: 34676395 doi: 10.1093/jb/mvab117 

【Patents】

1. 特願2022-040423、抗癌剤、医薬品組成物及び飲食品組成物、遠藤智史、阿部尚仁、山口英士、2022.03.15

2. 特許第7178075号、AKR1C3選択的阻害剤及びその用途、遠藤智史、松永俊之、五十里彰、豊岡尚樹、藤本直浩、2022.11.16

2021

【Original papers】

1. Endo, S.*, Nishiyama, T., Matuoka, T., Miura, T., Nishinaka, T., Matsunaga, T. and Ikari, A., Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells. Chem. Biol. Interact., 348, 109634 (2021) PMID: 34506768 doi: 10.1016/j.cbi.2021.109634 

2. Yamamoto, K. and Endo, S., Bombyx mori-derived aldose reductase AKR2E8 detoxifies aldehydes present in mulberry leaves. Chem. Biol. Interact., 351, 109717 (2021) PMID: 34737151 doi: 10.1016/j.cbi.2021.109717 

3. Kamase, K., Taguchi, M., Ikari, A., Endo, S. and Matsunaga, T., 9,10-Phenanthrenequinone provokes dysfunction of brain endothelial barrier through down-regulating expression of claudin-5. Toxicology, 461, 152896 (2021)

4. Ito, A., Nasako, H., Akizuki, R., Takashina, Y., Eguchi, H., Matsunaga, T., Yoshino, Y., Endo, S. and Ikari, A., Elevation of chemosensitivity of lung adenocarcinoma A549 spheroid cells by claudin-2 knockdown through activation of glucose transport and inhibition of Nrf2 signal. Int. J. Mol. Sci., 22, 6582 (2021) PMID: 34205320 doi: 10.3390/ijms22126582 

5. Morikawa, Y., Miyazono, H., Kamase, K., Suenami, K., Sasajima, Y., Sato, K., Endo, S., Monguchi, Y., Takekoshi, Y., Ikari, A. and Matsunaga, T., Protective effect of aldo-keto reductase 1B1 against neuronal cell damage elicited by 4'-fluoro-α-pyrrolidinononanophenone. Neurotox. Res., 39, 1360-1371 (2021) PMID: 34043181 doi: 10.1007/s12640-021-00380-8 

6. Kikuya, M., Furuichi, K., Hirao, T., Endo, S., Toyooka, N., Ito, K. and Aoki, S., Aldo-keto reductase inhibitors increase the anticancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia. J. Pharmacol. Sci., 147, 1-8 (2021) PMID: 34294359 doi: 10.1016/j.jphs.2021.05.001 

7. Endo, S.*, Kawai, M., Hoshi, M., Segawa, J., Fujita, M., Matsukawa, T., Fujimoto, N., Matsunaga, T. and Ikari　A., Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells. J. Biochem., 170, 89-96 (2021) PMID: 33729485 doi: 10.1093/jb/mvab025 

【Review articles and book chapters】

1.  Endo, S.*, Matsunaga, T., Nishinaka, T., The roles of AKR1B10 in human physiology and disease. Metabolites, 11, 332 (2021) PMID: 34063865 doi: 10.3390/metabo11060332 

【Patents】

1. 特願2021-044121、DHRS11阻害剤、遠藤智史、五十里彰、阿部尚仁、山口英士、2021.03.17

2020

【Original papers】

1. Endo, S.*, Matsunaga, T. and Hara,　A., Characterization of aldo-keto reductase 1C subfamily members encoded in two rat genes (akr1c19 and RGD1564865). Relationship to 9-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys., 700, 108755 (2020) PMID: 33482148 doi: 10.1016/j.abb.2021.108755 

2. Matsunaga, T., Okumura, N., Saito, H., Morikawa, Y., Suenami, K., Hisamatsu, A., Endo, S. and Ikari, A., Significance of aldo-keto reductase 1C3 and ATP-binding cassette transporter B1 in gain of irinotecan resistance in colon cancer cells. Chem. Biol. Interact., 332, 109295 (2020) PMID: 33096057 doi: 10.1016/j.cbi.2020.109295 

3. Endo, S.*, Oguri, H., Segawa, J., Kawai, M., Hu, D., Xia, S., Okada, T., Irie, K., Fujii, S., Gouda, H., Iguchi, K., Matsukawa, T., Fujimoto, N., Nakayama, T., Toyooka, N., Matsunaga, T. and Ikari, A., Development of novel AKR1C3 inhibitors as new potential treatment for castration-resistant prostate cancer. J. Med. Chem., 63, 10396-10411 (2020) PMID: 32847363 doi: 10.1021/acs.jmedchem.0c00939 

4. Yamamoto, K., Yamaguchi, M. and Endo, S., Functional characterization of an aldose reductase (bmALD1) obtained from the silkworm Bombyx mori. Insect Mol. Biol., 29, 490-497 (2020) 

5. Shiota, M., Endo, S., Fujimoto, N., Tsukahara, S., Ushijima, M., Kashiwagi, E., Takeuchi, A., Inokuchi, J., Uchiumi, T. and Eto, M., Polymorphisms in androgen metabolism genes with serum testosterone levels and prognosis in androgen-deprivation therapy. Urol. Oncol., 38, 849.e11-849.e18 (2020) PMID: 32712140 doi: 10.1016/j.urolonc.2020.06.033 

6. Nasako, H., Takashina, Y., Eguchi, H., Ito, A., Ishikawa, Y., Matsunaga, T., Endo, S. and Ikari, A., Increase in toxicity of anticancer drugs by PMTPV, a claudin-1-binding peptide, mediated via down-regulation of claudin-1 in human lung adenocarcinoma A549 cells. Int. J. Mol. Sci., 21, E5909 (2020) PMID: 32824620 doi: 10.3390/ijms21165909 

7. Eguchi, H., Matsunaga, T., Endo, S., Ichihara, K. and Ikari, A., Kaempferide enhances chemosensitivity of human lung adenocarcinoma A549 cells mediated by the decrease in phosphorylation of Akt and claudin-2 expression. Nutrients, 12, 1190 (2020) PMID: 32340376 doi: 10.3390/nu12041190 

8. Hara, A., Nishinaka, T., Abe, N., El-Kabbani, O., Matsunaga, T. and Endo, S.*, Dimeric dihydrodiol dehydrogenase is an efficient primate 1,5-anhydro-D-fructose reductase. Biochem. Biophys. Res. Commun., 526, 728-732 (2020) PMID: 32253031 doi: 10.1016/j.bbrc.2020.03.176 

9. Endo, S.*, Morikawa, Y., Kudo, Y., Suenami, K., Matsunaga, T., Ikari, A. and Hara, A., Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids. J. Steroid Biochem. Mol. Biol., 199, 105586 (2020) PMID: 31926269 doi: 10.1016/j.jsbmb.2020.105586 

10. Nasako, H., Akizuki, R., Takashina, Y., Ishikawa, Y., Shinoda, T., Shirouzu, M., Asai, T., Matsunaga, T., Endo, S. and Ikari, A., Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells. Biochim. Biophys. Acta., 1867, 118642 (2020) PMID: 31923533 doi: 10.1016/j.bbamcr.2019.118642 

【Patents】

1. 特願2020-157505、オートファジー阻害剤、遠藤智史、五十里彰、豊岡尚樹、岡田卓哉、藤本直浩、2020.09.18 [特開2022-051171、2022.03.31]

2019 and earlier

【Original papers】

1. Endo, S.*, Matsuoka, T., Nishiyama, T., Arai, Y., Kashiwagi, H., Abe, N., Oyama, M., Matsunaga, T. and Ikari, A., Transient decreases in intestinal barrier function by fravonol glycosides from Rosa multiflora. Nutr. Res., 72, 92-104 (2019) PMID: 31767206 doi: 10.1016/j.nutres.2019.10.010 

2. Matsunaga, T., Kawabata, S., Yanagihara, Y., Kezuka, C., Kato, M., Morikawa, Y., Endo, S., Chen, H., Iguchi, K., Ikari, A., Pathophysiological roles of autophagy and aldo-keto reductases in development of doxorubicin resistance in gastrointestinal cancer cells. Chem. Biol. Interact., 314, 108839 (2019) PMID: 31563593 doi: 10.1016/j.cbi.2019.108839 

3. Endo, S.*, Matsunaga, T. and Hara, A., Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity. Arch. Biochem. Biophys., 674, 108096 (2019) PMID: 31479646 doi: 10.1016/j.abb.2019.108096 

4. Maruhashi, H., Eguchi, H., Akizuki, R., Hamada, S., Furuta, T., Matsunaga, T., Endo, S., Ichihara, K., Ikari, A., Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11  expression in a spheroid culture model of lung squamous cell carcinoma. Sci. Rep., 9, 13753 (2019) PMID: 31551535 doi: 10.1038/s41598-019-50276-z 

5. Endo, S.*, Uchibori, M., Suyama, M., Fujita M., Arai, Y., Hu, D., Xia, S., Ma, B., Kabir, A., Kamatari, O.Y., Kuwata, K., Toyooka, N., Matsunaga T. and Ikari, A., Novel Atg4B inhibitors potentiate cisplatin therapy in lung cancer cells through blockade of autophagy. Comput. Toxicol., 12, 100095 (2019) doi: 10.1016/j.comtox.2019.100095 

6. Marunaka, K., Fujii, N., Kimura, T., Furuta, T., Hasegawa, H., Matsunaga, T., Endo, S. and Ikari A., Rescue of tight junctional localization of a claudin-16 mutant D97S by antimalarial medicine primaquine in Madin-Darby canine kidney cells. Sci. Rep., 9, 9647 (2019) PMID: 31273276 doi: 10.1038/s41598-019-46250-4 

7. Awale, S., Okada, T., Dibwe, D.F., Maruyama, T., Takahara, S., Okada, T., Endo, S., Toyooka, N., Design and synthesis of functionalized coumarins as potential anti-austerity agents that eliminates cancer cells' tolerance to nutrition starvation. Bioorg. Med. Chem. Lett., 29, 1779-1784 (2019) PMID: 31097375 doi: 10.1016/j.bmcl.2019.05.010 

8. Endo, S.*, Miyagi, N., Matsunaga T. and Ikari, A., Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity. Chem. Biol. Interact., 305, 12-20 (2019) 

9. Akizuki, R., Eguchi, H., Endo, S., Matsunaga, T. and Ikari A., ZO-2 suppresses cell migration mediated by a reduction in matrix metalloproteinase 2 in claudin-18-expressing lung adenocarcinoma A549 cells, Biol. Pharm. Bull, 42, 247-254 (2019) PMID: 30713254 doi: 10.1248/bpb.b18-00670 

10. Matsunaga, T., Tsuchimura, S., Azuma, N., Endo, S., Ichihara, K. and Ikari, A., Caffeic acid phenethyl ester potentiates gastric cancer cell sensitivity to doxorubicin and cisplatin by decreasing proteasome function. Anticancer Drugs, 30, 251-259 (2019) PMID: 30489290 doi: 10.1097/CAD.0000000000000715 

11. Morikawa, Y., Shibata, A., Sasajima, Y., Suenami, K., Sato, K., Takekoshi, Y., Endo, S., Ikari, A. and Matsunaga, T., Sibutramine facilitates apoptosis and contraction of aortic smooth muscle cells through elevating production of reactive oxygen species. Eur. J. Pharmacol., 841, 113-121 (2018) PMID: 30339816 doi: 10.1016/j.ejphar.2018.10.009 

12. Takashina, Y., Manabe, A., Hasegawa, H., Matsunaga, T., Endo, S. and Ikari, A., Sodium citrate increases expression and flux of Mg2+ transport carriers mediated by activation of MEK/ERK/c-Fos pathway in renal tubular epithelial cells. Nutrients, 10, E1345 (2018) PMID: 30241394 doi: 10.3390/nu10101345 

13. Manabe, A., Furukawa, C., Fujii, N., Matsunaga, T., Endo, S., Hasegawa H. and Ikari, A., Up-regulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells. J. Cell. Physiol., 234, 8951-8962 (2019) PMID: 30461012 doi: 10.1002/jcp.27565 

14. Eguchi, H., Akizuki, R., Maruhashi, R., Tsukimoto, M., Furuta, T., Matsunaga, T., Endo, S. and Ikari, A., Increase in resistance to anticancer drugs involves occludin in spheroid culture model of human lung adenocarcinoma A549 cells. Sci. Rep., 8, 15157 (2018) PMID: 30310131 doi: 10.1038/s41598-018-33566-w 

15. Sonoki, H., Tanimae, A., Furuta, T., Endo, S., Matsunaga, T., Ichihara, K. and Ikari, A., Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells. J. Nutr. Biochem., 56, 205-214 (2018) PMID: 29597147 doi: 10.1016/j.jnutbio.2018.02.016 

16. Akizuki, R., Maruhashi, R., Eguchi, H., Kitabatake, K., Tsukimoto, M., Furuta, T., Matsunaga, T., Endo, S. and Ikari, A., Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells. Biochim. Biophys. Acta., 1865, 769-780 (2018) PMID: 29524521 doi: 10.1016/j.bbamcr.2018.03.001 

17. Endo, S.#, Hoshi, M., Matsunaga, T., Inoue, T., Ichihara, K. and Ikari, A., Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis. Biochem. Biophys. Res. Commun., 497, 437-443 (2018) PMID: 29452093 doi: 10.1016/j.bbrc.2018.02.105 

18. Kawaai, K., Yamaguchi, T., Yamaguchi, E., Endo, S., Tada, N., Ikari, A. and Itoh, A., Photoinduced generation of acyl radicals from simple aldehydes, access to 3-acyl-4-arylcoumarin derivatives, and evaluation of their antiandrogenic activities. J. Org. Chem., 83, 1988-1996 (2018) PMID: 29327585 doi: 10.1021/acs.joc.7b02933 

19. Maruhashi, R., Akizuki, R., Sato, T., Matsunaga, T., Endo, S., Yamaguchi, M., Yamazaki, Y., Sakai, H. and Ikari, A. Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models. Biochim. Biophys. Acta, 1865, 470-479 (2017) PMID: 29247669 doi: 10.1016/j.bbamcr.2017.12.005 

20. Matsunaga, T., Kamase, K., Takasawa, H., Yamaji, Y., Endo, S., El-Kabbani, O., Ikari, A., Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1, Chem. Biol. Interact., 279, 10-20 (2017) PMID: 29108775 doi: 10.1016/j.cbi.2017.10.028 

21. Endo, S.*, Xia, S., Suyama, M., Morikawa, Y., Oguri, H., Hu, D., Ao, Y., Takahara, S., Horino, Y., Hayakawa, Y., Watanabe, Y., Gouda, H., Hara, A., Kuwata, K., Toyooka, N., Matsunaga, T. and Ikari, A., Synthesis of potent and selective inhibitors of aldo-keto reductase 1B10 and their efficacy against proliferation, metastasis and cisplatin resistance of lung cancer cells, J. Med. Chem., 60, 8441-8455 (2017) PMID: 28976752 doi: 10.1021/acs.jmedchem.7b00830 

22. Furukawa, C., Ishizuka, N., Hayashi, H., Fujii, N., Manabe, A., Tabuchi, Y., Matsunaga, T., Endo, S. and Ikari, A., Up-regulation of claudin-2 expression by aldosterone in colonic epithelial cells of mice fed with NaCl-depleted diets, Sci. Rep., 7, 12223 (2017) PMID: 28939904 doi: 10.1038/s41598-017-12494-1 

23. Matsunaga, T., Morikawa, Y., Kamase, K., Horinouchi, M., Sasajima, Y., Suenami, K., Sato, K., Takekoshi, Y., Endo, S., El-Kabbani, O. and Ikari, O., Enhancement of endothelial barrier permeability by Mitragynine, Biol. Pharm. Bull., 40, 1779-1783 (2017) PMID: 28966251 doi: 10.1248/bpb.b17-00117 

24. Manabe, A., Furukawa, C., Endo, S., Marunaka, K., Nishiyama, T., Fujii, N., Tabuchi, Y., Matsunaga, T. and Ikari, A., Chlorpheniramine increases paracellular permeability to marker fluorescein lucifer yellow mediated by internalization of occludin in murine colonic epithelial cells, Biol. Pharm. Bull., 40, 1299-1305 (2017) PMID: 28769011 doi: 10.1248/bpb.b17-00244 

25. Sonoki, H., Tanimae, A., Endo, S., Matsunaga, T., Furuta, T., Ichihara, K. and Ikari, A., Kaempherol and luteolin decrease claudin-2 expression mediated by inhibition of STAT3 in lung adenocarcinoma A549 cells, Nutrients, 9, E597 (2017) PMID: 28608828 doi: 10.3390/nu9060597 

26. Marunaka, K., Furukawa, C., Fujii, N., Kimura, T., Furuta, T., Matsunaga, T., Endo, S., Hasegawa, H., Anzai, N., Yamazaki, Y., Yamaguchi, M. and Ikari A., The RING Finger- and PDZ Domain-Containing Protein PDZRN3 Controls Localization of the Mg2+ Regulator Claudin-16 in Renal Tube Epithelial Cells., J. Biol. Chem., 292, 13034-13044 (2017) PMID: 28623232  doi: 10.1074/jbc.M117.779405 

27. Matsunaga, T., Morikawa, Y., Kamata, K., Shibata, A., Miyazono, H., Sasajima, Y., Suenami, K., Sato, K., Takekoshi, Y., Endo, S., El-Kabbani, O. and Ikari, A., α-Pyrrolidinononanophenone provokes apoptosis of neuronal cells through alterations in antioxidant properties, Toxicology, 386, 93-102 (2017) PMID: 28578026 doi: 10.1016/j.tox.2017.05.017 

28. Hara, A., Endo, S.*, Matsunaga, T., Soda, M. and El-Kabbani, O., Long-chain fatty acids inhibit human members of the aldo-keto reductase 1C subfamily, J. Biochem., 162, 371-379 (2017) PMID: 28992312 doi: 10.1093/jb/mvx041 

29. Hara, A., Endo, S.*, Matsunaga, T., El-Kabbani, O., Miura, T., Nishinaka T. and Terada, T., Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs., Biochem. Pharmacol., 138, 185-192. (2017) PMID: 28450226 doi: 10.1016/j.bcp.2017.04.023 

30. Matsunaga, T., Morikawa, Y., Tanigawa, M., Kamata, K., Shibata, A., Sasajima, Y., Suenami, K., Sato, K., Takekoshi ,Y., Endo, S., El-Kabbani, O. and Ikari, A., Structure-activity relationship for toxicity of α-pyrrolidinooctanophenone derivatives to endothelial cells, Forensic Toxicol., 35, 309-316 (2017) 

31. Hichino, A., Okamoto, M., Taga, S., Akizuki, R., Endo, S., Matsunaga, T. and Ikari, A., Down-regulation of claudin-2 expression and proliferation by epigenetic inhibitors in human lung adenocarcinoma A549 cells, J. Biol. Chem., 292, 2411-2421. (2017) PMID: 28057758 doi: 10.1074/jbc.M116.762807 

32. Endo, S.*, Takada, S., Honda, R.P., Müller, K., Weishaupt, J.H., Andersend, P.M., Ludolph, A.C., Kamatari, Y.O., Matsunaga, T., Kuwata, K., El-Kabbani, O. and Ikari, A., Instability of C154Y variant of aldo-keto reductase 1C3, Chem. Biol. Interact., 276, 194-202. (2017) PMID: 28025170 doi: 10.1016/j.cbi.2016.12.018 

33. Furukawa, C., Fujii, N., Manabe, A., Matsunaga, T., Endo, S., Hasegawa, H., Ito, Y., Yamaguchi, M., Yamazaki, Y. and Ikari, A., Up-regulation of transient receptor potential melastatin 6 channel expression by tumor necrosis factor-a in the presence of epidermal growth factor receptor tyrosine kinase inhibitor. J. Cell. Physiol., 232, 2841-2850 (2017) PMID: 27925186 doi: 10.1002/jcp.25709 

34. Kabir, A., Endo, S., Toyooka, N., Fukuoka, M., Kuwata, K. and Kamatari, Y.O., Evaluation of compound selectivity of aldo-keto reductases using differential scanning fluorimetry. J. Biochem., 161, 215-222 (2017) PMID: 28003428 doi: 10.1093/jb/mvw063 

35. Akizuki, R., Shimobaba, S., Matsunaga, T., Endo, S. and Ikari, A., Claudin-5, -7, and -18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma. Biochim. Biophys. Acta., 1864, 293-302. (2016) PMID: 27884700 doi: 10.1016/j.bbamcr.2016 

36. Fujii, N., Matsuo, Y., Matsunaga, T., Endo, S., Sakai, H., Yamaguchi, M., Yamazaki, Y., Sugatani, J. and Ikari, A., Hypotonic stress-induced down-regulation of claudin-1 and -2 mediated by dephosphorylation and clathrin-dependent endocytosis in renal tubular epithelial cells. J. Biol. Chem., 291, 24787-24799. (2016) PMID: 27733684 doi: 10.1074/jbc.M116.728196 

37. Hara, A., Endo, S.*, Matsunaga, T., Soda, M., El-Kabbani, O. and Yashiro, K., Inhibition of aldo-keto reductase family 1 member B10 by unsaturated fatty acids. Arch. Biochem. Biophys., 609, 69-76. (2016) PMID: 27665999 doi: 10.1016/j.abb.2016.09.010 

38. Matsunaga, T., Saito, H., Endo, S., Iguchi, K., Soda, M., El-Kabbani, O., Hara, A. and Ikari, A., Roles of aldo-keto reductase 1B10 and 1C3 and ATP-binding cassette transporter in docetaxel tolerance. Free Radic. Res., 50, 1296-1308. (2016) PMID: 27629782 doi: 10.1080/10715762.2016.1236373 

39. Kabir, A., Honda, R.P., Kamatari, Y.O., Endo, S., Fukuoka, M. and Kuwata, K., Effects of ligand binding on the stability of aldo-keto reductases: Implications for stabilizer or destabilizer chaperones. Protein Sci., 25, 2132-2141. (2016) PMID: 27595938  doi: 10.1002/pro.3036 

40. Matsunaga, T., Suzuki, A., Kezuka, C., Okumura, N., Iguchi, K., Inoue, I., Soda, M., Endo, S., El-Kabbani, O., Hara, A. and Ikari, A., Aldo-keto reductase 1B10 promotes development of cisplatin resistance in gastrointestinal cancer cells through down-regulating peroxisome proliferator-activated receptor-g-dependent mechanism. Chem. Biol. Interact., 256, 142-153. (2016) PMID: 27417252 doi: 10.1016/j.cbi.2016.07.008 

41. Endo, S.*, Miyagi, N., Matsunaga, T., Hara, A. and Ikari, A. Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase. Biochem. Biophys. Res. Commun., 472, 231-236. (2016) PMID: 26920053 doi: 10.1016/j.bbrc.2016.01.190 

42. Shimobaba, S., Taga, S., Akizuki, R., Endo, S., Matsunaga, T., Watanabe, R., Yamaguchi, M., Yamazaki, Y., Sugatani, J. and Ikari, A. Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 in human lung adenocarcinoma A549 cells. Biochim. Biophys. Acta., 1863, 1170-1178. (2016) PMID: 26919807 doi: 10.1016/j.bbamcr.2016.02.015. 

43. Ikari, A., Taga, S., Watanabe, R., Sato, T., Shimobaba, S., Sonoki, H., Endo, S., Matsunaga, T., Sakai, H., Yamaguchi, M., Yamazaki, Y. and Sugatani, J. Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells. Biochim. Biophys. Acta., 1848, 2326-2336. (2015) PMID: 26163137 doi: 10.1016/j.bbamem.2015.07.003 

44. Sonoki, H., Sato, T., Endo, S., Matsunaga, T., Yamaguchi, M., Yamazaki, Y., Sugatani, J and Ikari A. Quercetin decreases claudin-2 expression mediated by up-regulation of microRNA miR-16 in lung adenocarcinoma A549 cells. Nutrients, 7, 4578-4592. (2015) PMID: 26061016  doi: 10.3390/nu7064578 

45. Endo, S.*, Noda, M., Ikari, A., El-Kabbani, O., Hara A. and Matsunaga T., Characterization of hamster NAD+-dependent 3(17)β-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily. J. Biochem., 158, 425-434. (2015) PMID: 26002966 doi: 10.1093/jb/mvv057 

46. Matsunaga, T., Kezuka, C., Morikawa, Y., Suzuki, A., Endo, S., Iguchi, K., Miura, T., Nishinaka, T., Terada, T., El-kabbani, O., Hara, A. and Ikari, A., Up-regulation of carbonyl reductase 1 renders development of doxorubicin resistance in human gastrointestinal cancers. Biol. Pharm. Bull., 38, 1309-1319. (2015) PMID: 26328486 doi: 10.1248/bpb.b15-00176 

47. Hu, D., Miyagi, N., Arai, Y., Oguri, H., Miura, T. Nishinaka, T., Terada, T., Gouda, H., El-Kabbani, O., Xia, S., Toyooka, N., Hara, A., Matsunaga, T., Ikari, A. and Endo, S.*, Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1. Org. Biomol. Chem., 13, 7487-7499. (2015) PMID: 26068795 doi: 10.1039/c5ob00847f 

48. Ikari, A., Fujii, N., Hahakabe, S., Hayashi, H., Yamaguchi, M., Yamazaki, Y., Endo, S., Matsunaga, T. and Sugatani, J. Hyperosmolarity-induced down-regulation of claudin-2 mediated by decrease in PKCβ-dependent GATA-2 in MDCK cells. J. Cell. Physiol., 230, 2776-2787 (2015) PMID: 25825272 doi: 10.1002/jcp.25004 

49. Morikawa, Y., Kezuka, C., Endo, S., Ikari, A., Soda, M., Yamamura, K., Toyooka, N., El-Kabbani, O., Hara, A. and Matsunaga, T. Acquisition of doxorubicin resistance facilitates migrating and invasive potentials of gastric cancer MKN45 cells through up-regulating aldo–keto reductase 1B10, Chem. Biol. Interact., 250, 30-39. (2015) PMID: 25686905 doi: 10.1016/j.cbi.2015.02.005 

50. Endo, S.*, Matsunaga, T., Ikari, A., El-Kabbani, O., Hara, A. and Kitade, Y., Identification of a determinant for strict NADP(H)-specificity and high sensitivity to mixed-type steroid inhibitor of rabbit aldo-keto reductase 1C33 by site-directed mutagenesis, Arch. Biochem. Biophys., 569, 19-25. (2015) PMID: 25660042 doi: 10.1016/j.abb.2015.01.026 

51. Arai, Y., Endo, S.*, Miyagi, N., Abe, N., Miura, T., Nishinaka, T., Terada, T., Oyama, M., Goda, H., El-Kabbani, O., Hara, A., Matsunaga, T. and Ikari, A., Structure-activity relationships of flavonoids for carbonyl reductase 1 (CBR1) inhibition, Fitoterapia, 101, 51-56. (2015) PMID: 25549925 doi: 10.1016/j.fitote.2014.12.010 

52. Endo, S.*, Nishiyama, A., Suyama, M., Takemura, M., Soda, M., Huayue, C., Tajima, K., El-Kabbani, O., Bunai, Y., Hara, A., Matsunaga, T. and Ikari, A., Protective roles of aldo-keto reductase 1B10 and autophagy against toxicity induced by p-quinone metabolites of tert-butylhydroquinone in lung cancer A549 cells, Chem. Biol. Interact., 234, 282-289. (2015) PMID: 25289770 doi: 10.1016/j.cbi.2014.09.023 

53. Endo, S.*, Arai, Y., Matsunaga, T., Ikari, A., El-Kabbani, O., Hara, A. and Kitade, Y., AKR1C30 and AKR1C31 with site-directed mutagenesis: identifying the roles of residues 54 and 56 in the binding of substrates and inhibitors, Biol. Pharm. Bull., 37, 1848-1852. (2014) PMID: 25366490 doi: 10.1248/bpb.b14-00555 

54. Matsunaga, T., Yamaji, Y., Tomokuni, T., Morita, H., Morikawa, Y., Suzuki, A., Yonezawa, A., Endo, S., Ikari, A., Iguchi, K., El-Kabbani, O., Tajima, K. and Hara, A., Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome. Free Radic. Res., 48, 1371-1385. (2014) 

55. Endo, S.*, Hu, D., Matsunaga, T., Otsuji, Y., El-Kabbani, O., Kandeel, M., Ikari, A., Hara, A., Kitade, Y. and Toyooka, N., Synthesis of non-prenyl analogues of baccharin as selective and potent inhibitors for aldo-keto reductase 1C3. Bioorg. Med. Chem., 22, 5220-5233. (2014) PMID: 25182963 doi: 10.1016/j.bmc.2014.08.007 

56. Ikari, A., Watanabe, R., Sato, T., Taga, S., Shimobaba, S., Yamaguchi, M., Yamazaki, Y., Endo, S., Matsunaga, T and Sugatani, J., Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cells. Biochim. Biophys. Acta, 1843, 2079-2088. (2014) PMID: 24907662 doi: 10.1016/j.bbamcr.2014.05.017 

57. Matsunaga, T., Morikawa, Y., Haga, M., Endo, S., Soda, M., Yamamura K., El-Kabbani, O., Tajima, K., Ikari, A. and Hara, A., Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10. Toxicol. Appl. Pharmacol., 278, 180-189. (2014) PMID: 24813866 doi: 10.1016/j.taap.2014.04.024 

58. Matsunaga, T., Yamaguchi, A., Morikawa, Y., Kezuka, C., Takazawa, H., Endo, S., El-Kabbani, O., Tajima, K., Ikari, A. and Hara, A., Induction of aldo-keto reductases (AKR1C1 and AKR1C3) abolishes the efficacy of daunorubicin chemotherapy for leukemic U937 cells. Anticancer Drugs, 25, 868-877. (2014) PMID: 24743520 doi: 10.1097/CAD.0000000000000112 

59. Ikari, A., Tonegawa, C., Sanada, A., Kimura, T., Sakai, H., Hayashi, H., Hasegawa, H., Yamaguchi, M., Yamazaki, Y., Endo, S., Matsunaga, T. and Sugatani, J., Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells. J. Biol. Chem., 289, 13112-13123. (2014) PMID: 24659781  doi: 10.1074/jbc.M113.541193 

60. Endo, S.*, Matsunaga, T., Arai, Y., Tajima, K., El-Kabbani, O., Yamano, S., Bunai, Y., Hara, A. and Kitade, Y., Cloning and characterization of four rabbit aldo-keto reductases featuring broad substrate specificity for xenobiotic and endogenous carbonyl compounds: Their relationship with multiple forms of drug ketone reductases. Drug Metab. Dispos., 42, 803-812. (2014) PMID: 24510382 doi: 10.1124/dmd.113.056044 

61. Endo, S.*, Hu, D., Suyama, M., Matsunaga, T., Sugimoto, K., Matsuya, Y., El-Kabbani, O., Kuwata, K., Hara, A., Kitade, Y. and Toyooka, N., Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10. Bioorg. Med. Chem., 21, 6378-6384. (2013) PMID: 24071447 doi: 10.1016/j.bmc.2013.08.059 

62. Endo, S.*, Matsunaga, T., Matsumoto, A., Arai, Y., Ohno, S., El-Kabbani, O., Tajima, K., Bunai, Y., Yamano, S., Hara, A. and Kitade, Y., Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D2, and other endogenous and xenobiotic carbonyl compounds. Biochem. Pharmacol., 86, 1366-1375. (2013) PMID: 23994167 doi: 10.1016/j.bcp.2013.08.024 

63. Endo, S.*, Arai, Y., Hara, A., Kitade, Y., Bunai, Y., El-Kabbani, O. and Matsunaga T., Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenase. Biol. Pharm. Bull., 36, 1514-1518. (2013) PMID: 23995665  doi: 10.1248/bpb.b13-00342 

64. Endo, S.*, Matsunaga, T., Fujimoto, A., Kumada, S., Arai, Y., Miura, Y., Mikamo, H., El-Kabbani, O., Yamano, S., Iinuma, M. and Hara, A., Characterization of a rabbit morphine 6-dehydrogenase and its two isoforms which function as NAD+-dependent 3α(17β)-hydroxysteroid dehydrogenases. Arch. Biochem. Biophys., 529, 131-139. (2013) PMID: 23228597 doi: 10.1016/j.abb.2012.11.013 

65. Endo, S.*, Fujimoto, A., Kumada, S., Matsunaga, T., Ohno, S., Mano, J., Tajima, K., El-Kabbani, O. and Hara, A., Modulation of activity and inhibitor sensitivity of rabbit aldose reductase-like protein by oxidized glutathione and SH-reagents. Chem. Biol. Interact., 202, 146-152. (2013) PMID: 23261715 doi: 10.1016/j.cbi.2012.11.026 

66. Matsunaga, T., Hojo, A., Yamane, Y., Endo, S., El-Kabbani, O. and Hara, A., Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers. Chem. Biol. Interact., 202, 234-242 (2013) PMID: 23165153 doi: 10.1016/j.cbi.2012.09.024 

67. Soda, M., Endo, S., Matsunaga, T., Zhao, H. T., El-Kabbani, O., Iinuma, M., Yamamura, K. and Hara, A., Inhibition of human aldose reductase-like protein (AKR1B10) by α- and γ-mangostins, major components of pericarps of mangosteen. Biol. Pharm. Bull., 35, 2075-2080. (2012)

68. Endo, S.*, Matsunaga, T., Kumada, S., Fujimoto, A., Ohno, S., El-Kabbani, O., Hu, D., Toyooka, N., Mano, J., Tajima, K. and Hara, A., Characterization of rabbit aldose reductase-like protein with 3β-hydroxysteroid dehydrogenase activity. Arch. Biochem. Biophys., 527, 23-30. (2012)

69. Matsunaga, T., Hosogai, M., Arakaki, M., Endo, S., El-Kabbani, O. and Hara, A., 9,10-Phenanthrenequinone induces monocytic differentiation of U937 cells through regulating expression of aldo-keto reductase 1C3. Biol. Pharm. Bull., 35, 1598-1602. (2012)

70. Matsunaga, T., Endo, S., Takemura, M., Soda, M., Yamamura, K., Tajima, K., Miura, T., Terada, T., El-Kabbani, O. and Hara, A., Reduction of cytotoxic p-quinone metabolites of tert-butylhydroquinone by human aldo-keto reductase (AKR) 1B10. Drug Metab. Pharmacokinet., 27, 553-558. (2012)

71. Osman, W., Endo, S., Oh-Hashi, K., Kitamura, Y. and Kitade, Y., Molecular characterization and mutational analysis of recombinant diadenosine 5',5''-P(1),P(4)-tetraphosphate hydrolase from Plasmodium falciparum. Biol. Pharm. Bull., 35, 1191-1196. (2012)

72. Endo, S.*, Matsunaga, T., Kanamori, A., Otsuji, Y., Nagai, H., Sundaram, K., El-Kabbani, O., Toyooka, N., Ohta, S. and Hara, A., Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis. J. Nat. Prod., 75, 716-721. (2012)

73. Sundaram, K., Endo, S., Matsunaga, T., Tanaka, N., Hara, A. and El-Kabbani, O., Structure of the His269Arg mutant of the rat aldose reductase-like protein AKR1B14 complexed with NADPH. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 68, 400-403. (2012)

74. Matsunaga, T., Haga, M., Watanabe, G., Shinoda, Y., Endo, S., Kajiwara, Y., Tanaka, H., Inagaki, N., El-Kabbani, O. and Hara, A., 9,10-Phenanthrenequinone promotes secretion of pulmonary aldo-keto reductases with surfactant. Cell Tissue Res., 347, 407-417. (2012)

75. Soda, M., Hu, D., Endo, S., Takemura, M., Li, J., Wada, R., Ifuku, S., Zhao, H. T., El-Kabbani, O., Ohta, S., Yamamura, K., Toyooka, N., Hara, A. and Matsunaga, T., Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10. Eur. J. Med. Chem., 48, 321-329. (2012)

76. Minehira, D., Takeda, D., Urata, H., Kato, A., Adachi, I., Wang, X., Matsuya, Y., Sugimoto, K., Takemura, M., Endo, S., Matsunaga, T., Hara, A., Koseki, J., Narukawa, K., Hirono, S. and Toyooka, N., Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1. Bioorg. Med. Chem., 20, 356-367. (2012)

77. Matsunaga, T., Shinoda, Y., Inoue, Y., Shimizu, Y., Haga, M., Endo, S., El-Kabbani, O. and Hara, A., Aldo-keto reductase 1C15 as a quinone reductase in rat endothelial cell: its involvement in redox cycling of 9,10-phenanthrenequinone. Free Radic. Res., 45, 848-857. (2011)

78. Endo, S.*, Matsunaga, T., Fujita, A., Kuragano, T., Soda, M., Sundaram, K., Dhagat, U., Tajima, K., El-Kabbani, O. and Hara, A., Activation of aldo-keto reductase family member 1B14 (AKR1B14) by bile acids: Activation mechanism and bile acid-binding site. Biochimie, 93, 1476-1486. (2011)

79. Takemura, M., Endo, S.*, Matsunaga, T., Soda, M., Zhao, H. T., El-Kabbani, O., Tajima, K., Iinuma, M. and Hara, A., Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid. J. Nat. Prod., 74, 1201-1206. (2011)

80. El-Kabbani, O., Dhagat, U., Soda, M., Endo, S., Matsunaga, T. and Hara, A., Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis. Bioorg. Med. Chem. Lett., 21, 2564-2567. (2011)

81. Matsunaga, T., Yamane, Y., Iida, K., Endo, S., Banno, Y., El-Kabbani, O. and Hara, A., Involvement of the aldo-keto reductase, AKR1B10, in mitomycin-c resistance through reactive oxygen species-dependent mechanisms. Anticancer Drugs, 22, 402-408. (2011)

82. Matsunaga, T., Shinoda, Y., Inoue, Y., Endo, S., El-Kabbani, O. and Hara, A., Protective effect of rat aldo-keto reductase (AKR1C15) on endothelial cell damage elicited by 4-hydroxy-2-nonenal. Chem. Biol. Interact., 191, 364-370. (2011)

83. Endo, S.*, Matsunaga, T., Ohta, C., Soda, M., Kanamori, A., Kitade, Y., Ohno, S., Tajima, K., El-Kabbani, O. and Hara, A., Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. Chem. Biol. Interact., 191, 261-268. (2011)

84. Sundaram, K.#, Dhagat, U.#, Endo, S.# (#Equal first author contribution), Chung, R., Matsunaga, T., Hara, A. and El-Kabbani, O., Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis. Bioorg. Med. Chem. Lett., 21, 801-804. (2011)

85. Endo, S.*, Matsunaga, T., Fujita, A., Tajima, K., El-Kabbani, O. and Hara, A., Rat aldose reductase-like protein (AKR1B14) efficiently reduces the lipid peroxidation product 4-oxo-2-nonenal. Biol. Pharm. Bull., 33, 1886-1890. (2010)

86. El-Kabbani, O., Scammells, P. J., Day, T., Dhagat, U., Endo, S., Matsunaga, T., Soda, M. and Hara, A., Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors. Eur. J. Med. Chem., 45, 5309-5317. (2010)

87. Endo, S.*, Matsunaga, T., Kuragano, T., Ohno, S., Kitade, Y., Tajima, K., El-Kabbani, O. and Hara, A., Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10). Arch. Biochem. Biophys., 503, 230-237. (2010)

88. Dhagat, U.#, Endo, S.# (#Equal first author contribution), Soda, M., Hara, A. and El-Kabbani, O., Factorizing the role of a critical leucine residue in the binding of substrate to human 20α-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme. Bioorg. Med. Chem. Lett., 20, 5274-5276. (2010)

89. Asada, Y., Kuroishi, C., Ukita, Y., Sumii, R., Endo, S., Matsunaga, T., Hara, A. and Kunishima, N., Dimeric crystal structure of rabbit L-gulonate 3-dehydrogenase/lambda-crystallin: insights into the catalytic mechanism. J. Mol. Biol., 401, 906-920. (2010)

90. Zhao, H. T., Soda, M., Endo, S., Hara, A. and El-Kabbani, O., Selectivity determinants of inhibitor binding to the tumour marker human aldose reductase-like protein (AKR1B10) discovered from molecular docking and database screening. Eur. J. Med. Chem., 45, 4354-4357. (2010)

91. Endo, S.*, Matsunaga, T., Soda, M., Tajima, K., Zhao, H. T., El-Kabbani, O. and Hara, A., Selective inhibition of the tumor marker AKR1B10 by antiinflammatory N-phenylanthranilic acids and glycyrrhetic acid. Biol. Pharm. Bull., 33, 886-890. (2010)

92. Endo, S.*, Matsunaga, T., Kuwata, K., Zhao, H. T., El-Kabbani, O., Kitade, Y. and Hara, A., Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. Bioorg. Med. Chem., 18, 2485-2490. (2010)

93. Matsunaga, T., Arakaki, M., Kamiya, T., Haga, M., Endo, S., El-Kabbani, O. and Hara, A., Nitric oxide mitigates apoptosis in human endothelial cells induced by 9,10-phenanthrenequinone: role of proteasomal function. Toxicology, 268, 191-197. (2010)

94. Dhagat, U.#, Endo, S.# (#Equal first author contribution), Mamiya, H., Hara, A. and El-Kabbani, O., Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)α-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme. Acta Crystallogr. D Biol. Crystallogr., 66, 198-204. (2010)

95. Matsunaga, T., Endo, S., Soda, M., Zhao, H. T., El-Kabbani, O., Tajima, K. and Hara, A., Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis. Biochem. Biophys. Res. Commun., 389, 128-132. (2009)

96. Endo, S.*, Matsunaga, T., Mamiya, H., Ohta, C., Soda, M., Kitade, Y., Tajima, K., Zhao, H. T., El-Kabbani, O. and Hara, A., Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids. Arch. Biochem. Biophys., 487, 1-9. (2009)

97. Matsunaga, T., Arakaki, M., Kamiya, T., Endo, S., El-Kabbani, O. and Hara, A., Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells. Chem. Biol. Interact., 181, 52-60. (2009)

98. El-Kabbani, O., Scammells, P. J., Gosling, J., Dhagat, U., Endo, S., Matsunaga, T., Soda, M. and Hara, A., Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20α-hydroxysteroid dehydrogenase (AKR1C1). J. Med. Chem., 52, 3259-3264. (2009)

99. Zhao, H. T.#, Endo, S.# (#Equal first author contribution), Ishikura, S., Chung, R., Hogg, P. J., Hara, A. and El-Kabbani, O., Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductase. Cell. Mol. Life Sci., 66, 1570-1579. (2009)

100. Chung, R., Endo, S., Hara, A. and El-Kabbani, O., Crystallization and preliminary X-ray analysis of a rat aldose reductase-like protein (AKR1B14). Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 65, 395-397. (2009)

101. Dhagat, U.#, Endo, S.# (#Equal first author contribution), Mamiya, H., Hara, A. and El-Kabbani, O., Structure of the G225P/G226P mutant of mouse 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate. Acta Crystallogr. D Biol. Crystallogr., 65, 257-265. (2009)

102. Asada, Y.#, Endo, S.# (#Equal first author contribution), Inoue, Y., Mamiya, H., Hara, A., Kunishima, N. and Matsunaga, T., Biochemical and structural characterization of a short-chain dehydrogenase/reductase of Thermus thermophilus HB8: a hyperthermostable aldose-1-dehydrogenase with broad substrate specificity. Chem. Biol. Interact., 178, 117-126. (2009)

103. Endo, S.*, Matsunaga, T., Mamiya, H., Hara, A., Kitade, Y., Tajima, K. and El-Kabbani, O., Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress. Chem. Biol. Interact., 178, 151-157. (2009)

104. Carbone, V., Zhao, H. T., Chung, R., Endo, S., Hara, A. and El-Kabbani, O., Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase. Bioorg. Med. Chem., 17, 1244-1250. (2009)

105. Endo, S.* Maeda, S., Matsunaga, T., Dhagat, U., El-Kabbani, O., Tanaka, N., Nakamura, K. T., Tajima, K. and Hara, A., Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4). Arch. Biochem. Biophys., 481, 183-190. (2009)

106. Endo, S.*, Matsunaga, T., Kitade, Y., Ohno, S., Tajima, K., El-Kabbani, O. and Hara, A., Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase. Biochem. Biophys. Res. Commun., 377, 1326-1330. (2008)

107. Carbone, V., Chung, R., Endo, S., Hara, A. and El-Kabbani, O., Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20α-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity. Arch. Biochem. Biophys., 479, 82-87. (2008)

108. Matsunaga, T., Endo, S., Maeda, S., Ishikura, S., Tajima, K., Tanaka, N., Nakamura, K. T., Imamura, Y. and Hara, A., Characterization of human DHRS4: an inducible short-chain dehydrogenase/reductase enzyme with 3β-hydroxysteroid dehydrogenase activity. Arch. Biochem. Biophys., 477, 339-347. (2008)

109. Dhagat, U.#, Endo, S.# (#Equal first author contribution), Sumii, R., Hara, A. and El-Kabbani, O., Selectivity determinants of inhibitor binding to human 20α-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid. J. Med. Chem., 51, 4844-4848. (2008)

110. Asada, Y., Kuroishi, C., Ukita, Y., Sumii, R., Endo, S., Matsunaga, T., Hara, A. and Kunishima, N., Crystallization and preliminary X-ray crystallographic analysis of rabbit L-gulonate 3-dehydrogenase. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 64, 228-230. (2008)

111. Carbone, V., Endo, S., Sumii, R., Chung, R. P., Matsunaga, T., Hara, A. and El-Kabbani, O., Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-directed mutagenesis. Proteins, 70, 176-187. (2008)

112. Dhagat, U., Endo, S., Hara, A. and El-Kabbani, O., Inhibition of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors. Bioorg. Med. Chem., 16, 3245-3254. (2008)

113. Dhagat, U., Carbone, V., Chung, R. P., Schulze-Briese, C., Endo, S., Hara, A. and El-Kabbani, O., Structure of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 63, 825-830. (2007)

114. Endo, S.*, Sanai, M., Horie, K., Matsunaga, T., Ishikura, S., Tajima, K., El-Kabbani, O. and Hara, A., Characterization of rat and mouse NAD+-dependent 3α/17β/20α-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis. Arch. Biochem. Biophys., 467, 76-86. (2007)

115. Endo, S., Matsunaga, T., Nagano, M., Abe, H., Ishikura, S., Imamura, Y. and Hara, A., Characterization of an oligomeric carbonyl reductase of dog liver: its identity with peroxisomal tetrameric carbonyl reductase. Biol. Pharm. Bull., 30, 1787-1791. (2007)

116. Endo, S., Matsunaga, T., Horie, K., Tajima, K., Bunai, Y., Carbone, V., El-Kabbani, O. and Hara, A., Enzymatic characteristics of an aldo-keto reductase family protein (AKR1C15) and its localization in rat tissues. Arch. Biochem. Biophys., 465, 136-147. (2007)

117. Sanai, M., Endo, S., Matsunaga, T., Ishikura, S., Tajima, K., El-Kabbani, O. and Hara, A., Rat NAD+-dependent 3α-hydroxysteroid dehydrogenase (AKR1C17): a member of the aldo-keto reductase family highly expressed in kidney cytosol. Arch. Biochem. Biophys., 464, 122-129. (2007)

118. Dhagat, U., Carbone, V., Chung, R. P., Matsunaga, T., Endo, S., Hara, A. and El-Kabbani, O., A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20α-hydroxysteroid dehydrogenase. Med. Chem., 3, 546-550. (2007)

119. Endo, S., Matsumoto, K., Matsunaga, T., Ishikura, S., Tajima, K., El-Kabbani, O. and Hara, A., Substrate specificity of a mouse aldo-keto reductase (AKR1C12). Biol. Pharm. Bull., 29, 2488-2492. (2006)

120. Matsumoto, K., Endo, S., Ishikura, S., Matsunaga, T., Tajima, K., El-Kabbani, O. and Hara, A., Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family. Biol. Pharm. Bull., 29, 539-542. (2006)

【Review articles and book chapters】

1. Matsunaga, T., Wada, Y., Endo, S., Soda, M., El-Kabbani, O. and Hara, A., Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers. Front. Pharmacol., 3, 5. (2012)

2. Endo, S., Matsunaga, T., Kazuo Tajima, Hara, A., (分担執筆) : Conversion of AKR1C20 into an AKR1C6-type enzyme by site-directed mutagenesis. Enzymology and Molecular Biology of Carbonyl Metabolism 13 (H. Weiner, B. Plapp, R. Lindahl, and E. Maser, eds.), pp. 273-280, Purdue University Press, 2007年

3. Ishikura, S., Matsunaga, T., Endo, S., Matsumoto, K., Usami, N., El-Kabbani, O. and Hara, A., (分担執筆) : Characterization of Guinea Pig Liver D-Xylulose Reductase of the Uronate Pathway: Identity with Sorbitol Dehydrogenase. Enzymology and Molecular Biology of Carbonyl Metabolism 13 (H. Weiner, B. Plapp, R. Lindahl, and E. Maser, eds.), pp. 296-304, Purdue University Press, 2007年

【Patents】

1. 特願2019-54702、新規オートファジー阻害剤としてのAtg4B阻害剤、遠藤智史、松永俊之 、五十里彰 、鎌足雄司、田中義正、2019.03.22 [特開2020-152696、2020.09.24]

2. 特願2018-055182、AKR1C3選択的阻害剤及びその用途、遠藤智史、松永俊之、五十里彰、豊岡尚樹、藤本直浩、2018.03.22 [特開2019-167302、2019.10.03、特許第7178075号、2022.11.16]

3. 特願2016-159316、2-オキソ-2H-クロメン-3-カルボン酸アミド誘導体、遠藤智史、松永俊之、五十里彰、豊岡尚樹、早川芳弘、2016.08.15 [特開2018-027897、2018.02.22]

4. 特願2013-149089、AKR1C3阻害剤、遠藤智史、松永俊之、豊岡尚樹、2013.07.18 [特開2015-020966、2015.02.02]