researchmap:  https://researchmap.jp/7000014400

Original article

* Equally contributed first author, † Corresponding author

1. Nagase N, Kousaki H, Ogawa B, Horii K, Morimoto IN, Abe C, Ogawa T, Nin F. Two-tone suppression between the ultrasounds above and within the hearing range in mice. Exp Physiol. 2025 Feb 23.

2. Okamura Y, Gochi K, Ishikawa T, Hayashi T, Fuseya S, Suzuki R, Kanai M, Inoue Y, Murakami Y, Sadaki S, Jeon H, Hayama M, Ishii H, Tsunakawa Y, Ochi H, Sato S, Hamada M, Abe C, Morita H, Okada R, Shiba D, Muratani M, Shinohara M, Akiyama T, Kudo T, Takahashi S. Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel. Sci Rep. 2024 Nov 20;14(1):28774.

3. Bazek M, Sawa M, Horii K, Nakamura N, Iwami S, Wu CH, Inoue T, Nin F, Abe C†. Gravitational change-induced alteration of the vestibular function and gene expression in the vestibular ganglion of mice. J Physiol Sci. 2024 Sep 18;74(1):44.

4. Horii K, Ogawa B, Nagase N, Morimoto I, Abe C, Ogawa T, Choi S, Nin F. The cochlear hook region detects harmonics beyond the canonical hearing range. PNAS Nexus. 2024 Jul 12;3(7):pgae280.

5. Heishima K, Sugito N, Abe C, Hirata A, Sakai H, Akao Y. Targeting microRNA-145-mediated progressive phenotypes of early bladder cancer in a molecularly defined in vivo model. Molecular Therapy Nucleic Acids. 2023 Jul 3:33:960-982.

6. Abe C†, Katayama C, Bazek M, Ohbayashi K, Horii K, Tanida M, Nin F, Iwasaki Y. Hepatic glycogenolysis and hypometabolism induced by chemogenetic stimulation of C1 neurons. J Physiol. 2023 Jun;601(12):2293-2306.

7. Hayashi T, Fujita R, Okada R, Hamada M, Suzuki R, Fuseya S, Leckey J, Kanai M, Inoue Y, Sadaki S, Nakamura A, Okamura Y, Abe C, Morita H, Aiba T, Senkoji T, Shimomura M, Okada M, Kamimura D, Yumoto A, Muratani M, Kudo T, Shiba D, Takahashi S. Lunar gravity prevents skeletal muscle atrophy but not myofiber type shift in mice. Commun Biol. 2023 Apr 21;6(1):424. 

8. Abe C†, Katayama C, Bazek M, Nakamura Y, Ohbayashi K, Horii K, Fujimoto C, Tanida M, Iwasaki Y, Inoue T, Nin F, Morita H. Repeated activation of C1 neurons in medulla oblongata decreases anti-inflammatory effect via the hypofunction of the adrenal gland adrenergic response. Brain Behav Immun. 2023 Apr 8;111:138-150.

9. Abe C†, Katayama C, Ohbayashi K, Horii K, Ogawa B, Fujimoto C, Iwasaki Y, Nin F, Morita H. Galvanic vestibular stimulation-induced activation of C1 neurons in medulla oblongata protects against acute lung injury. Am J Physiol Regul Integr Comp Physiol. 2023 Feb 1;324(2):R152-R160.

10. Abe C†, Katayama C, Horii K, Okada R, Kamimura D, Nin F, Morita H. Changes in metabolism and vestibular function depend on gravitational load in mice. J Appl Physiol. 2023 Jan 1;134(1):10-17. 

11. Abe C†, Katayama C, Horii K, Ogawa B, Ohbayashi K, Iwasaki Y, Nin F, Morita H. Hypergravity load-induced hyperglycemia occurs due to hypothermia and increased plasma corticosterone level in mice. J Physiol Sci. 2022 Aug 1;72(1):18.

12. Tanaka S, Abe C, Abbott SBG, Zheng S, Yamaoka Y, Lipsey JE, Skrypnyk NI, Yao J, Inoue T, Nash WT, Stornetta DS, Rosin DL, Stornetta RL, Guyenet PG, and Okusa MD. Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2021758118.

13. Aoki H, Abe C, Hara A, Miyazaki T, Morita H, Kunisada T. Induced genetic ablation of Rest leads to the alteration of stimulus-induced response of the vagal nerve. Genes Cells. 2021 Feb;26(2):45-55.

14. Abe C*†, Yamaoka Y*, Maejima Y, Mikami T, Yokota S, Yamanaka A, Morita H†. VGLUT2-expressing Neurons in the Vestibular Nuclear Complex Mediate Gravitational Stress-Induced Hypothermia in Mice. Commun Biol. 2020 May 8;3(1):227.​

15. Abe C†, Yamaoka Y, Maejima Y, Mikami T, Morita H. Hypergravity-induced plastic alteration of the vestibulo-sympathetic reflex involves decrease in responsiveness of CAMK2-expressing neurons in the vestibular nuclear complex. J Physiol Sci. 2019 Nov;69(6):903-917.

16. Sugiyama K, Nagashima K, Miwa T, Shimizu Y, Kawaguchi T, Iida K, Tamaoki N, Hatakeyama D, Aoki H, Abe C, Morita H, Kunisada T, Shibata T, Fukumitsu H, Tezuka KI. FGF2-responsive genes in human dental pulp cells assessed using a rat spinal cord injury model. J Bone Miner Metab. 2019 May;37(3):467-474

17. Inoue T, Abe C, Kohro T, Tanaka S, Huang L, Yao J, Zheng S, Ye H, Inagi R, Stornetta RL, Rosin DL, Nangaku M, Wada Y, Okusa MD. Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/ reperfusion injury in the kidney. Kidney Int. 2019 Mar;95(3):563-576.

18. Sonoda S, Yoshimura M, Abe C, Morita H, Ueno H, Motojima Y, Saito R, Maruyama T, Hashimoto H, Tanaka Y, Ueta Y. Effects of hypergravity on the gene expression of the hypothalamic feeding-related neuropeptides in mice via vestibular inputs. Peptides. 2018 Jul;105:14-20.

19. Yamaoka Y, Abe C†, Morita H. Comparison among ultrasonic, electrical apparatus, and toxic chemicals for vestibular lesion in mice. J Neurosci Methods. 2017 Dec 2;295:58-67.

20. Abe C*, Inoue T*, Inglis MA, Viar KE, Huang L, Ye H, Rosin DL, Stornetta RL, Okusa MD, Guyenet PG. C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. Nat Neurosci. 2017 May;20(5):700-707.

21. Wenker IC, Abe C, Viar KE, Stornetta SL, Stornetta RL, Guyenet PG. Blood pressure regulation by the rostral ventrolateral medulla in conscious rats: effects of hypoxia, hypercapnia, baroreceptor denervation and anesthesia. J Neurosci. 2017 Apr 26;37(17):4565-4583.

22. Morita H, Abe C, Tanaka K. Long-term exposure to microgravity impairs vestibulo-cardiovascular reflex. Sci Rep. 2016 Sep 16;6:33405.

23. Shi Y, Abe C, Holloway BB, Shu S, Kumar NN, Weaver JL, Sen J, Perez-Reyes E, Stornetta RL, Guyenet PG, Bayliss DA. Nalcn is a "leak" sodium channel that regulates excitability of brainstem chemosensory neurons and breathing. J Neurosci. 2016 Aug 3;36(31):8174-87.

24. Basting TM, Abe C, Viar KE, Stornetta RL, Guyenet PG. Is plasticity within the retrotrapezoid nucleus responsible for the recovery of the PCO2 set-point after carotid body denervation in rats? J Physiol. 2016 Jun 15;594(12):3371-90.

25. Inoue T*, Abe C*, Sung SJ, Moscalu S, Jankowski J, Huang L, Ye H, Rosin DL, Guyenet PG, Okusa MD. Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes. J Clin Invest. 2016 May 2;126(5):1939-52.

26. Morita H, Obata K, Abe C, Shiba D, Shirakawa M, Kudo T, Takahashi S. Feasibility of a Short-Arm Centrifuge for Mouse Hypergravity Experiments. PLoS One. 2015 Jul 29;10(7):e0133981.

27. Abe C, Nagai Y, Yamaguchi A, Aoki H, Shimizu S, Akiyama T, Kawada T, Sugimachi M, Morita H. Reduced carotid baroreceptor distensibility-induced baroreflex resetting contributes to impairment of sodium regulation in rats fed a high-fat diet. Am J Physiol Heart Circ Physiol. 2015 Apr 15;308(8):H942-50.

28. Iwata C, Abe C, Nakamura M, Morita H. Hypergravity exposure for 14 days increases the effects of propofol in rats. Anesth Analg. 2014 Jan;118(1):125-31.

29. Abe C, Morita H. Drinking-induced bradyarrhythmias and cerebral injury in Dahl salt sensitive rats with sinoaortic denervation. J Appl Physiol. 2013 Nov;115(10):1533-9.

30. Abe C, Ueta Y, Morita H. Exposure to hypergravity during the preweaning but not postweaning period reduces vestibular-related stress responses in rats. J Appl Physiol. 2013 Oct 1;115(7):1082-7.

31. Tanaka K, Nishimura N, Sato M, Kanikowska D, Shimizu Y, Inukai Y, Abe C, Iwata C, Morita H, Iwase S, Sugenoya J. Arterial pressure oscillation and muscle sympathetic nerve activity after 20 days of head-down bed rest. Auton Neurosci. 2013 Oct;177(2):266-70.

32. Abe C, Iwata C, Morita H. Water drinking-related muscle contraction induces the pressor response via mechanoreceptors in conscious rats. J Appl Physiol. 2013 Jan;114(1):28-36.

33. Abe C, Tsuru Y, Iwata C, Ogihara R, Morita H. Intravenous infusion of hyperosmotic NaCl solution induces acute cor pulmonale in anesthetized rats. J Physiol Sci. 2013 Jan;63(1):55-62.

34. Cuong NT, Abe C, Binh NH, Hara A, Morita H, Ogura S. Sivelestat improves outcome of crush injury by inhibiting high-mobility group box 1 in rats. Shock. 2013 Jan;39(1):89-95.

35. Tanaka K, Abe C, Sakaida Y, Aoki M, Iwata C, Morita H. Subsensory galvanic vestibular stimulation augments arterial pressure control upon head-up tilt in human subjects. Auton Neurosci. 2012 Jan 26;166(1-2):66-71.

36. Abe C, Kawada T, Sugimachi M, Morita H. Interaction between vestibulo-cardiovascular reflex and arterial baroreflex during postural change in rats. J Appl Physiol. 2011 Dec;111(6):1614-21.

37. Abe C, Iwata C, Shiina T, Shimizu Y, Morita H. Effect of daily linear acceleration training on the hypergravity-induced vomiting response in house musk shrew (Suncus murinus). Neurosci Lett. 2011. Sep 20;502(3):138-42.

38. Matsuo O, Takahashi Y, Abe C, Tanaka K, Nakashima A, Morita H. Trial of integrated laboratory practice. Adv Physiol Educ. 2011 Jun;35(2):237-40.

39. Iwata C, Abe C, Tanaka K, Morita H. Role of the vestibular system in the arterial pressure response to parabolic-flight-induced gravitational changes in human subjects. Neurosci Lett. 2011 May 16;495(2):121-5.

40. Abe C, Tanaka K, Iwata C, Morita H. Vestibular-mediated increase in central serotonin plays an important role in hypergravity-induced hypophagia in rats. J Appl Physiol. 2010 Dec;109(6):1635-43.

41. Abe C, Shibata A, Iwata C, Morita H. Restriction of rear-up-behavior-induced attenuation of vestibulo-cardiovascular reflex in rats. Neurosci Lett. 2010 Oct 22;484(1):1-5.

42. Tanaka K, Tohnan M, Abe C, Iwata C, Yamagata K, Tanaka M, Tanaka N, Morita H. Development and evaluation of gas-pressurized elastic sleeves for extravehicular activity. Aviat Space Environ Med. 2010 Jul;81(7):671-6.

43. Tanaka K, Abe C, Iwata C, Yamagata K, Murakami N, Tanaka M, Tanaka N, Morita H. Mobility of a gas-pressurized elastic glove for extravehicular activity. Acta Astronautica. 2010 Apr-May;66(7-8):1039-1043.

44. Abe C, Tanaka K, Awazu C, Morita H. Galvanic vestibular stimulation counteracts hypergravity-induced plastic alteration of vestibulo-cardiovascular reflex in rats. J Appl Physiol. 2009 Oct;107(4):1089-94.

45. Tanaka K, Abe C, Awazu C, Morita H. Vestibular system plays a significant role in arterial pressure control during head-up tilt in young subjects. Auton Neurosci. 2009 Jun 15;148(1-2):90-6.

46. Abe C, Tashiro T, Tanaka K, Ogihara R, Morita H. A novel type of implantable and programmable infusion pump for small laboratory animals. J Pharmacol Toxicol Methods. 2009 Jan-Feb;59(1):7-12.  

47. Abe C, Tanaka K, Morita H. The vestibular system is integral in regulating plastic alterations in the pressor response to free drop mediated by the nonvestibular system. Neurosci Lett. 2008 Nov 14;445(2):149-52.

48. Abe C, Tanaka K, Awazu C, Morita H. Impairment of vestibular-mediated cardiovascular response and motor coordination in rats born and reared under hypergravity. Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R173-80.

49. Abe C, Tanaka K, Awazu C, Morita H. Strong galvanic vestibular stimulation obscures arterial pressure response to gravitational change in conscious rats. J Appl Physiol. 2008 Jan;104(1):34-40.

50. Morita H, Abe C, Awazu C, Tanaka K. Long-term hypergravity induces plastic alterations in vestibulo-cardiovascular reflex in conscious rats. Neurosci Lett. 2007 Feb 2;412(3):201-5.

51. Abe C, Tanaka K, Awazu C, Chen H, Morita H. Plastic alteration of vestibulo-cardiovascular reflex induced by 2 weeks of 3-G load in conscious rats. Exp Brain Res. 2007 Aug;181(4):639-46.

52. Morita H, Abe C, Tanaka K, Shiratori M, Oguri M, Shiga T. Neuromuscular electrical stimulation and ottoman-type seat effectively improve popliteal venous flow in sitting position. J Physiol Sci. 2006 Apr;56(2):183-6.

Review

1. Morita H, Kaji H, Ueta Y, Abe C. Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment. J Physiol Sci. 2020 Mar 14;70(1):17

2. Abe C†, Inoue T. Role of C1 neurons in anti-inflammatory reflex: Mediation between afferents and efferents. Neurosci Res. 2018 Nov;136:6-12.

3. Morita H, Abe C. Negative feedforward control of body fluid homeostasis by hepatorenal reflex. Hypertens Res. 2011 Aug;34(8):895-905

Book

1. Uni R, Abe C, Inagi R, and Inoue T. Role of the Nervous System in Acute Kidney Injury. Acute Kidney Injury and Regenerative Medicine. 2020 Chapter 21:297-316

​

国内総説

1. 安部力：神経系と内分泌系が制御する抗炎症機能，実験医学，41巻20号，3372-3377，2023

2. 安部力：前庭－血圧反射に注目した重力環境への適応戦略，Precision Medicine，4巻9号，863-868, 2021年

3. 安部力，森田啓之：前庭系を介する動脈血圧調節，自律神経，58巻1号，95-100，2021年

4. 安部力，井上剛，Patrice G. Guyenet：急性ストレスによる腎虚血再灌流障害の軽減効果には延髄C1ニューロンが関与する，実験医学，35巻13号，2262-2265，2017

5. 安部力，森田啓之：動脈血圧調節に対する前庭系の関与：前庭系の可塑性と起立性低血圧，循環制御，36巻2号，69-75，2015

6. 森田啓之，安部力：宇宙から帰還後の起立性低血圧－前庭系の関与，医学のあゆみ，243巻5号，425-431，2012

7. 森田啓之，安部力，田中邦彦：起立時の血圧調節における前庭－交感神経反射と圧受容器反射の役割，自律神経，49巻3号，169-172，2012年

8. 安部力，岩田ちひろ，森田啓之：前庭電気刺激による前庭入力遮断と前庭系の可塑的変化防止，自律神経，49巻3号，173-175，2012年

9. 安部力，田中邦彦，森田啓之：下肢静脈血行動態の特性から見た深部静脈血栓症，血栓止血誌，19: 495-500, 2008年

国内著書

1. 佐久間康夫，鯉淵典之，安部力ら：生理学用語ハンドブック，2024

2. 安部力：神経・内分泌系による免疫/炎症制御，集中治療医学，178-180，2023

3. 松尾　理，安部力，森田啓之，他4名：基礎統合実習－次世代のPhysician Scientistsが育つ場－，39-40, 2012

4. 岡田隆夫, 安部力，森田啓之，他9名：心臓・循環の生理学, メディカル・サイエンス・インターナショナル，317-353, 2011

5. 松尾 理, 安部力，森田啓之，他11名：カラー図解　症状の基礎からわかる病態生理　第二版, メディカル・サイエンス・インターナショナル，190-259, 2011

Awards

1. 学会賞, 第72回日本自律神経学会, 2019
   Society Award, Japan Society of Neurovegetative Research

2. 優秀論文賞, 第60回日本宇宙航空環境医学会, 2014
   The Best Article Award, Japan Society of Aerospace and Environmental Medicine

3. 平成23年度 入澤宏・彩記念若手研究奨励賞 [心臓・循環分野], 第89回日本生理学会, 2012
   Hiroshi and Aya Irisawa Memorial Promotion Award for Young Physiologists, Physiological Society of Japan

4. 奨励賞, 第12回Neurocardiology workshop, 2011
   Encouragement award, The 12th Neurocardiology workshop

5. 優秀賞, 第11回Neurocardiology workshop, 2010
   Award of excellence, The 11th Neurocardiology workshop

6. Poster presentation award, 30th International Society for Gravitational Physiology, 2009
   Poster Presentation Award, 30th Annual International Gravitational Physiology Meeting

7. 奨励賞, 第18回日本病態生理学会, 2008
   Young Scientist Presentation Award, Japanese Society of Pathophysiology

researchmap:  https://researchmap.jp/7000014400

Original article

researchmap:  https://https://researchmap.jp/7000006023

Original article

1. Takeda Y, Sato K,  Hosoki Y, Tachibanaki S, Koike C, Amano A. Mathematical analysis of phototransduction reaction parameters in rods and cones. Sci. Rep.12:19529, 2022 

2. Takeda Y., Matsuoka S. Impact of mitochondria on local calcium release in murine sinoatrial nodal cells. JMCC.164:42-56, 2022 

3. Takeda Y., Theoretical investigations into the quantitative mechanisms underlying the regulation of [cAMP]i, membrane excitability and [Ca2+]i during GLP-1 stimulation in pancreatic b cells. Yakugaku-Zasshi,136(3):467-471, 2016 

4. Takeda Y., Shimayoshi T, Holz GG, Noma A. Modeling analysis of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ mobilization under the control of glucagon-like peptide-1 in mouse pancreatic beta cells. Am. J. Physiol. Cell Physiol. Epub,2015, 310(5):C337-347, 2016 

5. Hosoki Y., Koike C., Takeda Y., Amano A.  杆体・錐体視細胞光応答機構初期過程モデルによる視物質－トランスデューシン間シグナル増幅現象の再現 (Simulation analysis of Light-dependent Phototransduction in Rod and Cone Photoreceptors)  Advanced Biomedical Engineering   52(3):145-155, 2014. 

6. Takeda Y., Nystoriak M.A., Nieves-Cintrón M., Luis Santana L.F. and Navedo M.F. Relationship between Ca2+ Sparklets and Sarcoplasmic Reticulum Ca2+ Load and Release in Rat Cerebral Arterial Smooth Muscle. Am J Physiol Heart Circ Physiol. 301(6):H2285-94, 2011. 

7.  Takeda Y., Amano A., Noma A., Nakamura Y., Fujimoto S. and Inagaki N. Systems Analysis of GLP-1 Receptor Signaling in Pancreatic b-cells. Am J Physiol Cell Physiol. 301(4):C792-803, 2011. 

8. Navedo M.F., Takeda Y., Nieves-Cintrón M., Molkentin J.D. and Santana L.F. Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells. Am J Physiol Cell Physiology 298(2):C211-220, 2010 

9. Takeda Y., Koh S.D., Sanders K.M. and Ward S.M. Differential expression of ionic conductances in interstitial cells of Cajal in the murine gastric antrum. J Physiol. 586(3):859-873, 2008 

10. Beckett E.A.H., Takeda Y., Yanase H., Sanders K.M. and Ward S.M.  Synaptic specializations exist between enteric motor nerves and interstitial cells of Cajal in the murine stomach. J Comp Neurol. 493(2):193-206, 2005.

11. Takeda Y., Ward S.M., Sanders K.M.  and Koh S.D.  Effects of the gap junction blocker glycyrrhetinic acid on gastrointestinal smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 288(4):G832-841, 2005.

雑誌

1.  心筋細胞フィジオーム理解のための電子教科書
   姫野友紀子, 天野晃, 竹田有加里, 野間昭典, 株式会社知能情報システム (担当:共編者(共編著者))、丸善雄松堂 2017年3月

2.  インクレチンによるインスリン分泌増強作用の理論解析
   Takeda Y. Theoretical Analysis of the mechanisms underlying incretin-induced amplification of insulin secretion． BIO Clinica, Incretin-Resent topics 88-90, 2016

3.  β細胞におけるGLP-1受容体を介するcAMP制御機構の数理モデル化とシミュレーション研究
   Takeda Y., Inagaki N. Modeling Analysis of GLP-1 Receptor Signaling cascade-mediated [cAMP] regulation in Pancreatic b-cells内分泌・糖尿病・代謝内科、35(2):141-148, 2012

Awards

2014年

JADEC International Research Promotion Award, Japan Association for Diabetes and Care 

2007年

Travel Award, The 21st International Symposium on Neurogastroenterology and Motility 

2006年

Outstanding International Graduate Students Award, University of Nevada, Reno, University of Nevada, Reno 

2005年

Outstanding International Graduate Students Award, University of Nevada, Reno, University of Nevada, Reno