Maladaptive Plasticity in Differentiated Cells.

Drugs of abuse, including cocaine and heroin, behave as signaling molecules that regulate cellular activities in different organs, including brain and heart. Multiple exposure to drugs lead to permanent changes in the targeted cells, a process known as maladaptive plasticity. We are interested in identifying epigenetic mechanisms that underly drug-induced maladaptive plasticity in neurons and heart cells.

Funding: NIH P30 Pilot Core Grant (CSAR/Temple U)