Publications from the group

  • Creswell R, Dombrowski Y. Innate and adaptive immune mechanisms regulating central nervous system remyelination. Curr Opin Pharmacol. 2022 Apr;63:102175. doi:10.1016/j.coph.2021.12.002

  • Kodji X, Kee Z, McKenna R, et al. Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation. Pharmaceuticals (Basel). 2021 Oct 23;14(11):1073. doi:10.3390/ph14111073

  • McMurran CE, Guzman de la Fuente A, Penalva R, et al. The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination. Proc Natl Acad Sci U S A. 2019;116(50):25311-25321. doi:10.1073/pnas.1905787116

  • Kuhn S, Gritti L, Crooks D, Dombrowski Y. Oligodendrocytes in Development, Myelin Generation and Beyond. Cells. 2019;8(11). doi:10.3390/cells8111424

  • de la Vega Gallardo N, Dittmer M, Dombrowski Y, Fitzgerald DC. Regenerating CNS myelin: Emerging roles of regulatory T cells and CCN proteins. Neurochem Int. 2019;130:104349. doi:10.1016/j.neuint.2018.11.024

  • Dittmer M, Young A, O’Hagan T, et al. Characterization of a murine mixed neuron-glia model and cellular responses to regulatory T cell-derived factors. Mol Brain. 2018;11(1):25. doi:10.1186/s13041-018-0367-6

  • Lau JM-F, Dombrowski Y. The innate immune receptor NLRP12 maintains intestinal homeostasis by regulating microbiome diversity. Cell Mol Immunol. 2018;15(3):193-195. doi:10.1038/cmi.2017.61

  • Bankhead P, Loughrey MB, Fernandez JA, et al. QuPath: Open source software for digital pathology image analysis. Sci Rep. 2017;7(1):16878. doi:10.1038/s41598-017-17204-5

  • Dombrowski Y, O’Hagan T, Dittmer M, et al. Regulatory T cells promote myelin regeneration in the central nervous system. Nat Neurosci. 2017;20(5):674-680. doi:10.1038/nn.4528

  • Borovaya A, Dombrowski Y, Zwicker S, et al. Isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris. Arch Dermatol Res. 2014;306(8):689-700. doi:10.1007/s00403-014-1477-3

  • Chandran PA, Keller A, Weinmann L, et al. The TGF-beta-inducible miR-23a cluster attenuates IFN-gamma levels and antigen-specific cytotoxicity in human CD8(+) T cells. J Leukoc Biol. 2014;96(4):633-645. doi:10.1189/jlb.3A0114-025R

  • Linehan E, Dombrowski Y, Snoddy R, Fallon PG, Kissenpfennig A, Fitzgerald DC. Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis. Aging Cell. 2014;13(4):699-708. doi:10.1111/acel.12223

  • Tillack C, Ehmann LM, Friedrich M, et al. Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-gamma-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment. Gut. 2014;63(4):567-577. doi:10.1136/gutjnl-2012-302853

  • Ala-Houhala MJ, Karppinen T, Vahavihu K, et al. Narrow-band ultraviolet B treatment boosts serum 25-hydroxyvitamin D in patients with psoriasis on oral vitamin D supplementation. Acta Derm Venereol. 2014;94(2):146-151. doi:10.2340/00015555-1685

  • Reinholz M, Kawakami Y, Salzer S, et al. HPV16 activates the AIM2 inflammasome in keratinocytes. Arch Dermatol Res. 2013;305(8):723-732. doi:10.1007/s00403-013-1375-0

  • Gollwitzer H, Dombrowski Y, Prodinger PM, et al. Antimicrobial peptides and proinflammatory cytokines in periprosthetic joint infection. J Bone Joint Surg Am. 2013;95(7):644-651. doi:10.2106/JBJS.L.00205

  • Ala-Houhala MJ, Vahavihu K, Snellman E, et al. A narrow-band ultraviolet B course improves vitamin D balance and alters cutaneous CYP27A1 and CYP27B1 mRNA expression levels in haemodialysis patients supplemented with oral vitamin D. Nephron Clin Pract. 2013;124(1-2):17-22. doi:10.1159/000355010

  • Dombrowski Y, Peric M, Koglin S, et al. Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes. Allergy. 2012;67(11):1400-1407. doi:10.1111/all.12022

  • Dombrowski Y, Koglin S, Schauber J. DNA-triggered AIM2 inflammasome activation in keratinocytes: Comment on Kopfnagel et al. Exp Dermatol. 2011. 20:1027-9. Exp Dermatol. 2012;21(6):474-476. doi:10.1111/j.1600-0625.2012.01466.x

  • Ala-Houhala MJ, Vahavihu K, Hasan T, et al. Narrow-band ultraviolet B exposure increases serum vitamin D levels in haemodialysis patients. Nephrol Dial Transplant. 2012;27(6):2435-2440. doi:10.1093/ndt/gfr700

  • Dombrowski Y, Schauber J. Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis. Exp Dermatol. 2012;21(5):327-330. doi:10.1111/j.1600-0625.2012.01459.x

  • Segerer SE, Rieger L, Kapp M, et al. MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts. Hum Reprod. 2012;27(1):200-209. doi:10.1093/humrep/der358

  • Gauglitz GG, Bureik D, Dombrowski Y, Pavicic T, Ruzicka T, Schauber J. Botulinum toxin A for the treatment of keloids. Skin Pharmacol Physiol. 2012;25(6):313-318. doi:10.1159/000342125

  • Schauber J, Dombrowski Y, Besch R. Pathogenic DNA: cytosolic DNA promotes inflammation in psoriasis. Cell Cycle. 2011;10(18):3038-3039. doi:10.4161/cc.10.18.16945

  • Mittelbronn M, Platten M, Zeiner P, et al. Macrophage migration inhibitory factor (MIF) expression in human malignant gliomas contributes to immune escape and tumour progression. Acta Neuropathol. 2011;122(3):353-365. doi:10.1007/s00401-011-0858-3

  • Dombrowski Y, Peric M, Koglin S, et al. Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. Sci Transl Med. 2011;3(82):82ra38. doi:10.1126/scitranslmed.3002001

  • Antal AS, Dombrowski Y, Koglin S, Ruzicka T, Schauber J. Impact of vitamin D3 on cutaneous immunity and antimicrobial peptide expression. Dermatoendocrinol. 2011;3(1):18-22. doi:10.4161/derm.3.1.14616

  • Dombrowski Y, Peric M, Koglin S, Ruzicka T, Schauber J. Control of cutaneous antimicrobial peptides by vitamin D3. Arch Dermatol Res. 2010;302(6):401-408. doi:10.1007/s00403-010-1045-4

  • Roth P, Junker M, Tritschler I, et al. GDF-15 contributes to proliferation and immune escape of malignant gliomas. Clin Cancer Res. 2010;16(15):3851-3859. doi:10.1158/1078-0432.CCR-10-0705

  • Krockenberger M, Engel JB, Schmidt M, et al. Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer. Anticancer Res. 2010;30(5):1653-1659.

  • Peric M, Lehmann B, Vashina G, et al. UV-B-triggered induction of vitamin D3 metabolism differentially affects antimicrobial peptide expression in keratinocytes. J Allergy Clin Immunol. 2010;125(3):746-749. doi:10.1016/j.jaci.2009.12.933

  • Reim F, Dombrowski Y, Ritter C, et al. Immunoselection of breast and ovarian cancer cells with trastuzumab and natural killer cells: selective escape of CD44high/CD24low/HER2low breast cancer stem cells. Cancer Res. 2009;69(20):8058-8066. doi:10.1158/0008-5472.CAN-09-0834

  • Peric M, Koglin S, Dombrowski Y, et al. VDR and MEK-ERK dependent induction of the antimicrobial peptide cathelicidin in keratinocytes by lithocholic acid. Mol Immunol. 2009;46(16):3183-3187. doi:10.1016/j.molimm.2009.08.010

  • Peric M, Koglin S, Dombrowski Y, et al. Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis. PLoS One. 2009;4(7):e6340. doi:10.1371/journal.pone.0006340

  • Engel JB, Honig A, Schonhals T, et al. Perifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylation. Eur J Obstet Gynecol Reprod Biol. 2008;141(1):64-69. doi:10.1016/j.ejogrb.2008.06.007

  • Krockenberger M, Dombrowski Y, Weidler C, et al. Macrophage migration inhibitory factor contributes to the immune escape of ovarian cancer by down-regulating NKG2D. J Immunol. 2008;180(11):7338-7348. doi:10.4049/jimmunol.180.11.7338

  • Gostner A, Blaut M, Schaffer V, et al. Effect of isomalt consumption on faecal microflora and colonic metabolism in healthy volunteers. Br J Nutr. 2006;95(1):40-50. doi:10.1079/bjn20051589

  • Schreiner B, Voss J, Wischhusen J, et al. Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands. FASEB J Off Publ Fed Am Soc Exp Biol. 2006;20(1):118-120. doi:10.1096/fj.05-4342fje