Publications

Lab members are indicated in bold. * equal contribution. # corresponding author.

2022

• Tsukumo S, Subramani PG, Seija N, Tabata M, Maekawa Y, Mori Y, Ishifune C, Itoh Y, Ota M, Fujio K, Di Noia JM, Yasutomo K. AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination. Science Advances 8 (34), eabq0008.

• Bertotti S, Fleming I, Cámara MLM, Centeno Cameán C, Carmona SJ, Agüero F, Balouz V, Zahn A, Di Noia JM, Alfonzo JD, Buscaglia CA. Characterization of ADAT2/3 molecules in Trypanosoma cruzi and regulation of mucin gene expression by tRNA editing. Biochem J. 2022 Feb 17;479(4):561-580. doi: 10.1042/BCJ20210850.

2021

• Feng Y, Li C, Stewart JA, Barbulescu P, Seija-Desivo N, Álvarez-Quilón A, Pezo RC, Perera MLW, Chan K, Tong AHY, Mohamad-Ramshan R, Berru M, Nakib D, Li G, Kardar GA, Carlyle JR, Moffat J, Durocher D, Di Noia JM, Bhagwat AS, Martin A. FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature 2021 600(7888):324-328. doi: 10.1038/s41586-021-04144-4.

• Lin YH, Liang Y, Wang HC, Tung J, Forster M, Subramani PG, Di Noia JM, Clare S, Langlais D, Nijnik A. Regulation of B lymphocyte development by histone H2A deubiquitinase BAP. Frontiers in Immunology 2021 doi: 10.3389/fimmu.2021.626418.

• Morande PE, Yan XJ, Sepulveda-Yanez JH, Seija N, Marquez ME, Sotelo NS, Abreu C, Crispo M, Fernández-Graña G, Rego N, Bois T, Methot SP, Palacios F, Remedi V, Rai KR, Buschiazzo A, Di Noia JM, Navarrete MA, Chiorazzi N#, Oppezzo P#. AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms. Blood. 2021 doi: 10.1182/blood.2020008654.

• Zhong M-C Lu Y, Qian J, Zahn A, Di Noia JM, Atar-Karo D. King I, Veillette A#. The SLAM family of receptors promotes humoral immunity by maintaining pro-survival effectors in activated germinal center B cells. J Exp Med. 2021 Mar 1;218(3):e20200756. doi: 10.1084/jem.20200756.

2020

• Safavi S, Larouche A*, Zahn A*, Patenaude A-M, Domanska D, Dionne K, Rognes T, Dingler F, Kang S-K, Liu Y, Johnson N, Hébert J, Verdun RE, Rada CA, Vega F, Nilsen H, Di Noia JM^#. The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID. Nucleic Acids Res Cancer, 2020, 2(3), doi.org/10.1093/narcan/zcaa019. [open access]

• Feng Y*, Seija N*, Di Noia JM# and Martin A# AID in Antibody Diversification: There and Back Again. Trends Immunol. 2020, 41, 586–600. doi:10.1016/j.it.2020.04.009.

  • • Selected for "Best of Trends in Immunology 2020"

2019

• Morande PE, Sivina M, Uriepero A, Seija N, Berca C, Fresia P, Landoni AI, Di Noia JM, Burger JA, Oppezzo P. Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia. Blood. 2019 Feb 27. pii: blood-2018-09-876292. doi: 10.1182/blood-2018-09-876292.

• Litzler LC, Zahn A, Meli AP, Hébert S, Patenaude AM, Methot SP, Sprumont A, Bois T, Kitamura D, Costantino S, King IL, Kleinman CL, Richard S, Di Noia JM#. PRMT5 is essential for B cell development and germinal center dynamics. Nature Communications, 2019 Jan 3;10(1):22. doi: 10.1038/s41467-018-07884-6. [open access]

2018

• Methot SP*, Litzler LC,*, Subramani PG, Eranki A, Fifield H, Patenaude AM, Gilmore JC, Santiago GE, Bagci H, Côté J-F, Larijani M, Verdun RE, Di Noia JM#. A licensing step links AID to transcription elongation for B cell mutagenesis. Nature Communications, 2018, 9(1):1248. doi: 10.1038/s41467-018-03387-6. [open access]

  • • F1000prime recommended.

2017

• Rodríguez-Cortez, VC, Martínez-Redondo P, Català-Moll F, Rodríguez-Ubreva J, Garcia-Gomez A, Subramani PG, Ciudad L, Hernando H, Pérez-García A, Company C, Urquiza JM, Ramiro AR, Di Noia JM, Vaquero A, Ballestar E. Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites. Scientific Reports. 2017, 7, 553.

• Methot SP# & Di Noia JM#. Molecular mechanisms of somatic hypermutation and class switch recombination. Advances in immunology. 2017, (133)37-87.

2016

• Couturier A, Fleury H; Patenaude A-M, Bentley V, Rodrigue A, Coulombe Y, Joshi N, Pauty N, Berman J, Dellaire G, Di Noia JM, Mes-Masson A-M, Masson J-Y. Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction. Nucl. Acids Res. 2016, 44(22):10879-10897. [open access]

• Cortizas E*, Zahn A*, Shiva S*, Reed JA, Vega F, Di Noia JM#, Verdun RE#. UNG protects B cells from AID induced telomere loss. J. Exp. Med. 2016; 213(11):2459-72. [open access]

  • • Chosen by JEM as one of the 17 articles of 2016 that raised the most interest.

    • F1000prime recommended.

• Zahn A & Di Noia JM#. AID in Somatic Hypermutation and Class Switch Recombination. In: Ratcliffe, M.J.H. (Editor in Chief), Encyclopedia of Immunobiology, Vol. 2, pp. 115–125. 2016. Oxford: Academic Press.

• Casellas R#, Basu U, Yewdell WT, Chaudhuri J, Robbiani DF, Di Noia JM#. Mutations, kataegis, and translocations in B lymphocytes: towards a mechanistic understanding of AID promiscuous activity. Nat. Rev. Immunol. 2016; 16:164-76.

• Litzler LC, Methot SP, Patenaude AM, Zahn A, Di Noia JM. Cell-based Assays to Monitor AID Activity. Bio-protocol 2016; 6(3): e1724. http://www.bio-protocol.org/e1724.551.[open access]

2015

• Methot SP & Di Noia JM#. Pharmacological manipulation of AID. Oncortarget 2015; 6:26550-26551.[open access]

• Di Noia JM. Unequal opportunity during class switching. Nature 2015; 525:44–45.

• Montamat-Sicotte D, Litzler LC, Abreu C, Safavi S, Zahn A, Orthwein A, Muschen M, Oppezzo P, Muñoz DP, Di Noia JM#. HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur. J. Immunol. 2015, 48:2365-2376.

  • • Commentary by Rebhandl and Geisberger Eur J Immunol. 2015, 48:2208-2211.

• Methot SP, Litzler LC, Trajtenberg F, Zahn A, Robert F, Pelletier J, Buschiazzo A, Magor BG, Di Noia JM#. Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm. J. Exp. Med. 2015, 212:581-596. [open access]

  • • Recommended at J Cell Biol, Featured at Science Daily, Mdlinx, Cienciaes (español).

    • Nouvelles UdeM

    • Award / Prix "Étudiant-chercheurs étoiles - Fonds de recherche Santé Quebec pour / to Stephen Methot [LINK]

    • "McGill MedStar Award" to Stephen Methot

• Collin R, Dugas V, Chabot-Roy G, Salem D, Zahn A, Di Noia JM, Rauch J, Lesage S. Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12. J. Autoimmun. 2015, 58:90-99.

2014

• Zahn A*, Eranki AK*, Patenaude AM, Methot SP, Fifield H, Cortizas EM, Foster P, Imai K, Durandy A, Larijani M, Verdun RE, Di Noia JM#. Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination. Proc. Natl. Acad. Sci. U.S.A.. 2014, 111(11):E988-997.

  • • F1000 recommended

    • Featured at Science Daily, Eureka Alert, MedicalXpress.

• Yu H, Pak H, Hammond-Martel I, Ghram M, Rodrigue A, Daou S,Barbour H, Corbeil L, Josée Hébert J, Drobetsky E, Masson JY, Di Noia JM, and Affar EA. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:285-90. [open access]

2013

• Cortizas EC, Zahn A, Hajjar ME, Patenaude AM, Di Noia JM, Verdun RE. Alternative End Joining and Classical-NHEJ Pathways Repair Different Types of Double Strand Breaks During Class Switch Recombination. J. immunol. 2013; 191(11):5751-63. [open access]

• Montamat-Sicotte D, Palacios F, Di Noia JM# and Oppezzo P#. Origins and consequences of AID expression in lymphoid neoplasms. Current Immunology Reviews, 2013; 9:75-85 [open access].

• Muñoz DP, Lee EL, Takayama S, Coppé JP, Heo SK, Boffelli D, Di Noia JM, Martin DIK. Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 2013; 110(32):E2977-86.

• Zahn A, Daugan M, Safavi S, Godin D, Cheong C, Lamarre A, Di Noia JM#. Separation of function between isotype switching and affinity maturation in vivo and circulating autoantibodies in UNG-deficient mice. J. Immunol. 2013; 190:5949-5960.

  • • Featured, “In This Issue” @ The Journal of Immunology, highlighting articles among the top 10% of articles published in the journal. [Listen to ImmunoCast].

    • Featured at MedicalXpress.

• Campo VA, Patenaude AM, Kaden S, Horb L, Firka D, Jiricny J, Di Noia JM#. MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils. Nucleic Acids Res. 2013; 41:3032-3046 [open access].

• Hu Y, Ericsson I, Torseth K, Methot SP, Sundheim O, Liabakk NB, Slupphaug G, Di Noia JM, Krokan HE, Kavli B. A Combined Nuclear and Nucleolar Localization Motif in Activation-Induced Cytidine Deaminase (AID) Controls Immunoglobulin Class Switching. J. Mol. Biol. 2013; 425:424-43.

2012

• Orthwein A & Di Noia JM. Activation induced deaminase: How much and where? Semin. Immunol. 2012; 24:246-54.

  • • Featured at MDlinx

• Orthwein A, Zahn A, Methot SP, Godin D, Conticello SG, Terada K and Di Noia JM#. Optimal functional levels of Activation Induced Deaminase specifically require the Hsp40 DnaJa1. EMBO J. 2012; 31:679-91.

• Orthwein A & Di Noia JM#. Moduler la diversification des anticorps pour combattre certaines maladies. Médecine Sciences Amérique; 2012; 1(2) online journal [open access (en français)].

2011

• De Marchi CR; Di Noia JM; Frasch AC; Amato Neto V; Almeida IC and Buscaglia CA. Evaluation of a Recombinant Trypanosoma cruzi Mucin-Like Antigen for Serodiagnosis of Chagas' Disease. Clin. Vaccine Immunol. 2011; 18:1850-5.

2010

• Patenaude A-M & Di Noia JM#. The mechanisms regulating the subcellular localization of AID. Nucleus 2010; 1(4): 325-331 [open access].

• Orthwein A, Patenaude A-M, Affar E-B, Lamarre A, Young JC and Di Noia JM#. Regulation of Activation Induced Deaminase stability and antibody gene diversification by Hsp90. J. Exp. Med. 2010; 207:2751-65. [free access].

  • • (Featured at MDlinx).

• Ramiro A# & Di Noia JM#. Regulatory mechanisms of AID function. In: DNA Deamination and the Immune System. S Fungmann, M Diaz & FN Papavasiliou Eds. Imperial College Press, London, UK. 2010.[Amazon].

2009

• Patenaude A-M, Orthwein A, Yi Hu, Campo VA, Kavli B, Buschiazzo A and Di Noia JM#. Nuclear import and cytoplasmic retention of Activation Induced Deaminase. Nat. Struct. Mol. Biol. 2009; 16:517-27.

2007

• Di Noia JM# and Neuberger MS#. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem., 2007; 76:1-22. Link