Publications
Click the title to go to the article. Lab members or cosupervised students are in bold. * equal contribution. # corresponding author.
2024
Subramani PG, Fraszczak J, Hellnes A, Estall J, Möröy T, Di Noia JM#. A conserved role of hnRNPL in regulating alternative splicing of transcriptional regulators necessary for B cell activation. EMBO Rep. 2024 May 14. doi: 10.1038/s44319-024-00152-3.
Lorenzo JP, Molla L, Amro EM, Ibarra IL, Ruf S, Neber C, Gkougkousis C, Ridani J, Subramani PG, Boulais J, Harjanto D, Vonica A, Di Noia JM, Dieterich C, Zaugg JB, Papavasiliou FN. APOBEC2 safeguards skeletal muscle cell fate through binding chromatin and regulating transcription of non-muscle genes during myoblast differentiation. Proc Natl Acad Sci U S A. 2024 121(17):e2312330121.
Liang Y, Wang HC, Seija N, Lin YH, Tung LT, Di Noia JM, Langlais D, Nijnik A. B-cell Intrinsic Regulation of Antibody Mediated Immunity by Histone H2A Deubiquitinase BAP1. Frontiers in immunology, 15:1353138, 2024.
Ridani J, Barbulescu P, Martin A, Di Noia JM#. Somatic Hypermutation. In Molecular Biology of B Cells, 3rd Edition - January 10, 2024, Editors: Honjo T, Reth M, Radbruch A, Alt F, Martin A.
Dolbec D, LehouxM, Asselin de Beauville A, Zahn A, Di NoiaJM#, Segura M#. Unmutated but T cell-dependent IgM antibodies targeting Streptococcus suis play an essential role in bacterial clearance. PLoS Pathog 20(1): e1011957. 2024. doi: 10.1371/journal.ppat.1011957.
2023
Hayran AB, Liabakk NB, Aas PA, Kusnierczyk A, Vågbø CB, Sarno A, Iveland TS, Chawla K, Zahn A, Di Noia JM, Slupphaug G, Kavli B. RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork. Nucleic Acids Res. 2023 Nov 24:gkad1115. doi: 10.1093/nar/gkad1115.
Litzler LC*, Zahn A*, Dionne KL, Sprumont A, Ferreira SR, Slattery MFR, Methot SP, Patenaude AM,Hebert S, Kabir N, Subramani PG, Jung S, Richard S, Kleinman C, Di Noia JM#. Protein Arginine Methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice. J Exp. Med. 2023 Sep 4;220(9):e20220381. doi: 10.1084/jem.20220381.
Lombard-Vadnais F, Chabot-Roy F, Zahn A, Rodriguez Torres S, Di Noia JM, Melichar HJ, Lesage S. Activation-induced cytidine deaminase expression by thymic B cells promotes T-cell tolerance and limits autoimmunity, iScience, 2023; 26(1), doi.org/10.1016/j.isci.2022.105852
2022
Tsukumo S, Subramani PG, Seija N, Tabata M, Maekawa Y, Mori Y, Ishifune C, Itoh Y, Ota M, Fujio K, Di Noia JM, Yasutomo K. AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination. Science Advances 8 (34), eabq0008.
Bertotti S, Fleming I, Cámara MLM, Centeno Cameán C, Carmona SJ, Agüero F, Balouz V, Zahn A, Di Noia JM, Alfonzo JD, Buscaglia CA. Characterization of ADAT2/3 molecules in Trypanosoma cruzi and regulation of mucin gene expression by tRNA editing. Biochem J. 2022 Feb 17;479(4):561-580. doi: 10.1042/BCJ20210850.
2021
Feng Y, Li C, Stewart JA, Barbulescu P, Seija-Desivo N, Álvarez-Quilón A, Pezo RC, Perera MLW, Chan K, Tong AHY, Mohamad-Ramshan R, Berru M, Nakib D, Li G, Kardar GA, Carlyle JR, Moffat J, Durocher D, Di Noia JM, Bhagwat AS, Martin A. FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature 2021 600(7888):324-328. doi: 10.1038/s41586-021-04144-4.
Lin YH, Liang Y, Wang HC, Tung J, Forster M, Subramani PG, Di Noia JM, Clare S, Langlais D, Nijnik A. Regulation of B lymphocyte development by histone H2A deubiquitinase BAP. Frontiers in Immunology 2021 doi: 10.3389/fimmu.2021.626418.
Morande PE, Yan XJ, Sepulveda-Yanez JH, Seija N, Marquez ME, Sotelo NS, Abreu C, Crispo M, Fernández-Graña G, Rego N, Bois T, Methot SP, Palacios F, Remedi V, Rai KR, Buschiazzo A, Di Noia JM, Navarrete MA, Chiorazzi N#, Oppezzo P#. AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms. Blood. 2021 doi: 10.1182/blood.2020008654.
Zhong M-C Lu Y, Qian J, Zahn A, Di Noia JM, Atar-Karo D. King I, Veillette A#. The SLAM family of receptors promotes humoral immunity by maintaining pro-survival effectors in activated germinal center B cells. J Exp Med. 2021 Mar 1;218(3):e20200756. doi: 10.1084/jem.20200756.
2020
Safavi S, Larouche A*, Zahn A*, Patenaude A-M, Domanska D, Dionne K, Rognes T, Dingler F, Kang S-K, Liu Y, Johnson N, Hébert J, Verdun RE, Rada CA, Vega F, Nilsen H, Di Noia JM#. The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID. Nucleic Acids Res Cancer, 2020, 2(3), doi.org/10.1093/narcan/zcaa019. [open access]
Feng Y*, Seija N*, Di Noia JM# and Martin A# AID in Antibody Diversification: There and Back Again. Trends Immunol. 2020, 41, 586–600. doi:10.1016/j.it.2020.04.009.
Selected for "Best of Trends in Immunology 2020"
2019
Morande PE, Sivina M, Uriepero A, Seija N, Berca C, Fresia P, Landoni AI, Di Noia JM, Burger JA, Oppezzo P. Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia. Blood. 2019 Feb 27. pii: blood-2018-09-876292. doi: 10.1182/blood-2018-09-876292.
Litzler LC, Zahn A, Meli AP, Hébert S, Patenaude AM, Methot SP, Sprumont A, Bois T, Kitamura D, Costantino S, King IL, Kleinman CL, Richard S, Di Noia JM#. PRMT5 is essential for B cell development and germinal center dynamics. Nature Communications, 2019 Jan 3;10(1):22. doi: 10.1038/s41467-018-07884-6. [open access]
2018
Methot SP*, Litzler LC,*, Subramani PG, Eranki A, Fifield H, Patenaude AM, Gilmore JC, Santiago GE, Bagci H, Côté J-F, Larijani M, Verdun RE, Di Noia JM#. A licensing step links AID to transcription elongation for B cell mutagenesis. Nature Communications, 2018, 9(1):1248. doi: 10.1038/s41467-018-03387-6. [open access]
2017
Rodríguez-Cortez, VC, Martínez-Redondo P, Català-Moll F, Rodríguez-Ubreva J, Garcia-Gomez A, Subramani PG, Ciudad L, Hernando H, Pérez-García A, Company C, Urquiza JM, Ramiro AR, Di Noia JM, Vaquero A, Ballestar E. Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites. Scientific Reports. 2017, 7, 553.
Methot SP# & Di Noia JM#. Molecular mechanisms of somatic hypermutation and class switch recombination. Advances in immunology. 2017, (133)37-87.
2016
Couturier A, Fleury H; Patenaude A-M, Bentley V, Rodrigue A, Coulombe Y, Joshi N, Pauty N, Berman J, Dellaire G, Di Noia JM, Mes-Masson A-M, Masson J-Y. Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction. Nucl. Acids Res. 2016, 44(22):10879-10897. [open access]
Cortizas E*, Zahn A*, Shiva S*, Reed JA, Vega F, Di Noia JM#, Verdun RE#. UNG protects B cells from AID induced telomere loss. J. Exp. Med. 2016; 213(11):2459-72. [open access]
Chosen by JEM as one of the 17 articles of 2016 that raised the most interest.
Zahn A & Di Noia JM#. AID in Somatic Hypermutation and Class Switch Recombination. In: Ratcliffe, M.J.H. (Editor in Chief), Encyclopedia of Immunobiology, Vol. 2, pp. 115–125. 2016. Oxford: Academic Press.
Casellas R#, Basu U, Yewdell WT, Chaudhuri J, Robbiani DF, Di Noia JM#. Mutations, kataegis, and translocations in B lymphocytes: towards a mechanistic understanding of AID promiscuous activity. Nat. Rev. Immunol. 2016; 16:164-76.
Litzler LC, Methot SP, Patenaude AM, Zahn A, Di Noia JM. Cell-based Assays to Monitor AID Activity. Bio-protocol 2016; 6(3): e1724. http://www.bio-protocol.org/e1724.551.[open access]
2015
Methot SP & Di Noia JM#. Pharmacological manipulation of AID. Oncortarget 2015; 6:26550-26551.[open access]
Di Noia JM. Unequal opportunity during class switching. Nature 2015; 525:44–45.
Montamat-Sicotte D, Litzler LC, Abreu C, Safavi S, Zahn A, Orthwein A, Muschen M, Oppezzo P, Muñoz DP, Di Noia JM#. HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur. J. Immunol. 2015, 48:2365-2376.
Commentary by Rebhandl and Geisberger Eur J Immunol. 2015, 48:2208-2211.
Methot SP, Litzler LC, Trajtenberg F, Zahn A, Robert F, Pelletier J, Buschiazzo A, Magor BG, Di Noia JM#. Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm. J. Exp. Med. 2015, 212:581-596. [open access]
Recommended at J Cell Biol, Featured at Science Daily, Mdlinx, Cienciaes (español).
Award / Prix "Étudiant-chercheurs étoiles - Fonds de recherche Santé Quebec pour / to Stephen Methot [LINK]
"McGill MedStar Award" to Stephen Methot
Collin R, Dugas V, Chabot-Roy G, Salem D, Zahn A, Di Noia JM, Rauch J, Lesage S. Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12. J. Autoimmun. 2015, 58:90-99.
2014
Zahn A*, Eranki AK*, Patenaude AM, Methot SP, Fifield H, Cortizas EM, Foster P, Imai K, Durandy A, Larijani M, Verdun RE, Di Noia JM#. Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination. Proc. Natl. Acad. Sci. U.S.A.. 2014, 111(11):E988-997.
Featured at Science Daily, Eureka Alert, MedicalXpress.
Yu H, Pak H, Hammond-Martel I, Ghram M, Rodrigue A, Daou S,Barbour H, Corbeil L, Josée Hébert J, Drobetsky E, Masson JY, Di Noia JM, and Affar EA. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:285-90. [open access]
2013
Cortizas EC, Zahn A, Hajjar ME, Patenaude AM, Di Noia JM, Verdun RE. Alternative End Joining and Classical-NHEJ Pathways Repair Different Types of Double Strand Breaks During Class Switch Recombination. J. immunol. 2013; 191(11):5751-63. [open access]
Montamat-Sicotte D, Palacios F, Di Noia JM# and Oppezzo P#. Origins and consequences of AID expression in lymphoid neoplasms. Current Immunology Reviews, 2013; 9:75-85 [open access].
Muñoz DP, Lee EL, Takayama S, Coppé JP, Heo SK, Boffelli D, Di Noia JM, Martin DIK. Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 2013; 110(32):E2977-86.
Zahn A, Daugan M, Safavi S, Godin D, Cheong C, Lamarre A, Di Noia JM#. Separation of function between isotype switching and affinity maturation in vivo and circulating autoantibodies in UNG-deficient mice. J. Immunol. 2013; 190:5949-5960.
Featured, “In This Issue” @ The Journal of Immunology, highlighting articles among the top 10% of articles published in the journal. [Listen to ImmunoCast].
Featured at MedicalXpress.
Campo VA, Patenaude AM, Kaden S, Horb L, Firka D, Jiricny J, Di Noia JM#. MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils. Nucleic Acids Res. 2013; 41:3032-3046 [open access].
Hu Y, Ericsson I, Torseth K, Methot SP, Sundheim O, Liabakk NB, Slupphaug G, Di Noia JM, Krokan HE, Kavli B. A Combined Nuclear and Nucleolar Localization Motif in Activation-Induced Cytidine Deaminase (AID) Controls Immunoglobulin Class Switching. J. Mol. Biol. 2013; 425:424-43.
2012
Orthwein A & Di Noia JM. Activation induced deaminase: How much and where? Semin. Immunol. 2012; 24:246-54.
Featured at MDlinx
Orthwein A, Zahn A, Methot SP, Godin D, Conticello SG, Terada K and Di Noia JM#. Optimal functional levels of Activation Induced Deaminase specifically require the Hsp40 DnaJa1. EMBO J. 2012; 31:679-91.
Orthwein A & Di Noia JM#. Moduler la diversification des anticorps pour combattre certaines maladies. Médecine Sciences Amérique; 2012; 1(2) online journal [open access (en français)].
2011
De Marchi CR; Di Noia JM; Frasch AC; Amato Neto V; Almeida IC and Buscaglia CA. Evaluation of a Recombinant Trypanosoma cruzi Mucin-Like Antigen for Serodiagnosis of Chagas' Disease. Clin. Vaccine Immunol. 2011; 18:1850-5.
2010
Patenaude A-M & Di Noia JM#. The mechanisms regulating the subcellular localization of AID. Nucleus 2010; 1(4): 325-331 [open access].
Orthwein A, Patenaude A-M, Affar E-B, Lamarre A, Young JC and Di Noia JM#. Regulation of Activation Induced Deaminase stability and antibody gene diversification by Hsp90. J. Exp. Med. 2010; 207:2751-65. [free access].
(Featured at MDlinx).
Ramiro A# & Di Noia JM#. Regulatory mechanisms of AID function. In: DNA Deamination and the Immune System. S Fungmann, M Diaz & FN Papavasiliou Eds. Imperial College Press, London, UK. 2010.[Amazon].
2009
Patenaude A-M, Orthwein A, Yi Hu, Campo VA, Kavli B, Buschiazzo A and Di Noia JM#. Nuclear import and cytoplasmic retention of Activation Induced Deaminase. Nat. Struct. Mol. Biol. 2009; 16:517-27.
2007
Di Noia JM# and Neuberger MS#. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem., 2007; 76:1-22. Link
Publications previous to 2007 [click]