Javier M Di Noia

Education

PhD, University of Buenos Aires, Exacts and Natural Sciences Faculty, Buenos Aires, Argentina (2000). Supervisor Dr A.C.C. Frasch.

Degree in Biological Sciences with Honours, Exacts and Natural Sciences Faculty, University of Buenos Aires, Buenos Aires, Argentina (1994).

Professional Experience

2001-2006 - Post doctoral fellow / Research Associate. Supervisor Dr Michael S Neuberger, Laboratory of Molecular Biology, Protein and Nucleic Acid Chemistry Division, Cambridge, UK.

2000-2001 - Postdoctoral fellow. Biotechnological Research Institute, University of San Martín, San Martin, Buenos Aires, Argentina.

1997-2000 - Teaching assistant. Biotechnological Research Institute, University of San Martín, San Martin, Buenos Aires, Argentina.

1993-2000 - Undergraduate fellow / PhD student. Institute of Biochemical Research “Luis F. Leloir”, University of Buenos Aires, Buenos Aires, Argentina.

Positions

@IRCM


Current
  • Director of Research unit on Mechanisms of genetic diversity (Since 2006).
  • Associate vice-president IRCM academic affairs. Student Affairs (Since 2016).
  • Full professor / Professeur titulaire (Since 2017).

Previous
  • 2012-2017 Associate professor
  • 2006-2012 Assistant professor

@Université de Montréal.


Current
  • Full research professor (Professeur chercheur titulaire),Department of Medicine. (Since 2018).
  • Accredited at the Department of Microbiology & Immunology (2007) and Department of Biochemistry (2011).

Previous
  • 2012-2018 Associate Research Professor (Chercheur agregé).
  • 2007-2012 Assistant Research Professor (Chercheur Adjoint).

McGill University

  • Adjunct Professor, Department of Medicine, Division of Experimental Medicine (Since 2008).
  • Adjunct Professor, Department of Microbiology and Immunology (Since 2016).

Awards

  • 2018 -2019 Chercheur boursier Senior Fonds de Recherche du Quebec - Santé.
  • 2013 - 2018 Canada Research Chair Tier 2 in genetic diversity.
  • 2008 - 2013 Canada Research Chair Tier 2 in genetic diversity.
  • 2008 - CIHR New Investigator, Canadian Institutes of Health Research.
  • 2007 - Chercher-boursier “junior 1”, Fonds de la Recherché en Santé du Quebec. (Declined)
  • 2004 - Career Development Fellowship, Medical Research Council (Cambridge, UK).
  • 2001 - Milstein Fellowship, Max Perutz Fund (Cambridge, UK).
  • 2001 - Fellowship for external post-doctoral training Antorchas Fund (Argentina).
  • 2000 - Post-doctoral Fellowship, C.O.N.I.C.E.T. (National Research Council, Argentina)
  • 1995 - Doctoral Fellowship, C.O.N.I.C.E.T. (National Research Council, Argentina).
  • 1994 - Jaime Campomar Fellowship, Campomar Fund, Institute of Biochemical Research "Luis F. Leloir" (Buenos Aires, Argentina).
  • 1994 - Fellowship for outstanding students in sciences and humanities, Antorchas Fund (Argentina).

Publications during training

Antibody gene diversification (postdoc)

  1. Di Noia JM, Williams GT, Chan DTY, Buerstedde JM, Baldwin GS, Neuberger MS. Dependence of antibody gene diversification on uracil excision. J Exp Med 2007; 204:3209-3219.
  2. Di Noia JM, Rada C, Neuberger MS. SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair. EMBO J. 2006; 5:585-95.
  3. Neuberger MS, Di Noia JM, Beale RC, Williams GT, Yang Z, Rada C. Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation. Nat Rev Immunol. 2005; 5:171-8.
  4. Rada C, Di Noia JM, Neuberger, MS. Mismatch Recognition and Uracil Excision Provide Complementary Paths to Both Ig Switching and the A/T-Focused Phase of Somatic Mutation. Mol Cell. 2004,16:163-171.
  5. Di Noia JM, Neuberger MS Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination. Eur. J. Immunol. 2004; 34:504-508.
  6. Neuberger MS, Harris RS, Di Noia J. Petersen-Mahrt SK. Immunity through DNA deamination. Trends Biochem Sci. 2003; 28:305-312.
  7. Di Noia J, Neuberger MS. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 2002; 419:43-48.

Trypanosoma cruzi antigenic diversity (PhD)

  1. Buscaglia CA, Campo VA, Frasch AC, Di Noia JM. Trypanosoma cruzi surface mucins: host-dependent coat diversity. Nat Rev Microbiol. 2006; 4:229-36.
  2. Campo VA, Buscaglia CA, Di Noia JM, Frasch AC. Immunocharacterization of the mucin-type proteins from the intracellular stage of Trypanosoma cruzi. Microbes Infect. 2006; 8:401-9.
  3. Buscaglia CA, Campo VA, Di Noia JM, Torrecilhas AC, De Marchi CR, Ferguson MA, Frasch AC, Almeida IC. The surface coat of the mammalian-dwelling infective trypomastigote stage of Trypanosoma cruzi is formed by highly diverse immunogenic mucins. J Biol Chem. 2004; 279:15860-15869.
  4. Campo V, Di Noia JM, Buscaglia CA, Aguero F, Sanchez DO, Frasch AC. Differential accumulation of mutations localized in particular domains of the mucin genes expressed in the vertebrate host stage of Trypanosoma cruzi. Mol Biochem Parasitol. 2004; 133:81-91.
  5. Di Noia JM, Buscaglia CA. Trypanosoma cruzi clonal diversity and the epidemiology of Chagas disease. Microbes Infect. 2003; 5: 419-427.
  6. Di Noia JM, Buscaglia CA, De Marchi CR, Almeida IC, Frasch ACC.. A Trypanosoma cruzi small surface molecule provides the first immunological evidence that Chagas' disease is due to a single parasite lineage. J Exp Med 2002; 195:401-413.
  7. Argibay PF, Di Noia JM, Hidalgo A, Mocetti E, Barbich M, Lorenti AS, Bustos D, Tambutti M, Hyon SH, Frasch ACC, Sanchez DO. Trypanosoma cruzi surface mucin TcMuc-e2 expressed on higher eukaryotic cells induces human T cell anergy, which is reversible. Glycobiology 2002; 12:25-32.
  8. Aguero F, Campo V, Cremona L, Jager A, Di Noia JM, Overath P, Sanchez DO, Frasch ACC. Gene discovery in the freshwater fish parasite Trypanosoma carassii: identification of trans-sialidase-like and mucin-like genes. Infect Immun 2002; 70:7140-7144.
  9. Pollevick GD*, Di Noia JM*, ML Salto, C Lima, MS Leguizamon, RM de Lederkremer, Frasch ACC. Trypanosoma cruzi surface mucins with exposed variant epitopes. J Biol Chem 2000; 275:27671-27680.
  10. Di Noia JM*, D'Orso I*, Sanchez DO, Frasch AC. AU-rich elements in the 3'-untranslated region of a new mucin-type gene family of Trypanosoma cruzi confers mRNA instability and modulates translation efficiency. J Biol Chem 2000; 275:10218-10227.
  11. Di Noia JM, D'Orso I, Aslund L, Sanchez DO, Frasch ACC. The Trypanosoma cruzi mucin family is transcribed from hundreds of genes having hypervariable regions. J Biol Chem 1998; 273:10843-10850.
  12. Di Noia JM, Pollevick GD, Xavier MT, Previato JO, Mendoca-Previato L, Sanchez DO, Frasch ACC. High diversity in mucin genes and mucin molecules in Trypanosoma cruzi. J Biol Chem 1996; 271:32078-32083.
  13. Di Noia JM, Sanchez DO, Frasch ACC. The protozoan Trypanosoma cruzi has a family of genes resembling the mucin genes of mammalian cells. J Biol Chem 1995; 270:24146-24149.