Welcome to the University of Chicago Digestive Disease Research Core Centers online compendium of protocols and SOPs. Here we will deposit procedures from each of our cores including: the Integrated Translational Research Core (ITR), the Host Microbe Core (HM), the Tissue Engineering and Cell Models Core (TECM) and the Tissue and Cell Analysis Core (TCA). For each of these procedures, we will include the protocol or SOP and a description of their benefits and limitations for each core. This will serve as an on-line reference for all present and future users and DDRCC members.