Centre for Microbial and Fermentation Technology (CMFT)
Department of Microbiology, Osmania University, Hyderabad, Telangana
-500007
Department of Microbiology, Osmania University, Hyderabad, Telangana
-500007
Venkateswarlu Kojja, Dinesh Kumar, Praveen Kumar Kalavagunta, Bhima Bhukya, Anjana Devi Tangutur, Prasanta Kumar Nayak, 2-(Diarylalkyl)aminobenzothiazole derivatives induce autophagy and apoptotic death through SIRT inhibition and P53 activation In MCF7 breast cancer cells, Computational Biology and Chemistry, Volume 116, 2025, https://doi.org/10.1016/j.compbiolchem.2025.108395.
Anumalla, M., Batchu, U.R., Singh, N.K. et al. Draft Genome Analysis of Delftia tsuruhatensis IICT-RSP4, a Strain with Uricase Potential Isolated from Soil. Indian J Microbiol (2025). https://doi.org/10.1007/s12088-024-01434-z
Optimized Biomass Production of Probiotic Bacterium Pediococcus acidilactici TMAB26 Using Pineapple Peel: A Response Surface Methodology Approach. Anuradha Barigela, Bhima Bhukya, Current Research in Nutrition & Food Science, 2024, 12 (3)
Ganapathiwar, S., Pappula, R., Banothu, A.K. et al. Causatum of Probiotic Yeast Saccharomyces cerevisiae SBO1 Supplementation on Growth and Aflatoxin Amelioration in Broilers. Indian J Microbiol (2023).
Lunavath R, Mohammad SH, Bhukya KK, Bhukya B., et al. (2023). Antimycotic effect of 3-phenyllactic acid produced by probiotic bacterial isolates against Covid-19 associated mucormycosis causing fungi. PLOS ONE 18(3): e0279118.
A Anthappagudem, S Enaganti, B Bhukya. Integration of mutational and molecular docking studies: An in silico approach to assess the stability and binding potential of CYP3A4. Journal of Applied Biology and Biotechnology 11 (1), 161-170.
SH Mohammad, B Bhukya. Biotransformation of toxic lignin and aromatic compounds of lignocellulosic feedstock into eco-friendly biopolymers by Pseudomonas putida KT2440. Bioresource Technology 363, 12800.
KK Bhukya, B Bhukya. Exploration of Antidiabetic, Cholesterol-Lowering, and Anticancer Upshot of Probiotic Bacterium Pediococcus pentosaceus OBK05 Strain of Buttermilk. Probiotics and Antimicrobial Proteins, 1-17
9. Kumar RN, Surekha MV, Ramalingam B, Kumar PU, Polasa K, Hemalatha R, Bhima B, et al (2022). Oral Toxicity Study for Salmonella Killing Lytic Bacteriophage NINP13076 in BALB/c Mice and Its Effect on Probiotic Microbiota. Curr Microbiol. Feb 7;79(3):89
10. Ashok, D., Thara, G., Dharavath, R. et al. Microwave Assisted Synthesis of Flavonoid Based 1,2,3-Triazole and Isoxazole Derivatives, Their Antibacterial, Antioxidant, and Anticancer Activities. Russ J Gen Chem 92, 718–724 (2022)
Sunkar B and Bhukya B (2022) An Approach to Correlate Chemical Pretreatment to Digestibility Through Biomass Characterization by SEM, FTIR and XRD. Front. Energy Res. 10:802522. doi: 10.3389/fenrg.2022.802522
Bhukya KK, Bhukya B (2021) Unravelingthe probiotic efficiency of bacterium Pediococcus pentosaceus OBK05 isolated from buttermilk: An invitro study for cholesterol assimilation potentialand antibiotic resistance status. PLoS ONE 16(11):e0259702
Nagamani Pammi, Kiran Kumar Bhukya, Ravi Kumar Lunavath and Bhima Bhukya. 2021. Bioprospecting of Palmyra Palm (Borassus flabellifer) Nectar: Unveiling the Probiotic and Therapeutic Potential of the Traditional Rural Drink. Frontiers in Microbiology. doi: 10.3389/fmicb.2021.683996.
14. Sunkar B, Bhukya B. Bi-phasic hydrolysis of corncobs for the extraction of total sugars and ethanol production using inhibitor resistant and thermotolerant yeast, Pichia kudriavzevii. Biomass and Bioenergy. 2021;153:106230. doi:10.1016/j.biombioe.2021.106230
Praveen Kumar Keshav, Chandrashekhar Banoth, Srinivas Naik Kethavath, Bhima Bhukya. 2021. Lignocellulosic ethanol production from cotton stalk: an overview on pretreatment, saccharification and fermentation methods for improved bioconversion process. Biomass Conversion and Biorefinery. https://doi.org/10.1007/s13399-021- 01468-z.
Anuradha Barigela and Bhima Bhukya. 2021. Probiotic Pediococcus acidilactici strain from tomato pickle displays anti-cancer activity and alleviates gut inflammation in-vitro. 3 Biotech. 11:23.
Srinivas Banoth, Anjana Devi Tangutur, Archana Anthappagudem, Janaki Ramaiah, Bhima Bhukya. 2020. Cloning and in vivo metabolizing activity study of CYP3A4 on amiodarone drug residues: A possible probiotic and therapeutic option. Biomedicine & Pharmacotherapy. 127 (2020) 110128.
18. Bindu Sunkar, Balakrishna Kannoju and Bhima Bhukya. 2020. Optimized Production of Xylanase by Penicillium purpurogenum and Ultrasound Impact on Enzyme Kinetics for the Production of Monomeric Sugars from Pretreated Corn Cobs. Frontiers in Microbiology. 11:772.
Kumar Ramachandrappa Naveen, Bhima Bhukya, Kumar Putchaa Uday, Ghosh Sudip. 2020. Bio-control of Salmonella spp. in carrot salad and raw chicken skin using lytic bacteriophages. LWT-Food Science and Technology. 122: 109039.
Praveen Kumar Keshav, Chandrasekhar Banoth, Archana Anthappagudem, Venkateswar Rao Linga, Bhima Bhukya. 2018. Sequential acid and enzymatic saccharification of steam exploded cotton stalk and subsequent ethanol production using Scheffersomyces stipitis NCIM. Industrial Crops & Products. 125: 462-467
Mohammed Al Saiqali, Anjana Devi Tangutur, Chandrasekhar Banoth, Bhima Bhukya. 2018. Antimicrobial and anticancer potential of low molecular weight polypeptides extracted and characterized from leaves of Azadirachta indica. International Journal of Biological Macromolecules. 114: 906–921.
Chandrasekhar Banoth, Bindu Sunkar, Pruthvi Raj Tondamanati, Bhima Bhukya. 2017. Improved physicochemical pretreatment and enzymatic hydrolysis of rice straw for bioethanol production by yeast fermentation. 3 Biotech. 7:334.
Banoth Srinivas, Ganapathiwar Swarupa Rani, Bhukya Kiran Kumar, Banoth Chandrasekhar, Kommalapati Vamsi Krishna, Tangutur Anjana Devi and Bhukya Bhima. 2016. Evaluating the probiotic and therapeutic potentials of Saccharomyces cerevisiae strain (OBS2) isolated from fermented nectar of toddy palm. AMB Express. 7(2): 1-14.
Kannoju Balakrishna, Ganapathiwar Swaruparani, Nunavath Hanumalal, Sunkar Bindu, Bhukya Bhima. 2017. Plausible exploitation of Jatropha de-oiled seed cake for lipase and phytase production and simultaneous detoxification by Candida parapsilosis isolated from poultry garbage. Bioresource Technology. 225: 215-224.
Dipti W. Pitta, Zhengxia Dou, Sanjay Kumar, Nagaraju Indugu, John Daniel Toth, Bonnie Vecchiarelli, and Bhima Bhukya. 2016. Metagenomic evidence of the prevalence and distribution patterns of antimicrobial resistance genes in dairy agroecosystems. Foodborne Pathogens and Disease. 13 (6): 1-7.
Dipti W. Pitta, Nagaraju Indugu, Sanjay Kumar, Bonnie Vecchiarelli, Rohini Sinha, Linda D. Baker, Bhima Bhukya, James D. Ferguson. 2016. Metagenomic assessment of the functional potential of the rumen microbiome in Holstein dairy cows. Anaerobe, 38: 50-60.
Dinesh Addla, Bhima, Balasubramanian Sridhar, Anjana Devi, Srinivas Kantevari. 2012. Design, synthesis and antimicrobial evaluation of novel 1-benzyl 2-butyl-4- chloroimidazole embodied 4-azafluorenones via molecular hybridization approach. Bioorganic & Medicinal Chemistry Letters 22: 7475–7480.
1. Ravula Shrikantha, Sirasani Satyanarayana, Rathod Aravind Kumar, Mohammad Saddam Hussain, Bhima Bhukya, Ravada Kishore, Jajula Kashanna, Ceric(IV) Ammonium Nitrate Mediated Cross Dehydrogenative Coupling Of Ortho-Benzoylbenzofurans With Phosphites And Their Anti-Microbial Evaluation. (2025). International Journal of Environmental Sciences, 770-779. https://doi.org/10.64252/w8c15r56
2. D Srilatha, S Chaitanya Kumari, Bhima Bhukya, K Anuradha. Screening and isolation of Bacillus isolates for Levansucrase activity and for Levan Production. South Asian Journal of Experimental Biology, 2024, 14 (6)
3. Swaruparani Ganapathiwar & Bhima Bhukya (2023). In vitro assessment for the probiotic potential of Pichia kudriavzevii. Bioinformation
4. Lunavath, Madhavi; Swamy, Mahadeva; Bhukya, Bhima. Isolation of plant probiotics (bacillus subtilis) and its effect on germination of tomato seeds at drought stress. Biochemical & Cellular Archives . Apr2023, Vol. 23 Issue 1, p149-156. 8p.
5. Saiqali MA, Tangutur AD, Bhukya B. Peptides and low molecular weight polypeptides of Azadirachta indica seeds as new weapons against cancer cells and superbugs. Phytomedicine Plus. 2021;1(4):100118. doi:10.1016/j.phyplu.2021.100118
6. Chandrasekhar Banoth, Srinivas Naik Kethavath, Praveen Kumar Keshav and Bhima Bhukya. 2020. Selection of stress tolerant Saccharomyces cerevisiae strains isolated from sloughing off soil for bioethanol production using Prosopis juliflora. Research Journal of Biotechnology. 15: 1.
7. Hanumalal Nunavath, Chandrasekhar Banoth, Venkateswar Rao Talluri, Bhima Bhukya. 2016. An analysis of horseradish peroxidase enzyme for effluent treatment. Bioinformation 12(6): 318-323.
8. Vasu Namani, B. Goud, Y. Bharathi Kumari, Ramesh Kumbham, Kannoju Balakrishna, Bhukya Bhima. 2015. Design, Synthesis and Biological Evaluation of Benzimidazolyl and Benzothiazolyl Picolinamide Derivatives as Antimicrobial Agents. Asian Journal of Chemistry. 27(12): 4575-4578.
9. B. Bhima, Y. Ramana Reddy, M. Pawani, Sudhakara Reddy, L. Venkateswar Rao and D.W. Pitta. 2015. Influence of Stress-Resistant Yeast Culture (OBV9) Supplementation on the Productive Performance of Water Buffalo. Asian Journal of Animal and Veterinary Advances. 10(6): 260-270.
10. Chandrasekhar B and Bhima B. 2015. Cellulose as Sole Substrate for Bio Ethanol Production: Development of Structural Molecular Model of Endoglucanase III from Trichoderma Reesei Using Bioinformatic Tools. Int J Pharm Sci Res. 6(3): 1132-36.
11. B. Bhima, Y. Ramana Reddy, M. Sudhakara Reddy, M. Pawani, L. Venkateswar Rao. 2014. Effect of thermo-tolerant yeast on intake and nutrient digestibility in Murrah buffalo steers (Bubalus bubalis) fed straw based complete diet. Veterinary World. 7(7): 501-504.
12. Jaheer. Md, Ranjith Reddy. P, Bhima. B, Narsimha. N, Sujitha. P, Srinivas. B & Ch. Sarala Devi. 2014. Synthesis, spectro-analytical, computational and biological studies of novel 6-methyl-3-(1-(4-oxo-2-phenylquinazolin-3(4H)-ylimino) ethyl)- 2H-pyran-2, 4(3H)-dione and its Co (II), Cu (II) and Hg (II) metal complexes. IOSR Journal of Applied Chemistry. 7(6): 1-12.
13. M. Sudhakara Reddy, Y. Ramana Reddy, B. Bhima, Y. Thirupathaiah, A. Rajasekhar Reddy, L. Venkateswar Rao. 2013. Effect of different levels of thermotolerant probiotic yeast supplementation on biochemical and immune parameters in broilers. World Journal of Pharmacy and Pharmaceutical Sciences. 2(6): 4911-4916
14. B. Kiran Kumar and B. Bhima. 2012. Detoxification of anti-nutrients (tannins) present in fruit extracts for probiotic yeast production. International J. Appl. Biol. and Pharmaceutical Tech., 3(3):275-279.
15. B. Bhima, T. Anjana Devi M. Sudhakara Reddy, Y. Ramana Reddy and L. Venkateswar Rao. 2011. Optimized protein extraction from Saccharomyces cerevisiae for 2-D gel electrophoresis. J. Theor. Exp. Biol., 8(1&2): 77-84.
16. Bhukya Bhima, Marrivada Sudhakara Reddy, Tanguturu Anjana Devi, Yerradoddi Ramana Reddy and Linga Venkateswar Rao. 2010. Screening and characterization of stress tolerant Saccharomyces cerevisiae isolated from brewery effluents for animal probiotic applications. IIOABJ., 1(4): 32-39.
17. B. Bhima, Y. Ramana Reddy, M. Pavani, M. Sudhakara Reddy and L. Venkateswar Rao. 2010. In vitro evaluation of straw based complete diets supplemented with probiotic yeast. Indian Vet. J., 87: 779-781.
18. B. Bhima, T. Anjana Devi, M. Sudhakara Reddy, Y. Ramana Reddy and L.Venkateswar Rao. 2010. Insights into the protein profiles of stress tolerant and mesophilic yeast by proteomics approach: a comparative study. International J. Appl. Biol. and Pharmaceutical Tech., 1(2):349-359.
19. B. Bhima, Y. Ramana Reddy, M. Pavani, M. Sudhakara Reddy and L. Venkateswar Rao. 2009. Rumen fermentation pattern in Murrah buffalo steers fed on straw based complete diet supplemented with thermotolerant probiotic yeast (Saccharomyces cerevisiae) at graded levels. Indian J. Anim. Nutr., 26(3): 239-242.
20. G.V.N. Reddy and B. Bhima. 2003. Effect of yeast culture based diet on growth and nutrient utilization in deoni bull calves. Indian J. Anim. Nutri., 20(1):101-104.
1. Editor of the Book ‘Introductory Microbiology’, B.Sc. I year, Sem – I, Published by Divya Lakshmi Publishers & Distributors
2. Editor of the Book ‘Laboratory Experiments in Microbiology’, Published by Professional Books Publisher
3. Editor of the Book ‘Microbial Biotechnology-Technological Challenges and Developmental Trends’. 2017. Reference book published by CRC/Apple academic press
4. Co-Editor of the Book ‘Mycology: Current and future developments’ Volume II. 2021. Reference book in press by Bentham Science.
5. Editor of the Book ‘Biotechnological Production of Various Fungal Metabolites and their Applications in White Biotechnology. Pp: 255-286 (32) (2022). (ISBN: 978-3-030-25506-0
Bhima Bhukya, Chandrasekhar Banoth, Praveen K. Keshav, MD. Saddam Hussain and Shanthipriya Ajmera Biotechnological Production of Various Fungal Metabolites and their Applications in White Biotechnology. Pp: 255-286 (32)
Bhima Bhukya, Srinivas Banoth and Archana Anthappagudem. 2019.Saccharomyces cerevisiae as potential probiotic: Stategies for iolation and selection. Applied Microbiology and Bioengineering (edited by Pratyoosh Shukla). Elsevier Inc.
S. Anju, Y. Aparna, Bhukya Bhima, and J. Sarada. 2018. Novel Insights on the Bacillus Quorum Sensing Mechanism: It’s Role in Competence, Virulence, Sporulation and Biofilm Formation. Implication of Quorum Sensing System in Biofilm Formation and Virulence (Edited by Pallaval Veera Bramhachari). Springer Nature. https://doi.org/10.1007/978-981-13-2429-1_21.
B. Bhima and Mohammed Al Saiqali. 2017. Antimicrobial Peptides from Plants and Their Applications. In Microbial Biotechnology: Technological Challenges and Developmental Trends. Apple academic press.
B. Bhima, N. Hanumalal and B. Chandrasekhar. 2017. Yeast Saccharomyces cerevisia efficientBiological Agent for Decolorization of Reactive Dyes used in Textile Industry. In Microbial Biotechnology: Technological Challenges and Developmental Trends. Apple academic press.
B. Bhima. 2012. Development of stress tolerant yeast for Probiotic and Pr Applications. Lifescience India. 1(3): 63-65.
L. Venkateswar Rao, B. Bhima, Y. Ramana Reddy, M. Pavani and M. Sudhakara 2010. Effect of different levels of thermotolerant probiotic yeast (Saccharomyces cere on intakes, nutrient digestibility and rumen fermentation pattern in straw based co diets fed Murrah buffalo steers. In: Current topics on bioprocesses in food industry. V Asiatech publishers, Inc. Pp. 58-70.
B. Bhima, Smita C. Pawar, M. Sudhakara Reddy and L. Venkateswar Rao. 2010. Iso Characterization and screening of Bacillus thuringiensis for Mosquito control conference proceedings of Implications of climate change on mosquito borne diseas its impact on public health. Excel India Publishers. Pp. 182-185.