Saachi Sachdev
Saachi Sachdev
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PhD student
PhD student
I joined the CCG group in 2024, with my supervision shared between
Dr Simone Zaccaria and Prof. Simona Parinello (Neurogenesis and Brain Cancer, UCL).
My research focuses on glioblastoma multiforme (GBM) initiation. Specifically, I hope to explore the timeline of tumour margin development in relation to the bulk. My hypothesis challenges traditional views and considers margin development and GBM infiltration into the healthy brain as an early event, prior to the tumour bulk formation. As well as understanding the formation of the margin, I am also interested in the evolutionary history of invasive clones, which are largely responsible for GBM recurrence, and aim to complete phylogenetic analyses to understand glioblastoma invasion.
My background consists of both experimental lab work and bioinformatics. I enjoy bridging these two aspects of research together as it helps to tackle scientific questions from multiple angles. More recently, I have developed experience in analysing single-cell data to understand tumour heterogeneity, and hope to pursue this during my PhD.
Education
10/2024 – Present | PhD in Computational Cancer Genomics, University College London, London, UK.
Thesis title: Understanding human glioblastoma initiation and its microenvironments (CRUK funded).
Supervisors: Prof. Simona Parinello and Dr Simone Zaccaria.10/2022 – 10/2023 | Master's in Research degree (M.Res.) in Cancer Bioinformatics, Imperial College London, London, UK.
Supervisors: Prof. Sadaf Ghaem-Maghami, Dr Haonan Lu (Imperial College London) and Dr Stephen-John Sammut (Institute of Cancer Research).09/2019 – 06/2022 | Bachelor's degree (B.Sc.) in Medical Biosciences, Imperial College London, London, UK.
Positions
12/2023 – 09/2024 | Research Technical Assistant, UCL Respiratory Medicine, University College London (UCL), London, UK.
Supervisors: Prof. Sam Janes and Dr Marko Nikolić.06/2022 – 09/2022 | Undergraduate Research Scientist, Breast Cancer Epigenetics, Imperial College London, London, UK.
Supervisors: Prof. Justin Stebbing and Dr Biancastella Cereser.06/2021 - 09/2021 | Biological Scientist Intern, Molecular Biology R&D, Synthace, London, UK.
Supervisors: Dr Nuno Leitão.
Roles
2024 – Present | PhD committee member at the Cancer Institute, UCL.
2024 – Present | Postgraduate Teaching Assistant (PGTA) for the Division of Medicine, UCL.
2021 – 2023 | Author at Imperial Bioscience Review, Imperial College London.
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