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Principal Researcher, Dr. Hyojin Lee (이효진)
(e-mail : hyojinlee@kist.re.kr)
Our group focuses on “synthesis smart nanomaterials for diagnosis and treatment of diseases”. We are developing nanoconstructs as a new type of drug delivery system since their “cargo” can be released by changes in environmental factors including ionic strength. Also. We are interested in bio-sensor surface modification to introduce the function that can allow to recognition of specific biomarkers in clinical sample for determination of diseases.
바이오 나노구조체 연구실은 생체 친화적 나노재료를 합성하여 질병을 진단하고 치료하는 연구에 중점을 두고 있습니다. 나노재료의 기초 특성을 조절하여 선택적으로 세포 내에 물질을 전달하는 신개념의 나노전달체를 개발하고 있으며, 나노물질 표면개질을 통한 바이오리셉터 도입방법 개발을 통해 바이오센서가 특정 질병인자를 인식할 수 있도록 기능을 부여하는 연구를 진행하고 있습니다.
Academic Career
Academic Career
2004 ~ 2007 B.S. in Bioengineering, Summa cum laude, Catholic University of Korea
2008 ~ 2012 Ph.D. in Bio Chemistry, Department of chemistry, Seoul National University
2012 ~ 2013 Post-doctoral fellowship, Division of Chemistry and Molecular Engineering, Brain Korea 21, Seoul National University
2013 ~ 2015 Post-doctoral fellowship, Department of Chemistry, Northwestern University
2015 ~ 2016 Post-doctoral fellowship, Korea Institute of Science and Technology (KIST)
2016 ~ 2020 President Post-doctoral fellowship, Korea Institute of Science and Technology (KIST)
2018 ~ 2022 Senior Researcher, Biomedical Research Institute, Korea Institute of Science and Technology (KIST)
2019 ~ Associate Professor, KIST School, Korea Institute of Science and Technology (KIST)
2023 ~ Principal Researcher, Biomaterials Research Center, KIST, Korea Institute of Science and Technology (KIST)
Representative Paper (†: Equal contribution, *:Corresponding Author)
Representative Paper (†: Equal contribution, *:Corresponding Author)
1. Seongchan Kim,You Kyeong Jeong,Chang Sik Cho,Seokhoon Lee,Chang Ho Sohn,Jeong Hun Kim,Youngdo Jeong,Dong Hyun Jo*,Sangsu Bae*,and Hyojin Lee*, "Enhancement of Gene Editing and Base Editing with Therapeutic Ribonucleoproteins through In Vivo Delivery Based on Absorptive Silica Nanoconstruct" Advanced Healthcare Materials (2023)
2. Seongchan Kim*, I-Seon Lee, Hyojin Lee*, “Combination Treatment of Hepatitis C Virus-Associated Hepatocellular Carcinoma by Simultaneously Blocking Genes in Multiple Organelles via Functionally Engineered Graphene Oxide ”Chemical Engineering Journal , (2023) 452, 15
3. WonseokChoi, JaehongKey, InchanYoun, HyojinLee*, SungminHan * , “Cavitation-assisted sonothrombolysis by asymmetrical nanostars for accelerated thrombolysis” J. Controlled Release, (2022) 350.
4. Sangmin Song, Seung-Hoon Um, Jaeho Park, Inho Ha, Jaehong Lee, Seongchan Kim, Hyojin Lee, Cheol-Hong Cheon, Seung Hwan Ko*, Yu-Chan Kim*, Hojeong Jeon* , “Rapid Synthesis of Multifunctional Apatite via the Laser-Induced Hydrothermal Process” ACS Nano, (2022) 16, 8, 12840-12951
5. Woongsun Choi, Eunhye Park, Seojin Bae, Kyung-Hak Choi, Sangeun Han, Kuk-Hui Son, Do Young Lee, Il-Joo Cho, Hyejeong Seong, Kyo Seon Hwang, Jwa-Min Nam, Jungkyu Choi*, Hyojin Lee*, Nakwon Choi*, “Multiplex SNP Genotyping Using SWITCH: Sequence-Specific Nanoparticle with Interpretative Toehold-Mediated Sequence Decoding in Hydrogel” Small, (2022) 18, 2105538.
6. Seongchan Kim, Taegon Oh, Hyojin Lee*, and Jwa-Min Nam*, “Trends and perspectives in bio- and eco-friendly sustainable nanomaterial delivery systems through biological barriers” Materials Chemistry Frontiers, (2022) published online.
7. Seongchan Kim, Shin Young Kim, Seung Joon Rho, Seung Hoon Kim, So Hyang Song, Chi Hong Kim, Hyojin Lee*, and Sung Kyoung Kim*, “Biocompatible N-acetyl-nanoconstruct Alleviates Lipopolysaccharide-induced Acute Lung Injury In Vivo” Scientific Reports, (2021) in press
8. Hyojin Lee*, Seongchan Kim, Kyeong Seob Hwang, Nu Ri Lim, Han Bin Oh, Il-Joo Cho, Jongbaeg Kim*, Ki Hun Kim*, Hong Nam Kim*, “Effect of carbon nanomaterial dimension on the functional activity and degeneration of neurons” Biomaterials, (2021) 279, 121232
9. Adaptive self-healing electronic epineurium for chronic bidirectional neural interfaces” K.I Song, H. Seo, D. Seong, S. Kim, K Yu, Y. Kim, J Kim, S. Kwon, H. Han, I Yoon*, H. Lee* and D Son*, Nature Communications (2020).
10. “Non-invasive Molecular Barcode Assay for Diagnosis of Sex Hormones Correlated with Precocious Puberty” H.Lee, KH Kim and K.H. Lee, Sensors and Actuators B Chemistry (2019).
11. “High Throughput Differential Identification of TMPRSS2-ERG Fusion Genes in Prostate Cancer Patient Urine” H.Lee, D.Lee, J. Park, S. Peter, and K.H. Lee, Biomaterials (2017).
12. “Transparent, Nanoporous, and Transferable Membrane-Based Cell–Cell Paracrine Signaling Assay” Y. Jang†, H.Lee†, K. Char and J.-M. Nam Advanced Materials (2015).
13. “Bio-Barcode Gel Assay for microRNA” H. Lee, J. Park and J.-M. Nam, Nature Communications (2014).
Researchers & Students
Researchers & Students
Dr. Kim, Seongchan (김성찬), NRF Postdoctoral Fellow
E-mail ) kimsc@kist.re.kr
Research Area : Materials and nanofabrication: Structure and functionalization, Biomaterials for drug/gene delivery system, Development of practical tools for genomic editing, Biosensors for diagnosis of viral disease and cancer, Understanding the interactions of nanomaterials and biological systems
Dr.Lee, Nan-Ee, (이난이), Postdoctoral Fellow
E-mail ) nan@kist.re.kr
Research Area : CRISPR-based genome-editing technology.
Generation of animal and cell-line models.
Gene therapy
Lee, Sian (이시안), MS-PhD student
E-mail ) t22201@kist.re.kr
Research Area : Biosensors, Drug dellivery system
Kim Seoyoung (김서영), MS student
E-mail ) 121503@kist.re.kr
Research Area : Drug delivery system, mRNA therapy
Yunkyeong Cho (조윤경), MS Student
E-mail ) yungyeung2@gmail.com
Research Area : Gene delivery system
Kim, Myeongsun (김명선), MS Student
E-mail)T21048@kist.re.kr
Research Area: Tumor therapy
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