Children

Postacute Sequelae of SARS-CoV-2 in Children

The image above summarizes 8,3373 publications that studied 80,071 children and adolescents. This is not a respiratory virus.

www.ox.ac.uk/news/2023-01-31-covid-19-leading-cause-death-children-and-young-people-us

SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patients April 2022

https://academic.oup.com/jmcb/article/14/4/mjac021/6572370?login=false

COVID-19 linked to type 2 diabetes onset in childrenPediatric patients aged 10 to 19 years old diagnosed with COVID-19 have a higher risk of new-onset type 2 diabetes within six months compared to those diagnosed with other respiratory infections, according to researchers at Case Western Reserve University School of Medicine.

2022: “SARS-CoV-2 causes more T-cell death than HIV.”

https://www.infectioncontroltoday.com/view/long-covid-19-spreads-wide-toxic-net-that-includes-kids

Long COVID-19 Spreads Wide Toxic Net That Includes KidsA huge peer reviewed study in PLOS Medicine underscores just how much of a threat long COVID-19 presents: 1 in 3 survivors display symptoms of the disease 3 to 6 months after initial infection.

American Academy of Pediatrics

Postacute Sequelae of SARS-CoV-2 in Children

https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2023-062570/196606/Postacute-Sequelae-of-SARS-CoV-2-in-Children?autologincheck=redirected

Postacute Sequelae of SARS-CoV-2 in ChildrenThe coronavirus disease 2019 (COVID-19) pandemic has caused significant medical, social, and economic impacts globally, both in the short and long term. Although most individuals recover within a few days or weeks from an acute infection, some experience longer lasting effects. Data regarding the postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC) in children, or long COVID, are only just emerging in the literature. These symptoms and conditions may reflect persistent symptoms from acute infection (eg, cough, headaches, fatigue, and loss of taste and smell), new symptoms like dizziness, or exacerbation of underlying conditions. Children may develop conditions de novo, including postural orthostatic tachycardia syndrome, myalgic encephalomyelitis/chronic fatigue syndrome, autoimmune conditions and multisystem inflammatory syndrome in children. This state-of-the-art narrative review provides a summary of our current knowledge about PASC in children, including prevalence, epidemiology, risk factors, clinical characteristics, underlying mechanisms, and functional outcomes, as well as a conceptual framework for PASC based on the current National Institutes of Health definition. We highlight the pediatric components of the National Institutes of Health-funded Researching COVID to Enhance Recovery Initiative, which seeks to characterize the natural history, mechanisms, and long-term health effects of PASC in children and young adults to inform future treatment and prevention efforts. These initiatives include electronic health record cohorts, which offer rapid assessments at scale with geographical and demographic diversity, as well as longitudinal prospective observational cohorts, to estimate disease burden, illness trajectory, pathobiology, and clinical manifestations and outcomes.

"COVID-19 was associated with a significantly increased risk for RSV infections among children aged 0–5 years in 2022. Similar findings were replicated for a study population of children aged 0–5 years in 2021. OurOur0 findings suggest that COVID-19 contributed to the 2022 surge of RSV cases in young children through the large buildup of COVID-19-infected children and the potential long-term adverse effects of COVID-19 on the immune and respiratory system." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582888/?fbclid=IwAR1aJys_yZlKRgw_jqjSN-RdnIO6Cq32701oavf1XacvRKbiFRf9Amog8ME - study directly follows: