T helper 17 (Th17) cells are a functionally heterogeneous population whose divergent roles in immunity and autoimmune disease are increasingly linked to their underlying metabolic states. Despite sharing a common identity, pathogenic and non-pathogenic Th17 cells follow distinct programs that drive vastly different immunological outcomes. In this talk, I will present a multi-faceted approach to dissecting this metabolic divide. First, I will describe an engineered nanovial-based enrichment strategy that enables the isolation of Th17 cells with high specificity through cytokine secretion profiling. Next, I will introduce a machine learning framework designed to classify single-cell transcriptomic data as pathogenic or non-pathogenic, providing a scalable and high-resolution tool for interrogating Th17 cell identity. Finally, I will present findings revealing aberrant mitochondrial lipid metabolism as a distinguishing feature of non-pathogenic Th17 cells, highlighting a previously underappreciated metabolic axis that may govern Th17 cell fate. Together, these findings offer new insight into the cellular and molecular checkpoints that separate nonpathogenic from pathogenic Th17 responses, with implications for therapeutic targeting in autoimmune and metabolic conditions.
The African clawed frog has been used as a model species in the laboratory for many decades, since it’s initial use in pregnancy tests starting in 1920. It is the most commonly used amphibian in laboratory studies in developmental biology, endocrinology, molecular biology, and toxicology. Recently, the species has been adapted as a model for assessing endocrine disruption by environmental contaminants. For example, the herbicide atrazine demasculinizes and feminizes exposed larvae at levels as low as 0.1 µg / L. Estrogens, such as estradiol (E2, which induces ovarian development in genetic male larvae) are often used as positive controls in these studies. Frogs vary in their sensitivity to E2 as much as 10,000 fold, however, depending on the source and commercial sources appear to be less sensitive to E2. We are currently examining potential molecular and biochemical mechanisms that may explain these differences in sensitivity. We believe that the variation (noise) in our data are important to understand. By selecting inbred strains to achieve repeatable results and reduce the “noise”, we are losing valuable information. We hypothesize that there is a greater variation in wild populations in Cape town, South Africa, the original source of nearly all invasive populations and commercial suppliers.
Scientists often master complex scientific secrets, while neglecting attention on building generational wealth. This session provides a practical playbook to build long-term wealth throughout a scientific career. We will detail the three laws of wealth building - Compounding, Diversification, and Capital - with technical concepts and case studies ranging from stock investing, real estate, and company building.
Mitigating industrial carbon emissions requires technologies that operate efficiently under realistic flow, thermal, and chemical constraints, where separation and reaction processes are often tightly coupled. Many existing approaches rely on powder-based materials and packed-bed reactors, which impose fundamental limitations on pressure drop, heat management, and scalability. In this talk, I will present recent work on monolithic material platforms designed to address these challenges by decoupling structural transport properties from surface chemistry.
The talk will focus on how mesoscale architecture in washcoated monolithic materials governs gas transport, thermal behavior, and reactive performance under integrated capture–reaction conditions. By systematically varying operating parameters such as flow rate, temperature, and feed composition, this work identifies structure–function relationships that emerge in structured reactor environments. These results highlight both the opportunities and constraints of monolithic architectures and illustrate how reactor-relevant material design can enable more efficient and scalable approaches to carbon management across engineering applications.
Astronomical observations indicate that roughly 85% of the matter in the Universe exists in an invisible, yet-to-be-discovered form known as dark matter. Unveiling its nature remains one of the most compelling challenges in modern physics. Around the world, numerous experiments are pursuing this mystery through complementary detection technologies aimed at determining what dark matter is made of.
One of the leading efforts in direct-detection, is LUX-ZEPLIN (LZ), the U.S. flagship dark matter experiment located deep underground at the Sanford Underground Research Facility in South Dakota. LZ employs a large, ultrapure liquid xenon time projection chamber (TPC) to search for tiny interaction signals from proposed dark matter particles, including a class of Weakly Interacting Massive Particles (WIMPs), one of the most compelling candidates.
In this talk, Dr. Kamaha will review the astrophysical evidence for dark matter, discuss leading theoretical candidates, and explain direct detection strategies, with particular emphasis on the xenon TPC technique used by LZ. She will conclude by presenting recent world-leading results from LZ as well as an outlook on the future of dark matter research.
In this talk, Dr. Khalid K. Osman will reflect on the research mission and evolving body of work of the Osman Lab, which sits at the intersection of infrastructure engineering, environmental justice, and community engaged research. His work is motivated by a central question of how infrastructure systems, particularly water and sanitation, can be designed, evaluated, and governed in ways that address historical harm, center lived experience, and respond to climate and social change. Drawing on projects across multiple U.S. cities, he will discuss how conventional engineering and regulatory frameworks often overlook critical dimensions of equity such as trust, affordability, and everyday experiences with infrastructure. He will highlight how community based participatory research, mixed methods, and sustained partnerships with community based organizations can expand what counts as evidence and lead to more grounded ways of evaluating system performance. The talk will weave together examples from household scale water quality monitoring, affordability and assistance programs, and risk communication during crises to show how social, institutional, and technical factors interact to shape infrastructure outcomes. Dr. Osman will also reflect on what inspired him to pursue this line of research, the commitments that guide his lab, and future directions including climate driven hazards, governance and policy design, and the development of scalable tools to support more equitable infrastructure decision making.
The AI revolution is rapidly reshaping the world, driven by a massive explosion in computing demands centered almost entirely around GPUs. However, as the market for AI chips continues to surge and model training requires millions of GPU-hours, the underlying hardware remains largely closed and proprietary. This talk introduces the Vortex GPGPU Platform, an initiative to break the black box of GPU acceleration. By providing an open-source, fully configurable multi-core GPU based on the RISC-V ISA, Vortex enables end-to-end exploration of heterogeneous computing. We will discuss how providing full design stacks—from compilers to hardware synthesis—empowers researchers to freely innovate on the algorithms and specialized architectures required to sustain the next generation of AI.
To help defend the host from pathogens and maintain tissue homeostasis, neutrophils – the most abundant immune cell in our body – need to generate physical forces to move, interact with their environments and kill their targets. Our lab aims to understand how neutrophils generate and transmit the physical forces needed for their host defense functions. Such knowledge will open the door to biophysics-inspired strategies for controlling and re-engineering neutrophil functions to improve immune responses. In this talk, I will discuss our lab’s current work toward understanding how neutrophils remodel and rupture the nucleus and plasma membrane to release chromatin to the extracellular environment during NETosis - an immune response that worsens inflammation. Our work identified novel mechanisms by which chromatin regulates the mechanical properties of cells, independently of gene expression, materially advancing our understanding of the biophysical roles of chromatin in cell physiology.
The study of relativity, spacetime, and black holes often requires one to incorporate a complex mixture of abstract mathematics and several areas within theoretical physics. To this day there remains significant gaps in our understanding of the dynamic ejection of matter from black holes. This nexus point requires lots of physics, geometry, and even more imaginative creativity to solve the mystery of these dark objects in our universe. Relativistic jet launching mechanisms can be described, in part, by the dynamic interplay of poloidal-toroidal magnetic fields emanating from accretion disk plasma under the rotational influence of the central black hole. It is this intricate relationship between black hole spin, magnetic fields, and the distribution of matter at high energies that is the essence of this synergy. This talk will break down these complex mechanisms and present a spin-tetrad formalism on a Kerr background to predict the fractional circular polarization degree in synchrotron-dominated AGN jets. The formalism yields closed-form and numerically tractable expressions that map directly to observables, enabling parameter inference on field geometry. A discussion on unresolved problems in jet formation and future theoretical descriptions will be provided.
Professor Debbie G. Senesky never dreamed she would send things to space as she spent most of her research career fascinated with the nano-scale properties of electronic materials. In this keynote presentation, she will review and discuss the benefits of gallium nitride (GaN) over the traditional silicon semiconductor platform for use in space exploration and extreme energy applications. In particular, she will share her 10-year journey to demonstrate gallium nitride (GaN) microelectronics in NASA's Glen Extreme Environment Test Rig (GEER) — an Earth-based tool that is used to simulate the Venus surface environment. In addition, she will discuss her group's recent "moonshot" mission to low-Earth orbit (LEO) to explore the use of prolonged microgravity (aboard the International Space Station) for the synthesis of metal-organic framework (MOF) crystals, an emerging nanomaterial.
Jaw development is an essential process of facial structure and function. In vertebrates, multipotent progenitor cells, known as the neural crest, develop into the cartilage and bones of the maxilla (upper jaw) and mandible (lower jaw). Here, we define the gene network regulating neural crest differentiation during development using single cell RNA sequencing. Neural crest cells were isolated from the maxillary and mandibular arch of mouse embryos and transcriptionally profiled at single cell resolution. The mesenchyme showed cellular heterogeneity and analysis of the cells from the maxillary and mandibular prominences showed distinct expression patterns. In situ analysis validated the expression patterns of these genes within the arches. We identified molecular signatures of distinct cell states and constructed putative developmental trajectories for each arch. Our results give insight into the gene regulatory networks coordinating neural crest differentiation into craniofacial cartilage and bone in the upper and lower jaw.
As society's insatiable appetite for electricity grows to support modern technology, it is increasingly important to develop improved ways to store energy using cheap, sustainable and abundant materials. Today's most dominant energy storage technology, lithium ion batteries, finds applications ranging from small devices to electric transportation and large scale electric grid storage. However, the limited abundance and geopolitical challenges associated with the critical minerals used in lithium ion batteries poses challenges for energy resiliency and affordability. It is therefore critical that we develop alternative and complementary battery technologies that use less critical materials. The major challenge in battery research is in developing new materials that meet the multiple requirements for each application.
To discover and characterize new materials, computational and machine learning approaches can play a major role. Computational approaches can be used to downselect from millions of possible candidate materials down to a few promising ones dramatically faster than trying to make and test all the materials in the lab. In this talk, I will give examples of how computation and machine learning are accelerating our ability to discover and understand new materials in ways that were not feasible before.
Determination of orbital parameters from radial velocities is a powerful method for characterizing binary stars and exoplanets. This is because radial velocity measurements are most secure at short periods, where the motion of the orbital components creates large Doppler shifts that are easily detected and quantified. This methodology is particularly useful when orbits are too compact for visual or astrometric characterization. Orbit solutions derived from radial velocity measurements typically stem from fitting the Keplerian elements of the radial velocity curve equation. Procedures used for this fitting tend to depend on complex iterative algorithms that can handle the necessary nonlinear regression and solve Kepler’s equation. To streamline this process, we created the user-friendly command-line interface Radial Velocity Two-Body (RV2B). RV2B is designed to find the global best-fit Keplerian elements given a celestial target’s radial velocity time-series data. To optimize execution time and memory efficiency, RV2B is written entirely in Rust, which is a modern low-level systems programming language with C-like performance. The workhorse of RV2B is a custom Genetic Algorithm that effectively converges across the global parameter space, without getting stuck in local minima. After finishing global convergence, RV2B uses the Levenberg-Marquardt and Hooke-Jeeves algorithms to converge locally to the best-fit solution. To validate the utility of RV2B, we use it to recover orbital parameters for a published catalog of binary stars. The results of this exercise demonstrate that RV2B is easy to use, memory-efficient, and effective at producing accurate orbital solutions. RV2B can be installed across all major operating systems in just a few minutes and is now publicly available on GitHub.
The South Pole Telescope (SPT) collaboration has started a campaign to monitor active galactic nuclei (AGN) that will grow to include more than 1,000 sources. Here, we show SPT AGN light curves and data for 100+ sources that are being made publicly available for the first time. We show data from the SPTpol instrument, which was designed for observations of the CMB at angular scales of 1 arcminute and larger and ran from 2012 to 2016. These observations come from the 500-square-degree SPTpol survey field, which was covered several times a day using detectors that were sensitive to radiation in bands with centers at 90 and 150 GHz. We discuss the data processing pipeline, the matched filter process, and the source selection parameters. We also show light curves for selected sources and variability statistics for the full sample. All of the data products we show here will be available for download through the SPT Treasury Record of AGN With Historical Activity and Time Series, or STRAWHAT, catalog. This is the first step in a larger release that will include polarized AGN light curves from SPTpol data and three-band polarized light curves from the ongoing SPT-3G survey. This project will serve as a basis for monitoring AGN with current and future CMB experiments like Simons Observatory as well as multi-wavelength studies with facilities like VRO-LSST.
Ubiquitous amongst any living organism is the need to conserve energy via processes such as respiration. Respiration requires the reduction of an electron acceptor, such as oxygen, to generate an ion gradient driving the synthesis of adenosine triphosphate (ATP) via the action of the ATP synthase. In the absence of oxygen, the preferred terminal electron acceptor, non-fermenting and denitrifying bacteria such as Pseudomonas aeruginosa can respire using nitrate instead of oxygen, reducing it to dinitrogen. In this study, we focused on the utilization of a specific N-oxide intermediate: nitric oxide (NO). NO is of particular interest due to its production as a toxin as part of the human immune response to infections.
This talk will provide an example of a common pathogen’s ability to use a substrate initially produced as an antimicrobial agent for energy conservation, highlighting the importance of considering the full repertoire of energy-conservation strategies used by pathogens to succeed in eradicating them.
This study examines the effects of microbiome on activation of host regeneration processes. As an injury model, we utilized the Drosophila limb, which does not normally regenerate. We find that supplementing Lactobacillus brevis ATCC 367 promotes activation of regeneration processes in the amputated limb, as characterized by change in wound healing, enhanced tissue survival, and eventually partial regrowth of the limb. To investigate how L. brevis influences host regeneration, we combined genome-scale metabolic modeling with experimental measurements, and found that L. brevis secretes the amino acid ornithine. Flies fed with L. brevis indeed show higher extract levels of ornithine and altered levels of enzymes that metabolize ornithine. Directly administering ornithine to the flies promotes regeneration processes in the limb. In summary, this study presents evidence that supplying a bacteria that secretes ornithine can promote regeneration processes in a host organ that does not normally regenerate. Further, L. brevis supplementation can be performed prior to injury, opening up the possibility of prophylactically improving response to injury.
Sleep is regulated by a homeostatic process and associated with an increased arousal threshold, but the genetic and neuronal mechanisms that implement these essential features of sleep remain poorly understood. To address these fundamental questions, we performed a genetic screen in the zebrafish model system informed by human genome-wide association studies. We found that mutation of the novel kinase serine/threonine kinase 32a (stk32a) results in increased sleep and impaired sleep homeostasis by acting downstream of neurotensin signaling and the serotonergic raphe. stk32a mutation reduces phosphorylation of neurofilament proteins, which are co-expressed with stk32a in neurons that regulate motor activity and in lateral line hair cells that detect environmental stimuli, and ablating these cells phenocopies stk32a mutation. Consistent with a role for hair cells in regulating sleep, we found that mutation of G-protein coupled receptor 156 (gpr156), which has been shown, with stk32a, to be necessary for appropriate development of the lateral line system, similarly phenocopies stk32a mutation and hair cell ablation. Finally, we found that neurotensin signaling inhibits specific sensory and motor populations, and suppresses stimulus-evoked responses of neurons that relay sensory information from hair cells to the brain. Our work thus shows that stk32a is an evolutionarily conserved sleep regulator that links neuropeptidergic and neuromodulatory systems to homeostatic sleep drive and changes in arousal threshold, which are implemented through suppression of specific sensory and motor systems.
Gallium arsenide (GaAs) solar cells offer among the highest photovoltaic efficiencies but remain limited by high manufacturing costs. Reducing cost while maintaining performance is therefore critical for large-scale deployment.
Here we demonstrate a simple, low-cost method to grow a thin gallium nitride (GaN) passivation layer directly on GaAs using ammonium chloride and gallium sources in a standard tube furnace. This approach avoids the complex gas-handling infrastructure required for conventional GaN growth, providing a scalable and economical alternative. Material characterization confirms the formation of a polycrystalline GaN layer that reduces surface recombination.
State-of-the-art devices for the Caltech Space Solar Power Project currently operate at 15.5% efficiency. Modeling suggests that improved surface passivation alone could yield a 1–2% absolute efficiency gain, moving performance toward the ~20% efficiency target required for SSPP viability. Ongoing work focuses on integrating this passivation approach into device structures to evaluate its impact on photovoltaic performance.
Magnetars, the most highly magnetized subset of neutron stars, remain enigmatic in nature; while likely formed through Core-collapse Supernovae (CCSNe), the origin of their large (>1013 G) magnetic fields and relationship to radio pulsars are unclear. Magnetars also exhibit a wide variety of emission types from periodic short bursts to Giant Flares and outbursts. Beyond this, magnetars are considered a leading candidate for the source of multiple unidentified phenomena within our Galaxy and beyond. In this talk, I use the DSA-110 radio telescope and archival multi-wavelength datasets to explore the formation of magnetars and the origins of two magnetar-candidate radio species: extragalactic Fast Radio Bursts (FRBs) and Galactic Long Period Radio Transients (LPRTs).
As AI-generated synthetic media becomes increasingly indistinguishable from authentic content, understanding how humans perceive and evaluate artificial stimuli is both a scientific and societal imperative. This talk presents findings from neuroimaging and behavioral experiments investigating whether the human brain contains reliable signals that distinguish real from AI-generated faces.
Using fMRI and machine learning-based neural decoding, we show that distinct patterns of brain activity emerge when participants view authentic versus synthetic faces — even when behavioral judgments approach chance. Multivariate classification of neural responses identifies regions involved in authenticity perception, revealing that the brain processes subtle cues related to artificiality that may not reach conscious awareness. Behavioral results further characterize the conditions under which human detection performance degrades, particularly as generative models improve in photorealism.
Robotic technology is evolving at a remarkable pace, and with this rapid evolution comes an urgent need for safe robotic autonomy. This talk presents the mathematical foundations for achieving collision avoidance on robotic systems, enabling robots to generate safe actions directly from real-world perception (e.g. camera, LiDAR). By bridging elliptic partial differential equations and modern control theory, we establish formal mathematical guarantees of safety while adapting changes in the environment. We validate these theoretical approaches on a variety of robotic platforms---including humanoids, quadrupeds, drones and manipulators---demonstrating the generality of the underlying mathematical principles, and their capacity to enable safe and reliable operation in real-world settings.
In the local universe, low-mass irregular galaxies (Mstar ~ 109 Msun) and Milky Way mass (Mstar ~ 1010 Msun) disk galaxies are typically star-forming, while massive, elliptical galaxies (Mstar ~ 1011 Msun) are usually “quenched” or not forming stars. Simulations have shown that supermassive black hole (SMBH) feedback shuts down star formation in these massive galaxies and is required to reproduce the observed galaxy population at low redshift. It is still not fully understood how SMBH feedback corresponds to galaxy morphology in detail. To elucidate the effects of SMBH feedback on galaxy morphology, we analyze a suite of 9 Milky Way-mass galaxies with live SMBH feedback from the “Feedback In Realistic Environments” (FIRE) simulations. Using circularity (𝜖 = Jz/Jc(E)) as a proxy for morphology, we investigate how heating and outflows/winds from SMBH feedback disrupt star formation and the subsequent morphological evolution of galaxies over cosmic time. We find that SMBH feedback reduces star formation across three evolutionary phases corresponding to spheroidal, thick disk, and thin disk morphologies. Notably, SMBH feedback targets the disk formation phase, resulting in a more spheroidal shape
The Terahertz Intensity Mapper (TIM) is one of the first instruments to apply far-infrared intensity mapping (240–420 μm) to study the cosmic history of star formation. Rather than resolving individual galaxies, intensity mapping measures the power spectrum of spatial and spectral intensity fluctuations across a three-dimensional data cube. This statistical approach enables TIM to trace the aggregate emission from dust-obscured galaxies and probe five billion years of cosmic evolution through the redshifted 157.7 μm [CII] fine-structure line, a primary coolant of the interstellar medium and well-established tracer of star-formation. TIM uses two R∼250 long-slit grating spectrometers, each with focal planes populated by horn-coupled aluminum kinetic inductance detectors (KIDs). KIDs are superconducting microresonators whose resonant frequencies shift in response to incident radiation. Each detector is designed to operate at a unique resonance frequency, allowing hundreds of pixels to be read out simultaneously on a single feedline using frequency-domain multiplexing, which enables large-format detector arrays. To achieve high yield and sensitivity, KID arrays require high quality factors and tightly controlled resonant frequencies. In practice, these frequencies can drift or scatter due to a range of physical, environmental, and system-level effects. This scatter can lead to resonator collisions, reduced yield, and loss of frequency-to-pixel mapping, all of which degrade instrument performance. We characterize frequency scatter in TIM KID arrays, identifying its main underlying causes, and describe strategies to mitigate its impact on array yield and performance.
How to track the health of an aquifer we cannot see or directly access? I work at the crossroads of seismology and hydrology to address this challenge.
By analyzing permanent but subtle ground vibrations recorded in California’s Central Valley, I track mechanical weakening driven by hydrologic perturbations (e.g. the water cycle, extreme weather events), to monitor the ever-changing health of aquifer systems. My goal is to quantify small variations in seismic wave propagation velocities (dv/v), which are highly sensitive to changes in effective stress. Leveraging coda wave interferometry methods, I explore how dv/v measurements can serve as proxies for basin-scale effective stress redistribution, poroelastic response and the accumulation or relaxation of subsurface damage.
I present preliminary results and ways in which my research helps gain better understanding of aquifer systems mechanics.