To help defend the host from pathogens and maintain tissue homeostasis, neutrophils – the most abundant immune cell in our body – need to generate physical forces to move, interact with their environments and kill their targets. Our lab aims to understand how neutrophils generate and transmit the physical forces needed for their host defense functions. Such knowledge will open the door to biophysics-inspired strategies for controlling and re-engineering neutrophil functions to improve immune responses. In this talk, I will discuss our lab’s current work toward understanding how neutrophils remodel and rupture the nucleus and plasma membrane to release chromatin to the extracellular environment during NETosis - an immune response that worsens inflammation. Our work identified novel mechanisms by which chromatin regulates the mechanical properties of cells, independently of gene expression, materially advancing our understanding of the biophysical roles of chromatin in cell physiology.
In this talk, Dr. Khalid K. Osman will reflect on the research mission and evolving body of work of the Osman Lab, which sits at the intersection of infrastructure engineering, environmental justice, and community engaged research. His work is motivated by a central question of how infrastructure systems, particularly water and sanitation, can be designed, evaluated, and governed in ways that address historical harm, center lived experience, and respond to climate and social change. Drawing on projects across multiple U.S. cities, he will discuss how conventional engineering and regulatory frameworks often overlook critical dimensions of equity such as trust, affordability, and everyday experiences with infrastructure. He will highlight how community based participatory research, mixed methods, and sustained partnerships with community based organizations can expand what counts as evidence and lead to more grounded ways of evaluating system performance. The talk will weave together examples from household scale water quality monitoring, affordability and assistance programs, and risk communication during crises to show how social, institutional, and technical factors interact to shape infrastructure outcomes. Dr. Osman will also reflect on what inspired him to pursue this line of research, the commitments that guide his lab, and future directions including climate driven hazards, governance and policy design, and the development of scalable tools to support more equitable infrastructure decision making.
Mitigating industrial carbon emissions requires technologies that operate efficiently under realistic flow, thermal, and chemical constraints, where separation and reaction processes are often tightly coupled. Many existing approaches rely on powder-based materials and packed-bed reactors, which impose fundamental limitations on pressure drop, heat management, and scalability. In this talk, I will present recent work on monolithic material platforms designed to address these challenges by decoupling structural transport properties from surface chemistry.
The talk will focus on how mesoscale architecture in washcoated monolithic materials governs gas transport, thermal behavior, and reactive performance under integrated capture–reaction conditions. By systematically varying operating parameters such as flow rate, temperature, and feed composition, this work identifies structure–function relationships that emerge in structured reactor environments. These results highlight both the opportunities and constraints of monolithic architectures and illustrate how reactor-relevant material design can enable more efficient and scalable approaches to carbon management across engineering applications.
Astronomical observations indicate that roughly 85% of the matter in the Universe exists in an invisible, yet-to-be-discovered form known as dark matter. Unveiling its nature remains one of the most compelling challenges in modern physics. Around the world, numerous experiments are pursuing this mystery through complementary detection technologies aimed at determining what dark matter is made of.
One of the leading efforts in direct-detection, is LUX-ZEPLIN (LZ), the U.S. flagship dark matter experiment located deep underground at the Sanford Underground Research Facility in South Dakota. LZ employs a large, ultrapure liquid xenon time projection chamber (TPC) to search for tiny interaction signals from proposed dark matter particles, including a class of Weakly Interacting Massive Particles (WIMPs), one of the most compelling candidates.
In this talk, Dr. Kamaha will review the astrophysical evidence for dark matter, discuss leading theoretical candidates, and explain direct detection strategies, with particular emphasis on the xenon TPC technique used by LZ. She will conclude by presenting recent world-leading results from LZ as well as an outlook on the future of dark matter research.
The study of relativity, spacetime, and black holes often requires one to incorporate a complex mixture of abstract mathematics and several areas within theoretical physics. To this day there remains significant gaps in our understanding of the dynamic ejection of matter from black holes. This nexus point requires lots of physics, geometry, and even more imaginative creativity to solve the mystery of these dark objects in our universe. Relativistic jet launching mechanisms can be described, in part, by the dynamic interplay of poloidal-toroidal magnetic fields emanating from accretion disk plasma under the rotational influence of the central black hole. It is this intricate relationship between black hole spin, magnetic fields, and the distribution of matter at high energies that is the essence of this synergy. This talk will break down these complex mechanisms and present a spin-tetrad formalism on a Kerr background to predict the fractional circular polarization degree in synchrotron-dominated AGN jets. The formalism yields closed-form and numerically tractable expressions that map directly to observables, enabling parameter inference on field geometry. A discussion on unresolved problems in jet formation and future theoretical descriptions will be provided.
Scientists often master complex scientific secrets, while neglecting attention on building generational wealth. This session provides a practical playbook to build long-term wealth throughout a scientific career. We will detail the three laws of wealth building - Compounding, Diversification, and Capital - with technical concepts and case studies ranging from stock investing, real estate, and company building.
Jaw development is an essential process of facial structure and function. In vertebrates, multipotent progenitor cells, known as the neural crest, develop into the cartilage and bones of the maxilla (upper jaw) and mandible (lower jaw). Here, we define the gene network regulating neural crest differentiation during development using single cell RNA sequencing. Neural crest cells were isolated from the maxillary and mandibular arch of mouse embryos and transcriptionally profiled at single cell resolution. The mesenchyme showed cellular heterogeneity and analysis of the cells from the maxillary and mandibular prominences showed distinct expression patterns. In situ analysis validated the expression patterns of these genes within the arches. We identified molecular signatures of distinct cell states and constructed putative developmental trajectories for each arch. Our results give insight into the gene regulatory networks coordinating neural crest differentiation into craniofacial cartilage and bone in the upper and lower jaw.
The South Pole Telescope (SPT) collaboration has started a campaign to monitor active galactic nuclei (AGN) that will grow to include more than 1,000 sources. Here, we show SPT AGN light curves and data for 100+ sources that are being made publicly available for the first time. We show data from the SPTpol instrument, which was designed for observations of the CMB at angular scales of 1 arcminute and larger and ran from 2012 to 2016. These observations come from the 500-square-degree SPTpol survey field, which was covered several times a day using detectors that were sensitive to radiation in bands with centers at 90 and 150 GHz. We discuss the data processing pipeline, the matched filter process, and the source selection parameters. We also show light curves for selected sources and variability statistics for the full sample. All of the data products we show here will be available for download through the SPT Treasury Record of AGN With Historical Activity and Time Series, or STRAWHAT, catalog. This is the first step in a larger release that will include polarized AGN light curves from SPTpol data and three-band polarized light curves from the ongoing SPT-3G survey. This project will serve as a basis for monitoring AGN with current and future CMB experiments like Simons Observatory as well as multi-wavelength studies with facilities like VRO-LSST.
Robotic technology is evolving at a remarkable pace, and with this rapid evolution comes an urgent need for safe robotic autonomy. This talk presents the mathematical foundations for achieving collision avoidance on robotic systems, enabling robots to generate safe actions directly from real-world perception (e.g. camera, LiDAR). By bridging elliptic partial differential equations and modern control theory, we establish formal mathematical guarantees of safety while adapting changes in the environment. We validate these theoretical approaches on a variety of robotic platforms---including humanoids, quadrupeds, drones and manipulators---demonstrating the generality of the underlying mathematical principles, and their capacity to enable safe and reliable operation in real-world settings.
Magnetars, the most highly magnetized subset of neutron stars, remain enigmatic in nature; while likely formed through Core-collapse Supernovae (CCSNe), the origin of their large (>1013 G) magnetic fields and relationship to radio pulsars are unclear. Magnetars also exhibit a wide variety of emission types from periodic short bursts to Giant Flares and outbursts. Beyond this, magnetars are considered a leading candidate for the source of multiple unidentified phenomena within our Galaxy and beyond. In this talk, I use the DSA-110 radio telescope and archival multi-wavelength datasets to explore the formation of magnetars and the origins of two magnetar-candidate radio species: extragalactic Fast Radio Bursts (FRBs) and Galactic Long Period Radio Transients (LPRTs).
Ubiquitous amongst any living organism is the need to conserve energy via processes such as respiration. Respiration requires the reduction of an electron acceptor, such as oxygen, to generate an ion gradient driving the synthesis of adenosine triphosphate (ATP) via the action of the ATP synthase. In the absence of oxygen, the preferred terminal electron acceptor, non-fermenting and denitrifying bacteria such as Pseudomonas aeruginosa can respire using nitrate instead of oxygen, reducing it to dinitrogen. In this study, we focused on the utilization of a specific N-oxide intermediate: nitric oxide (NO). NO is of particular interest due to its production as a toxin as part of the human immune response to infections.
This talk will provide an example of a common pathogen’s ability to use a substrate initially produced as an antimicrobial agent for energy conservation, highlighting the importance of considering the full repertoire of energy-conservation strategies used by pathogens to succeed in eradicating them.
The Terahertz Intensity Mapper (TIM) is one of the first instruments to apply far-infrared intensity mapping (240–420 μm) to study the cosmic history of star formation. Rather than resolving individual galaxies, intensity mapping measures the power spectrum of spatial and spectral intensity fluctuations across a three-dimensional data cube. This statistical approach enables TIM to trace the aggregate emission from dust-obscured galaxies and probe five billion years of cosmic evolution through the redshifted 157.7 μm [CII] fine-structure line, a primary coolant of the interstellar medium and well-established tracer of star-formation. TIM uses two R∼250 long-slit grating spectrometers, each with focal planes populated by horn-coupled aluminum kinetic inductance detectors (KIDs). KIDs are superconducting microresonators whose resonant frequencies shift in response to incident radiation. Each detector is designed to operate at a unique resonance frequency, allowing hundreds of pixels to be read out simultaneously on a single feedline using frequency-domain multiplexing, which enables large-format detector arrays. To achieve high yield and sensitivity, KID arrays require high quality factors and tightly controlled resonant frequencies. In practice, these frequencies can drift or scatter due to a range of physical, environmental, and system-level effects. This scatter can lead to resonator collisions, reduced yield, and loss of frequency-to-pixel mapping, all of which degrade instrument performance. We characterize frequency scatter in TIM KID arrays, identifying its main underlying causes, and describe strategies to mitigate its impact on array yield and performance.
As AI-generated synthetic media becomes increasingly indistinguishable from authentic content, understanding how humans perceive and evaluate artificial stimuli is both a scientific and societal imperative. This talk presents findings from neuroimaging and behavioral experiments investigating whether the human brain contains reliable signals that distinguish real from AI-generated faces.
Using fMRI and machine learning-based neural decoding, we show that distinct patterns of brain activity emerge when participants view authentic versus synthetic faces — even when behavioral judgments approach chance. Multivariate classification of neural responses identifies regions involved in authenticity perception, revealing that the brain processes subtle cues related to artificiality that may not reach conscious awareness. Behavioral results further characterize the conditions under which human detection performance degrades, particularly as generative models improve in photorealism.
This study examines the effects of microbiome on activation of host regeneration processes. As an injury model, we utilized the Drosophila limb, which does not normally regenerate. We find that supplementing Lactobacillus brevis ATCC 367 promotes activation of regeneration processes in the amputated limb, as characterized by change in wound healing, enhanced tissue survival, and eventually partial regrowth of the limb. To investigate how L. brevis influences host regeneration, we combined genome-scale metabolic modeling with experimental measurements, and found that L. brevis secretes the amino acid ornithine. Flies fed with L. brevis indeed show higher extract levels of ornithine and altered levels of enzymes that metabolize ornithine. Directly administering ornithine to the flies promotes regeneration processes in the limb. In summary, this study presents evidence that supplying a bacteria that secretes ornithine can promote regeneration processes in a host organ that does not normally regenerate. Further, L. brevis supplementation can be performed prior to injury, opening up the possibility of prophylactically improving response to injury.