Isaac joined Caltech as an Assistant Professor of Biochemistry in November 2024, after completing postdoctoral research in the laboratory of Prof. Patrick Cramer at the Max Planck Institute for Multidisciplinary Sciences in Germany. His laboratory, the Fianu Lab, focuses on understanding how gene activity is controlled and coordinated with genome maintenance, aiming to uncover the fundamental mechanisms that drive these critical biological functions in both health and disease.
As an expert in structural biology, molecular biology, and biochemistry, Isaac employs cryo-electron microscopy and other advanced techniques to reconstitute and visualize large macromolecular machines that regulate gene activity. Throughout his doctoral and postdoctoral training, he elucidated the structures of several transcription complexes, detailing how these assemblies are formed and function within our cells. His research provides valuable insights into how transcription complexes are removed from the DNA template, which is vital for both gene regulation and genome stability.
Isaac earned his MSc and PhD degrees from the University of Göttingen as part of the International Max Planck Research School for Molecular Biology, receiving a stipend from the Max Planck Society. Prior to his time in Germany, he completed his undergraduate training in Biochemistry at the University of Ghana in Accra.
Dr. Stacey Finley is holder of the Nichole A. and Thuan Q. Pham Professorship at the University of Southern California. She is Professor of Biomedical Engineering, and Quantitative & Computational Biology. Dr. Finley received her B.S. in Chemical Engineering from Florida A&M University and obtained her Ph.D. in Chemical Engineering from Northwestern University. She completed postdoctoral training at Johns Hopkins University in the Department of Biomedical Engineering. Dr. Finley joined the faculty at USC in 2013, and she leads the Computational Systems Biology Laboratory. Dr. Finley has a joint appointment in the Department of Chemical Engineering and Materials Science, and she is a member of the USC Norris Comprehensive Cancer Center. Dr. Finley is also a standing member of the MABS Study Section at NIH. Her research has been supported by grants from the NSF, NIH, and American Cancer Society.