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Group Leader:
Mariana Boroni, Ph.D. Mariana Boroni, Ph.D., is an associated researcher at the Brazilian National Cancer Institute (INCA), where she directs the Bioinformatics and Computational Biology Lab and serves as the coordinator of the Computational platform. She has a bachelor's degree in biochemistry and an M.Sc. in biochemistry from Universidade Federal de Viçosa, a Ph.D. in bioinformatics from Universidade Federal de Minas Gerais (visiting student at the NIH - National Institute of Health, Bethesda, US), and did her PostDoc in bioinformatics at the Ludwig Maximilians Universität München, Germany. Her group is interested in data analysis and the development of workflows/tools for the immuno-oncology interface, with a focus on high throughput sequencing approaches such as genomics, epigenomics, and transcriptomics in cellular and spatial resolution.
Lattes curriculum: http://lattes.cnpq.br/2407012834433865
email: mariana.boroni@inca.gov.br
phone: +55 21 3207-6550
Technologist:
Nicole Scherer, PhD. Dr. Nicole Scherer finished undergraduate studies in biological sciences (Universidade Federal do Rio Grande do Sul – UFRGS – Porto Alegre, Brazil), and began a master’s degree in genetics in the same institution with a project in plant evolution to be performed totally in silico. Being the only student working with bioinformatics in the genetics institute at that time, she decided to deepen her knowledge in the field and applied to do a PhD in Germany. During her graduate studies in bioinformatics (Faculty of Mathematics and Natural Sciences - Heinrich Heine University, Düsseldorf), she learned programming in Perl and R, and acquired the necessary skills in GNU/Linux for the use of bioinformatics software. In 2011 she joined LBBC as a technologist in bioinformatics at the Brazilian National Cancer Institute (INCA – Rio de Janeiro). The research center of INCA was planning to start a bioinformatics multi-user platform to serve all research groups of the institute. Since the acquisition of our first cluster, in 2013, she is the manager of the bioinformatics platform, offering technical and scientific support for over 40 users. She is engaged in education and outreach of bioinformatics and is a member of the directory board of the Brazilian Association of Bioinformatics and Computational Biology (AB3C), being on the organizing committee of the X-Meeting, the largest conference for bioinformatics in Brazil.
Lattes curriculum: http://lattes.cnpq.br/3555370764574908
email: nscherer@inca.gov.br
phone: +55 21 3207-6546
Current members:
Postdoctoral researchers:
Leandro Santos, PhD. Ph.D. and Masters in Biological Sciences (Biophysics) by the Biophysics Institute Carlos Chagas Filho (IBCCF) at the Federal University of Rio de Janeiro (UFRJ). Specialization in Forensic Biology from Castelo Branco University (UCB) / Bioforense and Graduated in Biomedicine from Severino Sombra University (USS / RJ). Post-doctorate by the Virus Molecular Biology Laboratory (IBCCF / UFRJ) and by the Laboratoire de Pharmacologie Cellulaire (IBMM - Montpellier / France). He has experience in omics data analysis using bioinformatics tools, phylogeny, comparative genomics, as well as modeling and molecular dynamics. Experience also in techniques of genetic manipulation of microorganisms, molecular biology and biochemistry, especially Sanger and NGS sequencing. Currently, postdoctoral fellow at the Laboratory of Bioinformatics and Computational Biology (LBBC) of the National Cancer Institute (INCA) where he has been developing a project to characterize and determine the function of different subpopulations of macrophages in relation to pro-inflammatory diseases, especially cancer. This project uses public single-cell sequencing (scRNA-seq) data in order to create an atlas of macrophages associated with solid tumors.
Lattes curriculum: http://lattes.cnpq.br/5119748444791109
Nayara Toledo, PhD. Ph.D. and Masters in Bioinformatics at the Universidade Federal de Minas Gerais (UFMG). Biologist graduated from the UFMG (Bachelor with emphasis in biotechnology and health). She has experience in Molecular Biology and transcriptomic analysis, with emphasis on alternative splicing. Currently, postdoctoral fellow at the Laboratory of Bioinformatics and Computational Biology (LBBC) of the National Cancer Institute (INCA), working mainly to investigate the mechanism underlying the ZNF429-mediated regulation in ovarian tumors, their targets and how this regulation affects the pathways involved in tumor biology and progression.
Lattes curriculum: http://lattes.cnpq.br/5054763686499204
Nayara Tessarollo, PhD. PhD in Biotechnology from the Federal University of Espírito Santo (2017) (sandwich period at Johns Hopkins University, Baltimore, USA). Master in Health Sciences with emphasis in Cellular and Molecular Biology from the René Rachou Research Center-FIOCRUZ/MG (2013). Bachelor in Biochemistry from the Federal University of Viçosa (2010). Post-doctorate in Oncology from the Cancer Institute of the State of São Paulo (ICESP). Currently, she is a postdoctoral student at the Laboratory of Bioinformatics and Computational Biology (LBBC) of the National Cancer Institute (INCA), developing the project high resolution characterization of the transcriptome of subpopulations of the tumor microenvironment of ovarian cancer and its impact on clinical outcome and therapy resistance. She has experience in the field of gene therapy, biochemistry, molecular and cell biology, immunology.
Lattes curriculum: http://lattes.cnpq.br/8607496356516938
Alessandra Serain PhD. PhD in Sciences from the Universidade Estadual de Campinas (2020) (internship period at the Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy). Bachelor in Pharmacy from the Universidade Estadual de Campinas (2014). Postdoctoral degree in Biochemistry and Bioluminescent Technologies from the Universidade Federal de São Carlos (Ufscar). She has experience in chemistry of natural products, studies of bioprospecting with culture of tumor cells, development of analytical methods for quantification of chemotherapy in plasma and solid tumor samples using mass spectrometry, application of bioluminescence in new technological systems of biosensors. She is currently a Postdoctoral student at the Laboratory of Bioinformatics and Computational Biology (LBBC) of the Instituto Nacional do Câncer (INCA), developing a research project with ovarian tumor and resistance to therapies through knowledge of subpopulations of the tumor microenvironment and analysis of snRNA-Seq and spatial transcriptomics.
Lattes curriculum: http://lattes.cnpq.br/0430250077903286
PhD. Students:
Cristiane Esteves Teixeira. Biologist, graduated from the Federal University of the State of Rio de Janeiro (UNIRIO). She has experience in molecular biology, genomic assembly and analysis, as well as applying artificial intelligence techniques to cancer biology. She holds a Master's degree in Oncology with an emphasis on Data Analysis from the Bioinformatics and Computational Biology Laboratory of the National Cancer Institute (LBBC-INCA/RJ). He is currently studying for a PhD in Oncology with an emphasis on Data Analysis at the same laboratory. In collaboration with the Big Data and Predictive Analysis Laboratory at the University of São Paulo (LABDAPS - USP), she is developing research projects aimed at predicting prognoses and identifying biomarkers using machine learning techniques based on multi-omics data (RNA-seq, miRNA-seq and DNA-seq), with a main focus on ovarian tumors.
Lattes curriculum: http://lattes.cnpq.br/4723769716945310
Gabriela Rapozo Guimarães. Graduated in Biomedicine with emphasis in Clinical Analysis at the Federal Fluminense University (UFF), where she acquired experience in virology and HPV during three years of Scientific Initiation in the Laboratory of Virological Diagnosis of UFF. She was a student at the Laboratory of Bionformatics and Computational Biology (LBBC), where she is currently a Master's student under the supervision of Mariana Boroni and co-supervision of Marcelo Mori (UNICAMP). The project aims to correlate the clinical impact of macrophage aging in triple negative breast cancer through spatial and single cell transcriptomics.
Lattes curriculum: http://lattes.cnpq.br/4915949596150748
Michelle Paredes Escobar. Bachelor in Engineering - BE, Biotechnology from the Armed Forces University - Ecuador (UFA-ESPE) and holds a Master's degree in Computational Biology from the Pontifical Catholic University of Ecuador. During her academic training, she was part of the Nanobiology and Nanomedicine Research Group, participating in projects focused on studying antimicrobial resistance in clinically relevant bacteria using NGS and Machine Learning technologies. Her master's project focused on the analysis of RNA-seq data in prostate cancer. Additionally, she worked as part of the technical staff at the Julio Villacreses Colmont SOLCA Manabí Oncological Hospital in Ecuador, with a focus on molecular diagnosis of myeloproliferative neoplasms. She is currently a PhD candidate in Oncology in a project focused on characterizing genetic variants associated with the treatment response of ovarian cancer.
Link Lattes: http://lattes.cnpq.br/8011641457155657
Masters Students:
Glenerson Batista. Bachelor of Biological Sciences, with a focus on Cellular Biology and Health, graduated with honors Cum Laude from the State University of Northern Rio de Janeiro Darcy Ribeiro (UENF). From 2018 to 2022, I conducted Scientific Initiation activities with a FAPERJ/UENF scholarship at the Cellular and Tissue Biology Laboratory, focusing on identifying patterns of expression and activity of Ionic Pumps in human tumors associated with HPV infections. Utilizing approaches involving cell line assays, immunofluorescence, and bioinformatics to assess the potential of these pumps as biomarkers. Additionally, I was an Enhancement Student in the Oncology Research Scholarship and Training Program at the Bioinformatics and Computational Biology Laboratory at the National Cancer Institute (INCA/RJ), where I explored the gene regulation mechanism by the transcription factor ZNF429 in ovarian tumor pathways. Currently, I am a master's student in the stricto sensu Postgraduate Program in Oncology (PPGO), also at the Bioinformatics and Computational Biology Laboratory at INCA, focusing on evaluating gene expression in High-Grade Serous Ovarian Cancer and its impact on therapy resistance.
Lattes curriculum: https://lattes.cnpq.br/1257237863199012
Gabriel Fonseca, BSc. Bachelor of Biological Sciences from the Federal Fluminense University (UFF), with emphasis on health and oncology. Was a Scientific Initiation (SI) student in Neurobiology laboratories at UFF, studying the structure and function of endocannabinoid receptors and their modulation by endogenous and exogenous neurotransmitters. Also worked as an SI student at the Laboratory of Bioinformatics and Computational Biology (LBBC-INCA/RJ), focusing on identifying biomarkers, which became their improvement project I. The goal of this project is to investigate the role of the transcription factor ZNF429 in regulating cellular pathways in pancreatic and ovarian cancer. Currently pursuing a Master's degree, developing a project aimed at evaluating the differential expression of isoforms derived from alternative splicing using single-cell RNA-seq data from samples of patients with high-grade serous ovarian cancer.
Lattes curriculum: http://lattes.cnpq.br/2132058819644177
Linkedin: Gabriel (Gabriel Fonseca) Fernando Costa Da Fonseca | LinkedIn
Laís Costa, BSc. Bachelor of Biomedicine from the Federal University of Rio de Janeiro (2023). She began her scientific journey at the Immunophysiology Laboratory of the Carlos Chagas Filho Institute of Biophysics, aiming to understand the responsive mechanisms of macrophages - in the context of purinergic signaling activation - against Leishmania amazonensis infection, being a FAPERJ scholarship holder. Consequently, she has experience in immunology with emphasis on the immunophysiology of innate immunity. Currently, she is a master's student in the Oncology Graduate Program, investigating the heterogeneity of the tumor microenvironment in patients with high-grade serous ovarian cancer, based on spatial transcriptomics.
Link para o Lattes: http://lattes.cnpq.br/7294321492191646
Under Improvement Student I:
Helena Zancanaro. Graduated in Pharmacy from the Federal University of Santa Catarina (UFSC), with an exchange semester at the University of Münster in 2023 (Mar-Aug). In 2024 (Jan-Feb) she was awarded a DAAD scholarship to study German at the University of Mannheim. She was a Scientific Initiation Fellow (2021-2024) at the Laboratory of Cancer Pharmacology and Biochemistry (LabCancer) and worked on projects related to the antioxidant pathway and therapeutic resistance in lung cancer (NSCLC) and studies related to the inflammatory profile of breast cancer (TNBC). She has experience in molecular biology and cell culture techniques. She is currently developing her project entitled “Characterization of circRNA-mirRNA-mRNA interaction networks in ovarian tumours with different tumour microenvironment profiles”.
Lattes Link: http://lattes.cnpq.br/9709551558987987
Rafaela Barros, BSc. UEMG-Ubá, the State University of Minas Gerais, awarded a degree in biological sciences. From 2021 to 2022, the exchange student attended the University of Sciences of Porto FCUP/PT. She completed an extension project titled "Report of the teacher: a trajectory of people as agents" while interning in the biology lab at UEMG. She also held a scholarship from the Institutional Program of Scholarships for Initiation to Teaching (PIBID) with a focus on the topic of "Astrocytes as a target for the inhibitory myelin protein Nogo-A in CNS development and disease." Her final year research project, "Epigenetic biomarkers for the identification of body fluids in forensic genetics," is another thing she is focusing on.
Link para o Lattes: ttps://lattes.cnpq.br/5528503003505016
Under Improvement Student II:
Bachelor in Biomedicine at IBMR University Center, specialist in Business Intelligence, Digital Marketing and Data Driven Strategy from PUCRS and Master’s in Oncology from the National Cancer Institute. Currently taking the Improvement II course and his project aims to evaluate the association between variants and the gene expression profile in tumor cells from the analysis of RNA sequencing of individual nuclei of patients with high-grade serous ovarian cancer (HGSOC).
Link Lattes: http://lattes.cnpq.br/7717094241976844
Victor Hugo Garcia de Oliveira Bachelor's degree in Biological Sciences from the Universidade do Oeste Paulista (UNOESTE). Master's degree from the Graduate Program in Environment and Regional Development. Postgraduate Lato Sensu in Molecular Biology Applied to Bioinformatics from the Federal Technological University of Paraná (UTFPR). During undergraduate studies, held a scientific initiation scholarship from the São Paulo Research Foundation (FAPESP). Has experience in general genetics, molecular genetics, and bioinformatics. Currently enrolled in the Advanced Training II program at LBBC-INCA, working on a project related to gene expression analysis in endometrial carcinosarcoma cases.
Lattes: http://lattes.cnpq.br/4068319796218363
Linkedin: www.linkedin.com/in/2b3556222
Scientific Initiation Student:
Andressa Fagundes. Currently at the LBBC, she is learning bench experimental methods and bioinformatics for her project, under the guidance of Dr. Nayara Tessarollo and co-supervision of Dr. Mariana Boroni, on the role of macrophages in the progression of ovarian cancer, stemming from work in the scRNA-seq group.
Lattes curriculum: http://lattes.cnpq.br/6083058381657677
Linkedin: https://www.linkedin.com/in/andressa-fagundes-6592b7141/
Geovanna Barroso de Farias. Undergraduate student in Biomedicine at the Instituto Brasileiro de Medicina e Reabilitação (IBMR). Currently a voluntary research intern at the Laboratory of Bioinformatics and Computational Biology (LBBC) at the Brazilian National Cancer Institute (INCA), where she is developing a project involving the creation of a predictive model using machine learning techniques to study miRNAs associated with prognosis in high-grade serous ovarian cancer (HGSC), under the supervision of Dr. Mariana Boroni and co-supervision of Msc. Cristiane Esteves Teixeira.
Linkedin: www.linkedin.com/in/geovannabfarias
Email: geovannab.farias@gmail.com
Pedro Videira. Underdegree student in biology with emphasis in biotechnology from the State University of Rio de Janeiro (UERJ). Currently at LBBC learning about spatial transcriptomics technology for his project under the guidance of Dr. Mariana Boroni and co-supervision of Cristóvão Antunes de Lanna on the spatial context of macrophage interactions with immune cells. With this, verify changes between data from different staging and resistance to therapies.
Lattes curriculum: http://lattes.cnpq.br/6424380990004157
Email: pedrovp161@gmail.com
Co-supervision:
Ana Carolina Pires, MSc. Bachelor’s degree in Biotechnology (2019) and Master’s degree in Sciences, with an emphasis in Microbiology (2023), both from UFRJ. Developed a master’s dissertation during the pandemic, using scRNA-seq to analyze public data of bronchoalveolar cells from COVID-19 patients. Simultaneously, participated in metabolomics projects in the same research area. Currently enrolled in the Aperfeiçoamento II program, under the supervision of Dr. Mariana Emerenciano, at the Acute Leukemia Genetics Laboratory (GenLab) at INCA, developing a project focused on the immune system in acute lymphoblastic leukemia, using single-cell RNA-seq data from pediatric patients. She is co-supervised by Dr. Mariana Boroni to develop expertise in bioinformatics.
Email: acpiresesilva@gmail.com
Bianca Braga Frade, Msc. PhD student in Morphological Sciences Program of the Federal University of Rio de Janeiro (PCM/UFRJ). Bianca is advised by Dr. Danielle Bonfim (ICB/UFRJ) and co-advised by Dr. Mariana Boroni (INCA). Bianca has a master's degree (2023) in Biological Sciences (Biophysics), from the Carlos Chagas Filho Institute of Biophysics (IBCCF/UFRJ). Has a bachelor’s (2021) in Biological Sciences: Medical Modality, with a specialization in Science and Technology (ICB/UFRJ). Bianca also has a Technician degree (2014) in Business Administration, from the Higher Institute of Education of Rio de Janeiro, of the Foundation for Support of the Technical School (ISERJ/FAETEC). She was CEO (2018) of the Antônio Paes de Carvalho Junior Company (APC/ICB/UFRJ). She works at the Stem Cell and Bone Regeneration Laboratory (LabCeR/ICB/UFRJ) and at the Bioinformatics and Computational Biology Laboratory (LBBC/INCA) studying the processes involving Fracture Regeneration, Aging and the Immune System. She is a substitute professor in the Undergraduate Program in Anatomy (PGA/ICB/UFRJ).
Link para lattes: http://lattes.cnpq.br/8515386850227587
Email: bb.frade@hotmail.com
Lucas Aleixo Leal. He has a degree in Biomedicine from the Federal University of Pernambuco (UFPE), where he carried out research using C. elegans as an experimental model for toxicological studies, as well as working with structural bioinformatics to prospect for new drugs aimed at treating neurodegenerative diseases. He was an undergraduate student at LBBC and is conducting studies using single-cell data to elucidate the role of tumor-associated macrophages in the clinical outcome of melanoma patients. He is currently a master's student.
Lattes curriculum: http://lattes.cnpq.br/1045077074450512
Linkedin: https://www.linkedin.com/in/lucas-aleixo-b1a3141b4/
Email: lucas.aleixoleal17@gmail.com
External collaborators:
Cristóvão Antunes de Lanna, PhD. Was a postdoctoral fellow at the Brazilian National Cancer Institute (INCA), working at LBBC as well as the Molecular Carcinogenesis Program (PCM). Bachelor in Biomedicine at the Rio de Janeiro State Federal University (2013), with a Masters degree in Biological Sciences (Biophysics) at the Carlos Chagas Filho Institute (IBCCF), from the Rio de Janeiro Federal University (2016), and a PhD in Oncology with an emphasis in Data Analysis at INCA (2023). Expertises include clinical analyses applied to laboratory animals, molecular biology, genomics, and transcriptomics. He is currently developing in silico analysis workflows including multi-omics data (genomics, transcriptomics, epigenomics) for the identification of novel therapeutic targets in a variety of tumors and tumor-derived cell lines.
Lattes curriculum: http://lattes.cnpq.br/0341173575404468
Willker Menezes da Rocha, PhD. Bachelor in Biomedicine at the Federal Fluminense University (UFF, 2011), with emphasis on Virology and Molecular Biology. Master's degree (2014) and Ph.D. (2019) in Applied Microbiology and Parasitology, at UFF, with emphasis on oncoviruses and gynecological cancers. Postdoctoral research at the Virology Research Center (PPGMPA – UFF, 2022). Serves as a university professor (UNESA), and as a technician in the Department of Veterinary Collective Health and Public Health – UFF. Has experience in molecular biology and virological diagnostics, biochemical analysis, microbiological analysis of animal-derived products, bioinformatics, and in data science and machine learning techniques. Currently a volunteer postdoctoral researcher at the Laboratory of Bioinformatics and Computational Biology (LBBC) at the National Cancer Institute (INCA), working on research involving gynecological cancers and transcriptomic data analysis.
Romulo Galvani, PhD. Biomedical from the Federal University of Rio de Janeiro. He holds a Master's Degree in Cancer Care (INCA-RJ) and a PhD in Immunology (UFRJ). He did Postdoctoral work in a project on Oral Tolerance mediated by B Lymphocytes at the Thymus Research Laboratory at Fiocruz. He has experience in Bioinformatics and is a collaborator of the Laboratory of Bioinformatics and Computational Biology at INCA-RJ. He went on a mission for 3 months at the Karolinska Institute where he worked in the Laboratory of researcher Lisa Westerberg with Bioinformatics and Immunology.
Lattes curriculum: http://lattes.cnpq.br/4019471385460431
Alumni:
Layse Gomes. Undergraduate student in Biological Sciences at Universidade Federal Fluminense with emphasis on health. During her graduation she has been part of extension projects and scientific initiations involving structural biology. She was a scientific initiation student at LBBC and has been developing her skills in bioinformatics tools for analysis with scRNA-seq (single-cell RNA-seq) data and studies the diversity of phenotypes of resident tissue macrophages (RTMs) through the association of gene expression patterns of coding genes and lncRNAs under the orientation of Dr. Leandro Santos and co-supervision of Dr. Mariana Boroni.
Email: laysegomes1600@gmail.com
Tamires Caixeta Alves, PhD. PhD in Genetics and Biochemistry from UFU (2024), in collaboration with the Teaching and Research Center of the Mario Penna Institute. Graduated (2016) and Master's (2019) in Biotechnology from the Federal University of Uberlândia - Patos de Minas campus. Was a post-doctoral student at the Bioinformatics and Computational Biology Laboratory (LBBC) of the National Cancer Institute (INCA). She has a strong background in Molecular Biology and Bioinformatics, with experience in analyzing next-generation sequencing data. She is currently conducting research into melanoma cancers.
Link para Lattes: http://lattes.cnpq.br/8597119747634649
E-mail: tamires.alves@ensino.inca.gov.br
ORCID: 0000-0002-1507-2811
Maria Fernanda Ribeiro Dias, PhD. She was a DTI researcher in the Genomas Brasil-INCA project, participating in research related to Computational Biology, Bioinformatics and Biotechnology. Postdoctoral research at Auburn University - USA (2022-2023), using computational methods to investigate interactions between macromolecules of infectious organisms. PhD in Biotechnology from INMETRO (2018), and Master's degree in Computational Modeling with an emphasis on bioinformatics from the National Scientific Computing Laboratory (2014). Degree in Biological Sciences from Universidade Estadual do Norte Fluminense Darcy Ribeiro (2010). She was a Biology teacher at the Espírito Santo state network (SEDU-ES) and worked as a pedagogical technician at the Regional Education Superintendence of Vila Velha-ES (SREVV-ES), composing the Monitoring and Evaluation Committee for External Assessments of the State of Espírito Santo (COMAES), researching Education and Educational Management System.
Link para o Lattes: http://lattes.cnpq.br/7262655947864771
Elvismary Molina de Armas, PhD at Computer Science at PUC-Rio (2019). Master in Applied Informatics at the University of Informatics Sciences of Cuba (UCI) and graduated as Engineer in Computer Science from the same university. She is currently linked to the Laboratory of Bioinformatics and Databases (BioBD) at PUC-Rio and is a postdoctoral student at the Laboratory of Bioinformatics and Computational Biology (LBBC) at the National Cancer Institute (INCA). She has experience in software development for bioinformatics and biomedical information management. Her current focus is the development of scientific workflows, specifically for calling genetic variants following the best practices of the state-of-the-art, as well as the development of algorithms and data structures to support bioinformatics tasks such as de novo assembly.
Lattes curriculum: https://lattes.cnpq.br/8882801043033251
Caroline P. Poubel, PhD. Postdoctoral fellow at the Brazilian National Cancer Institute (INCA), working in the Molecular Onco-Hematology Group as well as the Bioinformatics and Computational Biology Laboratory. She has a Bachelor's degree in Biomedicine from Fluminense Federal University (UFF), in addition to a Master and Doctorate in Oncology from INCA. She has worked in the field of Molecular Biology, primarily on studies of genetic and epigenetic alterations in the etiology of acute leukemias. She has become an expert in bioinformatics over the last five years, working with omics data using R and Bash programming. Her current research focuses on the role of enhancer RNAs (eRNAs) in gene transcription regulation using ChIP-seq and RNA-seq data.
Lattes curriculum: http://lattes.cnpq.br/6857179921103991
Linkedin: www.linkedin.com/in/caroline-poubel
Jéssica Gonçalves Vieira da Cruz, MSc. Improvement Student II at the Laboratory of Bioinformatics and Computational Biology at the National Cancer Institute. Graduation in Biomedicine with emphasis in Scientific Research from the Fluminense Federal University (UFF - Brazil) with a sandwich period at the University of Hull, United Kingdom. Has laboratory experience in general and applied microbiology, use of the PCR technique (polymerase chain reaction), Western Blotting, Ca ++ uptake assays, bacterial transformation and transfection of cells in culture for expression of mutated proteins. He did Improvement I and Master in our laboratory, aggregating omics (RNA-seq, ChIP-seq, methylation, proteomics) and clinical data in order to understand how the function of ZNF429 and the regulation of its potential targets impacts the survival of patients with adenocarcinoma high-grade serous ovary.
Lattes curriculum: http://lattes.cnpq.br/7271057089770480
Marco Antônio Pretti, MSc. Technician in biotechnology from the Federal Institute of Rio de Janeiro (IFRJ - Brazil) and graduated in Pharmacy from the Federal University of Rio de Janeiro (UFRJ - Brazil) with a sandwich degree at the Université de Bordeaux, France. He has experience in molecular biology, cell culture, gene therapy and cell transfection and transduction system. Developed an in silico immunological analysis on next-generation sequencing data as part of her master's project at the National Cancer Institute (INCA - Brazil). He spent one year doing a sandwich doctorate in France collaborating with the Gustave Roussy Institute and the Curie Institute in the framework of his PhD project and during this period he described the cross-reactivities of T lymphocytes using the electrostatic charge of the HLA molecule that interacts with CD8 T lymphocytes, and thus defended his PhD thesis entitled "Evaluation of the patential cross-reactivity of T cell receptors to tumor epitopes".
Lattes curriculum: http://lattes.cnpq.br/3857079614636425
Giovanna R. Maklouf. Biotechnology graduate from the Federal University of Amazonas (UFAM). As her master's project, developed the characterization of the ovarian cancer tumor microenvironment, integrating single-cell and bulk transcriptomics to investigate the impact of different subpopulations on patient outcomes. At present, is a PhD student at the Laboratory of Genomics and bioEnergy (LGE) at the State University of Campinas (Unicamp), where she works with high-throughput prospection of industrial phenotypes in collections of yeast isolates and engineering of strains of bioenergy interest. The prospection includes analysis of a variety of data (genomics, transcriptomics, QTL), part of these skills due to the knowledge acquired during the M.Sc. at LBBC.
Lattes curriculum: http://lattes.cnpq.br/9038517267899194
Brena Duraes Rangel dos Santos. Undergraduate Biomedicine student at the Brazilian Institute of Rehabilitation Medicine, she was a Scientific Initiation student at the LBBC-INCA.
Natasha Andressa Nogueira Jorge, PhD. Postdoc at LBBC-INCA. She has a PhD and a Master's degree in Systems and Computational Biology from the Oswaldo Cruz Foundation (FIOCRUZ-RJ) and a bachelor's degree in Biomedicine from the Rio de Janeiro State Federal University. In the last three years, she was in a 9-month internship at Cambridge University, working with microRNA RNA-Seq in a variety of blood cell types, has published two papers and co-supervised a Scientific Initiation student. Her main research areas are: noncoding RNAs, high-throughput sequencing, bioinformatics, riboswitches and transcriptomics.
Lattes curriculum: http://lattes.cnpq.br/2674218363518596
NatDaniel Andrade Moreira, PhD. He holds a degree in Biological Sciences from the Federal University of Rio Grande do Norte (2008), a Master's degree in Science (Biophysics) from the Federal University of Rio de Janeiro (2012) and a Ph. Oswaldo Cruz - FIOCRUZ. He has practice with various molecular biology techniques. He has experience in genetics, molecular biology, transcriptomics, genomics, bioinformatics and programming (R, Perl and Shell script). He has worked on assembly and annotation projects for transcriptomes and mitochondrial genomes, with emphasis on evolution and molecular systematics (phylogenetic analyses). He was a postdoctoral fellow at the Laboratory of Bioinformatics and Computational Biology (National Cancer Institute), working on analyzing data from high-performance sequencers in order to comprehensively characterize the molecular events in various tumor types. He is currently working on the Bioinformatics Platform (RPT04A), part of the Fiocruz Technological Platforms Network.
Lattes curriculum: http://lattes.cnpq.br/5022535003622760
Guilherme Duarte de Moraes. Technician in Programming by the ORT technology institute and graduating in Biological Sciences Bachelor's degree with an emphasis on ecology at Veiga de Almeida University (UVA). He is currently doing an intership at the Laboratory of Bioinformatics and Computational Biology of the Brazilian National Cancer Institute, developing machine learning techniques to identify lncRNAs with the potential to be prognostic biomarkers in metastatic melanoma.
Lattes curriculum: http://lattes.cnpq.br/7180272245037507
Palloma Porto Almeida, MSc. Bachelor in Biotechnology from the Federal University of Bahia (UFBA) and a Master's degree in Cellular and Structural Biology from the Federal University of Viçosa (UFV). She has experience in theoretical and experimental cell biology, bioterism and animal bioethics, flow cytometry, histopathology, purification of native and recombinant proteins, and scientific communication. Currently develops postgraduate research at the National Cancer Institute at the Laboratory of Bioinformatics and Computational Biology, working with analysis of single-cell RNA-sequencing data to identify subpopulations of macrophages in the melanoma tumor microenvironment and the association of these subpopulations with progressive disease, response to therapy and prognosis.
Lattes curriculum: http://lattes.cnpq.br/7725181602733235
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