The Thermo Scientific™ Orbitrap™ Ascend Structural Biology Tribrid™ mass spectrometer delivers ultimate experimental throughput, versatility, and ease-of-use. Achieve greater coverage using a revolutionary hardware design featuring two ion routing multipoles and multiple orthogonal fragmentation and ion manipulation options. Characterize intact proteoforms and post-translational modifications, complex native structures with Native MS option, and peptide level analyses such as HDX and crosslinking experiments. All while producing more with less instrument setup featuring automated Auto-Ready ion source for calibration and pre-built, optimized method templates to maximize convenience and ease-of-use. Be ready for tomorrow’s most challenging demands.

The Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ mass spectrometer is the industry-leading high-performance mass spectrometer with enhanced sensitivity facilitated by a Novel high-sensitivity API interface combines a High Capacity Transfer Tube and an Electrodynamic Ion Funnel for increased ion flux and lower limits of detection; Advanced Active Beam Guide (AABG) prevents neutrals and high velocity clusters from entering the resolving quadrupole; Advanced Quadrupole Technology (AQT) combines high selectivity and efficiency of transfer for the selected ions symmetrically across the isolation window; Advanced Vacuum Technology for improved transmission of high molecular weight ions to the Orbitrap analyzer; and high dynamic range ETD providing significantly increased fragment ion coverage.

The Orbitrap Fusion Tribrid MS can perform a wide variety of analyses, from in-depth discovery experiments to characterization of complex PTMs to comprehensive qual/quan workflows. 

The availability of multiple fragmentation techniques—CID, HCD, ETD, and EThCD—at any stage of MSn, with fragment ion detection in either the ion trap or Orbitrap mass analyzer, offers a new level of versatility and performance for the most challenging applications. 

Users can perform complex MSn experiments such as HCD followed by ETD or EThCD for glycopeptide characterization or HCD followed by CID for small-molecule structural analysis.

The high mass accuracy of the LTQ Orbitrap Velos increases the speed and confidence of identification in complex samples by minimizing false positive identification. 

The ultra-high resolution provides certainty in analytical results by enabling molecular weight determination for intact proteins and in-depth analysis of isobaric species. 

The new HCD cell in the LTQ Orbitrap Velos is more efficient, resulting in improved quantitation of isobaricallylabeled peptides, such as applications requiring Tandem Mass Tags (TMT).

The second-generation SYNAPT™ G2 platform from Waters provides a new dimension of performance to drive scientific discovery like never before. We’ve combined QuanTof™ – breakthrough quantitative Tof technology – and enhanced High Definition MS™ technologies to provide you with intuitive operation, application flexibility and a totally new level of performance for all your applications.

The high-field Orbitrap analyzer increases speed, sensitivity and dynamic range to dig deeper into your samples.

The ultrahigh resolution provides certainty in analytical results by enabling molecular weight determination for intact proteins and in-depth analysis of isobaric species. The unsurpassed resolution of the system is especially useful when dealing with complex and low abundance samples, in applications such as proteomics, metabolomics and lipidomics.

The Orbitrap Elite hybrid MS can perform a wide variety of experiments from in-depth discovery based experiments to comprehensive qual/quan experiments. The availability of multiple fragmentation techniques (CID, HCD and optional ETD) offers a new level of versatility and performance for the most challenging research applications.