Md.Tafim Hossain Hrithik

Undergraduate (promising MS student in 2021 Fall)

E-mail:hrithik11605@gmail.com

Insect Molecular Physiology

[Academy]

Andong National University (BS degree in 2021 August)

[Research]

I joined this lab to study molecular biology and its related technologies. Currently I am working with expression analysis of an immune-associated gene called Repat33. Actually, Repat33 is one of Repat gene family consisting more than 40 members. Repat33 is highly inducible gene in response to various microbial pathogens. Loss-of-function of Repat33 using RNA interference technique led to the test insects under significant immunosuppression. Interestingly, Repat33 expression is under control of eicosanoids. Thus, pathogen infection induces eicosanoid immune signaling pathway, which up-regulates Repat33 expression. However, we do not know how Repat33 mediates both cellular and humoral immune responses. One clue is coming from a bioinformatics analysis with a collaboration with Ahmed Shabbir. Repat33 possesses its C-terminal MBF2 motif. This suggests its role as a coactivator by linking immunity-specific transcriptional factor (such as FTZ-F1 or NFkB) to general transcriptional factor (TFIIA). I look for this functional possibility and continue my research efforts to address this hypothesis.