Course responsible: Andre S. Ribeiro
Moodle: https://moodle.tuni.fi/course/view.php?id=37457
Learning Outcomes: In this course, the student will learn about core mechanisms of regulation of gene expression in prokaryotic and eukaryotic organisms and how they affect phenotypes, and their interaction with the environment.
Specifically, the students will learn about prokaryotic and eukaryotic gene expression, mitochondrial genomics, RNA-omics, spatial genomics, and gene networks from specialists in the fields. In the end, the students should be able to conceive and implement methods from functional genomics to address research challenges in this and similar areas of research, and to understand ongoing biological adaptations to global environmental changes. Moreover, the students should be able to use the knowledge to produce projects and pitches for the bioindustry.
Requirements to complete course and evaluation:
The grading (0-5) will be based on:
1) Research Project Review with a Pitch (0 to 5 pts: 30% of the grading, must pass)
2) Final Exam (0 to 5 pts: 70% of the grading , must pass)
Study material
Lecture slides will be made available in Moodle.
Supporting material
"Molecular Biology of the Cell", by Bruce Alberts.
A list of scientific publications will be provided as lectures are given.
Prerequisites: To attend this course, the students should have attended basic university courses on Cell Biology, Molecular Genetics, and Molecular Biology.
Remarks: The course is suitable for postgraduate studies.
Additional information related to course: The course is lectured every year. The course is limited to 20 students per year.
Course responsible: Andre S. Ribeiro
Moodle:
Learning Outcomes: The student will be introduced to experimental techniques and analysis tools in single cell biology studies. The aim is to provide understanding of techniques of single cell observation and how to interpret the results. The focus will be the manipulation and measurements of gene expression in prokaryotic systems using live cell multi-modal microscopy systems and flow cytometry. The model organism will be Escherichia coli. Finally, students will gain understanding of the objectives, applicability and limitations of the methods used in quantitative single cell biology studies. Several lectures will be in a laboratory, so that the students learn how to handle devices, such as microscopes and flow cytometers.
Requirements to complete course and evaluation: To pass the course, the student is required to: a) Pass in all grading requisites. b) Attend at least 80% of the lessons. c) In each lecture, deliver a 1-2 pages report on the previous lecture. d) Pass the final assignment (project and its 30 min presentation in the last lecture). Attendance, participation, and Project work. Grade is PASS/FAIL Passed/failed = 6/0. There is no final exam in this course.
Prerequisites: Basic knowledge of molecular biology and/or systems biology. .
Remarks: The course is suitable for postgraduate studies.
Additional information related to course: The course is lectured every year. Only 6 students can attend the course every year, due to space limitations in the laboratory. The following criteria will be used to select which students will attend the course. From those enrolled and attending the first lecture, we will select according to the order of enrollment. If you do not attend the first lecture, the next person in the list will be given priority.