Publications

Publications 

2024

17. Adolph, MB., Cortez D. (2024). Mechanisms and Regulation of Replication Fork Reversal. DNA repair. 2024 Sep:141:103731. PMID: 39089193

16. Balakrishnan, S., Adolph, MB., Tsai, MS., Gallagher, K., Cortez, D., Chazin, WJ. (2024).  A structure based mechanism for the regulation of RAD51 by RADX. PNAS. 121 (12) e2316491121. PMID: 38466836

2023

15. Adolph, MB., Garje, AS., Balakrishnan, S., Morati, F., Modesti, M., Chazin WJ., Cortez D. (2023). CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity. J.Mol.Bio. 2023 Aug 10:168236. PMID: 37572935 

2022

14. Mohamed, T., Adolph, MB., Modesti, M., Cortez D. (2022). RADX forms oligomers to maintain replication fork stability. J. Biol. Chem: 298(3):101672. PMID: 35120927.

2021

13. Krishnamoorthy, A., Jackson, J., Mohamed T., Adolph MB., Vindigni, A., Cortez, D, (2021). RADX prevents genome instability by confining replication fork reversal to stalled forks. Mol. Cell. 81(14): 3007-3017.e5. PMID: 34107305

12. Adolph, MB., Mohamed TM., Balakrishnan S., Xue C., Morati F., Modesti M., Greene EC., Chazin W.J., Cortez D. (2021). RADX controls RAD51 filament dynamics to regulate replication fork stability. Mol. Cell, 81(5):1074-1083. PMID: 33453169 

2020

11. Conner KL., Shaik AN., Marshall KA., Floyd AM., Ekinci, E, Lindquist J, Sawant A, Lei W, Adolph MB, Chelico L, Siriwardena SU, Bhagwat A, Kim S, Cote ML, Patrick SM. (2020). APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response. NAR Cancer, 2(4):zcaa033. PMID: 33196045

10. McDaniel, Y.Z., Wang, D., Love, RP., Adolph, MB., Mohammadzadeh N., Linda Chelico, L., Mansky, L.M. (2020). Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure. Nucl. Acids Res., 48(3): 1353-1371. PMID: 31943071

2019

9. Adolph, MB., Ara, A., Chelico, L. (2019). APOBEC3 host restriction factors of HIV-1 can change the template switching frequency of reverse transcriptase. J.Mol. Biol. 431(7):1339-1352. PMID: 30797859

2018

8. Adolph, MB., Love RP., Chelico L. (2018). Biochemical basis of APOBEC3 deoxycytidine deaminase activity on diverse DNA substrates. ACS Infect. Dis., 4(3):224-238. PMID: 29347817

2017

7. Adolph, MB., Love, RP., Feng, Y., Chelico L. (2017). Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B. Nucl. Acids Res., 45(20): 11925-11940. PMID: 28981865

6. Adolph, MB., Ara, A., Feng, Y., Wittkopp, CJ., Emerman, M., Fraser, JS., Chelico L. (2017). Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization. Nucl. Acids Res., 45(6): 3378-3394. PMID: 28158858

5. Ara, A., Love RP., Follack, TB., Ahmed, K., Adolph, MB., Chelico, L. (2017). Mechanism of enhanced HIV restriction by virion coencapsidated cytidine deaminases APOBEC3F and APOBEC3G. J. Virol., 91(3) e02230-16. PMID: 27881650

2016

4. Wittkopp, CJ., Adolph MB., Wu, LI., Chelico L., Emerman, M. (2016). A single nucleotide polymorphism in human APOBEC3C enhances restriction of lentivirus. PLoS Path., 12(10):e1005865. PMID: 27732658

3. Starrett, GJ., Luengas, EM., McCann, JL., Ebrahimi, D., Tezmiz NA., Lov, RP., Feng, Y., Adolph, MB., Chelico, L., Law, EK., Carpenter, MA., Harris, RS. (2016). The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis. Nat. Commun., 7:12918. PMID: 27650891

2015

2. Feng, Y., Love, RP., Ara, A., Baig, TT., Adolph, MB., Chelico L. (2015). Natural polymorphisms and oligomerization of human APOBEC3H contribute to single-stranded DNA scanning ability. J. Biol. Chem., 290(45):27188-203. PMID: 26396192

2013

1. Adolph, M.B., Webb, J., and Chelico L. (2013) Retroviral Restriction Factor APOBEC3G Delays the Initiation of DNA Synthesis by HIV-1 Reverse Transcriptase. PLoS ONE, 8(5), e64196. PMID: 23717565