Adolph Lab
Saint Louis University School of Medicine
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The Adolph lab uses biochemical and cell biology techniques to understand the mechanisms used by DNA binding proteins (SSBs) to protect and manage single-stranded DNA intermediates during DNA replication and repair. DNA binding proteins are important for maintaining the stability of the genome. The pathways associated with these proteins are involved in how cells respond to damage and how cancer cells respond to therapeutic agents.
Major Questions in the lab:
1.What novel DNA binding protein containing complexes are important at the replication fork?
2. What sites of exposed DNA do these complexes localize to?
3. How are these DNA binding proteins regulated on their own and as part of complexes?
4. Are these proteins or their pathways targets for therapeutic intervention?
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