Embedded Files
07:00-08:30
Breakfast
08:45-11:00
Introductory remarks
08:45-9:00: Jana Selent & Antonella Di Pizio
Session 1: Macromolecular interactions in signaling pathways
Chairs: Milka Vrecl and Marcello Leopoldo
09:00-9:30: Gebhard Schertler (Paul Scherrer Institute, Switzerland)
“Advances in the structure determination of effector complexes and GPCR signaling complexes”
09:30-10:00: Franz Hagn (Technical University of Munich, Germany)
"Structural plasticity of GPCRs and G-proteins probed by solution-state NMR"
10:00-10:30: Irina Tikhonova (Queen’s University Belfast, Northern Ireland)
“Detecting and characterizing the membrane-embedded allosteric sites"
10:30-10:45: Beki Kan (Acibadem MAA University, Turkey)
“GPR37 structure and function in autophagy”
10:45-11:00 Christian Gruber (Medical University of Vienna, Austria)
“De novo design of macrocyclic peptide-drug conjugates for the κ-opioid receptor”
11:00-11:30
Coffee Break
11:30-13:00
Session 2: Progress and challenges in GPCR signaling in health and disease
Chairs: Iro Georgoussi and Necla Birgul
11:30-12:00: Graeme Milligan (University of Glasgow, UK)
“From fatty acids to physiological function: The story of G protein coupled receptor 84”
12:00-12:30: Chris Bailey (University of Bath, UK)
“Mu opioid receptors: Tolerance and bias”
12:30-12:45: Christos Karoussiotis (National Centre for Scientific Research “Demokritos”, Greece)
“The κ-opioid receptor-induced autophagy is implicated in stress-driven synaptic alterations”
12:45-13:00 Gemma Navarro (University of Barcelona, Spain)
“Allosterism in the adenosine A2a and Cannabinoid heteromer”
13:00
Lunch and Group picture
14:30-16:30
Session 3: A holistic approach of GPCR signal transduction
Chairs: Marcus Muttenthaler and Martha Sommer
14:30-15:00: Nina Vardjan (University of Ljubljana, Slovenia)
“Metabolic excitability of astrocytes mediated by noradrenergic and lactate GPCR signalling”
15:00-15:30: Achilleas Gravanis (University of Crete, Greece)
“Cross-talk of Neurotrophin receptors with GPCR receptors in Neurogenesis and Neuroprotection”
15:30-16:00: Helene Castel (University of Rouen Normandie, France )
"Original therapeutic "tumor trap" by actioning a chemopeptide GPCR to treat brain cancer"
16:00-16:15: Monika Perisic (University of Vienna, Austria)
“Fluorescent peptide tracers for oxytocin receptor visualization”
16:15-16:30: Alexei Sirbu (Max Delbruck Center, Germany)
“Cell swelling serves as an allosteric modulator of the β2ΑR signaling”
16:30-17:00
Coffee Break
17:00-18:30
Session 4: Development of molecular modulators in signaling mechanisms
Chairs: Antonella Di Pizio and Irina Tikhonova
17:00-17:30: Marcello Leopoldo (University of Bari, Italy)
"Development of potent human formyl peptide receptor 1 antagonists and studies in gastric cancer”
17:30-18:00: György M Keserű (Research Centre for Natural Sciences, Hungary)
“The role of the secondary binding pocket in GPCR pharmacology”
18:00-18:15: Kristina Puls, (Free University of Berlin, Germany)
“Solving an Old Puzzle: How Salvinorin A Recognizes the Kappa Opioid Receptor”
18:15-18:30 Foteini Patera, (University of Nottingham, UK)
“Validation of a fluorescent ligand for the A2B Adenosine Receptor: A selective tool for study adenosine receptor subtypes”
18:30-20:30
Poster Session
20:30
Dinner
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