Friday 5th May

Session 5: ECIs in the frontiers of GPCR research and innovation

Chairs: Aida Shahraki and Jiafei Mao 

09:00-9:30: Moran Shalev-Benami (Weizmann Institute of Science, Israel)
“Can novel structures of 7TM ancestors reveal a missing link to GPCR signaling pathways” 

09:30-10:00 Ogun Adebali (Sabanci University, Turkey)
"Evolution of Calcium sensing receptors: Insights into protein function and hyper/hypocalcemia-causing mutations” 

10:00-11:00 Short Term Scientific Missions achievements

10:00-10:15 David Reiner-Link (University of Copenhagen, Denmark) 

“A long story & a short-differential signaling profiles of dopamine D2 receptor isoforms” 

10:15-10:30 Anemari Horvat (University of Ljubljana, Slovenia) “Alterations in octopamine/tyramine GPCR expression and neurodegeneration in aging brain” 

10:30-10:45 Brian Medel-Lacruz, (Hospital del Mar Research Institute, Spain)

"Molecular Simulations for Exploring GPCR Dynamics: Unbinding Events and Chemical Shift Predictions” 

10:45-11:00 Marta Martins, CBIOS Research Center for   Biosciences & Health Technologies, Portugal)

“The impact of the Golgi ion channel TMBIM4 on cancer cell survival and invasion”

Session 6: The complexity of GPCR activation  

Chair: Mickey Kosloff

11:30-12:00 Evi Kostenis (University of Bonn, Germany)
“Ligand bias, functional selectivity, and multidimensional GPCR signaling: time for a change of ligand classification”

12:00-12:30   Peter W. Hildebrand (University of Leipzig, Germany)
“Mechanistic insights into receptor mediated G protein activation”