Spoke 2 integrates different multidisciplinary professional expertise with the aim of supporting the generation of innovative AI solutions for data collection and analysis in healthcare. The mission is to achieve a shared and distributed platform collecting clinical data from patients, both in the raw form and pre-processed, that can open new frontiers in medical research. The analysis of such data and the generation of clusters of patients who share similar physical parameters and clinical conditions may represent a step forward in understanding the clinical response of patients to certain treatments, thus contributing to creating new knowledge for the diagnosis and prevention of tumor diseases as well as for the assessment of the risk and expected response to a therapeutic plan. In this perspective, the generation of Digital Twins that are representative of a specific population of patients, can provide a digital research tool to perform preventive analysis of the treatments and suggest new parameters for further separating the cohorts of patients.