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Our research projects are highly interdisciplinary, ranging from Medicinal Chemistry, Organic Synthesis to Photochemistry, and are aimed at developing novel reversible and covalent binders for nucleic acid, susceptible of biocompatible activation, with recognizing properties toward guanine quadruplexes (G-quadruplexes, G4). Such an interest is driven by the suggestion that the selective targeting of G4 represents the "chemical way" to control gene expression and to induce site-directed mutations, which might eventually lead to novel therapeutic agents for the treatment of cancer and diagnostic application.
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