We design and finely-tune selective ligands for nucleic acids through organic synthesis, with a focus on targeting and sensing G-quadruplex structures. Our work explores their potential in diagnostics and next-generation anticancer therapies. We also study the synthesis and reactivity of triggerable alkylating and cross-linking agents for DNA and RNA under biocompatible conditions.
Lab News
06/10/2025 - Welcome to Elisabetta and Nicola! They just started their Master Thesis in the Lab! Enjoy your time here!
01/10/2025 - Welcome back to Maria! Today she's starting her Ph.D. Journey
25/09/2025 - Congrats to Martina for earning her Master's Degree in Chemistry!
18/07/2025 - Congrats to Alice! She's now a Bachelor in Biotechnology!
17/07/2025 - Congrats to Andrea for defending his Master's thesis!
16/07/2025 - Congrats to Maria and Alessandro, they became Masters in Chemistry today, Cum Laude!
16/04/2025 - Today Francesca defended her PhD thesis about the novel enzymatic synthesis of Cefazolin with a brilliant presentation and discussion! Enjoy your bright future!
17/03/2025 - Congrats to Giorgia, Valentina and Filippo for their article just accepted in Nucleic Acids Research!
17/03/2025 - Welcome to our new B.Sc. student Alice Zani! She will work on the synthesis of novel NDI conjugates with antibacterial properties.
28/02/2025 - The G4IW Winter School is over :(. It was a pleasant occasion to gather up with eminent scientists, young researchers and beautiful people! Can't wait for next year's edition! Go check some pictures in the "Group pictures" section!
24/02/2025 - The Interaction Wins Winter School on G-Quadruplexes organized by Valentina has started! See you there!
19/02/2025 - Congrats to Valentina, Filippo and Mauro for their paper "Core-Extended Naphthalene Diimide Dyads as Light-Up Probes with Targeted Cytotoxicity Toward Tumor Cells" just published in Biomolecules!
17/02/2025 - The G4Lab is out for the CINMPIS congress, see you on Thursday, 20th!