Comprehensive Structural Characterization

Specializing in the thorough structural characterization of both unknown and synthesized materials, our team provides a comprehensive analysis of molecular composition, purity, and desired modifications. This multifaceted approach leverages a wide array of state-of-the-art analytical tools to confirm chemical identity, elucidate molecular architecture, and ensure quality standards are met.

1. Nuclear Magnetic Resonance (NMR) Spectroscopy (1H, 13C, 2D-NMR): By examining chemical shifts, coupling constants, and through-bond correlations, NMR offers precise insights into molecular connectivity. Two-dimensional techniques (e.g., COSY, HSQC, HMBC) reveal more complex structural relationships, enabling confident determination of stereochemistry and functional group placement.

2. Mass Spectrometry (MS, HRMS, ESI-MS): MS provides accurate measurements of molecular weight and fragmentation patterns, vital for confirming molecular formulas and detecting minor impurities. High-resolution MS (HRMS) further refines these measurements, pinpointing even slight variations in isotopic composition.

3. Infrared (IR) and Raman Spectroscopy: Both IR and Raman analyses facilitate the identification of key functional groups by tracking characteristic vibrational frequencies. These complementary techniques help confirm the presence or absence of specific bonds, guiding further structural refinement.

4. Ultraviolet-Visible (UV-Vis) and Circular Dichroism (CD) Spectroscopy: UV-Vis measurements reveal electronic transitions and the presence of chromophores, while CD is particularly useful for investigating chiral centers and overall secondary or tertiary conformations in biomolecules or complex organic structures.

5. High-Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC-MS): Chromatographic methods isolate and quantify individual components, verifying purity levels and identifying trace impurities. GC-MS is especially valuable for volatile or semi-volatile compounds, while HPLC accommodates a broad range of polarities and molecular weights.

By integrating these powerful analytical techniques—each contributing unique information about molecular structure, purity, and physicochemical properties—a complete and reliable profile of any compound can be established. This holistic characterization underpins research and product development, supports rigorous quality control, and ensures compliance with regulatory requirements.