Current Position:
Advanced Cardiology Imaging Fellow
Cardiovascular Division
Department of Medicine
University of Minnesota
Current Position:
Assistant Professor
Cardiovascular Division
Department of Medicine
University of Minnesota
Current Position:
Clinical Cardiac Electrophysiology Fellow
Cardiovascular Division
Department of Medicine
University of Minnesota
Current Position:
Associate Professor
Cardiovascular Division
Department of Medicine
University of Minnesota
Current Position:
Assistant Professor
Cardiovascular Division
Department of Medicine
University of Minnesota
Current Position:
Staff Physician and Clinical Assistant Professor
Arizona Veterans Research & Education Foundation
Current Position:
Assistant Professor
Gastroenterology
Minneapolis VA Medical Center
Current Position:
Core Investigator
Center for Care Delivery and Outcomes Research
Minneapolis VA Health Care System
Current Status:
Assistant Professor
Division of Hematology, Oncology, and Transplantation
Department of Medicine
University of Minnesota
Research Mentor(s) During Training: Ingunn Stromnes, PhD
Schmiechen ZC, Nanda HA, Burrack AL, Hickok GH, Butler JZ, Cruz-Hinojoza E, Maurice NJ, Geuenich MJ, Yu C, Tsai AK, Lonetree CL, Ellefson MA, Hilk AL, Larsen BM, Miller EA, Rizzo AB, Campbell KR, Shen SS, Stromnes IM. IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma. Cancer Immunol Res. 2025 Jun 4;13(6):847-866. doi: 10.1158/2326-6066.CIR-24-0758. PMID: 40072469; PMCID: PMC12134750.
Phung QH, Tsai AK, Park BU, Schat R, Spong R, Tsai LJ, Kulkarni AA, Antonarakis ES, Gupta A. Case Report: Metastatic small bowel adenocarcinoma with DNA mismatch repair deficiency in an organ transplant recipient treated with anti-PD-1 immunotherapy. Front Oncol. 2025 Jun 12;15:1579364. doi: 10.3389/fonc.2025.1579364. PMID: 40575172; PMCID: PMC12197958.
Schmiechen ZC, Nanda HA, Burrack AL, Hickok GH, Butler JZ, Cruz-Hinojoza E, Maurice NJ, Geuenich MJ, Yu C, Tsai AK, Lonetree CL, Ellefson MA, Hilk AL, Larsen BM, Miller EA, Rizzo AB, Campbell KR, Shen SS, Stromnes IM. IL-15 complex enhances agonistic anti-CD40 + anti-PDL1 by correcting the T-bet to Tox ratio in CD8+ T cells infiltrating pancreatic ductal adenocarcinoma. Cancer Immunol Res. 2025 Mar 12. doi: 10.1158/2326-6066.CIR-24-0758. Epub ahead of print. PMID: 40072469.
Ghirardelli Smith OC, Tsai AK, Zhong M, Dejban P, Nelson AC, Dolan M, Antonarakis ES, Murugan P. Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient. Front Oncol. 2025 Feb 25;15:1547258. doi: 10.3389/fonc.2025.1547258. PMID: 40071092; PMCID: PMC11893418.
Tsai AK, Stromnes IM. CD39 deletion in TCR-engineered T cells enhances antitumour immunity. Gut. 2024 Apr 5;73(5):716-717. doi: 10.1136/gutjnl-2023-330424. PMID: 37898545; PMCID: PMC10997453.
Kagalwalla S, Tsai AK, George M, Waldock A, Davis S, Jewett P, Vogel RI, Ganguli I, Booth C, Dusetzina SB, Rocque GB, Blaes AH, Gupta A. Consuming Patients' Days: Time Spent on Ambulatory Appointments by People With Cancer. Oncologist. 2024 May 3;29(5):400-406. doi: 10.1093/oncolo/oyae016. PMID: 38339991; PMCID: PMC11067814.
Tsai AK, Kagalwalla S, Langer J, Le-Kumar T, Le-Kumar V, Antonarakis ES. Pembrolizumab for metastatic castration-resistant prostate cancer: trials and tribulations. Expert Opin Biol Ther. 2024 Jan-Feb;24(1-2):51-62. doi: 10.1080/14712598.2024.2311750. Epub 2024 Jan 31. PMID: 38284349.
W.V. Johnson, Q.H. Phung, V.R. Patel, A.K. Tsai, N Arora, M.A. Klein, A.D. Westanmo, A.H. Blaes, A. Gupta. 2023. Trajectory of Healthcare Contact Days for Veterans With Advanced Gastrointestinal Malignancy. Oncologist. Online ahead of print.
A.K. Tsai, I.M. Stromnes. D39 deletion in TCR-engineered T cells enhances antitumour immunity. Gut. Online ahead of print.
V.R. Patel, V. Ramesh, A.K. Tsai, R. Sedhom, A.D. Westanmo, A.H. Blaes, R.I. Vogel, H.M. Parsons, T.P. Hanna, I. Ganguli, S.B. Dusetzina, G.B. Rocque, C.M. Booth, A. Gupta. 2023. Health Care Contact Days Experienced by Decedents With Advanced GI Cancer. JCO Oncol. Pract. 19(11):1031-1038.
V.R. Patel, A.K. Tsai, A. Blaes, R.B. Parikh, A.S. Adamson, A. Gupta. 2023. Association Between Price and Appropriateness of Cancer-Related Medical Information Generated by Chat-Based Artificial Intelligence Models. JCO Clin. Cancer Inform. 7:e2300041.
S. Kaczanowska, A.M. Joseph, J. Guo, A.K. Tsai, J.J. Lasola, K. Younger, Y. Zhang, C.V. Gonzales, E. Davila. 2017. A Synthetic CD8α:MyD88 Coreceptor Enhances CD8+ T-cell Responses to Weakly Immunogenic and Lowly Expressed Tumor Antigens. Cancer Res. 77(24):7049-7058. doi: 10.1158/0008-5472.CAN-17-0653. Epub 2017 Oct 20. PMID: 29055013
A.K. Tsai, A.Y. Khan, C.E. Worgo, L.L Wang, Y. Liang, E. Davila. 2017. A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies. Cancer Immunol. Res. 5(9):790-803. doi: 10.1158/2326-6066.CIR-17-0009. Epub 2017 Aug 3. PMID: 28775208
A.K. Tsai, E. Davila. 2016. Producer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumors. Oncoimmunology 5(5):e1122158. PMID: 27467930
A.K. Tsai, B.T. Steffen, J.M. Ordovas, R. Straka, X. Zhou, N.Q. Hanson, D. Arnett, M.Y. Tsai. 2011. Short-term fenofibrate treatment reduces elevated plasma Lp-PLA2 mass and sVCAM-1 levels in a subcohort of hypertriglyceridemic GOLDN participants. Transl. Res. 158(2):99-105. PMID: 21757154
S. Oh, A.K. Tsai, J.R. Ohlfest, A. Panoskaltsis-Mortari, D.A. Vallera. 2011. Evaluation of a bispecific biological drug designed to simultaneously target glioblastoma and its neovasculature in the brain. J. Neurosurg.114(6):1662-71. PMID: 21294620
Y. Dong, B.T. Steffen, J. Cao, A.K. Tsai, J. Ordovas, R. Straka, X. Zhou, E. Kabagambe, N.Q. Hanson, D. Arnett, M.Y. Tsai. 2011. Effects of fenofibrate on plasma oxidized LDL and 8-isoprostane in a sub-cohort of GOLDN participants. Atherosclerosis 214(2):422-5. PMID: 21159339
A.K. Tsai, S. Oh, H. Chen, Y. Shu, J.R. Ohlfest, D.A. Vallera. 2011. A novel bispecific ligand-directed toxin designed to simultaneously target EGFR on human glioblastoma cells and uPAR on tumor neovasculature. J. Neurooncol. 103(2):255-66. PMID: 20830604
Tsai AK, N. Li, N.Q. Hanson, M.Y. Tsai, W. Tang. 2009. Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population. Atherosclerosis 207(2):487-91. PMID: 19596330
Current Position:
Assistant Professor of Clinical Medicine
Hematology & Oncology
University of Illinois, Chicago
Current Position:
Assistant Professor
Division of Hematology, Oncology, and Transplantation
Department of Medicine
University of Minnesota
Current Position:
Assistant Professor
Division of Hematology, Oncology, and Transplantation
Department of Medicine
University of Minnesota
Current Position:
Assistant Professor
Division of Hematology, Oncology, and Transplantation
Department of Medicine
University of Minnesota
Current Position:
Assistant Professor of Clinical Medicine
Keck School of Medicine
University of Southern California
Current Position:
Assistant Professor
Division of Hematology, Oncology, and Transplantation
Department of Medicine
University of Minnesota
Current Position:
Faculty
Division of Nephrology & Hypertension
Department of Medicine
University of Minnesota
Research Mentor(s) During Training: John Osborn, PhD and Louise Evans, PhD
de la Cruz-Lynch A, Dailey-Krempel B, Dayton A, Nguyen DT, Tyshynsky R, Van Helden D, Lahti M, Carney J, Evans L, Vulchanova L, Osborn J. A Novel Catheter-Based Method for Denervation of Afferent Renal Nerves in Sheep. Cardiovasc Eng Technol. 2025 Aug;16(4):455-464. doi: 10.1007/s13239-025-00786-x. Epub 2025 May 6. PMID: 40329016; PMCID: PMC12224471.
de la Cruz-Lynch A, Dailey-Krempel B, Dayton A, Nguyen DT, Tyshynsky R, Van Helden D, Lahti M, Carney J, Evans L, Vulchanova L, Osborn J. A Novel Catheter-Based Method for Denervation of Afferent Renal Nerves in Sheep. Cardiovasc Eng Technol. 2025 May 6. doi: 10.1007/s13239-025-00786-x. Epub ahead of print. PMID: 40329016.
Evans LC, Dayton A, Osborn JW. Renal nerves in physiology, pathophysiology and interoception. Nat Rev Nephrol. 2025 Jan;21(1):57-69. doi: 10.1038/s41581-024-00893-3. Epub 2024 Oct 3. PMID: 39363020.
Evans LC, Dailey-Krempel B, Lauar MR, Dayton A, Vulchanova L, Osborn JW. Renal interoception in health and disease. Auton Neurosci. 2024 Oct;255:103208. doi: 10.1016/j.autneu.2024.103208. Epub 2024 Jul 31. PMID: 39128142.
Evans LC, Dayton A, Osborn JW. Renal nerves in physiology, pathophysiology and interoception. Nat Rev Nephrol. 2024 Oct 3. doi: 10.1038/s41581-024-00893-3. Epub ahead of print. PMID: 39363020.
Lauar MR, Almutlaq RN, Guntipally S, Anidu B, Kram R, Ross J, Osborn JW, Dayton A, Evans LC. Removing Interoceptive Input from the Kidney to the Brain Reduces Salt Appetite in DOCA Hypertensive Rats. Kidney Int. 2024 Oct 4:S0085-2538(24)00695-1. doi: 10.1016/j.kint.2024.08.033. Epub ahead of print. PMID: 39370041.
Evans LC, Dailey-Krempel B, Lauar MR, Dayton A, Vulchanova L, Osborn JW. Renal interoception in health and disease. Auton Neurosci. 2024 Jul 31;255:103208. doi: 10.1016/j.autneu.2024.103208. Epub ahead of print. PMID: 39128142.
Baumann D, Van Helden D, Evans LC, Vulchanova L, Dayton A, Osborn JW. IL-1R Mediated Activation of Renal Sensory Nerves in DOCA-Salt Hypertension. Hypertension. 2024 Aug;81(8):1811-1821. doi: 10.1161/HYPERTENSIONAHA.123.22620. Epub 2024 Jun 6. PMID: 38841853; PMCID: PMC11254549.
Baumann D, Van Helden D, Evans LC, Vulchanova L, Dayton A, Osborn JW. IL-1R-Mediated Activation of Renal Sensory Nerves in DOCA-Salt Hypertension. Hypertension. 2024 Jun 6. doi: 10.1161/HYPERTENSIONAHA.123.22620. Epub ahead of print. PMID: 38841853.
A. Dayton, R.N. Almutlaq, S. Guntipally, J. Ross, L.C. Evans. 2023. T-cells regulate albuminuria but not hypertension, renal histology, or the medullary transcriptome in the Dahl SSCD247+/+ rat. Am. J. Physiol. Renal Physiol. 326(1):F95-F104.
P. Drawz, D. Baumann, A. Dayton. 2023. Renal denervation: recent developments in clinical and preclinical research. Curr. Opin. Nephrol. Hypertens. 32(5):404-411.
J.D. Bukowy, H. Foss, S.D. McGarry, A.K. Lowman, S.L. Hurrell, K.A. Iczkowski, A. Banerjee, S.A. Bobholz , A. Barrington, A. Dayton, J. Unteriner, K. Jacobsohn, W.A. See, M.T. Nevalainen, A.S. Nencka, T. Ethridge, D.F. Jarrard, P.S. LaViolette. 2020. Accurate segmentation of prostate cancer histomorphometric features using a weakly supervised convolutional neural network. J. Med. Imaging 7(5):057501. PMID: 33062803
V. Kumar, L.C. Evans, T. Kurth, C. Yang, C. Wollner, V. Nasci, N.N Zheleznova, J. Bukowy, A. Dayton, A.W. Cowley Jr. 2019. Therapeutic Suppression of mTOR (Mammalian Target of Rapamycin) Signaling Prevents and Reverses Salt-Induced Hypertension and Kidney Injury in Dahl Salt-Sensitive Rats. Hypertension 73(3):630-639. PMID: 30595123
J.D. Bukowy, A. Dayton, C. Cloutier, A.D. Manis, A. Staruschenko, J.H. Lombard, L.C. Solberg Woods, D.A. Beard, A.W. Cowley Jr. 2018. Region-Based Convolutional Neural Nets for Localization of Glomeruli in Trichrome-Stained Whole Kidney Sections. J. Am. Soc. Nephrol. 29(8):2081-2088. PMID: 29921718
L.C. Evans, A. Dayton, C. Yang, P. Liu, T. Kurth , K.W. Ahn, Steve Komas, F.C. Stingo, P.W. Laud, M. Vannucci, M. Liang, A.W. Cowley Jr. 2018. Transcriptomic analysis reveals inflammatory and metabolic pathways that are regulated by renal perfusion pressure in the outer medulla of Dahl-S rats. Physiol. Genomics 50(6):440-447.
A.W. Cowley Jr., C. Yang, N.N. Zheleznova, A. Staruschenko, T. Kurth, L. Rein, V. Kumar, K. Sadovnikov, A. Dayton, M. Hoffman, R.P. Ryan, M.M Skelton, F. Salehpour, M. RanjI, A. Geurts. 2016. Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. Hypertension 67(2):440-50. PMID: 26644237
A.W. Cowley Jr., C. Yang, V. Kumar, J. Lazar, H. Jacob, A.M. Geurts, P. Liu, A. Dayton, T. Kurth, M. Liang. 2016. Pappa2 is linked to salt-sensitive hypertension in Dahl S rats. Physiol. Genomics 48(1):62-72. PMID: 26534937
A. Dayton, E.C. Exner, J.D. Bukowy, T.J. Stodola, T. Kurth, M. Skelton, A.S. Greene, A.W. Cowley Jr. 2016. Breaking the Cycle: Estrous Variation Does Not Require Increased Sample Size in the Study of Female Rats. Hypertension 68(5):1139-1144. PMID: 27672030
Current Position:
Assistant Professor
Division of Nephrology & Hypertension
Department of Medicine
University of Minnesota
Current Position:
Assistant Professor
Division of Pulmonary and Critical Care
Department of Medicine
University of Minnesota
Current Position:
Staff Scientist
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda, MD
Current Position:
Assistant Professor
Division of Rheumatology
Department of Internal Medicine
University of New Mexico