We are designing biologics to target HIV-infected cells. Treatments are available for HIV that reduce the amount of this virus in the blood to very low, almost undetectable, levels. However, HIV remains hidden within them - known as 'latent' infection - that can reactivate and cause disease if treatment stops. If we could eradicate this pool of latently infected cells, we could cure people of HIV for good. We are testing how these novel TriKEs activate natural killer cells and eliminate HIV or SIV infected cells in the laboratory.