Novel biologics
Small molecules can be designed to enhance the anti-cancer response of a patient's existing natural killer cells. Our lab has generated several small molecules that are being tested clinically.
Bi-specific Killer Engager (BiKE)
These small molecules consist of two halves - one that binds to tumor cells and the other that activates a key receptor, CD16, on the natural killer cell surface. When the natural killer cell encounters this biologic bound to the tumor cell, it knows to attack the tumor cell.
Tri-specific Killer Engager (TriKE)
Like, BiKEs these small molecules have a tumor-binding and CD16-binding parts, but also have a cytokine to activate the natural killer cells and enhance the survival, cell division and movement leading to a more effective therapy.
...and more!
We are currently testing new drug formats and delivery mechanisms.