Publications

Management of Anti-Seizure Medications during Pregnancy: Advancements in The Past Decade.

Avachat C, Barry JM, Lyu X, Sherwin CM, Birnbaum AK.

Pharmaceutics. 2022 Dec 6;14(12):2733. doi: 10.3390/pharmaceutics14122733.

PMID: 3655922

Maternal Exposure and Neonatal Effects of Drugs of Abuse.

Barry JM, Birnbaum AK, Jasin LR, Sherwin CM.

J Clin Pharmacol. 2021 Aug;61 Suppl 2:S142-S155. doi: 10.1002/jcph.1928.

PMID: 34396555

Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know

Illamola, S. M., Amaeze, O. U., Krepkova, L. V., Birnbaum, A. K., Karanam, A., Job, K. M., Bortnikova, V. V., Sherwin, C., & Enioutina, E. Y. 

Frontiers in Pharmacology (2020), 10, 1483. https://doi.org/10.3389/fphar.2019.01483

PMID: 31998122

Severity of Topiramate-Related Working Memory Impairment Is Modulated by Plasma Concentration and Working Memory Capacity.

Callisto SP, Illamola SM, Birnbaum AK, Barkley CM, Bathena SPR, Leppik IE, Marino SE.

J Clin Pharmacol. 2020 Sep;60(9):1166-1176. doi: 10.1002/jcph.1611. Epub 2020 Apr 16.

PMID: 32297992 

Antiepileptic Drug Exposure in Infants of Breastfeeding Mothers With Epilepsy

Birnbaum, A. K., Meador, K. J., Karanam, A., Brown, C., May, R. C., Gerard, E. E., Gedzelman, E. R., Penovich, P. E., Kalayjian, L. A., Cavitt, J., Pack, A. M., Miller, J. W., Stowe, Z. N., Pennell, P. B., & MONEAD Investigator Group. 

JAMA Neurology (2019), 77(4), 441–450. https://doi.org/10.1001/jamaneurol.2019.4443

PMID: 31886825

Lamotrigine Clearance Increases by 5 Weeks Gestational Age: Relationship to Estradiol Concentrations and Gestational Age

Karanam, A., Pennell, P. B., French, J. A., Harden, C. L., Allien, S., Lau, C., Barnard, S., Callisto, S. P., & Birnbaum, A. K.

Annals of Neurology (2018), 84(4), 556–563. https://doi.org/10.1002/ana.25321

PMID: 30168175

Simultaneous quantification of thirteen cannabinoids and metabolites in human plasma by liquid chromatography tandem mass spectrometry in adult epilepsy patients.

Roslawski MJ, Remmel RP, Karanam A, Leppik IE, Marino SE, Birnbaum AK.

Ther Drug Monit. 2018 Dec 4. doi: 10.1097/FTD.0000000000000583. [Epub ahead of print]

PMID: 30520828

Preclinical Efficacy and Characterization of Candidate Vaccines for Treatment of Opioid Use Disorders Using Clinically Viable Carrier Proteins.

Baruffaldi F, Kelcher AH, Laudenbach M, Gradinati V, Limkar A, Roslawski M, Birnbaum A, Lees A, Hassler C, Runyon S, Pravetoni M.

Mol Pharm. 2018 Nov 5;15(11):4947-4962. doi: 10.1021/acs.molpharmaceut.8b00592. Epub 2018 Oct 10. PMID: 30240216

Lamotrigine pharmacokinetics following oral and stable-labeled intravenous administration in z and elderly adult epilepsy patients: Effect of age. 

Polepally AR, Brundage RC, Remmel RP, Leppik IE, Pennell PB, White JR, Ramsay RE, Kistner BM, Birnbaum AK.

Epilepsia. 2018 Aug 12. doi: 10.1111/epi.14519. [Epub ahead of print]

PMID: 30101556

Brain's compensatory response to drug-induced cognitive impairment. 

Babu Henry Samuel I, Barkley C, Marino SE, Wang C, Han SM, Birnbaum AK, Cibula JE, Ding M.

J Clin Exp Neuropsychol. 2018 May 2:1-13. doi: 10.1080/13803395.2018.1458822. [Epub ahead of print]

PMID: 29720037

Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats. 

Raleigh MD, Laudenbach M, Baruffaldi F, Peterson SJ, Roslawski MJ, Birnbaum AK, Carroll FI, Runyon SP, Winston S, Pentel PR, Pravetoni M.

J Pharmacol Exp Ther. 2018 May;365(2):346-353. doi: 10.1124/jpet.117.247049. Epub 2018 Mar 13.

PMID: 29535156

Factors in Variability of Serial Gabapentin Concentrations in Elderly Patients with Epilepsy. 

Conway JM, Eberly LE, Collins JF, Macias FM, Ramsay RE, Leppik IE, Birnbaum AK.

Pharmacotherapy. 2017 Oct;37(10):1197-1203. doi: 10.1002/phar.2012. Epub 2017 Sep 19.

PMID: 28801938

The impact of exposure to antidepressant medications during pregnancy on neonatal outcomes: a review of retrospective database cohort studies.

Tak CR, Job KM, Schoen-Gentry K, Campbell SC, Carroll P, Costantine M, Brixner D, Birnbaum AK, Sherwin CMT.

Eur J Clin Pharmacol. 2017 Jun 9. doi: 10.1007/s00228-017-2269-4. [Epub ahead of print] Review.

PMID: 28600701

Phxnlme: An R package that facilitates pharmacometric workflow of Phoenix NLME analyses.

Lim CN, Liang S, Feng K, Chittenden J, Henry A, Mouksassi S, Birnbaum AK.

Comput Methods Programs Biomed. 2017 Mar;140:121-129. doi: 10.1016/j.cmpb.2016.12.002. Epub 2016 Dec 7.

PMID: 28254068

Antiseizure, antidepressant, and antipsychotic medication prescribing in elderly nursing home residents.

Bathena SPR, Leppik IE, Kanner AM, Birnbaum AK.

Epilepsy Behav. 2017 Apr;69:116-120. doi: 10.1016/j.yebeh.2017.01.027. Epub 2017 Feb 24.

PMID: 28242474

Prevalence of epilepsy/seizures as a comorbidity of neurologic disorders in nursing homes.

Birnbaum AK, Leppik IE, Svensden K, Eberly LE.

Neurology. 2017 Feb 21;88(8):750-757. doi: 10.1212/WNL.0000000000003629. Epub 2017 Jan 20.

PMID: 28108639

Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients.

Ahmed GF, Bathena SP, Brundage RC, Leppik IE, Conway JM, Schwartz JB, Birnbaum AK.

AAPS J. 2017 Mar;19(2):551-556. doi: 10.1208/s12248-016-0022-z. Epub 2017 Jan 9.

PMID: 28070716

Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy.

Patel SI, Birnbaum AK, Cloyd JC, Leppik IE.

CNS Drugs. 2015 Dec;29(12):1009-22. doi: 10.1007/s40263-015-0289-0. Review.

PMID: 26603741

Pharmacokinetic-Pharmacodynamic Modeling of Intravenous and Oral Topiramate and Its Effect on the Symbol-Digit Modalities Test in Adult Healthy Volunteers.

Lim CN, Birnbaum AK, Brundage RC, Leppik IE, Cloyd JC, Clark A, Marino SE.

J Clin Pharmacol. 2016 Jun;56(6):714-22. doi: 10.1002/jcph.646. Epub 2015 Dec 21.

PMID: 26395889

Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology.

Polepally AR, Remmel RP, Brundage RC, Leppik IE, Rarick JO, Ramsay RE, Birnbaum AK.

J Clin Pharmacol. 2015 Oct;55(10):1101-8. doi: 10.1002/jcph.522. Epub 2015 Aug 18.

PMID: 25903807

Pharmacokinetic-pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers.

Ahmed GF, Marino SE, Brundage RC, Pakhomov SV, Leppik IE, Cloyd JC, Clark A, Birnbaum AK.

Br J Clin Pharmacol. 2015 May;79(5):820-30. doi: 10.1111/bcp.12556.

PMID: 25403343

Treating epilepsy in the elderly: more art than science.

Leppik IE, Birnbaum AK.

Cleve Clin J Med. 2014 Aug;81(8):499-500. doi: 10.3949/ccjm.81a.14030. No abstract available.

PMID: 25085988

MODEL-BASED LAMOTRIGINE CLEARANCE CHANGES DURING PREGNANCY: CLINICAL IMPLICATION.

Polepally AR, Pennell PB, Brundage RC, Stowe ZN, Newport DJ, Viguera AC, Ritchie JC, Birnbaum AK.

Ann Clin Transl Neurol. 2014 Feb;1(2):99-106.

PMID: 24883336

Safety of an intravenous formulation of lamotrigine.

Conway JM, Birnbaum AK, Leppik IE, Pennell PB, White JR, Rarick JO, Remmel RP.

Seizure. 2014 May;23(5):390-2. doi: 10.1016/j.seizure.2014.01.019. Epub 2014 Jan 31.

PMID: 24560492

Population pharmacokinetics of unbound and total drug concentrations following intravenously administered carbamazepine in elderly and younger adult patients with epilepsy.

Ahmed GF, Brundage RC, Marino SE, Cloyd JC, Leppik IE, Pennell PB, Ramsay RE, Birnbaum AK.

J Clin Pharmacol. 2013 Mar;53(3):276-84. doi: 10.1002/jcph.8. Epub 2013 Feb 13.

PMID: 23408495

Valproic acid pathway: pharmacokinetics and pharmacodynamics.

Ghodke-Puranik Y, Thorn CF, Lamba JK, Leeder JS, Song W, Birnbaum AK, Altman RB, Klein TE.

Pharmacogenet Genomics. 2013 Apr;23(4):236-41. doi: 10.1097/FPC.0b013e32835ea0b2. No abstract available.

PMID: 23407051

Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.

Puranik YG, Birnbaum AK, Marino SE, Ahmed G, Cloyd JC, Remmel RP, Leppik IE, Lamba JK.

Pharmacogenomics. 2013 Jan;14(1):35-45. doi: 10.2217/pgs.12.180.

PMID: 23252947

Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC-MS assay for delayed analyses of pharmacokinetic samples in rats.

Jones JM, Raleigh MD, Pentel PR, Harmon TM, Keyler DE, Remmel RP, Birnbaum AK.

J Pharm Biomed Anal. 2013 Feb 23;74:291-7. doi: 10.1016/j.jpba.2012.10.033. Epub 2012 Nov 15.

PMID: 23245263

Selective effects of a morphine conjugate vaccine on heroin and metabolite distribution and heroin-induced behaviors in rats.

Raleigh MD, Pravetoni M, Harris AC, Birnbaum AK, Pentel PR.

J Pharmacol Exp Ther. 2013 Feb;344(2):397-406. doi: 10.1124/jpet.112.201194. Epub 2012 Dec 7.

PMID: 23220743

Challenges of epilepsy in elderly people.

Leppik IE, Walczak TS, Birnbaum AK.

Lancet. 2012 Sep 29;380(9848):1128-30. doi: 10.1016/S0140-6736(12)61517-7. No abstract available.

PMID: 23021270

Validation of tacrolimus equation to predict troughs using genetic and clinical factors.

Passey C, Birnbaum AK, Brundage RC, Schladt DP, Oetting WS, Leduc RE, Israni AK, Guan W, Matas AJ, Jacobson PA.

Pharmacogenomics. 2012 Jul;13(10):1141-7. doi: 10.2217/pgs.12.98.

PMID: 22909204

The effect of topiramate plasma concentration on linguistic behavior, verbal recall and working memory.

Marino SE, Pakhomov SV, Han S, Anderson KL, Ding M, Eberly LE, Loring DW, Hawkins-Taylor C, Rarick JO, Leppik IE, Cibula JE, Birnbaum AK.

Epilepsy Behav. 2012 Jul;24(3):365-72. doi: 10.1016/j.yebeh.2012.04.120. Epub 2012 May 30.

PMID: 22658432