SCA27B for Me
A guide to understanding a form of ataxia
caused by a repeat expansion in the gene FGF14, SCA27B.
Welcome to SCA27B for Me. This is intended to be an educational tool for those who wish to learn more about the repeat expansion form of FGF14-related ataxia called SCA27B.
This condition is also known as autosomal dominant adult-onset spinocerebellar ataxia type 50 (SCA50), ATX-FGF14, or FGF14-related late-onset cerebellar ataxia.
SCA27B for Me consists of 3 modules:
Background information about genetics
SCA27B
Genetic counseling and genetic testing
There are currently two known types of FGF14-RELATED ATAXIA: SCA27A and SCA27B. Both types are caused by pathogenic (disease-causing) changes in the gene FGF14, but the genetic change is different between the two types. This educational tool is focused on SCA27B, which is caused by a repeat expansion in the gene FGF14.
For information about SCA27A, you can visit this page or this page.
Navigate this site in sequential order by using the NEXT and BACK buttons that appear at the bottom of each page or use the dropdown menus located at the top of the site to review the pages in any order.
SCA27B for Me was created by Leah Hardy,¹ Master of Science in Genetic Counseling, under the guidance of Dr. Margit Burmeister, PhD.²
¹Department of Human Genetics, University of Michigan, Ann Arbor, MI
²Molecular & Behavioral Neuroscience Institute, Department of Computational Medicine & Bioinformatics, Department of Human Genetics, Department of Psychiatry, University of Michigan, Ann Arbor, MI