In people with SCA27B, symptoms typically begin to appear when people are in their 50s or 60s. This can vary from person to person, even within a family, with some individuals showing the first signs of the disease in their 30s and some not showing any signs until their 80s.4,5 

At first, symptoms may be EPISODIC (lasting from minutes to days and occurring daily to monthly) or CONSTANT (lasting continuously).4

The most common symptoms of SCA27B are:

• Gait ataxia (difficulty walking)

• Appendicular ataxia (difficulty controlling the movement of arm, hands, legs, and feet)

• Dysarthria (difficulty speaking)

• Nystagmus (uncontrollable rapid eye movements)

• Double vision or blurry vision

• Dizziness

• Postural tremor (shaking when holding body parts in particular positions)4,5 

The symptoms of SCA27B become worse over time (progress), although symptoms tend to worsen slowly over a long period of time (slowly progressive).6 

People with SCA27B do not tend to lose cognitive skills (thinking, learning, reasoning, remembering) as their physical condition progresses.6