Pulmonary Arterial Hypertension (PAH) is a disease referring to high blood pressure in the pulmonary arteries. PAH is characterized by vascular remodeling, and often results in heart failure with a 48% 3 year survival rate (Gerringer). The current method of treating PAH uses invasive procedures and medications with severe side effects (Humbert). The only cure is a lung transplant (Pursell). Furthermore, PAH is a widespread disease as estimates show that 15-25 million people were afflicted with PAH in 2020 (Dubroff).
Our device was able to replicate the in vivo configuration of mice pulmonary artery samples. It is also compatible with the multi-photon microscope, which allows for more accurate imaging that facilitates more in-depth studies of PAH and other vascular pathology research. With adjustments, the device can be used for other types of tissues and is also compatible with other imaging tools.