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Research published today in Nature sheds light on a small part of the so-called “dark genome” — the 98 per cent of the human genome whose biological function is largely not known. In the study, an international multidisciplinary team reported the first high-resolution images and structural details of a genetic.... read more.

Understanding exactly how antiviral drugs interact with viruses at a molecular level will be key to developing the broad-spectrum therapies needed to battle against the SARS-CoV-2 pandemic and get ready to fight the next one, according to.... read more.

A University of Alberta virology lab has uncovered how an oral antiviral drug works to attack the SARS-CoV-2 virus, in findings published May 10 in the Journal of Biological Chemistry. The researchers demonstrated the underlying mechanism of action by which the antiviral drug molnupiravir changes the.... read more.

A University of Alberta laboratory has uncovered the mechanism of action for a recently approved influenza drug in newly published research. The scientists discovered that the drug baloxavir marboxil binds highly efficiently to an enzyme that is key to how the influenza virus replicates inside an infected patient. They also showed how a mutation of the influenza virus, which can.... read more.

Researchers at the University of Alberta have discovered a novel, second mechanism of action by the antiviral drug remdesivir against SARS-CoV-2, according to findings published today in the Journal of Biological Chemistry. The research team previously.... read more.

Scientists at the University of Alberta have shown that the drug remdesivir is highly effective in stopping the replication mechanism of the coronavirus that causes COVID-19, according to new research published today in the Journal of Biological Chemistry. The paper follows closely on research published by the same lab in late February that demonstrated how.... read more.

A group of University of Alberta researchers who have discovered why the drug remdesivir is effective in treating the coronaviruses that cause Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) expect it might also be effective for treating patients infected with the new COVID-19 strain. "Even if you know a drug works, it can be.... read more.

University of Alberta researchers have found the Ebola polymerase (enzyme), which may lead to more effective research and better treatments for the often fatal infection, and other related viral diseases. "Our study reports the expression, purification and biochemical characterization of an active, recombinant EBOV polymerase complex that is responsible for the propagation of the Ebola virus. It will give researchers worldwide the.... read more.