当研究室の最近の論文リスト（doiは直接論文のページにリンクしています） 

Recent Papers from our lab (the doi link will take you directly to the journal page)

2023

1. Yamamoto, H., Matsumura, R., Nakashima, M., Adachi, M., Ogawa, K., Hongo, K., Mizobata, T., and Kawata, Y. (2023) Effects of the Polyphenols Delphinidin and Rosmarinic Acid on the Inducible Intra-cellular Aggregation of Alpha-Synuclein in Model Neuron Cells. Appl Biochem Biotechnol  Jan 19. doi: 10.1007/s12010-023-04362-8.

2022

2. Nakata, Y., Kitazaki, Y., Kanaoka, H., Shingen, E., Uehara, R., Hongo, K., Kawata, Y., and Mizobata, T. (2022) Formation of Fibrils by the Periplasmic Molecular Chaperone HdeB from Escherichia coli. Int J Mol Sci 23:13243; doi: 10.3390/ijms232113243

3. Cheng, A., Wang, Y. F., Shinoda, Y., Kawahata, I., Yamamoto, T., Jia, W. B., Yamamoto, H., Mizobata, T., Kawata, Y., and Fukunaga, K. (2022) Fatty acid-binding protein 7 triggers alpha-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress. Acta Pharmacol Sin 43, 552-562 doi: 10.1038/s41401-021-00675-8.

2021

4. Kawahata, I., Sekimori, T., Wang, H., Wang, Y., Sasaoka, T., Bousset, L., Melki, R., Mizobata, T., Kawata, Y., and Fukunaga, K. (2021) Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated alpha-Synuclein Uptake in Cultured Dopaminergic Neurons. Biomedicines  9:49. doi: 10.3390/biomedicines9010049.

5. Fukui, N., Yamamoto, H., Miyabe, M., Aoyama, Y., Hongo, K., Mizobata, T., Kawahata, I., Yabuki, Y., Shinoda, Y., Fukunaga, K., and Kawata, Y. (2021) An alpha-synuclein decoy peptide prevents cytotoxic alpha-synuclein aggregation caused by fatty acid binding protein 3. J Biol Chem 296, 100663 296:100663. doi: 10.1016/j.jbc.2021.100663. 

2019

6. Yamamoto, H., Fukui, N., Adachi, M., Saiki, E., Yamasaki, A., Matsumura, R., Kuroyanagi, D., Hongo, K., Mizobata, T., and Kawata, Y. (2019) Human Molecular Chaperone Hsp60 and Its Apical Domain Suppress Amyloid Fibril Formation of alpha-Synuclein. Int J Mol Sci 21 pii: ijms21010047. doi: 10.3390/ijms21010047.

7. Miyawaki, S., Uemura, Y., Hongo, K., Kawata, Y., and Mizobata, T. (2019) Acid-denatured small heat shock protein HdeA from Escherichia coli forms reversible fibrils with an atypical secondary structure. J Biol Chem 294, 1590-1601 doi: 10.1074/jbc.RA118.005611.

2018

8. Mizobata, T., and Kawata, Y. (2018) The versatile mutational "repertoire" of Escherichia coli GroEL, a multidomain chaperonin nanomachine. Biophys Rev 10, 631-640 doi: 10.1007/s12551-017-0332-0. 

(Review)

2017

9. Kameda, H., Usugi, S., Kobayashi, M., Fukui, N., Lee, S., Hongo, K., Mizobata, T., Sekiguchi, Y., Masaki, Y., Kobayashi, A., Oroguchi, T., Nakasako, M., Takayama, Y., Yamamoto, M., and Kawata, Y. (2017) Common structural features of toxic intermediates from alpha-synuclein and GroES fibrillogenesis detected using cryogenic coherent X-ray diffraction imaging. J Biochem 161, 55-65 doi: 10.1093/jb/mvw052.

2016

10. Yamakawa, M. Y., Uchino, K., Watanabe, Y., Adachi, T., Nakanishi, M., Ichino, H., Hongo, K., Mizobata, T., Kobayashi, S., Nakashima, K., and Kawata, Y. (2016) Anthocyanin suppresses the toxicity of Abeta deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer's disease. Nutr Neurosci 19, 32-42 doi: 10.1179/1476830515Y.0000000042.

11. Ojha, B., Fukui, N., Hongo, K., Mizobata, T., and Kawata, Y. (2016) Suppression of amyloid fibrils using the GroEL apical domain. Sci Rep 6, 31041 doi: 10.1038/srep31041.

12. Ida, M., Ando, M., Adachi, M., Tanaka, A., Machida, K., Hongo, K., Mizobata, T., Yamakawa, M. Y., Watanabe, Y., Nakashima, K., and Kawata, Y. (2016) Structural basis of Cu, Zn-superoxide dismutase amyloid fibril formation involves interaction of multiple peptide core regions. J Biochem 159, 247-260 doi: 10.1093/jb/mvv091.

13. Fukui, N., Araki, K., Hongo, K., Mizobata, T., and Kawata, Y. (2016) Modulating the Effects of the Bacterial Chaperonin GroEL on Fibrillogenic Polypeptides through Modification of Domain Hinge Architecture. J Biol Chem 291, 25217-25226 doi: 10.1074/jbc.M116.751925.

2013

14. Mizuta, T., Ando, K., Uemura, T., Kawata, Y., and Mizobata, T. (2013) Probing the dynamic process of encapsulation in Escherichia coli GroEL. PLoS One 8, e78135  doi: 10.1371/journal.pone.0078135. 

15. Iwasa, H., Kameda, H., Fukui, N., Yoshida, S., Hongo, K., Mizobata, T., Kobayashi, S., and Kawata, Y. (2013) Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates. Biochemistry 52, 9202-9211  doi: 10.1021/bi401135j