An experimental chimeric hepatitis E virus vaccine elicits both local and systemic immune responses

Melisa Florencia Müller, Jacinto Sacur, Julia Matias Brancher, María Daniela Vera, Lorena Arce, María Fernanda Raya-Tonetti, Haruki Kitazawa, Julio Villena, María Guadalupe Vizoso-Pinto

Frontiers in Microbiology

2024

Orally Administered Lactobacilli Strains Modulate Alveolar Macrophages and Improve Protection Against Respiratory Superinfection

Leonardo Albarracin, Stefania Dentice Maidana, Kohtaro Fukuyama, Mariano Elean, Julio Nicolás Argañaraz Aybar, Yoshihito Suda, Keita Nishiyama, Haruki Kitazawa, Julio Villena

Biomolecules

2024

Modulation of the Gut–Lung Axis by Water Kefir and Kefiran and Their Impact on Toll-like Receptor 3-Mediated Respiratory Immunity

Stefania Dentice Maidana, Julio Nicolás Argañaraz Aybar, Leonardo Albarracin, Yoshiya Imamura, Luciano Arellano-Arriagada, Fu Namai, Yoshihito Suda, Keita Nishiyama, Julio Villena, Haruki Kitazawa

Biomolecules

2024

Effect of Lactiplantibacillus plantarum cell-free culture on bacterial pathogens isolated from cystic fibrosis patients: in vitro and in vivo studies

Carla Luciana Abán, Silvia Orosco, Julio Nicolás Argañaraz Aybar, Leonardo Albarracín, Analía Venecia, Liliana Perret, Sonia Ortiz Mayor, Keita Nishiyama, Juan Carlos Valdéz, Haruki Kitazawa, Julio Villena, Nadia Gobbato

Frontiers in Microbiology

2024

Identification of Nonsynonymous SNPs in Immune-Related Genes Associated with Pneumonia Severity in Pigs

Hiroki Shinkai, Kasumi Suzuki, Tomohito Itoh, Gou Yoshioka, Takato Takenouchi, Haruki Kitazawa, Hirohide Uenishi

Genes

2024

Exploring strain-level diversity in the gut microbiome through mucin particle adhesion

Keita Nishiyama, Ryuta Murakami, Masaki Nakahata, Binghui Zhou, Nanami Hashikura, Hiroki Kaneko, Fu Namai, Wakako Ikeda-Ohtsubo, Jin-Zhong Xiao, Haruki Kitazawa, Toshitaka Odamaki

Applied and Environmental Microbiology

2024

Role of immunomodulatory probiotics in alleviating bacterial diarrhea in piglets: a systematic review

Sudeb Saha, Fu Namai, Keita Nishiyama, Julio Villena, Haruki Kitazawa

Journal of Animal Science and Biotechnology

2024

Modulation of the Toll-like Receptor 3-Mediated Intestinal Immune Response by Water Kefir

Stefania Dentice Maidana, Ramiro Ortiz Moyano, Mariano Elean, Yoshiya Imamura, Leonardo Albarracín, Fu Namai, Yoshihito Suda, Keita Nishiyama, Julio Villena, Haruki Kitazawa

Microbiology Research

2024

Broad specificity of monoclonal IgA (TEPC15-IgA) for enteric bacteria via phosphorylcholine-mediated interaction

Saeka KOYAMA, Kaori ITO, Katsuki USAMI, Shino WADA, Tsukasa YAMASHITA, Wakako IKEDA-OHTSUBO, Haruki KITAZAWA, Ryota HIRAKAWA, Jahidul ISLAM, Mutsumi FURUKAWA, Tomonori NOCHI

Journal of Veterinary Medical Science

2024

Antagonistic Effects of Corynebacterium pseudodiphtheriticum 090104 on Respiratory Pathogens

Ramiro Ortiz Moyano, Stefania Dentice Maidana, Yoshiya Imamura, Mariano Elean, Fu Namai, Yoshihito Suda, Keita Nishiyama, Vyacheslav Melnikov, Haruki Kitazawa, Julio Villena

Microorganisms

2024

Comprehensive characterization of γ-aminobutyric acid (GABA) production by Levilactobacillus brevis CRL 2013: insights from physiology, genomics, and proteomics

Pablo G. Cataldo, María Paulina Urquiza Martínez, Julio Villena, Haruki Kitazawa, Lucila Saavedra, Elvira M. Hebert

Frontiers in Microbiology

2024

The Mucus-Binding Factor Mediates Lacticaseibacillus rhamnosus CRL1505 Adhesion but Not Immunomodulation in the Respiratory Tract

Binghui Zhou, Mariano Elean, Lorena Arce, Kohtaro Fukuyama, Kae Tomotsune, Stefania Dentice Maidana, Sudeb Saha, Fu Namai, Keita Nishiyama, María Guadalupe Vizoso-Pinto, Julio Villena, Haruki Kitazawa

Microorganisms

2024

Development of an intestinal epithelial cell line and organoids derived from the same swine and characterization of their antiviral responses

Kaho MATSUMOTO, Fu NAMAI, Ayako MIYAZAKI, Yoshiya IMAMURA, Kohtaro FUKUYAMA, Wakako IKEDA-OHTSUBO, Keita NISHIYAMA, Julio VILLENA, Kohtaro MIYAZAWA, Haruki KITAZAWA

Bioscience of Microbiota, Food and Health

2024

Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity

A. K. M. Humayun Kober, Sudeb Saha, Mutamed Ayyash, Fu Namai, Keita Nishiyama, Kazutoyo Yoda, Julio Villena, Haruki Kitazawa

Nutrients

2024

Bacterium-like Particles from Corynebacterium pseudodiphtheriticum as Mucosal Adjuvant for the Development of Pneumococcal Vaccines

Ramiro Ortiz Moyano, Fernanda Raya Tonetti, Mariano Elean, Yoshiya Imamura, Kohtaro Fukuyama, Yoshihito Suda, Vyacheslav Melnikov, Alexander Suvorov, María Guadalupe Vizoso-Pinto, Haruki Kitazawa, Julio Villena

Vaccines

2024

Establishment of porcine fecal-derived ex vivo microbial communities to evaluate the impact of livestock feed on gut microbiome

Yuji TSUJIKAWA, Keita NISHIYAMA, Fu NAMAI, Yoshiya IMAMURA, Taiga SAKUMA, Sudeb SAHA, Masahiko SUZUKI, Mitsuki SAKURAI, Ryo IWATA, Kengo MATSUO, Hironori TAKAMORI, Yoshihito SUDA, Binghui ZHOU, Itsuko FUKUDA, Julio VILLENA, Iwao SAKANE, Ro OSAWA, Haruki KITAZAWA

Bioscience of Microbiota, Food and Health

2024

Genetic aspects of immunoglobulins and cyclophilin A in milk as potential indicators of mastitis resistance in Holstein cows

Yoshinobu Uemoto, Teppei Katsura, Yuma Endo, Koutaro Tanaka, Tao Zhuang, Megumi Urakawa, Toshimi Baba, Gaku Yoshida, Haifei Wang, Haruki Kitazawa, Hitoshi Shirakawa, Takehiko Nakamura, Tomonori Nochi, Hisashi Aso

Journal of Dairy Science

2024

A Comparison between Crossbred (Holstein × Local Cattle) and Bangladeshi Local Cattle for Body and Milk Quality Traits

Sudeb Saha, Md. Nazmul Hasan, Md. Nazim Uddin, B. M. Masiur Rahman, Mohammad Mehedi Hasan Khan, Syed Sayeem Uddin Ahmed, Haruki Kitazawa

Dairy

2024

In vitro evaluation of the immunomodulatory and wakame assimilation properties of Lactiplantibacillus plantarum strains from swine milk

Ryusuke Ohgi, Sudeb Saha, Binghui Zhou, Taiga Sakuma, Mitsuki Sakurai, Yuhka Nakano, Fu Namai, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Keita Nishiyama, Julio Villena, Haruki Kitazawa

Frontiers in Microbiology

2024

Lacticaseibacillus rhamnosus CRL1505 Peptidoglycan Modulates the Inflammation-Coagulation Response Triggered by Poly(I:C) in the Respiratory Tract

Hortensia Zelaya, Luciano Arellano-Arriagada, Kohtaro Fukuyama, Kaho Matsumoto, Gabriela Marranzino, Fu Namai, Susana Salva, Susana Alvarez, Graciela Agüero, Haruki Kitazawa, Julio Villena

International Journal of Molecular Sciences

2023

Immunobiotic Ligilactobacillus salivarius FFIG58 Confers Long-Term Protection against Streptococcus pneumoniae

Mariano Elean, Fernanda Raya Tonetti, Kohtaro Fukuyama, Luciano Arellano-Arriagada, Fu Namai, Yoshihito Suda, Nadia Gobbato, Keita Nishiyama, Julio Villena, Haruki Kitazawa

International Journal of Molecular Sciences

2023

Neural control of redox response and microbiota-triggered inflammation in Drosophila gut

Naoyuki Fuse, Haruka Hashiba, Kentaro Ishibashi, Takuro Suzuki, Quang-Dat Nguyen, Kiho Fujii, Wakako Ikeda-Ohtsubo, Haruki Kitazawa, Hiromu Tanimoto, Shoichiro Kurata

Frontiers in Immunology

2023

In Silico Comparative Genomic Analysis Revealed a Highly Conserved Proteolytic System in Lactobacillus delbrueckii

Mariano Elean, Leonardo Albarracin, Julio Villena, Haruki Kitazawa, Lucila Saavedra, Elvira M. Hebert

International Journal of Molecular Sciences

2023

Establishment of a porcine bronchial epithelial cell line and its application to study innate immunity in the respiratory epithelium

Kohtaro Fukuyama, Tao Zhuang, Eita Toyoshi, Fernanda Raya Tonetti, Sudeb Saha, Binghui Zhou, Wakako Ikeda-Ohtsubo, Keita Nishiyama, Hisashi Aso, Julio Villena, Haruki Kitazawa

Frontiers in Immunology

2023

Recent Advances in the Use of Probiotics to Improve Meat Quality of Small Ruminants: A Review

Sudeb Saha, Kohtaro Fukuyama, Marina Debnath, Fu Namai, Keita Nishiyama, Haruki Kitazawa

Microorganisms

2023

Partial Characterization and Immunomodulatory Effects of Exopolysaccharides from Streptococcus thermophilus SBC8781 during Soy Milk and Cow Milk Fermentation

Hajime Nakata, Yoshiya Imamura, Sudeb Saha, René Emanuel Lobo, Shugo Kitahara, Shota Araki, Mikado Tomokiyo, Fu Namai, Masanori Hiramitsu, Takashi Inoue, Keita Nishiyama, Julio Villena, Haruki Kitazawa

Foods

2023

Hypermucoviscous Carbapenem-Resistant Klebsiella pneumoniae ST25 Infect Human Intestinal Epithelial Cells and Induce Moderate Inflammation

Stefania Dentice Maidana, Mariano Elean, Kohtaro Fukuyama, Yoshiya Imamura, Leonardo Albarracín, Sudeb Saha, Yoshihito Suda, Shoichiro Kurata, María Ángela Jure, Haruki Kitazawa, Julio Villena

International Journal of Molecular Sciences

2023

Oral Administration of Lacticaseibacillus rhamnosus CRL1505 Modulates Lung Innate Immune Response against Klebsiella pneumoniae ST25

Stefania Dentice Maidana, Yoshiya Imamura, Mariano Elean, Leonardo Albarracín, Keita Nishiyama, Yoshihito Suda, Shoichiro Kurata, María Ángela Jure, Haruki Kitazawa, Julio Villena

Microorganisms

2023

Genome‐wide detection of changes in allelic frequency in Landrace pigs selected for resistance to mycoplasma pneumonia of swine

Yoshinobu Uemoto, Kasumi Ichinoseki, Toshimi Matsumoto, Nozomi Oka, Hironori Takamori, Hiroshi Kadowaki, Chihiro Shibata, Eisaku Suzuki, Toshihiro Okamura, Hisashi Aso, Haruki Kitazawa, Masahiro Satoh, Hirohide Uenishi, Keiichi Suzuki

Animal Science Journal

2023

The Respiratory Commensal Bacterium Corynebacterium pseudodiphtheriticum as a Mucosal Adjuvant for Nasal Vaccines

Ramiro Ortiz Moyano, Fernanda Raya Tonetti, Kohtaro Fukuyama, Mariano Elean, Mikado Tomokiyo, Yoshihito Suda, Vyacheslav Melnikov, Haruki Kitazawa, Julio Villena

Vaccines

2023

Sharing of Moonlighting Proteins Mediates the Symbiotic Relationship among Intestinal Commensals

Keita Nishiyama, Cheng-Chung Yong, Nobuko Moritoki, Haruki Kitazawa, Toshitaka Odamaki, Jin-Zhong Xiao, Takao Mukai

Applied and Environmental Microbiology

2023

Post-immunobiotics increase resistance to primary respiratory syncytial virus infection and secondary pneumococcal pneumonia

F. Raya Tonetti, M. Tomokiyo, K. Fukuyama, M. Elean, R. Ortiz Moyano, H. Yamamuro, R. Shibata, S. Quilodran-Vega, S. Kurata, J. Villena, H. Kitazawa

Beneficial Microbes

2023

Lactiplantibacillus plantarum Strains Modulate Intestinal Innate Immune Response and Increase Resistance to Enterotoxigenic Escherichia coli Infection

Ayelen Baillo, Julio Villena, Leonardo Albarracín, Mikado Tomokiyo, Mariano Elean, Kohtaro Fukuyama, Sandra Quilodrán-Vega, Silvina Fadda, Haruki Kitazawa

Microorganisms

2022

The Mucus Binding Factor Is Not Necessary for Lacticaseibacillus rhamnosus CRL1505 to Exert Its Immunomodulatory Activities in Local and Distal Mucosal Sites

Kae Tomotsune, Fernanda Raya Tonetti, Hiroya Mizuno, Mariano Elean, Kohtaro Fukuyama, Binghui Zhou, Wakako Ikeda-Ohtsubo, Keita Nishiyama, Akihiro Yamamura, Hideaki Karasawa, Shinobu Ohnuma, Akira Horii, Tadao Saito, Haruki Kitazawa, Julio Villena

International Journal of Molecular Sciences

2022

Polymorphisms in Pattern Recognition Receptor Genes Are Associated with Respiratory Disease Severity in Pig Farms

Kasumi Suzuki, Hiroki Shinkai, Gou Yoshioka, Toshimi Matsumoto, Takato Takenouchi, Junji Tanaka, Masanori Shimizu, Haruki Kitazawa, Hirohide Uenishi

Animals

2022

Immunomodulatory Effects of Probiotics: A Novel Preventive Approach for the Control of Bovine Mastitis

A. K. M. Humayun Kober, Sudeb Saha, Md. Aminul Islam, Muhammad Shahid Riaz Rajoka, Kohtaro Fukuyama, Hisashi Aso, Julio Villena, Haruki Kitazawa

Microorganisms

2022

The Ability of Postimmunobiotics from L. rhamnosus CRL1505 to Protect against Respiratory Syncytial Virus and Pneumococcal Super-Infection Is a Strain-Dependent Characteristic

Fernanda Raya Tonetti, Patricia Clua, Kohtaro Fukuyama, Guillermo Marcial, Jacinto Sacur, Gabriela Marranzino, Mikado Tomokiyo, Guadalupe Vizoso-Pinto, Apolinaria Garcia-Cancino, Shoichiro Kurata, Haruki Kitazawa, Julio Villena

Microorganisms

2022

Lactiplantibacillus plantarum LOC1 Isolated from Fresh Tea Leaves Modulates Macrophage Response to TLR4 Activation

Masahiko Suzuki, Leonardo Albarracin, Yuji Tsujikawa, Kohtaro Fukuyama, Iwao Sakane, Julio Villena, Haruki Kitazawa

Foods

2022

Modulation of Alveolar Macrophages by Postimmunobiotics: Impact on TLR3-Mediated Antiviral Respiratory Immunity

Mikado Tomokiyo, Fernanda Raya Tonetti, Hikari Yamamuro, Ryoko Shibata, Kohtaro Fukuyama, Nadia Gobbato, Leonardo Albarracin, Muhammad Shahid Riaz Rajoka, A. K. M. Humayun Kober, Wakako Ikeda-Ohtsubo, Julio Villena, Haruki Kitazawa

Cells

2022

Respiratory Commensal Bacteria Increase Protection against Hypermucoviscous Carbapenem-Resistant Klebsiella pneumoniae ST25 Infection

Stefania Dentice Maidana, Ramiro Ortiz Moyano, Juan Vargas, Kohtaro Fukuyama, Shoichiro Kurata, Vyacheslav Melnikov, María Jure, Haruki Kitazawa, Julio Villena

Pathogens

2022

Genomic Characterization of Lactiplantibacillus plantarum Strains Possessing Differential Antiviral Immunomodulatory Activities

Leonardo Albarracin, Fernanda Raya Tonetti, Kohtaro Fukuyama, Yoshihito Suda, Binghui Zhou, Ayelén A. Baillo, Silvina Fadda, Lucila Saavedra, Shoichiro Kurata, Elvira M. Hebert, Haruki Kitazawa, Julio Villena

Bacteria

2022

Genomic and Immunological Characterization of Hypermucoviscous Carbapenem-Resistant Klebsiella pneumoniae ST25 Isolates from Northwest Argentina

Leonardo Albarracin, Ramiro Ortiz Moyano, Juan Martin Vargas, Bruno G. N. Andrade, Juan Cortez Zamar, Stefania Dentice Maidana, Kohtaro Fukuyama, Shoichiro Kurata, María Ángela Jure, Haruki Kitazawa, Julio Villena

International Journal of Molecular Sciences

2022

Techno-functional properties and immunomodulatory potential of exopolysaccharide from Lactiplantibacillus plantarum MM89 isolated from human breast milk

Muhammad Shahid Riaz Rajoka, Hafiza Mahreen Mehwish, Haruki Kitazawa, Francisco J. Barba, Laureline Berthelot, Muhammad Umair, Qinchang Zhu, Zhendan He, Liqing Zhao

Food Chemistry

2022

Editorial: Malnutrition and Infections

Julio Villena, Haruki Kitazawa, Imad Al Kassaa, Susana Alvarez

Frontiers in Nutrition

2022

The role of respiratory microbiota in the protection against viral diseases: respiratory commensal bacteria as next-generation probiotics for COVID-19

Bruno G. N. ANDRADE, Rafael R. C. CUADRAT, Fernanda Raya TONETTI, Haruki KITAZAWA, Julio VILLENA

Bioscience of Microbiota, Food and Health

2022

Immunomodulation Potential of Probiotics: A Novel Strategy for Improving Livestock Health, Immunity, and Productivity

A. K. M. Humayun Kober, Muhammad Shahid Riaz Rajoka, Hafiza Mahreen Mehwish, Julio Villena, Haruki Kitazawa

Microorganisms

2022

Soymilk-fermented with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L improves immune-health in pigs

Y. Suda, K. Kagawa, K. Fukuyama, M. Elean, B. Zhou, M. Tomokiyo, M. Aminul Islam, M.S.R. Rajoka, A.K.M. Humayun Kober, T. Shimazu, S. Egusa, Y. Terashima, H. Aso, W. Ikeda-Ohtsubo, J. Villena, H. Kitazawa

Beneficial Microbes

2022

Prevention of mastitis in multiparous dairy cows with a previous history of mastitis by oral feeding with probiotic Bacillus subtilis

Megumi Urakawa, Tao Zhuang, Hidetoshi Sato, Satoru Takanashi, Kozue Yoshimura, Yuma Endo, Teppei Katsura, Tsuyoshi Umino, Koutaro Tanaka, Hitoshi Watanabe, Hiroko Kobayashi, Naokazu Takada, Tomoyuki Kozutsumi, Hiroaki Kumagai, Takafumi Asano, Kohko Sazawa, Nobuhisa Ashida, Guoqi Zhao, Michael T. Rose, Haruki Kitazawa, Hitoshi Shirakawa, Kouichi Watanabe, Tomonori Nochi, Takehiko Nakamura, Hisashi Aso

Animal Science Journal

2022

Lactobacillus delbrueckii CRL 581 Differentially Modulates TLR3-Triggered Antiviral Innate Immune Response in Intestinal Epithelial Cells and Macrophages

Mariano Elean, Leonardo Albarracin, Kohtaro Fukuyama, Binghui Zhou, Mikado Tomokiyo, Shugo Kitahara, Shota Araki, Yoshihito Suda, Lucila Saavedra, Julio Villena, Elvira M. Hebert, Haruki Kitazawa

Microorganisms

2021

Novel LysM motifs for antigen display on lactobacilli for mucosal immunization

Fernanda Raya-Tonetti, Melisa Müller, Jacinto Sacur, Haruki Kitazawa, Julio Villena, Maria Guadalupe Vizoso-Pinto

Scientific Reports

2021

NOD2 Genotypes Affect the Symptoms and Mortality in the Porcine Circovirus 2-Spreading Pig Population

Kasumi Suzuki, Hiroki Shinkai, Gou Yoshioka, Toshimi Matsumoto, Junji Tanaka, Noboru Hayashi, Haruki Kitazawa, Hirohide Uenishi

Genes

2021

Immunobiotic Lactobacilli Improve Resistance of Respiratory Epithelial Cells to SARS-CoV-2 Infection

Md. Aminul Islam, Leonardo Albarracin, Mikado Tomokiyo, Juan Carlos Valdez, Jacinto Sacur, Maria Guadalupe Vizoso-Pinto, Bruno G. N. Andrade, Rafael R. C. Cuadrat, Haruki Kitazawa, Julio Villena

Pathogens

2021

The gut microbiota induces Peyer’s-patch-dependent secretion of maternal IgA into milk

Katsuki Usami, Kanae Niimi, Ayumi Matsuo, Yoshihisa Suyama, Yoshifumi Sakai, Shintaro Sato, Kohtaro Fujihashi, Hiroshi Kiyono, Saeka Uchino, Mutsumi Furukawa, Jahidul Islam, Kaori Ito, Taiki Moriya, Yutaka Kusumoto, Michio Tomura, Russell C. Hovey, Junichi Sugawara, Hiroshi Yoneyama, Haruki Kitazawa, Kouichi Watanabe, Hisashi Aso, Tomonori Nochi

Cell Reports

2021

Genome-wide association studies for production, respiratory disease, and immune-related traits in Landrace pigs

Yoshinobu Uemoto, Kasumi Ichinoseki, Toshimi Matsumoto, Nozomi Oka, Hironori Takamori, Hiroshi Kadowaki, Chihiro Kojima-Shibata, Eisaku Suzuki, Toshihiro Okamura, Hisashi Aso, Haruki Kitazawa, Masahiro Satoh, Hirohide Uenishi, Keiichi Suzuki

Scientific Reports

2021

Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris

Marcela Espinoza-Monje, Jorge Campos, Eduardo Alvarez Villamil, Alonso Jerez, Stefania Dentice Maidana, Mariano Elean, Susana Salva, Haruki Kitazawa, Julio Villena, Apolinaria García-Cancino

Microorganisms

2021

Draft genome sequences of two hypermucoviscous carbapenem-resistant ST25 Klebsiella pneumoniae strains causing respiratory and systemic infections

María Angela Jure, Leonardo Albarracin, Juan Martin Vargas, Stefania Dentice Maidana, Juan Cortez Zamar, Haruki Kitazawa, Julio Villena

Journal of Global Antimicrobial Resistance

2021

The Respiratory Commensal Bacterium Dolosigranulum pigrum 040417 Improves the Innate Immune Response to Streptococcus pneumoniae

Fernanda Raya Tonetti, Mikado Tomokiyo, Ramiro Ortiz Moyano, Sandra Quilodrán-Vega, Hikari Yamamuro, Paulraj Kanmani, Vyacheslav Melnikov, Shoichiro Kurata, Haruki Kitazawa, Julio Villena

Microorganisms

2021

Evaluation of Porcine Intestinal Epitheliocytes as an In vitro Immunoassay System for the Selection of Probiotic Bifidobacteria to Alleviate Inflammatory Bowel Disease

Nana Sato, Mao Yuzawa, Md Islam Aminul, Mikado Tomokiyo, Leonardo Albarracin, Valeria Garcia-Castillo, Wakako Ideka-Ohtsubo, Noriyuki Iwabuchi, Jin-zhong Xiao, Apolinaria Garcia-Cancino, Julio Villena, Haruki Kitazawa

Probiotics and Antimicrobial Proteins

2021

Dolosigranulum pigrum Modulates Immunity against SARS-CoV-2 in Respiratory Epithelial Cells

Md. Aminul Islam, Leonardo Albarracin, Vyacheslav Melnikov, Bruno G. N. Andrade, Rafael R. C. Cuadrat, Haruki Kitazawa, Julio Villena

Pathogens

2021

Ligilactobacillus salivarius Strains Isolated From the Porcine Gut Modulate Innate Immune Responses in Epithelial Cells and Improve Protection Against Intestinal Viral-Bacterial Superinfection

Yuhki Indo, Shugo Kitahara, Mikado Tomokiyo, Shota Araki, Md. Aminul Islam, Binghui Zhou, Leonardo Albarracin, Ayako Miyazaki, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Takato Takenouchi, Hirohide Uenishi, Hisashi Aso, Hideki Takahashi, Shoichiro Kurata, Julio Villena, Haruki Kitazawa

Frontiers in Immunology

2021

Immunobiotic Feed Developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the Soymilk By-Product Okara Improves Health and Growth Performance in Pigs

Yoshihito Suda, Nana Sasaki, Kyoma Kagawa, Mariano Elean, Binghui Zhou, Mikado Tomokiyo, Md. Aminul Islam, Muhammad Shahid Riaz Rajoka, A. K. M. Humayun Kober, Tomoyuki Shimazu, Shintaro Egusa, Yuji Terashima, Hisashi Aso, Wakako Ikeda-Ohtsubo, Julio Villena, Haruki Kitazawa

Microorganisms

2021

Lactiplantibacillus plantarum as a Potential Adjuvant and Delivery System for the Development of SARS-CoV-2 Oral Vaccines

Julio Villena, Chang Li, Maria Guadalupe Vizoso-Pinto, Jacinto Sacur, Linzhu Ren, Haruki Kitazawa

Microorganisms

2021

Effect of Dietary Supplementation of Immunobiotic Lactiplantibacillusplantarum N14 Fermented Rakkyo (Allium chinense) Pickled Juice on the Immunocompetence and Production Performance of Pigs

Md. Aminul Islam, Kenji Hashiguchi, A.K.M. Humayun Kober, Kyoko Morie, Binghui Zhou, Mikado Tomokiyo, Tomoyuki Shimazu, Hisashi Aso, Julio Villena, Yoshihito Suda, Haruki Kitazawa

Animals

2021

Characterisation of sugar nucleotides in colostrum of dairy domestic farms animals

Yuri Mineguchi, Kyosuke Goto, Yuna Sudo, Kentaro Hirayama, Hirotoshi Kashiwagi, Izumi Sasagase, Haruki Kitazawa, Sadaki Asakuma, Kenji Fukuda, Tadasu Urashima

International Dairy Journal

2021

Improvement of Disease Resistance in Livestock: Application of Immunogenomics and CRISPR/Cas9 Technology

Md. Aminul Islam, Sharmin Aqter Rony, Mohammad Bozlur Rahman, Mehmet Ulas Cinar, Julio Villena, Muhammad Jasim Uddin, Haruki Kitazawa

Animals

2020

Functional and Genomic Characterization of Ligilactobacillus salivarius TUCO-L2 Isolated From Lama glama Milk: A Promising Immunobiotic Strain to Combat Infections

Sandra Quilodrán-Vega, Leonardo Albarracin, Flavia Mansilla, Lorena Arce, Binghui Zhou, Md Aminul Islam, Mikado Tomokiyo, Imad Al Kassaa, Yoshihito Suda, Haruki Kitazawa, Julio Villena

Frontiers in Microbiology

2020

Bayesian latent class evaluation of three tests for the screening of subclinical caprine mastitis in Bangladesh

Md. Aminul Islam, Sharmin Aqter Rony, Haruki Kitazawa, AKM Anisur Rahman

Tropical Animal Health and Production

2020

Selection of Immunobiotic Ligilactobacillus salivarius Strains from the Intestinal Tract of Wakame-Fed Pigs: Functional and Genomic Studies

Binghui Zhou, Leonardo Albarracin, Yuhki Indo, Lorena Arce, Yuki Masumizu, Mikado Tomokiyo, Md. Aminul Islam, Valeria Garcia-Castillo, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Hidetoshi Morita, Hideki Takahashi, Shoichiro Kurata, Julio Villena, Haruki Kitazawa

Microorganisms

2020

Editorial: Nutrition, Immunity and Viral Infections

Julio Villena, Takeshi Shimosato, María Guadalupe Vizoso-Pinto, Haruki Kitazawa

Frontiers in Nutrition

2020

IL‐12p40 gene expression in lung and hilar lymph nodes of MPS‐resistant pigs

Akiko Sakuma, Shizuka Sugawara, Hikaru Hidaka, Mitsuru Nakajo, Yoshihito Suda, Tomoyuki Shimazu, Michael T. Rose, Megumi Urakawa, Tao Zhuang, Guoqi Zhao, Kouichi Watanabe, Tomonori Nochi, Haruki Kitazawa, Kazuo Katoh, Keiichi Suzuki, Hisashi Aso

Animal Science Journal

2020

Alveolar Macrophages Are Key Players in the Modulation of the Respiratory Antiviral Immunity Induced by Orally Administered Lacticaseibacillus rhamnosus CRL1505

Valeria Garcia-Castillo, Mikado Tomokiyo, Fernanda Raya Tonetti, Md. Aminul Islam, Hideki Takahashi, Haruki Kitazawa, Julio Villena

Frontiers in Immunology

2020

Draft Genome Sequence of Ligilactobacillus salivarius FFIG58, Isolated from the Intestinal Tract of Wakame-Fed Pig

Binghui Zhou, Leonardo Albarracin, Yuki Masumizu, Yuhki Indo, M. Aminul Islam, Valeria Garcia-Castillo, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Hisashi Aso, Julio Villena, Haruki Kitazawa

Microbiology Resource Announcements

2020

Draft Genome Sequence of Ligilactobacillus salivarius TUCO-L2, Isolated from Lama glama Milk

Leonardo Albarracin, Sandra Quilodrán-Vega, Kohtaro Fukuyama, Mikado Tomokiyo, M. Aminul Islam, Lorena Arce, Haruki Kitazawa, Julio Villena

Microbiology Resource Announcements

2020

Immunobiotic Lactobacillus jensenii TL2937 Alleviates Dextran Sodium Sulfate-Induced Colitis by Differentially Modulating the Transcriptomic Response of Intestinal Epithelial Cells

Nana Sato, Valeria Garcia-Castillo, Mao Yuzawa, Md. Aminul Islam, Leonardo Albarracin, Mikado Tomokiyo, Wakako Ikeda-Ohtsubo, Apolinaria Garcia-Cancino, Hideki Takahashi, Julio Villena, Haruki Kitazawa

Frontiers in Immunology

2020

New immunobiotics from highly proteolytic Lactobacillus delbrueckii strains: their impact on intestinal antiviral innate immune response

M. Elean, L. Albarracín, P.G. Cataldo, A. Londero, H. Kitazawa, L. Saavedra, J. Villena, E.M. Hebert

Beneficial Microbes

2020

Evaluation of Fat Accumulation and Adipokine Production during the Long-Term Adipogenic Differentiation of Porcine Intramuscular Preadipocytes and Study of the Influence of Immunobiotics

Asuka Tada, AKM Humayun Kober, Md. Aminul Islam, Manami Igata, Michihiro Takagi, Masahiko Suzuki, Hisashi Aso, Wakako Ikeda-Ohtsubo, Kazutoyo Yoda, Kenji Miyazawa, Fang He, Hideki Takahashi, Julio Villena, Haruki Kitazawa

Cells

2020

Erratum: Fukuyama, K., et al. Evaluation of the Immunomodulatory Ability of Lactic Acid Bacteria Isolated from Feedlot Cattle Against Mastitis Using a Bovine Mammary Epithelial Cells In Vitro Assay. Pathogens 2020, 9, 410

Kohtaro Fukuyama, Md. Aminul Islam, Michihiro Takagi, Wakako Ikeda-Ohtsubo, Shoichiro Kurata, Hisashi Aso, Maria Elena Fatima Nader-Macías, Graciela Vignolo, Julio Villena, Haruki Kitazawa

Pathogens

2020

Factors affecting decreasing viscosity of the culture medium during the stationary growth phase of exopolysaccharide-producing <i>Lactobacillus fermentum</i> MTCC 25067

Bharat MENGI, Shinya IKEDA, Daiki MURAYAMA, Hiroki BOCHIMOTO, Shinpei MATSUMOTO, Haruki KITAZAWA, Tadasu URASHIMA, Kenji FUKUDA

Bioscience of Microbiota, Food and Health

2020

The Role of Alveolar Macrophages in the Improved Protection against Respiratory Syncytial Virus and Pneumococcal Superinfection Induced by the Peptidoglycan of Lactobacillus rhamnosus CRL1505

Patricia Clua, Mikado Tomokiyo, Fernanda Raya Tonetti, Md. Aminul Islam, Valeria García Castillo, Guillermo Marcial, Susana Salva, Susana Alvarez, Hideki Takahashi, Shoichiro Kurata, Haruki Kitazawa, Julio Villena

Cells

2020

Intestinal Microbiota and Immune Modulation in Zebrafish by Fucoidan From Okinawa Mozuku (Cladosiphon okamuranus)

Wakako Ikeda-Ohtsubo, Adrià López Nadal, Edoardo Zaccaria, Masahiko Iha, Haruki Kitazawa, Michiel Kleerebezem, Sylvia Brugman

Frontiers in Nutrition

2020

The Modulation of Mucosal Antiviral Immunity by Immunobiotics: Could They Offer Any Benefit in the SARS-CoV-2 Pandemic?

Julio Villena, Haruki Kitazawa

Frontiers in Physiology

2020

Evaluation of the Immunomodulatory Ability of Lactic Acid Bacteria Isolated from Feedlot Cattle Against Mastitis Using a Bovine Mammary Epithelial Cells In Vitro Assay

Kohtaro Fukuyama, Md. Aminul Islam, Michihiro Takagi, Wakako Ikeda-Ohtsubo, Shoichiro Kurata, Hisashi Aso, Graciela Vignolo, Julio Villena, Haruki Kitazawa

Pathogens

2020

Exopolysaccharides From Streptococcus thermophilus ST538 Modulate the Antiviral Innate Immune Response in Porcine Intestinal Epitheliocytes

Hiroya Mizuno, Kae Tomotsune, Md. Aminul Islam, Ryutaro Funabashi, Leonardo Albarracin, Wakako Ikeda-Ohtsubo, Hisashi Aso, Hideki Takahashi, Katsunori Kimura, Julio Villena, Yasuko Sasaki, Haruki Kitazawa

Frontiers in Microbiology

2020

The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic

Ramiro Ortiz Moyano, Fernanda Raya Tonetti, Mikado Tomokiyo, Paulraj Kanmani, María Guadalupe Vizoso-Pinto, Hojun Kim, Sandra Quilodrán-Vega, Vyacheslav Melnikov, Susana Alvarez, Hideki Takahashi, Shoichiro Kurata, Haruki Kitazawa, Julio Villena

Microorganisms

2020

Modulation of Toll-like receptor-mediated innate immunity in bovine intestinal epithelial cells by lactic acid bacteria isolated from feedlot cattle

F. Mansilla, M. Takagi, V. Garcia-Castillo, H. Aso, M.E. Nader-Macias, G. Vignolo, H. Kitazawa, J. Villena

Beneficial Microbes

2020

Lipoteichoic Acid Is Involved in the Ability of the Immunobiotic Strain Lactobacillus plantarum CRL1506 to Modulate the Intestinal Antiviral Innate Immunity Triggered by TLR3 Activation

Hiroya Mizuno, Lorena Arce, Kae Tomotsune, Leonardo Albarracin, Ryutaro Funabashi, Daniela Vera, Md. Aminul Islam, Maria Guadalupe Vizoso-Pinto, Hideki Takahashi, Yasuko Sasaki, Haruki Kitazawa, Julio Villena

Frontiers in Immunology

2020

The Exopolysaccharide of Lactobacillus fermentum UCO-979C Is Partially Involved in Its Immunomodulatory Effect and Its Ability to Improve the Resistance against Helicobacter pylori Infection

Valeria Garcia-Castillo, Guillermo Marcial, Leonardo Albarracín, Mikado Tomokiyo, Patricia Clua, Hideki Takahashi, Haruki Kitazawa, Apolinaria Garcia-Cancino, Julio Villena

Microorganisms

2020

Transcriptome Analysis of The Inflammatory Responses of Bovine Mammary Epithelial Cells: Exploring Immunomodulatory Target Genes for Bovine Mastitis

Md. Aminul Islam, Michihiro Takagi, Kohtaro Fukuyama, Ryoya Komatsu, Leonardo Albarracin, Tomonori Nochi, Yoshihito Suda, Wakako Ikeda-Ohtsubo, Victor Rutten, Willem van Eden, Julio Villena, Hisashi Aso, Haruki Kitazawa

Pathogens

2020

Efficient Selection of New Immunobiotic Strains With Antiviral Effects in Local and Distal Mucosal Sites by Using Porcine Intestinal Epitheliocytes

Leonardo Albarracin, Valeria Garcia-Castillo, Yuki Masumizu, Yuhki Indo, Md Aminul Islam, Yoshihito Suda, Apolinaria Garcia-Cancino, Hisashi Aso, Hideki Takahashi, Haruki Kitazawa, Julio Villena

Frontiers in Immunology

2020

In-Vitro Cell Culture for Efficient Assessment of Mycotoxin Exposure, Toxicity and Risk Mitigation

Ran Xu, Niel A. Karrow, Umesh K. Shandilya, Lv-hui Sun, Haruki Kitazawa

Toxins

2020

Transcriptome Modifications in the Porcine Intramuscular Adipocytes during Differentiation and Exogenous Stimulation with TNF-α and Serotonin

Asuka Tada, Md Islam, AKM Kober, Kohtaro Fukuyama, Michihiro Takagi, Manami Igata, Leonardo Albarracin, Wakako Ikeda-Ohtsubo, Kenji Miyazawa, Kazutoyo Yoda, Fang He, Hideki Takahashi, Julio Villena, Hisashi Aso, Haruki Kitazawa

International Journal of Molecular Sciences

2020

Immunomodulatory Properties of Bacterium-Like Particles Obtained From Immunobiotic Lactobacilli: Prospects for Their Use as Mucosal Adjuvants

Fernanda Raya Tonetti, Lorena Arce, Susana Salva, Susana Alvarez, Hideki Takahashi, Haruki Kitazawa, Maria Guadalupe Vizoso-Pinto, Julio Villena

Frontiers in Immunology

2020

Nasal priming with immunobiotic lactobacilli improves the adaptive immune response against influenza virus

Fernanda Raya Tonetti, Md. Aminul Islam, Maria Guadalupe Vizoso-Pinto, Hideki Takahashi, Haruki Kitazawa, Julio Villena

International Immunopharmacology

2020

Characterization of the immunomodulatory and anti-Helicobacter pylori properties of the human gastric isolate Lactobacillus rhamnosus UCO-25A

Valeria Garcia-Castillo, Ana María Marín-Vega, Alejandra Ilabaca, Leonardo Albarracín, Guillermo Marcial, Haruki Kitazawa, Apolinaria Garcia-Cancino, Julio Villena

Biofouling

2019

Addition of Wakame seaweed (Undaria pinnatifida) stalk to animal feed enhances immune response and improves intestinal microflora in pigs

Tomoyuki Shimazu, Liushiqi Borjigin, Kazuo Katoh, Sang‐gun Roh, Haruki Kitazawa, Keietsu Abe, Yoshihito Suda, Hayato Saito, Hiroshi Kunii, Ken Nihei, Yoshinobu Uemoto, Hisashi Aso, Keiichi Suzuki

Animal Science Journal

2019

Paraimmunobiotic Bifidobacteria Modulate the Expression Patterns of Peptidoglycan Recognition Proteins in Porcine Intestinal Epitheliocytes and Antigen Presenting Cells

Hikaru Iida, Masanori Tohno, Md. Aminul Islam, Nana Sato, Hisakazu Kobayashi, Leonardo Albarracin, AKM Humayun Kober, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Hisashi Aso, Tomonori Nochi, Ayako Miyazaki, Hirohide Uenishi, Noriyuki Iwabuchi, Jin-zhong Xiao, Julio Villena, Haruki Kitazawa

Cells

2019

Isolation and Immunocharacterization of Lactobacillus salivarius from the Intestine of Wakame-Fed Pigs to Develop Novel “Immunosynbiotics”

Yuki Masumizu, Binghui Zhou, A.K.M. Humayun Kober, Md. Aminul Islam, Hikaru Iida, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Leonardo Albarracin, Tomonori Nochi, Hisashi Aso, Keiichi Suzuki, Julio Villena, Haruki Kitazawa

Microorganisms

2019

Evaluation of the Immunomodulatory Activities of the Probiotic Strain Lactobacillus fermentum UCO-979C

Valeria Garcia-Castillo, Ryoya Komatsu, Patricia Clua, Yuhki Indo, Michihiro Takagi, Susana Salva, Md. Aminul Islam, Susana Alvarez, Hideki Takahashi, Apolinaria Garcia-Cancino, Haruki Kitazawa, Julio Villena

Frontiers in Immunology

2019

Draft Genome Sequence of Lactobacillus plantarum CRL681, Isolated from Argentinean Artisanal Fermented Sausages

Silvina Fadda, Julio Villena, Leonardo Albarracin, Lucila Saavedra, M. Aminul Islam, Graciela M. Vignolo, Haruki Kitazawa, Elvira Maria Hebert

Microbiology Resource Announcements

2019

Draft Genome Sequence of Weissella viridescens UCO-SMC3, Isolated from the Slime of Helix aspersa Müller Snails

Apolinaria Garcia-Cancino, Leonardo Albarracin, Marcela Espinoza-Monje, Jorge Campos-Martin, Valeria Garcia-Castillo, Yuka Nakano, Wakako Ikeda-Ohtsubo, Cristian Guitierrez-Zamorano, Hidetoshi Morita, Haruki Kitazawa, Julio Villena

Microbiology Resource Announcements

2019

Deciphering the influence of paraimmunobiotic bifidobacteria on the innate antiviral immune response of bovine intestinal epitheliocytes by transcriptomic analysis

L. Albarracin, R. Komatsu, V. Garcia-Castillo, H. Aso, N. Iwabuchi, J.-Z. Xiao, F. Abe, H. Takahashi, J. Villena, H. Kitazawa

Beneficial Microbes

2019

Screening and Characterization of Immunobiotic Lactic Acid Bacteria with Porcine Immunoassay Systems

Valeria Garcia-Castillo, Leonardo Albarracin, Haruki Kitazawa, Julio Villena

Methods in Molecular Biology

2018

Characterization of the immunomodulatory and anti-Helicobacter pylori properties of the human gastric isolate Lactobacillus rhamnosus UCO-25A

Valeria Garcia-Castillo, Ana María Marín-Vega, Alejandra Ilabaca, Leonardo Albarracin, Guillermo Marcial, Haruki Kitazawa, Apolinaria García Cancino, Julio Villena

Biofouling

2019

Transcriptome Modifications in Porcine Adipocytes via Toll-Like Receptors Activation

Manami Igata, Md. Aminul Islam, Asuka Tada, Michihiro Takagi, A. K. M. Humayun Kober, Leonardo Albarracin, Hisashi Aso, Wakako Ikeda-Ohtsubo, Kenji Miyazawa, Kazutoyo Yoda, Fang He, Hideki Takahashi, Julio Villena, Haruki Kitazawa

Frontiers in Immunology

2019

Virus Latency and the Impact on Plants

Hideki Takahashi, Toshiyuki Fukuhara, Haruki Kitazawa, Richard Kormelink

Frontiers in Microbiology

2019

Draft Genome Sequence of Probiotic Lactobacillus brevis TUCO-5E, Isolated from Porcine Milk

Sandra Rayen Quilodran-Vega, Leonardo Albarracin, Elvira Maria Hebert, Lucila Saavedra, Alexis Fonseca, Alexis Salas-Burgos, Haruki Kitazawa, Julio Villena

Microbiology Resource Announcements

2018

Receptors and Signaling Pathways for Recognition of Bacteria in Livestock and Crops: Prospects for Beneficial Microbes in Healthy Growth Strategies

Julio Villena, Haruki Kitazawa, Saskia C. M. Van Wees, Corné M. J. Pieterse, Hideki Takahashi

Frontiers in Immunology

2018

Phenotypic and functional analysis of bovine peripheral blood dendritic cells before parturition by a novel purification method

Tao Zhuang, Megumi Urakawa, Hidetoshi Sato, Yuko Sato, Teruaki Taguchi, Tsuyoshi Umino, Shiro Katto, Koutaro Tanaka, Kozue Yoshimura, Naokazu Takada, Hiroko Kobayashi, Megumi Ito, Michael T. Rose, Yoshio Kiku, Yuya Nagasawa, Haruki Kitazawa, Kouichi Watanabe, Tomonori Nochi, Tomohito Hayashi, Hisashi Aso

Animal Science Journal

2018

Lactobacillus fermentum UCO-979C beneficially modulates the innate immune response triggered by Helicobacter pylori infection in vitro

V. Garcia-Castillo, H. Zelaya, A. Ilabaca, M. Espinoza-Monje, R. Komatsu, L. Albarracín, H. Kitazawa, A. Garcia-Cancino, J. Villena

Beneficial Microbes

2018

Development of immune and microbial environments is independently regulated in the mammary gland

K Niimi, K Usami, Y Fujita, M Abe, M Furukawa, Y Suyama, Y Sakai, M Kamioka, N Shibata, E J Park, S Sato, H Kiyono, H Yoneyama, H Kitazawa, K Watanabe, T Nochi, H Aso

Mucosal Immunology

2018

Immunobiotics for the Bovine Host: Their Interaction with Intestinal Epithelial Cells and Their Effect on Antiviral Immunity

Julio Villena, Hisashi Aso, Victor P. M. G. Rutten, Hideki Takahashi, Willem van Eden, Haruki Kitazawa

Frontiers in Immunology

2018

Genomic Characterization of Lactobacillus delbrueckii TUA4408L and Evaluation of the Antiviral Activities of its Extracellular Polysaccharides in Porcine Intestinal Epithelial Cells

Paulraj Kanmani, Leonardo Albarracin, Hisakazu Kobayashi, Elvira Maria Hebert, Lucila Saavedra, Ryoya Komatsu, Brian Gatica, Ayako Miyazaki, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Hisashi Aso, Shintaro Egusa, Takashi Mishima, Alexis Salas-Burgos, Hideki Takahashi, Julio Villena, Haruki Kitazawa

Frontiers in Immunology

2018

Exopolysaccharides from Lactobacillus delbrueckii OLL1073R-1 modulate innate antiviral immune response in porcine intestinal epithelial cells

Paulraj Kanmani, Leonardo Albarracin, Hisakazu Kobayashi, Hikaru Iida, Ryoya Komatsu, A.K.M. Humayun Kober, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Hisashi Aso, Seiya Makino, Hiroshi Kano, Tadao Saito, Julio Villena, Haruki Kitazawa

Molecular Immunology

2018

Draft Genome Sequence of Immunobiotic Lactobacillus rhamnosus Strain IBL027, a Potential Adjuvant for Mucosal Vaccine Development

María Guadalupe Vizoso-Pinto, Lucila Saavedra, Elvira Maria Hebert, Fernanda Raya Tonetti, Leonardo Albarracín, Susana Alvarez, Haruki Kitazawa, Julio Villena

Genome Announcements

2017

Editorial: Immunobiotics—Interactions of Beneficial Microbes with the Immune System

Julio Villena, Haruki Kitazawa

Frontiers in Immunology

2017

Peptidoglycan from Immunobiotic Lactobacillus rhamnosus Improves Resistance of Infant Mice to Respiratory Syncytial Viral Infection and Secondary Pneumococcal Pneumonia

Patricia Clua, Paulraj Kanmani, Hortensia Zelaya, Asuka Tada, A. K. M. Humayun Kober, Susana Salva, Susana Alvarez, Haruki Kitazawa, Julio Villena

Frontiers in Immunology

2017

Respiratory Commensal Bacteria Corynebacterium pseudodiphtheriticum Improves Resistance of Infant Mice to Respiratory Syncytial Virus and Streptococcus pneumoniae Superinfection

Paulraj Kanmani, Patricia Clua, Maria G. Vizoso-Pinto, Cecilia Rodriguez, Susana Alvarez, Vyacheslav Melnikov, Hideki Takahashi, Haruki Kitazawa, Julio Villena

Frontiers in Microbiology

2017

Effects of mycoplasmal pneumonia of swine (MPS) lung lesion‐selected Landrace pigs on MPS resistance and immune competence in three‐way crossbred pigs

Liushiqi Borjigin, Tomoyuki Shimazu, Yuki Katayama, Kouichi Watanabe, Haruki Kitazawa, Sang‐gun Roh, Hisashi Aso, Kazuo Katoh, Masahiro Satoh, Yoshihito Suda, Akiko Sakuma, Mituru Nakajo, Keiichi Suzuki

Animal Science Journal

2017

Probiotic Microorganisms: A Closer Look

Julio Villena, Haruki Kitazawa

Microorganisms

2017

Draft Genome Sequence of Lactobacillus plantarum MPL16, a Wakame-Utilizing Immunobiotic Strain Isolated from Swine Feces

Julio Villena, Lucila Saavedra, Elvira Maria Hebert, Yoshihito Suda, Yuki Masumizu, Leonardo Albarracin, Patricia Clua, Wakako Ikeda-Ohtsubo, Haruki Kitazawa

Genome Announcements

2017

Draft Genome Sequence of the Immunobiotic Strain Lactobacillus jensenii TL2937

Julio Villena, Yuki Masumizu, Hikaru Iida, Wakako Ikeda-Ohtsubo, Leonardo Albarracin, Seiya Makino, Sou Ohkawara, Katsunori Kimura, Lucila Saavedra, Elvira Maria Hebert, Haruki Kitazawa

Genome Announcements

2017

Transcriptomic Analysis of the Innate Antiviral Immune Response in Porcine Intestinal Epithelial Cells: Influence of Immunobiotic Lactobacilli

Leonardo Albarracin, Hisakazu Kobayashi, Hikaru Iida, Nana Sato, Tomonori Nochi, Hisashi Aso, Susana Salva, Susana Alvarez, Haruki Kitazawa, Julio Villena

Frontiers in Immunology

2017

Development of an in vitro immunobiotic evaluation system against rotavirus infection in bovine intestinal epitheliocytes

H. Kobayashi, P. Kanmani, T. Ishizuka, A. Miyazaki, J. Soma, L. Albarracin, Y. Suda, T. Nochi, H. Aso, N. Iwabuchi, J.-Z. Xiao, T. Saito, J. Villena, H. Kitazawa

Beneficial Microbes

2017

Intestinal Innate Antiviral Immunity and Immunobiotics: Beneficial Effects against Rotavirus Infection

Julio Villena, Maria Guadalupe Vizoso-Pinto, Haruki Kitazawa

Frontiers in Immunology

2016

Respiratory Antiviral Immunity and Immunobiotics: Beneficial Effects on Inflammation-Coagulation Interaction during Influenza Virus Infection

Hortensia Zelaya, Susana Alvarez, Haruki Kitazawa, Julio Villena

Frontiers in Immunology

2016

Draft Genome Sequence of Lactobacillus plantarum TL2766, a Strain with the Ability To Ferment Wakame

Julio Villena, Lucila Saavedra, Elvira Maria Hebert, Yuki Masumizu, Nana Sato, A. K. M. Humayun Kober, Leonardo Albarracin, Wakako Ikeda-Ohtsubo, Seiya Makino, Katsunori Kimura, Sou Ohkawara, Haruki Kitazawa

Genome Announcements

2016

Immunobiotic Lactobacillus strains reduce small intestinal injury induced by intraepithelial lymphocytes after Toll-like receptor 3 activation

Asuka Tada, Hortensia Zelaya, Patricia Clua, Susana Salva, Susana Alvarez, Haruki Kitazawa, Julio Villena

Inflammation Research

2016

Isolation of lactic acid bacteria bound to the porcine intestinal mucosa and an analysis of their moonlighting adhesins

Hideki KINOSHITA, Satoko OHUCHI, Kensuke ARAKAWA, Masamichi WATANABE, Haruki KITAZAWA, Tadao SAITO

Bioscience of Microbiota, Food and Health

2016

Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line

Liushiqi Borjigin, Tomoyuki Shimazu, Yuki Katayama, Kouichi Watanabe, Haruki Kitazawa, Sang‐gun Roh, Hisashi Aso, Kazuo Katoh, Takafumi Uchida, Yoshihito Suda, Akiko Sakuma, Mituru Nakajo, Keiichi Suzuki

Animal Science Journal

2016

Isolation of lactic acid bacteria from swine milk and characterization of potential probiotic strains with antagonistic effects against swine-associated gastrointestinal pathogens

Sandra Rayén Quilodrán-Vega, Julio Villena, José Valdebenito, María José Salas, Cristian Parra, Alvaro Ruiz, Haruki Kitazawa, Apolinaria García

Canadian Journal of Microbiology

2016

Cyclophilin A is a new M cell marker of bovine intestinal epithelium

Tetsuya Hondo, Shunsuke Someya, Yuya Nagasawa, Shunsuke Terada, Hitoshi Watanabe, Xiangning Chen, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose, Tomonori Nochi, Hisashi Aso

Cell and Tissue Research

2016

Immunoregulatory effects triggered by immunobiotic Lactobacillus jensenii TL2937 strain involve efficient phagocytosis in porcine antigen presenting cells

Kohichiro Tsukida, Takuya Takahashi, Hikaru Iida, Paulraj Kanmani, Yoshihito Suda, Tomonori Nochi, Shuichi Ohwada, Hisashi Aso, Sou Ohkawara, Seiya Makino, Hiroshi Kano, Tadao Saito, Julio Villena, Haruki Kitazawa

BMC Immunology

2016

Immunogenic properties and mycoplasmal pneumonia of swine (MPS) lung lesions in Large White pigs selected for higher peripheral blood immune capacity

Liushiqi Borjigin, Tomoyuki Shimazu, Yuki Katayama, Meihua Li, Takumi Satoh, Kouichi Watanabe, Haruki Kitazawa, Sang‐gun Roh, Hisashi Aso, Kazuo Katoh, Takafumi Uchida, Yoshihito Suda, Akiko Sakuma, Mituru Nakajo, Keiichi Suzuki

Animal Science Journal

2016

Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine

Liushiqi Borjigin, Tomoyuki Shimazu, Yuki Katayama, Meihua Li, Takumi Satoh, Kouichi Watanabe, Haruki Kitazawa, Sang‐gun Roh, Hisashi Aso, Kazuo Katoh, Takafumi Uchida, Yoshihito Suda, Akiko Sakuma, Mituru Nakajo, Keiichi Suzuki

Animal Science Journal

2016

Draft Genome Sequence of Lactobacillus plantarum CRL1506, an Immunomodulatory Strain Isolated from Goat Milk

Lucila Saavedra, Elvira María Hebert, Leonardo Albarracin, Susana Salva, Susana Alvarez, Haruki Kitazawa, Julio Villena

Genome Announcements

2016

Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling

Takamasa Ishizuka, Paulraj Kanmani, Hisakazu Kobayashi, Ayako Miyazaki, Junichi Soma, Yoshihito Suda, Hisashi Aso, Tomonori Nochi, Noriyuki Iwabuchi, Jin-zhong Xiao, Tadao Saito, Julio Villena, Haruki Kitazawa

PLOS ONE

2016

Serotonin Improves High Fat Diet Induced Obesity in Mice

Hitoshi Watanabe, Tatsuya Nakano, Ryo Saito, Daisuke Akasaka, Kazuki Saito, Hideki Ogasawara, Takeshi Minashima, Kohtaro Miyazawa, Takashi Kanaya, Ikuro Takakura, Nao Inoue, Ikuo Ikeda, Xiangning Chen, Masato Miyake, Haruki Kitazawa, Hitoshi Shirakawa, Kan Sato, Kohji Tahara, Yuya Nagasawa, Michael T. Rose, Shyuichi Ohwada, Kouichi Watanabe, Hisashi Aso

PLOS ONE

2016

Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937

H. Kobayashi, L. Albarracin, N. Sato, P. Kanmani, A.K.M.H. Kober, W. Ikeda-Ohtsubo, Y. Suda, T. Nochi, H. Aso, S. Makino, H. Kano, S. Ohkawara, T. Saito, J. Villena, H. Kitazawa

Beneficial Microbes

2016

Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice

Suguru Shigemori, Takafumi Watanabe, Kai Kudoh, Masaki Ihara, Shireen Nigar, Yoshinari Yamamoto, Yoshihito Suda, Takashi Sato, Haruki Kitazawa, Takeshi Shimosato

Microbial Cell Factories

2015

Nasal priming with immunobiotic Lactobacillus rhamnosus modulates inflammation–coagulation interactions and reduces influenza virus-associated pulmonary damage

Hortensia Zelaya, Asuka Tada, Maria Guadalupe Vizoso-Pinto, Susana Salva, Paulraj Kanmani, Graciela Agüero, Susana Alvarez, Haruki Kitazawa, Julio Villena

Inflammation Research

2015

Extracellular cyclophilin A possesses chemotaxic activity in cattle

Satoru Takanashi, Tomonori Nochi, Miku Abe, Nanami Itaya, Megumi Urakawa, Katsuyoshi Sato, Tao Zhuang, Saori Umemura, Tomohito Hayashi, Yoshio Kiku, Haruki Kitazawa, Michael T. Rose, Kouichi Watanabe, Hisashi Aso

Veterinary Research

2015

IN VITRO MASS-SCREENING OF LACTIC ACID BACTERIA AS POTENTIAL BIOSORBENTS OF CESIUM AND STRONTIUM IONS

Hideki Kinoshita, Yuka Sato1, Fumika Ohtake, Mitsuharu Ishida, Toshikazu Komoda, Haruki Kitazawa2, Tadao Saito, Kazuhiko Kimura

Journal of microbiology, biotechnology and food sciences

2015

The toll-like receptor family protein RP105/MD1 complex is involved in the immunoregulatory effect of exopolysaccharides from Lactobacillus plantarum N14

Yo Murofushi, Julio Villena, Kyoko Morie, Paulraj Kanmani, Masanori Tohno, Tomoyuki Shimazu, Hisashi Aso, Yoshihito Suda, Kenji Hashiguchi, Tadao Saito, Haruki Kitazawa

Molecular Immunology

2015

Prion Protein Binds to Aldolase A Produced by Bovine Intestinal M Cells

Yuya Nagasawa, Yu Takahashi, Wataru Itani, Hitoshi Watanabe, Yusuke Hidaka, Shotaro Morita, Kei Suzuki, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Morikazu Imamura, Takashi Yokoyama, Motohiro Horiuchi, Suehiro Sakaguchi, Shirou Mohri, Michael T. Rose, Tomonori Nochi, Hisashi Aso

Open Journal of Veterinary Medicine

2015

Advanced Application of Porcine Intramuscular Adipocytes for Evaluating Anti-Adipogenic and Anti-Inflammatory Activities of Immunobiotics

Masahiko Suzuki, Asuka Tada, Paulraj Kanmani, Hitoshi Watanabe, Hisashi Aso, Yoshihito Suda, Tomonori Nochi, Kenji Miyazawa, Kazutoyo Yoda, Fang He, Masataka Hosoda, Tadao Saito, Julio Villena, Haruki Kitazawa

PLOS ONE

2015

Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice

Yeqin Wang, Yoshinari Yamamoto, Suguru Shigemori, Takafumi Watanabe, Kazushi Oshiro, Xinyu Wang, Pengfei Wang, Takashi Sato, Shinichi Yonekura, Sachi Tanaka, Haruki Kitazawa, Takeshi Shimosato

Molecular Therapy

2015

Recent Advances and Future Perspective in Microbiota and Probiotics

Haruki Kitazawa, Susana Alvarez, Alexander Suvorov, Vyacheslav Melnikov, Julio Villena, Borja Sánchez

BioMed Research International

2015

Diversity of Microflora in Colonic Mucus from Severe Ulcerative Colitis Patients Analyzed by Terminal Restriction Fragment Length Polymorphism and Clone Libraries of Bacterial 16S rRNA Gene Sequences

I-Nung Huang, Yuri Sato, Mitsuo Sakamoto, Moriya Ohkuma, Shinobu Ohnuma, Takeshi Naitoh, Chikashi Shibata, Akira Horii, Junko Nishimura, Haruki Kitazawa, Tadao Saito

Advances in Microbiology

2014

Lactobacillus delbrueckii TUA4408L and its extracellular polysaccharides attenuate enterotoxigenic Escherichia coli‐induced inflammatory response in porcine intestinal epitheliocytes via Toll‐like receptor‐2 and 4

Satoshi Wachi, Paulraj Kanmani, Yohsuke Tomosada, Hisakazu Kobayashi, Toshihito Yuri, Shintaro Egusa, Tomoyuki Shimazu, Yoshihito Suda, Hisashi Aso, Makoto Sugawara, Tadao Saito, Takashi Mishima, Julio Villena, Haruki Kitazawa

Molecular Nutrition & Food Research

2014

Immunobiotic Lactobacillus jensenii as immune-health promoting factor to improve growth performance and productivity in post-weaning pigs

Yoshihito Suda, Julio Villena, Yu Takahashi, Shoichi Hosoya, Yohsuke Tomosada, Kohichiro Tsukida, Tomoyuki Shimazu, Hisashi Aso, Masanori Tohno, Mitsuharu Ishida, Seiya Makino, Shuji Ikegami, Haruki Kitazawa

BMC Immunology

2014

Regulation of Toll-Like Receptors-Mediated Inflammation by Immunobiotics in Bovine Intestinal Epitheliocytes: Role of Signaling Pathways and Negative Regulators

Julio Villena, Hisashi Aso, Haruki Kitazawa

Frontiers in Immunology

2014

Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505

Haruki Kitazawa, Julio Villena

Frontiers in Immunology

2014

Immunobiotic Lactobacillus rhamnosus strains differentially modulate antiviral immune response in porcine intestinal epithelial and antigen presenting cells

Julio Villena, Eriko Chiba, Maria Vizoso-Pinto, Yohsuke Tomosada, Takuya Takahashi, Takamasa Ishizuka, Hisashi Aso, Susana Salva, Susana Alvarez, Haruki Kitazawa

BMC Microbiology

2014

Quantitative Microbiological Evaluation of <i>Salmonella</i> Typhimurium Shed in Diarrhea, Loose, and Normal Stools of Infected Pigs

Tsuyoshi Tanaka, Yasuo Imai, Naosuke Kumagae, Takashi Sasaki, Narutoshi Ochiai, Katsuyoshi Uruno, Haruki Kitazawa, Tadao Saito, Shizuo Sato

Open Journal of Veterinary Medicine

2014

Immunological characterization of peripheral blood leukocytes using vaccine for mycoplasmal pneumonia of swine (MPS) in swine line selected for resistance toMPS

Tomoyuki Shimazu, Liushiqi Borjigin, Yuki Katayama, Meihua Li, Takumi Satoh, Kouichi Watanabe, Haruki Kitazawa, Sang‐gun Roh, Hisashi Aso, Kazuo Katoh, Yoshihito Suda, Akiko Sakuma, Mituru Nakajo, Keiichi Suzuki

Animal Science Journal

2014

Genetic selection for resistance to mycoplasmal pneumonia of swine (MPS) in theLandrace line influences the expression of soluble factors in blood afterMPSvaccine sensitization

Tomoyuki Shimazu, Liushiqi Borjigin, Yuki Katayama, Meihua Li, Takumi Satoh, Kouichi Watanabe, Haruki Kitazawa, Sang‐gun Roh, Hisashi Aso, Katoh Kazuo, Yoshihito Suda, Akiko Sakuma, Mituru Nakajo, Keiichi Suzuki

Animal Science Journal

2014

Immunobiotic lactobacilli reduce viral-associated pulmonary damage through the modulation of inflammation–coagulation interactions

Hortensia Zelaya, Kohichiro Tsukida, Eriko Chiba, Gabriela Marranzino, Susana Alvarez, Haruki Kitazawa, Graciela Agüero, Julio Villena

International Immunopharmacology

2014

Evaluation of the Immunoregulatory Capacities of Feed Microbial Materials in Porcine Intestinal Immune and Epithelial Cells

Naosuke Kumagae, Julio Villena, Yohsuke Tomosada, Hisakazu Kobayashi, Paulraj Kanmani, Hisashi Aso, Takashi Sasaki, Motohiko Yoshida, Hiroshi Tanabe, Isao Shibata, Tadao Saito, Haruki Kitazawa

Open Journal of Veterinary Medicine

2014

Effect of Peripheral 5-HT on Glucose and Lipid Metabolism in Wether Sheep

Hitoshi Watanabe, Ryo Saito, Tatsuya Nakano, Hideyuki Takahashi, Yu Takahashi, Keisuke Sumiyoshi, Katsuyoshi Sato, Xiangning Chen, Natsumi Okada, Shunsuke Iwasaki, Dian W. Harjanti, Natsumi Sekiguchi, Hiroaki Sano, Haruki Kitazawa, Michael T. Rose, Shyuichi Ohwada, Kouichi Watanabe, Hisashi Aso

PLoS ONE

2014

Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937

Julio Villena, Haruki Kitazawa

Frontiers in Immunology

2014

Bifidobacterium breve MCC-117 Induces Tolerance in Porcine Intestinal Epithelial Cells: Study of the Mechanisms Involved in the Immunoregulatory Effect

Kozue MURATA, Yohsuke TOMOSADA, Julio VILLENA, Eriko CHIBA, Tomoyuki SHIMAZU, Hisashi ASO, Noriyuki IWABUCHI, Jin-zhong XIAO, Tadao SAITO, Haruki KITAZAWA

Bioscience of Microbiota, Food and Health

2014

Advanced application of porcine intestinal epithelial cells for the selection of immunobiotics modulating toll-like receptor 3-mediated inflammation

Shoichi Hosoya, Julio Villena, Eriko Chiba, Tomoyuki Shimazu, Yoshihito Suda, Hisashi Aso, Tadao Saito, Haruki Kitazawa

Journal of Microbiology, Immunology and Infection

2013

Immunological characterization of peripheral blood leukocytes using vaccine for mycoplasmal pneumonia of swine (MPS) in swine line selected for resistance toMPS

Tomoyuki Shimazu, Liushiqi Borjigin, Yuki Katayama, Meihua Li, Takumi Satoh, Kouichi Watanabe, Haruki Kitazawa, Sang‐gun Roh, Hisashi Aso, Kazuo Katoh, Yoshihito Suda, Akiko Sakuma, Mituru Nakajo, Keiichi Suzuki

Animal Science Journal

2013

Modulation of Mucosal Antiviral Immune Response at the Female Genital Tract by Immunobiotic Lactic Acid Bacteria

Maria Guadalupe Vizoso-Pinto, Julio Villena, Virginia Rodriguez, Haruki Kitazawa, Susana Salva, Susana Alvarez

Journal of Immunological Techniques in Infectious Diseases

2013

Immunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection

Eriko Chiba, Yohsuke Tomosada, Maria Guadalupe Vizoso-Pinto, Susana Salva, Takuya Takahashi, Kohichiro Tsukida, Haruki Kitazawa, Susana Alvarez, Julio Villena

International Immunopharmacology

2013

Biosorption of heavy metals by lactic acid bacteria and identification of mercury binding protein

Hideki Kinoshita, Yui Sohma, Fumika Ohtake, Mitsuharu Ishida, Yasushi Kawai, Haruki Kitazawa, Tadao Saito, Kazuhiko Kimura

Research in Microbiology

2013

Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection

Yohsuke Tomosada, Eriko Chiba, Hortensia Zelaya, Takuya Takahashi, Kohichiro Tsukida, Haruki Kitazawa, Susana Alvarez, Julio Villena

BMC Immunology

2013

Bifidobacteria Upregulate Expression of Toll-Like Receptor Negative Regulators Counteracting Enterotoxigenic Escherichia coli Mediated Inflammation in Bovine Intestinal Epitheliocytes

Kozue Murata, Julio Villena, Yohsuke Tomosada, Risa Hara, Eriko Chiba, Tomoyuki Shimazu, Hisashi Aso, Yoshihito Suda, Noriyuki Iwabuchi, Jin-Zhong Xiao, Tadao Saito, Haruki Kitazawa

Open Journal of Veterinary Medicine

2013

Advanced application of bovine intestinal epithelial cell line for evaluating regulatory effect of lactobacilli against heat-killed enterotoxigenic Escherichia coli-mediated inflammation

Naoya Takanashi, Yohsuke Tomosada, Julio Villena, Kozue Murata, Takuya Takahashi, Eriko Chiba, Masanori Tohno, Tomoyuki Shimazu, Hisashi Aso, Yoshihito Suda, Shuji Ikegami, Hiroyuki Itoh, Yasushi Kawai, Tadao Saito, Susana Alvarez, Haruki Kitazawa

BMC Microbiology

2013

New screening methods for probiotics with adhesion properties to sialic acid and sulphate residues in human colonic mucin using the Biacore assay

I-N. Huang, T. Okawara, M. Watanabe, Y. Kawai, H. Kitazawa, S. Ohnuma, C. Shibata, A. Horii, K. Kimura, N. Taketomo, J.-Z. Xiao, K. Iwatsuki, T. Saito

Journal of Applied Microbiology

2013

Immunoregulatory Effect of Bifidobacteria Strains in Porcine Intestinal Epithelial Cells through Modulation of Ubiquitin-Editing Enzyme A20 Expression

Yohsuke Tomosada, Julio Villena, Kozue Murata, Eriko Chiba, Tomoyuki Shimazu, Hisashi Aso, Noriyuki Iwabuchi, Jin-zhong Xiao, Tadao Saito, Haruki Kitazawa

PLoS ONE

2013

Effect of Myostatin on Chemokine Expression in Regenerating Skeletal Muscle Cells

Shunsuke Iwasaki, Masato Miyake, Shinichiro Hayashi, Hitoshi Watanabe, Yuya Nagasawa, Shunsuke Terada, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose, Hisashi Aso

Cells Tissues Organs

2013

Advanced application of porcine intestinal epithelial cells for the selection of immunobiotics modulating toll-like receptor 3-mediated inflammation

Shoichi Hosoya, Julio Villena, Eriko Chiba, Tomoyuki Shimazu, Yoshihito Suda, Hisashi Aso, Tadao Saito, Haruki Kitazawa

Journal of Microbiology, Immunology and Infection

2013

Food preservative potential of gassericin A‐containing concentrate prepared from cheese whey culture supernatant of Lactobacillus gasseri LA39

Kiyoshi NAKAMURA, Kensuke ARAKAWA, Yasushi KAWAI, Narimi YASUTA, Takahiro CHUJO, Masamichi WATANABE, Hiroyuki IIOKA, Masashi TANIOKA, Junko NISHIMURA, Haruki KITAZAWA, Koichi TSURUMI, Tadao SAITO

Animal Science Journal

2012

Expression of Myostatin in Neural Cells of the Olfactory System

Shunsuke Iwasaki, Masato Miyake, Hitoshi Watanabe, Eri Kitagawa, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose, Hisashi Aso

Molecular Neurobiology

2012

Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression

Yusuke Ito, Suguru Shigemori, Takashi Sato, Tomoyuki Shimazu, Konomi Hatano, Hajime Otani, Haruki Kitazawa, Takeshi Shimosato

FEBS Open Bio

2012

Proposal of screening method for intestinal mucus adhesive lactobacilli using the enzymatic activity of glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH)

Hideki KINOSHITA, Shun IMOTO, Yoshihito SUDA, Mitsuharu ISHIDA, Masamichi WATANABE, Yasushi KAWAI, Haruki KITAZAWA, Koh MIURA, Akira HORII, Tadao SAITO

Animal Science Journal

2012

A newly established bovine intestinal epithelial cell line is effective for in vitro screening of potential antiviral immunobiotic microorganisms for cattle

Eriko Chiba, Julio Villena, Shoichi Hosoya, Naoya Takanashi, Tomoyuki Shimazu, Hisashi Aso, Masanori Tohno, Yoshihito Suda, Yasushi Kawai, Tadao Saito, Kenji Miyazawa, Fang He, Haruki Kitazawa

Research in Veterinary Science

2012

An Adhesin-Like Protein, Lam29, from Lactobacillus mucosae ME-340 Binds to Histone H3 and Blood Group Antigens in Human Colonic Mucus

Masamichi WATANABE, Hideki KINOSHITA, I-Nung HUANG, Kei EGUCHI, Takuya TSURUMI, Yasushi KAWAI, Haruki KITAZAWA, Katsunori KIMURA, Naoki TAKETOMO, Daisuke KIKUCHI, Tomohiko SASE, Koh MIURA, Hitoshi OGAWA, Chikashi SHIBATA, Akira HORII, Tadao SAITO

Bioscience, Biotechnology, and Biochemistry

2012

Orally administered Lactobacillus rhamnosus modulates the respiratory immune response triggered by the viral pathogen-associated molecular pattern poly(I:C)

Julio Villena, Eriko Chiba, Yohsuke Tomosada, Susana Salva, Gabriela Marranzino, Haruki Kitazawa, Susana Alvarez

BMC Immunology

2012

Immunobiotic Lactobacillus jensenii Modulates the Toll-Like Receptor 4-Induced Inflammatory Response via Negative Regulation in Porcine Antigen-Presenting Cells

Julio Villena, Rie Suzuki, Hitomi Fujie, Eriko Chiba, Takuya Takahashi, Yohsuke Tomosada, Tomoyuki Shimazu, Hisashi Aso, Shyuichi Ohwada, Yoshihito Suda, Shuji Ikegami, Hiroyuki Itoh, Susana Alvarez, Tadao Saito, Haruki Kitazawa

Clinical and Vaccine Immunology

2012

A Distinct Regulatory Role of Th17 Cytokines IL-17A and IL-17F in Chemokine Secretion from Lung Microvascular Endothelial Cells

Hitomi Fujie, Kaijun Niu, Michiru Ohba, Yoshihisa Tomioka, Haruki Kitazawa, Kengo Nagashima, Takashi Ohrui, Muneo Numasaki

Inflammation

2012

Purification and characterization of two phospho-β-galactosidases, LacG1 and LacG2, from Lactobacillus gasseri ATCC33323T

Hiroyuki Honda, Seiji Nagaoka, Yasushi Kawai, Robèr Kemperman, Jan Kok, Yukiko Yamazaki, Yoshio Tateno, Haruki Kitazawa, Tadao Saito

The Journal of General and Applied Microbiology

2012

Immunobiotic Lactobacillus jensenii Elicits Anti-Inflammatory Activity in Porcine Intestinal Epithelial Cells by Modulating Negative Regulators of the Toll-Like Receptor Signaling Pathway

Tomoyuki Shimazu, Julio Villena, Masanori Tohno, Hitomi Fujie, Shoichi Hosoya, Takeshi Shimosato, Hisashi Aso, Yoshihito Suda, Yasushi Kawai, Tadao Saito, Seiya Makino, Shuji Ikegami, Hiroyuki Itoh, Haruki Kitazawa

Infection and Immunity

2012

Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut-associated lymphoid tissues

Masanori Tohno, Takeshi Shimosato, Hisashi Aso, Haruki Kitazawa

Veterinary Immunology and Immunopathology

2011

Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells

Shoichi Hosoya, Julio Villena, Tomoyuki Shimazu, Masanori Tohno, Hitomi Fujie, Eriko Chiba, Takeshi Shimosato, Hisashi Aso, Yoshihito Suda, Yasushi Kawai, Tadao Saito, Susana Alvarez, Shuji Ikegami, Hiroyuki Itoh, Haruki Kitazawa

Veterinary Research

2011

Toll-like receptor-2-activating bifidobacteria strains differentially regulate inflammatory cytokines in the porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics

Hitomi Fujie, Julio Villena, Masanori Tohno, Kyoko Morie, Tomoyuki Shimazu, Hisashi Aso, Yoshihito Suda, Takeshi Shimosato, Noriyuki Iwabuchi, Jin-Zhong Xiao, Tomoko Yaeshima, Keiji Iwatsuki, Tadao Saito, Muneo Numasaki, Haruki Kitazawa

FEMS Immunology & Medical Microbiology

2011

Molecular cloning, tissue expression, and subcellular localization of porcine peptidoglycan recognition proteins 3 and 4

Wataru Ueda, Masanori Tohno, Tomoyuki Shimazu, Hitomi Fujie, Hisashi Aso, Yasushi Kawai, Muneo Numasaki, Tadao Saito, Haruki Kitazawa

Veterinary Immunology and Immunopathology

2011

Chemical and immunological characterization of extracellular polysaccharides produced by Lactobacillus plantarum No.14.

Kenji Hashiguchi, Yuko Nagata, Mutsuko Yoshida, Yo Murohushi, Haruki Kitazawa

Japanese Journal of Lactic Acid Bacteria

2011

Cytokeratin 18 is a specific marker of bovine intestinal M cell

Tetsuya Hondo, Takashi Kanaya, Ikuro Takakura, Hitoshi Watanabe, Yu Takahashi, Yuya Nagasawa, Shunsuke Terada, Shyuichi Ohwada, Kouichi Watanabe, Haruki Kitazawa, Michael T. Rose, Takahiro Yamaguchi, Hisashi Aso

American Journal of Physiology-Gastrointestinal and Liver Physiology

2011

Transcytosis of Murine-Adapted Bovine Spongiform Encephalopathy Agents in an In Vitro Bovine M Cell Model

Kohtaro Miyazawa, Takashi Kanaya, Ikuro Takakura, Sachi Tanaka, Tetsuya Hondo, Hitoshi Watanabe, Michael T. Rose, Haruki Kitazawa, Takahiro Yamaguchi, Shigeru Katamine, Noriyuki Nishida, Hisashi Aso

Journal of Virology

2010

Identification of a new adhesin-like protein from Lactobacillus mucosae ME-340 with specific affinity to the human blood group A and B antigens

M. Watanabe, H. Kinoshita, M. Nitta, R. Yukishita, Y. Kawai, K. Kimura, N. Taketomo, Y. Yamazaki, Y. Tateno, K. Miura, A. Horii, H. Kitazawa, T. Saito

Journal of Applied Microbiology

2010

Improvements in Seasonal Allergic Disease with Lactobacillus plantarum No. 14

Yuko NAGATA, Mutsuko YOSHIDA, Haruki KITAZAWA, Eiji ARAKI, Toshiharu GOMYO

Bioscience, Biotechnology, and Biochemistry

2010

HPLC purification and re-evaluation of chemical identity of two circular bacteriocins, gassericin A and reutericin 6

K. Arakawa, Y. Kawai, Y. Ito, K. Nakamura, T. Chujo, J. Nishimura, H. Kitazawa, T. Saito

Letters in Applied Microbiology

2010

CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9

Takeshi Shimosato, Megumi Fujimoto, Masanori Tohno, Takashi Sato, Mariko Tateo, Hajime Otani, Haruki Kitazawa

Biochemical and Biophysical Research Communications

2010

Oral Administration of Phosphorylated Dextran Regulates Immune Response in Ovalbumin-Immunized Mice

Chiho Nagasawa, Junko Nishimura-Uemura, Masanori Tohno, Takeshi Shimosato, Yasushi Kawai, Shuji Ikegami, Munehiro Oda, Tadao Saito, Haruki Kitazawa

Asian-Australasian Journal of Animal Sciences

2009

Characterization of newly established bovine intestinal epithelial cell line

Kohtaro Miyazawa, Tetsuya Hondo, Takashi Kanaya, Sachi Tanaka, Ikuro Takakura, Wataru Itani, Michael T. Rose, Haruki Kitazawa, Takahiro Yamaguchi, Hisashi Aso

Histochemistry and Cell Biology

2009

Immunomodulation in gut-associated lymphoid tissue of neonatal chicks by immunobiotic diets

K. Sato, K. Takahashi, M. Tohno, Y. Miura, T. Kamada, S. Ikegami, H. Kitazawa

Poultry Science

2009

Negative effect of divalent metal cations on production of gassericin T, a bacteriocin produced by Lactobacillus gasseri, in milk-based media

Kensuke Arakawa, Yasushi Kawai, Junko Nishimura, Haruki Kitazawa, Tadao Saito

International Dairy Journal

2009

Effects of gassericins A and T, bacteriocins produced by Lactobacillus gasseri, with glycine on custard cream preservation

K. Arakawa, Y. Kawai, H. Iioka, M. Tanioka, J. Nishimura, H. Kitazawa, K. Tsurumi, T. Saito

Journal of Dairy Science

2009

DNA Sequencing and Homologous Expression of a Small Peptide Conferring Immunity to Gassericin A, a Circular Bacteriocin Produced by Lactobacillus gasseri LA39

Yasushi Kawai, Joni Kusnadi, Rober Kemperman, Jan Kok, Yoshiyuki Ito, Mikiko Endo, Kensuke Arakawa, Hideaki Uchida, Junko Nishimura, Haruki Kitazawa, Tadao Saito

Applied and Environmental Microbiology

2009

Utilization of the Porcine System to Study Lymphotoxin-β Regulation in Intestinal Lymphoid Tissue

Tomoyuki Shimazu, Masanori Tohno, Shinichiro Katoh, Takeshi Shimosato, Hisashi Aso, Yasushi Kawai, Tadao Saito, Haruki Kitazawa

Biochemical Genetics

2009

Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lac Z

Takeshi SHIMOSATO, Masanori TOHNO, Takashi SATO, Junko NISHIMURA, Yasushi KAWAI, Tadao SAITO, Haruki KITAZAWA

Animal Science Journal

2009

Cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Lactobacillus plantarum LA 318 recognizes human A and B blood group antigens

Hideki Kinoshita, Nozomi Wakahara, Masamichi Watanabe, Tomomi Kawasaki, Hiroki Matsuo, Yasushi Kawai, Haruki Kitazawa, Sinobu Ohnuma, Koh Miura, Akira Horii, Tadao Saito

Research in Microbiology

2008

Bacteriocin production of probiotic Lactobacillus gasseri LA39 isolated from human feces in milk‐based media

Kensuke ARAKAWA, Yasushi KAWAI, Kenji FUJITANI, Junko NISHIMURA, Haruki KITAZAWA, Ken‐ichi KOMINE, Kenzo KAI, Tadao SAITO

Animal Science Journal

2008

Anterior Pituitary Progenitor Cells Express Costimulatory Molecule 4Ig-B7-H3

Yasuhiro Nagai, Hisashi Aso, Hideki Ogasawara, Sachi Tanaka, Yoshikazu Taketa, Kouichi Watanabe, Shyuichi Ohwada, Michael T. Rose, Haruki Kitazawa, Takahiro Yamaguchi

The Journal of Immunology

2008

Microbial Community Analysis of Food-Spoilage Bacteria in Commercial Custard Creams Using Culture-Dependent and Independent Methods

K. Arakawa, Y. Kawai, H. Iioka, M. Tanioka, J. Nishimura, H. Kitazawa, K. Tsurumi, T. Saito

Journal of Dairy Science

2008

Differentiation of a murine intestinal epithelial cell line (MIE) toward the M cell lineage

Takashi Kanaya, Kohtaro Miyazawa, Ikuro Takakura, Wataru Itani, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose, Huw R. McConochie, Hideyuki Okano, Takahiro Yamaguchi, Hisashi Aso

American Journal of Physiology-Gastrointestinal and Liver Physiology

2008

Identification of Five Phospho-β-glycosidases from Lactobacillus gasseri ATCC33323T Cultured in Lactose Medium

Seiji NAGAOKA, Hiroyuki HONDA, Satoru OHSHIMA, Yasushi KAWAI, Haruki KITAZAWA, Yoshio TATENO, Yukiko YAMAZAKI, Tadao SAITO

Bioscience, Biotechnology, and Biochemistry

2008

Cell surface Lactobacillus plantarum LA 318 glyceraldehyde-3-phosphate dehydrogenase (GAPDH) adheres to human colonic mucin

H. Kinoshita, H. Uchida, Y. Kawai, T. Kawasaki, N. Wakahara, H. Matsuo, M. Watanabe, H. Kitazawa, S. Ohnuma, K. Miura, A. Horii, T. Saito

Journal of Applied Microbiology

2008

Immunostimulatory Oligodeoxynucleotide Containing TTTCGTTT Motif from Lactobacillus rhamnosus GG DNA Potentially Suppresses OVA‐specific IgE Production in Mice

I. D. Iliev, M. Tohno, D. Kurosaki, T. Shimosato, F. He, M. Hosoda, T. Saito, H. Kitazawa

Scandinavian Journal of Immunology

2008

Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine

Masanori Tohno, Tomoyuki Shimazu, Hisashi Aso, Akiko Uehara, Haruhiko Takada, Akiko Kawasaki, Yukari Fujimoto, Koichi Fukase, Tadao Saito, Haruki Kitazawa

Molecular Immunology

2008

Development of molecular immunoassay system for probiotics via toll‐like receptors based on food immunology

Haruki KITAZAWA, Masanori TOHNO, Takeshi SHIMOSATO, Tadao SAITO

Animal Science Journal

2008

Toll-like receptor 4 and cytokine expression involved in functional immune response in an originally established porcine intestinal epitheliocyte cell line

Masayuki Moue, Masanori Tohno, Tomoyuki Shimazu, Taketomo Kido, Hisashi Aso, Tadao Saito, Haruki Kitazawa

Biochimica et Biophysica Acta (BBA) - General Subjects

2008

Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-2 (NOD2)

Masanori Tohno, Wataru Ueda, Yuko Azuma, Tomoyuki Shimazu, Shinichiro Katoh, Ji Ming Wang, Hisashi Aso, Haruhiko Takada, Yasushi Kawai, Tadao Saito, Haruki Kitazawa

Molecular Immunology

2008

β-Galactosidase, phospho-β-galactosidase and phospho-β-glucosidase activities in lactobacilli strains isolated from human faeces

H. Honda, F. Kataoka, S. Nagaoka, Y. Kawai, H. Kitazawa, H. Itoh, K. Kimura, N. Taketomo, Y. Yamazaki, Y. Tateno, T. Saito

Letters in Applied Microbiology

2007

Enzymatic digestion of the milk protein β-casein releases potent chemotactic peptide(s) for monocytes and macrophages

Haruki Kitazawa, Kumiko Yonezawa, Masanori Tohno, Takeshi Shimosato, Yasushi Kawai, Tadao Saito, Ji Ming Wang

International Immunopharmacology

2007

Advanced molecular immunoassay system for immunobiotic lactic acid bacteria using a transfectant of Toll‐like receptor 2

Masanori TOHNO, Takeshi SHIMOSATO, Yasushi KAWAI, Hisashi ASO, Shuji IKEGAMI, Naoki TAKETOMO, Tadao SAITO, Haruki KITAZAWA

Animal Science Journal

2007

Staining patterns for actin and villin distinguish M cells in bovine follicle-associated epithelium

Takashi Kanaya, Hisashi Aso, Kohtaro Miyazawa, Taketomo Kido, Takeshi Minashima, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose, Takahiro Yamaguchi

Research in Veterinary Science

2007

Molecular cloning of porcine RP105/MD-1 involved in recognition of extracellular phosphopolysaccharides from Lactococcus lactis ssp. cremoris

Masanori Tohno, Tomoyuki Shimazu, Wataru Ueda, Daisuke Anzawa, Hisashi Aso, Junko Nishimura, Yasushi Kawai, Yasuo Saito, Tadao Saito, Haruki Kitazawa

Molecular Immunology

2007

Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice

Kohtaro Miyazawa, Takashi Kanaya, Sachi Tanaka, Ikuro Takakura, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose, Suehiro Sakaguchi, Shigeru Katamine, Takahiro Yamaguchi, Hisashi Aso

Histochemistry and Cell Biology

2006

Quantitative evaluation of adhesion of lactobacilli isolated from human intestinal tissues to human colonic mucin using surface plasmon resonance (BIACORE assay)

H. Kinoshita, H. Uchida, Y. Kawai, H. Kitazawa, K. Miura, K. Shiiba, A. Horii, T. Saito

Journal of Applied Microbiology

2007

Lactic Acid Bacteria (LAB) Bind to Human B- or H-Antigens Expressed on Intestinal Mucosa

Hideaki UCHIDA, Yasushi KAWAI, Hideki KINOSHITA, Haruki KITAZAWA, Koh MIURA, Kenichi SHIIBA, Akira HORII, Katsunori KIMURA, Naoki TAKETOMO, Munehiro ODA, Takaji YAJIMA, Tadao SAITO

Bioscience, Biotechnology, and Biochemistry

2006

Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine

Masanori Tohno, Takeshi Shimosato, Masayuki Moue, Hisashi Aso, Kouichi Watanabe, Yasushi Kawai, Takahiro Yamaguchi, Tadao Saito, Haruki Kitazawa

Veterinary Research

2006

Lactobacilli binding human A-antigen expressed in intestinal mucosa

Hideaki Uchida, Hideki Kinoshita, Yasushi Kawai, Haruki Kitazawa, Koh Miura, Kenichi Shiiba, Akira Horii, Katsunori Kimura, Naoki Taketomo, Munehiro Oda, Takaji Yajima, Tadao Saito

Research in Microbiology

2006

Oral Administration of an Immunostimulatory DNA Sequence from Bifidobacterium longum Improves Th1/Th2 Balance in a Murine Model

Noritoshi TAKAHASHI, Haruki KITAZAWA, Noriyuki IWABUCHI, Jin-Zhong XIAO, Kazuhiro MIYAJI, Keiji IWATSUKI, Tadao SAITO

Bioscience, Biotechnology, and Biochemistry

2006

Immunostimulatory oligodeoxynucleotide from Bifidobacterium longum suppresses Th2 immune responses in a murine model

N Takahashi, H Kitazawa, N Iwabuchi, J Z Xiao, K Miyaji, K Iwatsuki, T Saito

Clinical and Experimental Immunology

2006

An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE productionin vitro

Noritoshi Takahashi, Haruki Kitazawa, Takeshi Shimosato, Noriyuki Iwabuchi, Jin-zhong Xiao, Keiji Iwatsuki, Sadayuki Kokubo, Tadao Saito

FEMS Immunology & Medical Microbiology

2006

Apoptotic process of porcine intestinal M cells

Kohtaro Miyazawa, Hisashi Aso, Takashi Kanaya, Taketomo Kido, Takeshi Minashima, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose, Koji Tahara, Tadashi Yamasaki, Takahiro Yamaguchi

Cell and Tissue Research

2005

Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C...G-3' stem structure

Takeshi Shimosato, Toshiro Kimura, Masanori Tohno, Iliyan Dimitrov Iliev, Shinichiro Katoh, Yoshiyuki Ito, Yasushi Kawai, Takashi Sasaki, Tadao Saito, Haruki Kitazawa

Cellular Microbiology

2006

Localization of interleukin-18 and its receptor in somatotrophs of the bovine anterior pituitary gland

Yasuhiro Nagai, Tomonori Nochi, Kouichi Watanabe, Keisuke Watanabe, Hisashi Aso, Haruki Kitazawa, Masatoshi Matsuzaki, Shyuichi Ohwada, Takahiro Yamaguchi

Cell and Tissue Research

2005

A swine toll-like receptor 2-expressing transfectant as a potential primary screening system for immunobiotic microorganisms

Masanori Tohno, Haruki Kitazawa, Takeshi Shimosato, Mayumi Matsumoto, Shinichiro Katoh, Yasushi Kawai, Tadao Saito

FEMS Immunology & Medical Microbiology

2005

Toll-like receptor 2 is expressed on the intestinal M cells in swine

Masanori Tohno, Takeshi Shimosato, Haruki Kitazawa, Shinichiro Katoh, Iliyan Dimitrov Iliev, Toshiro Kimura, Yasushi Kawai, Kouichi Watanabe, Hisashi Aso, Takahiro Yamaguchi, Tadao Saito

Biochemical and Biophysical Research Communications

2005

Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer's patches

Takeshi Shimosato, Masanori Tohno, Haruki Kitazawa, Shinichiro Katoh, Kouichi Watanabe, Yasushi Kawai, Hisashi Aso, Takahiro Yamaguchi, Tadao Saito

Immunology Letters

2005

Strong immunostimulation in murine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern

Iliyan D. Iliev, Haruki Kitazawa, Takeshi Shimosato, Shinichiro Katoh, Hirotsugu Morita, Fang He, Masataka Hosoda, Tadao Saito

Cellular Microbiology

2005

Augmentation of TH-1 type response by immunoactive AT oligonucleotide from lactic acid bacteria via Toll-like receptor 9 signaling

Takeshi Shimosato, Haruki Kitazawa, Shinichiro Katoh, Masanori Tohno, Iliyan Dimitrov Iliev, Chiho Nagasawa, Toshiro Kimura, Yasushi Kawai, Tadao Saito

Biochemical and Biophysical Research Communications

2005

Cloning and Characterization of Swine Interleukin-17, Preferentially Expressed in the Intestines

Shinichiro Katoh, Haruki Kitazawa, Takeshi Shimosato, Masanori Tohno, Yasushi Kawai, Tadao Saito

Journal of Interferon and Cytokine Research

2004

Dextran from Leuconostoc mesenteroides Augments Immunostimulatory Effects by the Introduction of Phosphate Groups

Toshihiro Sato, Junko Nishimura-Uemura, Takeshi Shimosato, Yasushi Kawai, Haruki Kitazawa, Tadao Saito

Journal of Food Protection

2004

Development of immune assay system for both CpG and non‐CpG DNA from lactic acid bacteria using a transfectant of swine Toll‐like receptor 9

Takeshi SHIMOSATO, Haruki KITAZAWA, Masanori TOHNO, Shinichiro KATOH, Yasushi KAWAI, Tadao SAITO

Animal Science Journal

2004

A New Assay Using Surface Plasmon Resonance (SPR) to Determine Binding of the Lactobacillus acidophilus Group to Human Colonic Mucin

Hideaki UCHIDA, Kenji FUJITANI, Yasushi KAWAI, Haruki KITAZAWA, Akira HORII, Kenichi SHIIBA, Kazuya SAITO, Tadao SAITO

Bioscience, Biotechnology, and Biochemistry

2004

Structural and Functional Differences in Two Cyclic Bacteriocins with the Same Sequences Produced by Lactobacilli

Yasushi Kawai, Yasuyuki Ishii, Kensuke Arakawa, Koichiro Uemura, Boku Saitoh, Junko Nishimura, Haruki Kitazawa, Yukiko Yamazaki, Yoshio Tateno, Takatoshi Itoh, Tadao Saito

Applied and Environmental Microbiology

2004

Structural Analysis of a New Anti-Hypertensive Peptide (β-Lactosin B) Isolated from a Commercial Whey Product

M. Murakami, H. Tonouchi, R. Takahashi, H. Kitazawa, Y. Kawai, H. Negishi, T. Saito

Journal of Dairy Science

2004

Immunostimulatory oligonucleotide, CpG-like motif exists in Lactobacillus delbrueckii ssp. bulgaricus NIAI B6

Haruki Kitazawa, Hiroshi Watanabe, Takeshi Shimosato, Yasushi Kawai, Takatoshi Itoh, Tadao Saito

International Journal of Food Microbiology

2003

Functional alteration of murine macrophages stimulated with extracellular polysaccharides from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1

Junko Nishimura-Uemura, Haruki Kitazawa, Yasushi Kawai, Takatoshi Itoh, Munehiro Oda, Tadao Saito

Food Microbiology

2003

Swine Toll-like receptor 9 recognizes CpG motifs of human cell stimulant

Takeshi Shimosato, Haruki Kitazawa, Shinichiro Katoh, Yoshihisa Tomioka, Risuke Karima, Satoshi Ueha, Yasushi Kawai, Takanori Hishinuma, Kouji Matsushima, Tadao Saito

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

2003

Heterologous expression of gassericin A, a bacteriocin produced by Lactobacillus gasseri LA39

Yasushi KAWAI, Kensuke ARAKAWA, Ayako ITOH, Boku SAITOH, Yasuyuki ISHII, Junko NISHIMURA, Haruki KITAZAWA, Takatoshi ITOH, Tadao SAITO

Animal Science Journal

2003

Rapid activation of Mac‐1(CD11b/CD18) molecules on macrophages by a new chemotactic factor ‘Gasserokine’ produced by Lactobacillus gasseri JCM1131T

Haruki KITAZAWA, Tomohiko INO, Yasushi KAWAI, Takatoshi ITOH, Tadao SAITO

Animal Science Journal

2002

A novel immunostimulating aspect of Lactobacillus gasseri: induction of “Gasserokine” as chemoattractants for macrophages

Haruki Kitazawa, Tomohiko Ino, Yasushi Kawai, Takatoshi Itoh, Tadao Saito

International Journal of Food Microbiology

2002

Lactobacillus reuteri LA6 and Lactobacillus gasseri LA39 isolated from faeces of the same human infant produce identical cyclic bacteriocin

Yasushi Kawai, Yasuyuki Ishii, Koichiro Uemura, Haruki Kitazawa, Tadao Saito, Takatoshi Itoh

Food Microbiology

2001

AT oligonucleotides inducing B lymphocyte activation exist in probiotic Lactobacillus gasseri

Haruki Kitazawa, Satoshi Ueha, Shihoko Itoh, Hiroshi Watanabe, Kei Konno, Yasushi Kawai, Tadao Saito, Takatoshi Itoh, Takahiro Yamaguchi

International Journal of Food Microbiology

2001

cDNA cloning and expression of swine IL-7 from neonatal intestinal epithelium

Satoshi Ueha, Haruki Kitazawa, Yoshihisa Tomioka, Yasushi Kawai, Tadao Saito, Takatoshi Itoh

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

2001

Primary Amino Acid and DNA Sequences of Gassericin T, a Lactacin F-Family Bacteriocin Produced by Lactobacillus gasseri SBT2055

Yasushi KAWAI, Boku SAITOH, Osamu TAKAHASHI, Haruki KITAZAWA, Tadao SAITO, Hadjime NAKAJIMA, Takatoshi ITOH

Bioscience, Biotechnology, and Biochemistry

2000

Augmentation of macrophage functions by an extracellular phosphopolysaccharide from Lactobacillus delbrueckii ssp. bulgaricus

Haruki Kitazawa, Yasuyuki Ishii, Junko Uemura, Yasushi Kawai, Tadao Saito, Tsutomu Kaneko, Katsuhiko Noda, Takatoshi Itoh

Food Microbiology

2000

A New Screening Method for Probiotic Lactic Acid Bacteria in the Lactobacillus acidophilus Group by Using Carbohydrate Probes

Tadao SAITO, Atsushi MATSUMURA, Haruki KITAZAWA, Yasushi KAWAI, Takatoshi ITOH, Honoh HASHIBA

Animal Science and Technology

2000

Isolation and Structural Analysis of Antihypertensive Peptides That Exist Naturally in Gouda Cheese

T. Saito, T. Nakamura, H. Kitazawa, Y. Kawai, T. Itoh

Journal of Dairy Science

2000

New Binding Assay and Preparative Trial of Cell-Surface Lectin from Lactobacillus acidophilus Group Lactic Acid Bacteria

Atsushi Matsumura, Tadao Saito, Masahiro Arakuni, Haruki Kitazawa, Yasushi Kawai, Takatoshi Itoh

Journal of Dairy Science

1999

Molecular Cloning and Sequencing of Two Phospho-β-galactosidase I and II Genes of Lactobacillus gasseri JCM1031 Isolated from Human Intestine

Tadao SAITO, Masakatsu SUZUKI, Kei KONNO, Haruki KITAZAWA, Yasushi KAWAI, Takatoshi ITOH, Yoshiyuki KAMIO

Bioscience, Biotechnology, and Biochemistry

1998

Structural Analysis of New Antihypertensive Peptides Derived from Cheese Whey Protein by Proteinase K Digestion

Amhar Abubakar, Tadao Saito, Haruki Kitazawa, Yasushi Kawai, Takatoshi Itoh

Journal of Dairy Science

1998

Application of Two-dimensional Mapping for an Analysis of Galactosyllactoses in Yogurt

Tadao SAITO, Tomoya TSUJI, Haruki KITAZAWA, Yasushi KAWAI, Takatoshi ITOH

Bioscience, Biotechnology, and Biochemistry

1998

Phosphate group requirement for mitogenic activation of lymphocytes by an extracellular phosphopolysaccharide from Lactobacillus delbrueckii ssp. bulgaricus

Haruki Kitazawa, Toko Harata, Junko Uemura, Tadao Saito, Tsutomu Kaneko, Takatoshi Itoh

International Journal of Food Microbiology

1998

Gassericin A; an Uncommon Cyclic Bacteriocin Produced by Lactobacillus gasseri LA39 Linked at N- and C-Terminal Ends

Yasushi KAWAI, Tadao SAITO, Haruki KITAZAWA, Takatoshi ITOH

Bioscience, Biotechnology, and Biochemistry

1998

IL-7 activates alpha4beta1 integrin in murine thymocytes

H Kitazawa, K Muegge, R Badolato, J M Wang, W E Fogler, D K Ferris, C K Lee, S Candéias, M R Smith, J J Oppenheim, S K Durum

Journal of Immunology

1997

Isolation of a New Minor Protein (Ovofactor-1), Which Has a Cell Growth Promoting Activity, from Hen’s Egg White by Heparin Affinity Chromatography

Tadashi Nakamura, Tadao Saito, Haruki Kitazawa, Sanae Takeuchi, Takatoshi Itoh

Bioscience, Biotechnology, and Biochemistry

1995

Induction of IFN-γ and IL-1α production in macrophages stimulated with phosphopolysaccharide produced by Lactococcus lactis ssp. cremoris

Haruki Kitazawa, Takatoshi Itoh, Yoshihisa Tomioka, Michinao Mizugaki, Takahiro Yamaguchi

International Journal of Food Microbiology

1996

Isolation of a New Minor Protein (Ovofactor-1), Which Has a Cell Growth Promoting Activity, from Hen’s Egg White by Heparin Affinity Chromatography

Tadashi Nakamura, Tadao Saito, Haruki Kitazawa, Sanae Takeuchi, Takatoshi Itoh

Bioscience, Biotechnology, and Biochemistry

1995

Expression of mRNA encoding IFN α in macrophages stimulated with Lactobacillus gasseri

Haruki Kitazawa, Yoshihisa Tomioka, Kazuki Matsumura, Hisashi Aso, Michinao Mizugaki, Takatoshi Itoh, Takahiro Yamaguchi

FEMS Microbiology Letters

1994

Fractionation of Glycopeptides from Bovine κ-Casein and Hen Ovomucin via Lysozyme Affinity Chromatography

Tadao SAITO, Tadashi NAKAMURA, Toshihide KABUKI, Haruki KITAZAWA, Takatoshi ITOH

Animal Science and Technology

1994

Characteristics of Bovine Colostral Immunoglobulin G1 with Lectin-like and Mitogenic Activities

Tadao SAITO, Makoto MIURA, Yasue FUJIOKA, Haruki KITAZAWA, Takatoshi ITOH

Animal Science and Technology

1994

Hemagglutination Activity ofLactobacillus acidophilusGroup Lactic Acid Bacteria

Masahiro Yamada, Tadao Saito, Takahiro Toba, Haruki Kitazawa, Junko Uemura, Takatoshi Itoh

Bioscience, Biotechnology, and Biochemistry

1994

An Analysis of Mitogenic Response of Phosphopolysaccharide, a B-cell Mitogen Produced by Lactococcus lactis ssp. cremoris, to Spleen Cells

Haruki KITAZAWA, Takahiro YAMAGUCHI, Yuko FUJIMOTO, Takatoshi ITOH

Animal Science and Technology

1993

Comparative Activity of B-Cell Mitogen, a Phosphopolysaccharide, Produced by L. lactis ssp. cremoris on Various Lymphocytes

Haruki KITAZAWA, Takahiro YAMAGUCHI, Yuko FUJIMOTO, Takatoshi ITOH

Animal Science and Technology

1993

Mitogenic Activity of Cell Wall Components from Lactobacillus acidophilus

Masahiro YAMADA, Haruki KITAZAWA, Junko UEMURA, Tadao SAITOH, Takatoshi ITOH

Nihon Chikusan Gakkaiho

1993

B-Cell Mitogen Produced by Slime-Forming, Encapsulated Lactococcus lactis ssp. cremoris Isolated from Ropy Sour Milk, Viili

Haruki Kitazawa, Takahiro Yamaguchi, Makoto Miura, Tadao Saito, Takatoshi Itoh

Journal of Dairy Science

1993

Interferon Induction by Murine Peritoneal Macrophage Stimulated with Lactobacillus gasseri

Kazuki MATSUMURA, Haruki KITAZAWA, Takatoshi ITOH, Takahiro YAMAGUCHI

Animal Science and Technology

1992

B-Cell Mitogenic Activity of Slime Products Produced from Slime-Forming, Encapsulated Lactococcus lactis ssp. cremoris

Haruki Kitazawa, Takahiro Yamaguchi, Takatoshi Itoh

Journal of Dairy Science

1992

Regulation of Swine Myogenic Cell Differentiation before the Onset of Fusion

Takahiro YAMAGUCHI, Haruki KITAZAWA

Animal Science and Technology

1992

Interferon Induction in Murine Peritoneal Macrophage by Stimulation with Lactobacillus acidophilus

Haruki Kitazawa, Kazuki Matsumura, Takatoshi Itoh, Takahiro Yamaguchi

Microbiology and Immunology

1992

Specific Adsorption of Immunoglobulin G1 in Bovine Colostrum on Sephadex and Its Mitogenic Activity on Mouse Splenocytes.

Makoto MIURA, Tadao SAITO, Haruki KITAZAWA, Takatoshi ITOH, Tamio INAMOTO

Agricultural and Biological Chemistry

1991

Induction of Macrophage Cytotoxicity by Slime Products Produced by Encapsulated Lactococcus lactis ssp. cremoris.

Haruki KITAZAWA, Takatoshi ITOH, Takahiro YAMAGUCHI

Animal Science and Technology

1991

Functional Alteration of Macrophages by a Slime-Forming Lactococcus lactis ssp. cremoris

Haruki Kitazawa, Masahito Nomura, Takatoshi Itoh, Takahiro Yamaguchi

Journal of Dairy Science

1991

Long-term Culture of Swine Myogenic Cells

Takahiro YAMAGUCHI, Haruki KITAZAWA, Tadahiko HOSHINO

Animal Science and Technology

1991

Antitumoral Activity of Slime-forming, Encapsulated Lctococcus lactis subsp. cremoris isolated from Scandinavian Ropy Sour Milk, "viili"

Haruki KITAZAWA, Takahiro TOBA, Takatoshi ITOH, Nobuko KUMANO, Susumu ADACHI, Takahiro YAMAGUCHI

Animal Science and Technology

1991

Antitumor Activity of Ropy Sour Milks in Murine Solid Tumor

Haruki KITAZAWA, Takahiro TOBA, Takatoshi ITOH, Nobuko KUMANO, Susumu ADACHI

Animal Science and Technology

1990

A Novel Phosphopolysaccharide from Slime-Forming Lactococcus lactis subspecies cremoris SBT 0495

Hajime Nakajima, Shuuji Toyoda, Takahiro Toba, Takatoshi Itoh, Takao Mukai, Haruki Kitazawa, Susumu Adachi

Journal of Dairy Science

1990

Effects of Ropy Sour Milk on the Metastasis of Lewis Lung Carcinoma in Mice

Haruki Kitazawa, Takahiro Toba, Takatoshi Itoh, Susumu Adachi, Nobuko Kumano

Agricultural and Biological Chemistry

1988

INHIBITORY EFFECT OF AUTOCLAVED SKIM MILK ON SOLID SARCOMA-180 IN MICE 

H KITAZAWA, T TOBA, T ITOH, S ADACHI, N KUMANO

MILCHWISSENSCHAFT-MILK SCIENCE INTERNATIONAL

1987