We leverage the inherent optical properties of biological systems to see the unseen. By developing label-free, coherence-based imaging and advanced spectroscopic technologies, our lab investigates cellular biomechanics and tissue structures in their natural state. These high-resolution, non-invasive "optical fingerprints" allow us to detect disease states and understand biological questions without the need for synthetic labels, ensuring the highest degree of physiological accuracy in every diagnosis.

Innovation in our lab is driven by the integration of instrumentation, advanced data analysis, and molecular sensing. We don’t just use existing tools; we engineer the next generation of optical hardware and multiphoton systems. From designing new imaging modalities to exploring the synergy between light and ultrasonic density waves (SDT), our work pushes the boundaries of biomedical engineering to create precise, data-driven solutions for complex biological challenges.

Our therapeutic approach transforms light into a surgical tool for selective destruction. By optimizing Photodynamic Therapy (PDT), we use light-activated photosensitizers to generate reactive oxygen species that target tumors and multi-drug resistant infections. Our research specifically addresses the global crisis of antibiotic resistance; we use mild photodynamic action to disrupt bacterial defenses—such as efflux pumps and membrane barriers—effectively restoring the power of conventional treatments.

The true frontier of our research lies in the "systemic spark"—using light to trigger a global immune response. Beyond local tumor destruction, we engineer light-triggered strategies to train the immune system to recognize cancer as a threat. By damaging tumor cells with surgical precision, we release "danger signals" that alert the body’s defenses, turning a local light application into a powerful, systemic anti-tumor immunity that can track and attack cancer cells wherever they hide.