Caffeine
There has been debate about the combined effects of creatine and caffeine on exercise performance. Some studies suggest that caffeine might counteract some benefits of creatine on muscle strength and sprint performance, but results are not conclusive.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Combining creatine with NSAIDs such as ibuprofen or aspirin could potentially affect kidney function, especially when used frequently or in higher doses. This combination could increase the risk of kidney damage, as both substances may affect renal function.
Diuretics
Creatine may cause water retention, and when combined with diuretics, which are meant to expel water from the body, it can strain the body’s ability to maintain fluid balance. This could increase the risk of dehydration.
Blood Sugar Modifying Medications
There is some evidence that creatine may affect blood glucose levels, which could be an area of concern for those using medications for diabetes, as it might alter the effects of these drugs.
Always consult with a healthcare provider or a pharmacist before starting any new supplement regimen, especially if you are already taking prescribed medications.
It is essential to monitor for any unusual symptoms or side effects when combining creatine with other medications and to adjust usage as advised by healthcare professionals.