Research Projects
Development of NMR methods ...
To obtain new information.
To speed-up data acquisition and economize spectrometer time.
To improve spectral resolution and signal dispersion.
To obtain multiple information from a single dataset (Time-shared NMR ...)
Design of multidimensional Pure Shift NMR methods.
Broadband 1H homodecoupled NMR experiments with optimized sensitivity: HOBS
Ultra high-resolution NMR spectropscopy combining complementary resolution-enhanced techniques (band-selection, spectral aliasing, non-uniform sampling..).
Analysis of highly overlapped spectral regions with special focusing in near-identical NMR spectra of similar compounds.
Generation of unfeasible NMR spectra by pure shift NMR Covariance co-processing
Measurement of the magnitude and/or the sign of homonuclear and heteronuclear coupling constants.
Design of NMR methods
Determination and application of long-range proton-carbon coupling constants in organic molecules and natural products
Coupling constants involving other heteronuclei (15N,31P, 19F, 29Si...)
Determination of multiple couplings from a single NMR experiment.
Obtention of simplified multiplet patterns using modern techniques (homodeocupling, selective-spin-state excitation, IPAP, E.COSY...)
Determination of Residual Dipolar Coupling Constants (RDCs) in anisotropic media.
Application of modern NMR techniques to solve structural, conformational, relative configurations and dynamic properties of organic, natural products, organometallic and supramolecular chemical identities.
Determination of molecular Sizes by diffusion NMR studies.
Analysis of complex mixtures
Metabonomic studies by NMR (ecometabonomics, chiral metabonomics ...)
Characterization of products, impurities, intermediates and proposal of reaction mechanisms in biocatalytc enzymatic reactions
Use of combined analytical tools: