Tango is adaptable to just about any genre, though some minor alterations to the game are suggested. For example, you might want to revise the list of skills to be appropriate to science fiction, high fantasy, post-apocalyptic, crime noir, superheroes, or pulp adventure. The terminology the system uses can easily match the genre, with "adventures" becoming "missions," "ranged weapons" becoming "guns," "settlements" become "space stations," or "kits" becoming "cybernetics."
Your game's setting will also influence how the system works and what terms are used. One high fantasy setting might include dragons as vehicles while another could add custom races other than human for players to choose from. The equipment available to players will vary as well, and not just the list of options; some settings might call for fragile gear that's difficult to repair, while another might add consumable potions that heal wounds.