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     Functional Dissection of Cancer Signature Genes

    Over 90% of solid tumors are aneuploid and many show chromosomal instability. The long term goal of our research is to explore and exploit aneuploidy in breast cancers. 

     We are investigating both subcellular structures (centromeres, kinetochores and centrosomes) and regulatory mechanisms (the mitotic checkpoint or spindle assembly checkpoint) involved in control of aneuploidy or chromosomal instability. We aim to identify essential genes for aneuploid cancer cell survival and test whether they can be used for aneuploid cancer prognosis and treatment.

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Career Advice

Department of Biological Sciences

University of Toledo

Tel: 419-530-7853 (office)
     419-530-7857 (lab)

Email: sliu@utnet.utoledo.edu

Mail: University of Toledo, MS601
Wolfe Hall 4254,
2801 West Bancroft St.
Toledo, OH 43606
2017 Fall lab:
 Ejaz, Song-Tao, Yibo, Sreemita, Chris, Lindsey, Mike, Hailey, Jenna, Katelyn

Lab Highlights:
December  2017: 
  • The lab has attended ASCB in Philadelphia.
  • We are grateful that the Elsa U. Pardee Foundation has decided to fund our project to develop small molecules to enhance CDC20:MAD2 interaction. 
Recent Publications: 

Luo, Y.B., Ahmad, E., and Liu, S.T. (2018) MAD1: Kinetochore Receptors and Catalytic Mechanisms. Front. Cell Dev. Biol. | doi: 10.3389/fcell.2018.00051. Review.

Ji, W., Luo, Y.B., Ahmad, E., and Liu, S.T. (2018) Direct interactions of Mitotic Arrest Deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling.J Biol Chem. 2018 Jan 12;293(2):484-496. doi: 10.1074/jbc.RA117.000555. Epub 2017 Nov 21. PMID:29162720.

Liu, S.T. and *Zhang, H. (2016) The mitotic checkpoint complex (MCC): looking back and forth after 15 years.  AIMS Molecular Science, 3(4): 597-634. Review for a special issue on Cell Signaling and Signal Transduction. doi: 10.3934/molsci.2016.4.597 [link]