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     Functional Dissection of Cancer Signature Genes

    Over 90% of solid tumors are aneuploid and many show chromosomal instability. The long term goal of our research is to explore and exploit aneuploidy in breast cancers. 

     We are investigating both subcellular structures (centromeres, kinetochores and centrosomes) and regulatory mechanisms (the mitotic checkpoint or spindle assembly checkpoint) involved in control of aneuploidy or chromosomal instability. We aim to identify essential genes for aneuploid cancer cell survival and test whether they can be used for aneuploid cancer prognosis and treatment.

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Career Advice

Department of Biological Sciences

University of Toledo

Tel: 419-530-7853 (office)
     419-530-7857 (lab)

Email: sliu@utnet.utoledo.edu

Mail: University of Toledo, MS601
Wolfe Hall 4254,
2801 West Bancroft St.
Toledo, OH 43606

Undergraduate Researchers Needed
for the 2018 fall semester!!!

We are looking for self-motivated undergraduate students who are interested in molecular cell biology to join our team to make mutants of a key mitosis regulator and check their effects using live cell imaging. 

If you are interested, contact Dr. Liu ASAP.

Lab Highlights:
August 2018: 
  • Congratulations to Jenna LaBelle on passing her MSc defense and her new job at Brigham Women's Hospital!
July 2018:
  • Congratulations to Dr. Mike Moenk on his new position at Charles River!

Recent Publications: 

Luo, Y.B., Ahmad, E., and Liu, S.T. (2018) MAD1: Kinetochore Receptors and Catalytic Mechanisms. Front. Cell Dev. Biol. | doi: 10.3389/fcell.2018.00051. Review.

Ji, W., Luo, Y.B., Ahmad, E., and Liu, S.T. (2018) Direct interactions of Mitotic Arrest Deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling.J Biol Chem. 2018 Jan 12;293(2):484-496. doi: 10.1074/jbc.RA117.000555. Epub 2017 Nov 21. PMID:29162720.