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          Over 90% of solid tumors are aneuploid. The long term goal of our research is to understand and control aneuploidy in cancers. We are investigating both subcellular structures (centromeres, kinetochores and centrosomes) and regulatory mechanisms (the mitotic checkpoint or spindle assembly checkpoint) involved in aneuploidy occurences. We also aim to identify essential genes for aneuploid cancer cell survival and test whether they can be used for aneuploid cancer prognosis and treatment.

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Career Advice

Department of Biological Sciences

University of Toledo

 

Tel: 419-530-7853 (office)

 419-530-7857 (lab)

Email: sliu@utnet.utoledo.edu

 

Mail: University of Toledo, MS601

Wolfe Hall 4254,

2801 West Bancroft St.

Toledo, OH43606

mitosis art

Lab Outreach: Our Lab, Your Lab
Citizen Science: diversity of cell division

     We are interested in collecting images of cell division in all types of organisms. You are welcome to share your images with us. Alternatively, interested K-12 students, teachers or parents are welcome to visit the lab on the last Saturdays of every month. Bring your own samples to watch under microscope if you wish. Email Dr. Liu for appointment.


Lab Highlights:
 
4-22-2017
Chad Burkholder and Stephen Millner presented in the 22nd Department of Biological Sciences Undergraduate Research Symposium. Chad won 1st prize. Congratulations!




Recent Publications: 


1.     Liu, S.T. and *Zhang, H. (2016) The mitotic checkpoint complex (MCC): looking back and forth after 15 years.  AIMS Molecular Science, 3(4): 597-634. Review for a special issue on Cell Signaling and Signal Transduction
doi: 10.3934/molsci.2016.4.597 [link]

2.     *Ji, W., *Arnst, C.A., *Tipton, A.R., Bekier, M.E. 2nd, Taylor, W. R., Yen, T.J. and Liu, S.T. (2016) OTSSP167 abrogates mitotic checkpoint through inhibiting multiple mitotic kinases. PLOS ONE. PMID: 27082996. [link