Over 90% of solid tumors are aneuploid. The long term goal of our research is to understand and control aneuploidy in cancers. We are investigating both subcellular structures (centromere, kinetochores and centrosomes) and regulatory mechanisms (the mitotic checkpoint or spindle assembly checkpoint) involved in chromosome segregation. We also aim to identify essential genes for aneuploid cancer cell survival and test whether they can be used for aneuploid cancer prognosis and treatment.
more for the public more for students and researchers
Department of Biological Sciences
University of Toledo
Tel: 419-530-7853 (office)
Mail: University of Toledo, MS601
Wolfe Hall 4254,
2801 West Bancroft St.
Lab Outreach: Our Lab, Your Lab
Citizen Science: diversity of cell division
We are interested in collecting images of
cell division in all kinds of organisms. You are welcome to share your images
with us. Alternatively, interested K-12 students, teachers or parents are
welcome to visit the lab on the last Saturdays of every month. Bring your own
samples to watch under microscope if you wish. Email Dr. Liu for appointment.
|2015-2016 Lab Highlights:|
Dr. Michael Moenk:
Funded! ““Research Supplement to Promote Re-Entry into Biomedical and Behavioral Research Careers” (PA-15-321)”
Graduate Student Wenbin Ji:
1. Wenbin has been selected as a summer intern by Cayman Chemicals.
2. 2014 Spring, 2014 Fall, 2015 Fall Department Graduate Students’ Research Day Poster presentation winner
Graduate Student Christopher Arnst:
2015 Fall Department Graduate Students’ Research Day Poster presentation winner
High School Student Sanjay Jinka (Anthony Wayne High School, 2015 summer), supervised by Dr. Michael Moenk.
Awards: 2016 "The OSU College of Medicine Future Physicians Award for Most Outstanding Project" and "Mercy Medical Award for Most Outstanding Project".
News: High School Senior Studying Cancer Cells
1. Liu, S.T. and *Zhang, H. (2016) The mitotic checkpoint complex (MCC): looking back and forth after 15 years. AIMS Molecular Science, 3(4): 597-634. Review for a special issue on Cell Signaling and Signal Transduction.
doi: 10.3934/molsci.2016.4.597 [link]
2. *Ji, W., *Arnst, C.A., *Tipton, A.R., Bekier, M.E. 2nd, Taylor, W. R., Yen, T.J. and Liu, S.T. (2016) OTSSP167 abrogates mitotic checkpoint through inhibiting multiple mitotic kinases. PLOS ONE. PMID: 27082996. [link]