Over 90% of solid tumors are aneuploid. The long term goal of our research is to understand and control aneuploidy in cancers. We are investigating both subcellular structures (centromeres, kinetochores and centrosomes) and regulatory mechanisms (the mitotic checkpoint or spindle assembly checkpoint) involved in aneuploidy occurences. We also aim to identify essential genes for aneuploid cancer cell survival and test whether they can be used for aneuploid cancer prognosis and treatment.
more for the public more for students and researchers
Department of Biological Sciences
University of Toledo
Tel: 419-530-7853 (office)
Mail: University of Toledo, MS601
Wolfe Hall 4254,
2801 West Bancroft St.
Lab Outreach: Our Lab, Your Lab
Citizen Science: diversity of cell division
We are interested in collecting images of
cell division in all types of organisms. You are welcome to share your images
with us. Alternatively, interested K-12 students, teachers or parents are
welcome to visit the lab on the last Saturdays of every month. Bring your own
samples to watch under microscope if you wish. Email Dr. Liu for appointment.
Chad Burkholder and Stephen Millner presented in the 22nd Department of Biological Sciences Undergraduate Research Symposium. Chad won 1st prize. Congratulations!
1. Liu, S.T. and *Zhang, H. (2016) The mitotic checkpoint complex (MCC): looking back and forth after 15 years. AIMS Molecular Science, 3(4): 597-634. Review for a special issue on Cell Signaling and Signal Transduction.
doi: 10.3934/molsci.2016.4.597 [link]
2. *Ji, W., *Arnst, C.A., *Tipton, A.R., Bekier, M.E. 2nd, Taylor, W. R., Yen, T.J. and Liu, S.T. (2016) OTSSP167 abrogates mitotic checkpoint through inhibiting multiple mitotic kinases. PLOS ONE. PMID: 27082996. [link]