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ABL1

V-abl Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein which in humans is encoded by the ABL1 gene located on chromosome 9.

Orthologs
Species Human Mouse
Entrez 25 11350
Ensembl ENSG00000097007 ENSMUSG00000026842
UniProt P00519 Q3SYK5
RefSeq (mRNA) NM_005157 NM_009594
RefSeq (protein) NP_005148 NP_033724
Location (UCSC) Chr 9:
132.58 - 132.75 Mb
Chr 2:
31.51 - 31.63 Mb

PubMed search [1] [2]

Mouse Knockout
 Phenotype Death 1 to 2 weeks post-birth
 Tissues Affected
 Thymus, spleen
 Literature Cited
  (Schwartzberg et al., 1991; Tybulewicz et al., 1991)

Human Diseases
 Summary of Mutations t(9;22) translocation results in fusion with the BCR gene
 PhenotypeChronic myelogeneous leukemia (CML), acute
lymphoblastic leukemia (ALL), myelogenous leukemia
(AML) (de Klein et al., 1982; Heisterkamp et al., 1983)



Specificity
 Abl [pY] [E/T/M] [N/E/D] [P/V/L]  (Songyang et al., 1993)

 Peptide arrays (Coming Soon!)    
           


Structures
 ABL1 

1OPJ, 1OPK, 1OPL

 SH2 

1AB2

 SH3 + SH2  

2ABL



Protein-Protein Interactions


STRING
Human    Mouse    Fruitfly
Evolution
 Family ABL
 Human Ortholog Abl2
 Origin Monosiga brevicollis
 Class IA

Phosphorylation
PhosphoELM

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