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Welcome to SH2domain.org
Alignment
Contact
Diseases
Evolution
Human SH2 Domains
Mouse Knockout
SH2 Domain
- ABL1
- ABL2
- APS
- BCAR3
- BKS
- BLK
- BLNK
- BMX
- BRDG1
- BRK
- BTK
- CBL
- CBLB
- CBLC
- CHN1
- CHN2
- CISH
- CRK
- CRKL
- CSK
- DAPP1
- FER
- FES
- FGR
- FRK
- FYN
- GADS
- GRAP
- GRB10
- GRB14
- GRB2
- GRB7
- HCK
- HSH2D
- ITK
- JAK1
- JAK2
- JAK3
- LCK
- LNK
- LYN
- MATK
- MIST
- NCK1
- NCK2
- PI3KR2
- PI3KR3
- PIK3R1
- PLCG1
- PLCG2
- PTPN11
- PTPN6
- RASA1
- RIN1
- RIN2
- RIN3
- SH2B
- SH2D1A
- SH2D1B
- SH2D2A
- SH2D3A
- SH2D3C
- SH2D4A
- SH2D4B
- SH2D5
- SH3BP2
- SHB
- SHC1
- SHC2
- SHC3
- SHC4
- SHD
- SHE
- SHF
- SHIP
- SHIP2
- SLAP
- SLAP2
- SLNK
- SLP76
- SOCS1
- SOCS2
- SOCS3
- SOCS4
- SOCS5
- SOCS6
- SOCS7
- SPT6
- SRC
- SRMS
- STAT1
- STAT2
- STAT3
- STAT4
- STAT5A
- STAT5B
- STAT6
- SYK
- TEC
- TENC1
- TNS
- TNS3
- TNS4
- TXK
- TYK2
- VAV1
- VAV2
- VAV3
- YES
- ZAP70
Specificity
Structures

Alignment

A Clustal alignment of the 120 SH2 domains found in humans (see PDF files below)

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