Unit 2: Biomolecules
EQ: What do we know and want to know about what is happening to baby Matthew?
Phenomenon: Baby Matthew was born perfectly healthy, but within a few days has become very sick and is failing to thrive.
- Biomolecules Pre-Assessment
- Unit Opener
- Fill out Unit Tracker TS1 boxes
EQ: What are biomolecules?
Phenomenon: Biomolecules have structures we can use to organize and understand them
- Inquiry Cube
- Inquiry slide show (student worksheet) to predict what is on the bottom of the cube. Note: it is best if you put the “DNA” side down.
- Pattern Matching worksheet. Biomolecules
- Fill out Unit Tracker TS2 boxes
EQ: What are the functions of biomolecules? How are biomolecules put together and broken apart?
Phenomenon: The taste of a cracker changes the longer you hold it in your mouth.
- Biomolecules: Synthesis and Dehydration
- Biomolecules Video (video worksheet)
- Biological Molecules POGIL (pages 1 & 2 only)
EQ: What are the functions of biomolecules? How are biomolecules put together and broken apart?
- Dehydration synthesis and hydrolysis activity
- Fill out Unit Tracker TS3 boxes
Biomolecules and Intro to Metabolism Assessment
EQ: How do organisms make and break molecules?
Phenomenon: A moth only eats sugar but the moth is not made of just sugar (and would NOT taste sweet).
- Start Enzyme Notes / Presentation up to slide 12 (taking notes using Cornell Notes template)
- Optional Introductory Activity: PopBeadase Activity
EQ: How do organisms make and break molecules?
Phenomenon: A moth only eats sugar but the moth is not made of just sugar (and would NOT taste sweet).
- Back to Enzyme Notes (take notes on slides 12-23 using Cornell Notes template)
- Enzymes Video and Worksheet
- Formative Assessment on Enzyme Structure/Function
EQ: How do organisms make and break molecules?
Phenomenon: A moth only eats sugar but the moth is not made of just sugar (and would NOT taste sweet).
- Enzyme Lab & Desmos Graphing. Start at slide 20 of Enzyme Notes
- Enzyme Lab Rubric
EQ: How do organisms make and break molecules?
Phenomenon: A moth only eats sugar but the moth is not made of just sugar (and would NOT taste sweet).
- Enzyme Lab Board Discussion and students work on lab conclusion
- Practice on Pepsin Enzyme
- Fill out Unit Tracker TS4 boxes
EQ: What is DNA? How does its structure determine its function?
Phenomenon: Some individuals are born with genetic disorders while some are not.
- Warm up DNA KWL
- DNA Preassessment
EQ: What is DNA? How does its structure determine its function?
Phenomenon: Some individuals are born with genetic disorders while some are not.
- DNA Notes (slides 1-7) (notes handout)
- DNA extraction activity with cheek cells
EQ: What is DNA? How does its structure determine its function?
Phenomenon: Some individuals are born with genetic disorders while some are not.
EQ: What is DNA? How does its structure determine its function?
Phenomenon: Some individuals are born with genetic disorders while some are not.
EQ: What is DNA? How does its structure determine its function?
Phenomenon: Some individuals are born with genetic disorders while some are not.
- Transcription/Translation Activity
- Protein Synthesis Race (alternative)
- Sickle Cell Anemia (extension)
- Intro slideshow to assist with the Muscular Dystrophy activity (60 min.) (Slideshow is also linked in activity, so no need to present it separately)
- Students are not required to take notes on these slides because they use the content in the activity.
- Finish “L” part of KWL at the beginning of this task set (what did we learn about DNA?
- Do Gene Expression and Cell Types Article and Questions - Estrogen Receptor Mutation. GoFormative Quick Code for this article and questions: ECNNOR. Using GoFormative for this allows you to display student answers and discuss their claims, reasoning, and evidence.
- Quiz: DNA → Protein → Trait
- Fill out Unit Tracker TS5 boxes
EQ: What is baby Matthew’s diagnosis and how can it account for his symptoms?
Phenomenon (return to anchoring phenomenon): A baby is born and seems perfectly healthy, but after a few days starts to exhibit strange symptoms that could lead to physical impairment or even death. What is causing the problem? Can the baby be saved?
- Slideshow for Metabolism
- Teacher assigns pairs of students to a metabolic disease from the “inborn errors of the metabolism” diagram. There are 15 diseases in the GoFormative and each student pair is given a number 1-15. Students answer the question number for their assigned disease on the GoFormative: Genetic Diseases of the Metabolism
- After answering their assigned question, each student pair writes a CER paragraph claiming whether or not their assigned disease could be Matthew’s diagnosis (question #16). Class discusses which of the potential metabolic diseases they think baby Matthew really has.
- Fill out Unit Tracker TS6 boxes