Essential Knowledge 3.D.4

Changes in signal transduction pathways can alter cellular response.

Conditions where signal transduction is blocked or defective can be deleterious, preventative or prophylactic. Examples include:

• Diabetes, heart disease, neurological disease, autoimmune disease, cancer, cholera
• Effects of neurotoxins, poisons, pesticides
• Drugs (Hypertensives, Anesthetics, Antihistamines and Birth Control Drugs)

NOTE: Specific mechanisms of these diseases and action of drugs are beyond the scope of the course and the AP Exam.

Students should be able to:

LO 3.37 Justify claims based on scientific evidence that changes in signal transduction pathways can alter cellular response.

LO 3.38 Describe a model that expresses key elements to show how change in signal transduction can alter cellular response.

LO 3.39 Construct an explanation of how certain drugs affect signal reception and, consequently, signal transduction pathways.