Past R & D experience

My Work as Assistant Professor ( NIPER-A)                                    ( Oct 2018 - Mar 2020)

1. Rohit Parkale, Priyanka Pulugu, Prasoon Kumar* Developing easy-to-use, cost-effective wound dressing material by coating commercial cotton bandages with nanomaterials, International Journal of Material Research, 2023 (Accepted) [IF: 0.678]

2. Priyanka Pulugu, Neha Arya, Prasoon Kumar*, Akshay Srivastava*, Polystyrene-based Slippery Surfaces Enable the Generation and Easy Retrieval of Tumor Spheroids, ACS Applied Bio Materials, 2022 (Accepted) [IF: 4.7 ]

3. Patel, Sagarkumar; Globisch, Christoph; Pulugu, Priyanka ; K, Prasoon; Jain, Alok; Shard, Amit*, Discovery of 2-(4-(3,4-dichlorophenyl)piperazin-1-yl)-1-(imidazo[1,2-a]pyrimidin-3-yl)ethan-1-one, a  Pyruvate Kinase M2 Activator as an Efficacious Agent Against Cancer, European Journal of Pharmaceutical Sciences, Vol. 170, Pg. 106112, 2022 [IF - 5.112]

4. Priyanka Pulugu, Shital  Rokade, Sumant Ghosh, Kaushik  Choudhury, Neha Arya, Prasoon Kumar* "A perspective on implantable  biomedical  materials  and devices for diagnostic applications" Current Opinion in Biomedical Engineering, 2021 ( Accepted) [Impact factor - 4.245]

5. Kumar P, Rajeshwari Sinha, Pratyoosh Shukla , Artificial intelligence and synthetic biology approaches for human gut microbiome, Critical review in Food Science and  Nutrition (Accepted), 2020 [Impact factor - 7.896]

6. Vaibhav Shitole, Komal Bhamare; Prasoon Kumar; Pinaki Sengupta, Technological advancement in dry blood matrix based microsampling technique and its  clinical relevance , Bioanalysis 2020, DOI: 10.4155/bio-2020-0211 [Impact factor : 2.371]

7. Pallavi Kulkarni, Rohit Parkale, Surbhi Khare, Prasoon Kumar, Neha Arya* Cell immobilization strategies for tissue engineering: Recent trends and future perspectives, Editor: Tripathi A and Melo JS (eds) Immobilization Strategies: Biomedical, Bioengineering and Environmental Applications, Springer-Nature, Singapore, Pte Ltd. 2021(Book Chapter) 

8. Harbhajan Ahirwar, Y Zhou, Chinmaya Mohapatra, S Ramakrishna, Prasoon Kumar*, Himansu Sekhar Nanda,* , Bioimplants for Orthopedic Fracture: Improving the Surface and Bulk Properties using Nanomaterials , Coatings, 10 (3), 264, 2020 [Impact factor : 2.436]

9. "Vashistha R, Kumar P, Dangi A K, Chhabra D, Sharma N, Shukla P, Quest for cardiovascular interventions: precise modeling and 3D printing, Journal of Biological Engineering ( Accepted), 2019 [ Impact factor: 5.256]

10. Kumar P, Agarwal P, Chatterjee K, Challenges and Opportunities in Dried Blood Spot: A Design and Interface Perspective, Journal of Biomedical and Pharmaceutical Analysis (Accepted), 2019 [Impact factor : 2.983]

11. Agarwal P, Gandhi P.S, Majumder M, Kumar P*, Insight into the design and fabrication of a leaf mimicking micropump, Physical Review Applied  (Accepted), 2019 [Impact factor : 4.782]

12. Kumar P*, Agarwal P, Gandhi P.S, Majumder M , Design, fabrication and working of a leaf mimicking micropump at 6th International Conference on Microfluidics & Lab-on-Chip organized by SelectBio, Novotel Hotel, Mumbai Maharashtra, 2019 (Oral Talk)

13. Kumar P*, P Mit, P Navanit, C Kaushik, Innovative capillary pump for micro-sampling of simulated blood for diagnostic applications , International Conference on Med-Tech Innovation in Primary Health Care, IIPH, Gandhinagar, Gujarat, 2018 (Oral presentation)

My  Post-Doc Work ( IISc Bangalore)                                                  ( Mar 2017- Sep, 2018)

I am currently working on design and fabrication of micro/nanofluidic devices for gut-on-chip applications. An understanding the pathophysiology of the gut is necessary to develop effective medical therapies and drugs to treat diarrheal diseases. The project aims to develop a device combining the principles of biomaterials, tissue engineering, cell culture, lab-on-chip devices and data science - a truly interdisciplinary project

1. Kumar P, P Arpana, C Kaushik, A simple, scalable method of fabrication of nanofibrous cell culture inserts by direct deposition of electrospun nanofibers on 3D printed substrates, International Conference on BioMaterials, BioEngineering, and BioTheranostics, VIT, Vellore, Tamil Nadu (BioMET-2018) (Oral)

2. Kaushik Choudhury, R. K Singh, Kumar P, Ajay Kumar, Atul Srivastava, Controlling the size distribution of nanoparticles through the use of physical boundaries during laser ablation in liquids, Nano-Structures & Nano-Object, 2018 [ Impact factor: 4.25] 

3. Kumar P*, P Mit, P Navanit, Innovative capillary pump for micro-sampling of simulated blood for diagnostic applications , International Conference on Med-Tech Innovation in Primary Health Care, IIPH, Gandhinagar, Gujarat, 2018 (Oral)

4. Kumar P, Agarwal P, Chatterjee K, Challenges and Opportunities in Dried Blood Spot: A Design and Interface Perspective, Journal of Biomedical and Pharmaceutical Analysis (Accepted), 2019 [Impact factor : 2.983]

5. Agarwal P, Kumar H, Kumar P*, Rapid and even spreading of complex fluids over a large area in porous substrates  Applied Physics Letter(AIP) (Accepted), 2020 [Impact factor - 3.597]

6. Kumar P, Dhaval Kedaria, Chinmaya Mahapatra, M. Monisha, Kaushik Chatterjee, Designer Cell Culture Insert with Nanofibrous Membrane toward Engineering an Epithelial Tissue Model Validated by Cellular Nanomechanics, Nanoscale Advances, 2021 ( Accepted)

My  Ph.D. Work (IITB Monash Research Academy)                         ( July 2011- Dec 2016)

Synopsis of Work: The micro/nanovascularised polymers play a vital role in tissue engineering, advanced drug delivery, self-healing and cooling materials and complex micro/nanofluidics applications. In the current work, we have theoretically and computationally studied the design parameters of fish gills which contribute towards its excellent gas/solute exchange organ. Thereafter, we designed and fabricated microvascularised thin PDMS matrices and demonstrated their fluid flow and gas/solute exchange capabilities. These fabricated microvascularised PDMS matrices further enabled us to study the role of microchannel density, the level of randomness and shape of a reservoir on volumetric flow and solute exchange through the above matrices when used as 3D micro/nanofluidic devices. The roles of above factors were further substantiated by findings of theoretical and modeling studies. Thus, based on above learning, we eventually generated bio-inspired, multiscale, micro/nanovascularised PDMS matrices using sacrificial micro-nanostructures generated by electrospinning and Hele-shaw apparatus, a lithography-free method. Further, dye flow experiments affirmed the continuity and connectivity among channels and solute diffusion studies demonstrated their capabilities to be used for different applications mentioned above. We have also designed and fabricated bio-inspired artificial leaves using simple, scalable micro technologies and demonstrated their enhanced micro pumping as well as pressure head sustenance capabilities. Further, studied the parameters affecting its performance through experimental and theoretical methods and expressed formulation as a design tool for optimization and scale-up of the micropumps. Thus, our studies demonstrate design and fabrication of 3D micro/nanofluidic devices by simple, scalable, inexpensive processes taking inspiration from nature. This will accelerate the research in the biomedical and chemical field for different applications. 

Publications (Journal, Conferences, thesis, and Patents)

1. Kumar P, P S Gandhi, M Majumder, Design and fabrication of thin micro vascularised polymer matrices inspired from secondary lamellae of fish gills," "Bioinspiration, Biomimetics, and Bioreplication VI", International Conference, SPIE/NDE, (Las Vegas, USA), 9797-40, 2016 [ ERA-'A'] [Impact Factor - 0.502]

2. Kumar P, P S Gandhi, M Majumder, Multiscale fabrication of scalable biomimetic 3-D, integrated micro-nanochannels network in PDMS for solute exchange, 11th International Conference on Micromanufacturing, 2016 (UC Irvine, USA) (Conference proceedings, Poster and Oral Presentation)

3. Kumar P, Gandhi P.S, Majumder M, Interfacing 3D micro/-nanochannel networks with branch-shaped reservoir enhances fluid flow and mass transfer, Journal of Microengineering and Micromechanics (IOP), 2017, 27, 015026 (11pp)  [Impact Factor - 2.141]

4. Kumar P, UL Tanveer, Gandhi P.S, Majumder M, Nature-inspired, scalable, lithography-less fabrication of multi-scale fluid channel networks, Biomedical Physics and Engineering Express (IOP) 3 (2017) 045007 [ Impact factor - 1.126]

5. Kumar P., Gandhi P.S, Majumder M, Design and fabrication of thin PDMS matrices having biomimetic vascular channel network, International Conference on Biomaterials, Biodiagnostics, Tissue engineering, drug delivery and Regenerative Medicine (BiTERM, 2016), New Delhi, India ( Poster)

6. Kumar P., Gandhi P.S, Majumder M, Enhanced capillary pumping through Leaf-inspired micropumps in biomedical microdevices, National conference Convergence of Pharmaceutical Sciences and Biomedical technology, NIPER, Ahmadabad, Gujarat (CPSBT-2018) (Oral) (WINNER 1st Prize)

7. Kumar P, Scalable fabrication of bio-inspired, 3D micro/nanofluidic devices, IITB-Monash Research Academy, (Ph.D. thesis)

8. Kumar P, Gandhi P.S, Mainak Majumder, Scalable fabrication of bio-inspired 3D micro/nanofluidic device, Patent (Under review)

9. Kumar P, Gandhi P.S, Majumder M, Enhanced capillary pumping through evaporation assisted leaf-mimicking micropumps, arXiv:1807.11464 [physics.app-ph], 2018

10. Kumar P, Gandhi P.S, Majumder M, Optimal morphometric factors responsible for enhanced gas exchange by fish gills, arXiv:1805.07744 [physics.bio-ph], 2018

 The part of work was carried out at Suman Mashruwala Advance Microengineering Lab, Mechanical Engineering, IIT Bombay, Mumbai ( http://www.me.iitb.ac.in/~mems) and Nano-Scale Engineering Lab, Department of Mechanical and Aerospace Engineering, Monash University, Clayton ( http://users.monash.edu.au/~mainakm/) 

My  R & D Job Work  (CSIO Chandigarh & AIIMS, New Delhi)                    (Oct 2010- Jun 2011)                                                   

Synopsis of Work: Cephalometric analysis has long helped researchers and orthodontic practitioners for evaluation of facial growth, understanding facial morphology and its ethnic variations, orthodontic diagnosis and treatment planning for patients presenting with malocclusion and dentofacial deformities. In this work, we proposed an optimized template matching (OTM) algorithm which could automatically localize hard and soft tissue anatomical landmarks on lateral cephalometric images. Moreover, the algorithm for landmark identification and 6 basic cephalometric analysis were incorporated in VB.NET based software named AUTO CEPH (a semi-automated software for cephalometric analysis). The optimized template matching (OTM) algorithm may prove to be a promising approach in automatic detection of anatomical landmarks on cephalometric images.

Publications (Journal and Conferences):

1. Vasamsetti S, Sardana V, Kumar P, Kharbanda, O.P., Sardana, H.K., A Novel Approach for Automatic Landmark Identification in Cephalometric Images Using Optimized Template Matching, Journal of Medical Imaging and Health Informatics, 2015. 5(3) 458-470 [ Impact factor: 0.549]

2. Singla, P., Kumar P., Das A, Sardana V, Sardana H.K., Image registration: A pre-step in patient's position verification in radiation therapy in International Conference on Image Information Processing (ICIIP), 2012

3. S Vasamsetti, V Sardana, P Kumar, HK Sardana, Feature Extraction through Wavelet Decomposition for Automatic Detection of Landmarks on Cephalogram Images, International Conference on Biomedical Engineering ICBME 2011 MIT, Manipal

The part of work was carried out at Computational Instrumentation Lab,  Central Scientific Instruments Organization (CSIR), Chandigarh ( http://www.csio.res.in/) and Center for Dental Education and Research, AIIMS, New Delhi ( http://www.aiims.edu/aiims/departments/spcenter/cder/cder.htm) 

My MTech Work  (IIT Kanpur)                                                                 (Jan, 2009- Aug-2010)

Synopsis of Work: The electrospun micro-/nano fiber systems have potential applications in tissue engineering, energy, textiles etc but in the absence of tools and methods to characterize their mechanical properties, their potential application has been limited. The polystyrene micro-/nanofibrous matrices were fabricated by electrospinning and experimentally characterized for their physical, structural and mechanical (tensile) properties. Thereafter,  a computational model of fibrous matrices was designed in MATLAB and mechanical simulations to access the tensile properties was carried out using FEM in LS-DYNA. It was observed that the simulation results showed consistency with the experimental results for mechanical behavior of fibrous structures. Thus, our study enabled the understanding of mechanics of nanofibrous matrices and led to a platform technology for predicting the mechanical properties of any fibrous structures from their structural properties.

Publications (Journal, Conferences, and thesis):

1. Rizvi, M.S., Kumar P., Pal A, Katti, D.S., Mathematical model of the mechanical behavior of micro/nanofibrous materials designed for extracellular matrix substitutes. Acta Biomaterialia, 2012. 8(11): p. 4111-4122 [ Impact factor: 6.638]

2. Kumar P., Kumar R., Geometric modeling of an electrospun micro-/nano-fiber system for simulation of physical properties, International Journal of Science and Research, 2015. 4(4) p.1261-1266 [ Impact factor: 0.23]

3. Kumar P., Rajesh Vasita, Understanding the relation between structural and mechanical properties of electrospun mesh by uniaxial tensile testing, Journal of Applied Polymer Science, 2017, 45012  [Impact factor: 2.188 ]

4. Kumar P., Rajesh Vasita Study of structural and mechanical relationship of electrospun fiber matrices through uni-axial tensile testing, International Conference on Biomaterials, Biodiagnostics, Tissue engineering, drug delivery and Regenerative Medicine (BiTERM, 2016), New Delhi, India ( Oral and Poster)

5. Kumar P Understanding the mechanics of electrospun micro/nanofibrous system under the guidance of Prof. D. S Katti and Late Prof. Anupam Pal (Masters Thesis )

The part of work was carried out at Tissue Engineering and Drug Delivery Lab and Biomechanics Lab, Department of Biological Sciences and Bioengineering,  IIT Kanpur ( http://www.iitk.ac.in/bsbe/) and Biomaterials & Biomimetics Laboratory, School of Life Sciences, Central University of Gujarat (http://www.bnblab.in/)

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