Dynamics and Neuromodulation of Migraine

Markus A. Dahlem's focus on mobile health and migraine research is nested within his wider interest in modeling neurovascular coupling and pain. 

New article: "The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization".

Main research areas: 

  • Modeling cortical energetics, water and ion homeostasis, and vascular regulation,
  • Modeling pain, migraine headache and chronic pain,
  • Neuromodulation (electromagnetic stimulation of the brain),


  • Hodgkin-Huxley model with time-dependent ion concentrations
  • Reaction-diffusion models with non-local coupling
  • Non-linear dynamics and bifurcation methods
  • Intrinsic optical imaging

Further research interest:

  • Models from genotype to (cellular) phenotype in migraine, 
  • Neurovascular coupling: Regulation of cerebrovascular tone by perivascular nerves, glia, and blood pressure and its hydraulic functions,
  • Modeling impaired visual processing (e.g., fortifications, visual snow).
  • Tracking and control (Kalman filter): use of vital signs, sleep patterns, physical activity, and stress level

Research experience includes theoretical research on cutting–edge complex systems theory applied to neurological diseases, such as migraine, stroke, and traumatic brain injury from concussions to traumatic chronic encephalopathy to severe injuries.  [more]

NEW talks from July 2014 video talks (on migraine dynamics)  

Neurology is too important to be left to the neurology department—Biomedical engineering, physics, and quantified self solutions will help better manage migraines.
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