Precision medicine: Dynamics, Neuromodulation & Digital Therapies of Migraine

Markus A. Dahlem's focus on migraine and pain research is nested within his wider interest using statistical physics in digital health.

Main research areas:

• Simulation of brain wave trajectories in cerebral cortex for stroke diagnosis
• Modeling cortical energetics, water and ion homeostasis, and vascular regulation,
• Modeling pain, migraine headache and chronic pain,
• Neuromodulation (electromagnetic stimulation of the brain),
• Mobile health, wearable medical devices

Methods:

• Hodgkin-Huxley model with time-dependent ion concentrations
• Reaction-diffusion models

• with non-local couplingNon-linear dynamics and bifurcation methods
• Intrinsic optical imaging
• Usability-studies

Further research interest:

• Models from genotype to (cellular) phenotype in migraine,
• Neurovascular coupling: Regulation of cerebrovascular tone by perivascular nerves, glia, and blood pressure and its hydraulic functions,
• Modeling impaired visual
• processing (e.g., fortifications, visual snow).Tracking and control (Kalman filter): use of vital signs, sleep patterns, physical activity, and stress level

Research experience includes theoretical research on cutting–edge complex systems theory applied to neurological diseases, such as migraine, stroke, and traumatic brain injury from concussions to traumatic chronic encephalopathy to severe injuries. [more]

Talks from July 2014 video talks (on migraine dynamics)