研究業績

２０１５年

1. H. Abo, K. Soga, A. Tanaka, H. Tateno, J. Hirabayashi, K. Yamamoto.: Mutated leguminous lectin containing a heparin-binding like motif in a carbohydrate-binding loop specifically binds to heparin. PLoS ONE in press.

2. K. Soga, H. Abo, S. -Y. Qin, T. Kyotoh, K. Hiemori, H. Tateno, N. Matsumoto, J. Hirabayashi, K. Yamamoto.: Mammalian Cell surface display as a novel method for developing engineered lectins with novel Characteristics. Biomolecules 5, 1540-1562 (2015).

3. A. Kishimoto, M. Watanabe, K. Terauchi, T. Kojima, Y. Kameda, K.Yamamoto, N. Matsumoto. Ubiquitous versus restricted expression of the two mouse dendritic cell C-type lectin receptors, DCIR1 and DCAR2, among myeloid cells. Biochem. Biophys. Res. Commun. 467, 383-388 (2015).

4. Oura, F., Yajima, Y., Nakata, M., Taniue, K., Akiyama, T., Nakada, H., Yamamoto, K., Fujita-Yamaguchi, Y.: Susceptibility to proteases of anti-Tn-antigen MLS128 binding glycoproteins expressed in human colon cancer cells. BioScience trends 9, 49-55 (2015).

２０１４年

1. K. Yamamoto.: Intracellular lectins are involved in quality control of glycoproteins (review). Proc. Jap. Acad. Ser. B. 90, 67-82 (2014).

2. K. Takeda, S. Qin, N. Matsumoto, K. Yamamoto.: Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion. Biochem. Biophys. Res. Commun. 454, 436-440 (2014).

3. M. Nagae, M., A. Ikeda, Y. Kitago, M. Matsumoto, K. Yamamoto, Y. Yamaguchi.: Crystal structures of carbohydrate recognition domain of Blood Dendritic Cell Antigen-2 (BDCA2) demonstrated a common domain-swapping dimer. Proteins 82, 1512-1518 (2014).

4. M. Nagae, K. Soga, M.K. Morita, S. Hanashima, A. Ikeda, K. Yamamoto, and Y. Yamaguchi.: Phytohemagglutinin from Phaseolus vulgaris (PHA-E) displays a novel glycan recognition mode using a common legume lectin fold. Glycobiology 24, 368-378 (2014).

5. K. Yamamoto.: Intracellular lectin, ERGIC-53. SpringerReference Glycoscience: Biology and Medicine, Article ID395341, Chapter ID:46 (2014).

6. K. Yamamoto.: Assessment of weak sugar-binding ability using lectin tetramer and membrane-based glycans. Methods Mol. Biol. 1200, 413-418 (2014).

7. K. Yamamoto.: Carbohydrate-binding specificity of lectins using multiplexed glyco-bead array. Methods Mol. Biol. 1200, 319-326 (2014).

8. Y. Kobayashi, H. Tateno, H. Ogawa, K. Yamamoto, J. Hirabayashi.: Comprehensive list of lectins: origins, natures, and carbohydrate specificities. Methods Mol Biol. 1200, 555-77 (2014).

２０１３年

1. Soga, K., Teruya, F., Tateno, H., Hirabayashi, J., Yamamoto, K.: Terminal N-acetylgalactosamine-specific leguminous lectin from Wisteria japonica as a probe for human lung squamous cell carcinoma. PLoS ONE 8(12) e83886 (2013).

2. Nagae, M., Yamanaka, K, Hanashima, S., Ikeda, A., Matsumoto, K., Satoh, T., Matsumoto, N., Yamamoto, K., and Yamaguchi, Y.: Recognition of bisecting N-acetylglucosamine: Structural basis for asymmetric interaction with the mouse lectin dendritic cell inhibitory receptor 2. J. Biol. Chem. 288, 33598-33610 (2013).

3. N. Suzuki, D. Nawa, H. Tateno, T. Yasuda, S. Oda, H. Mitani, T. Nishimaki, T. Katsumura, H. Oota, T. Hanihara, A. Oga, J. Hirabayashi, K. Yamamoto.: Generation of monoclonal antibodies against Galβ1-4Gal epitope: a key tool in studies of species-specific glycans expressed in fish, amphibians, and birds. Glycobiology, 23, 91-105 (2013)

4. N. Suzuki , D. Nawa, T. Su, C. Lin, K. Khoo, K. Yamamoto.: Distribution of the Galβ1-4Gal epitope among birds: Species-specific loss of the glycan structure in chicken and its relatives. PLoS ONE 8(3) e59291 (2013).

5. Y. Chen, S. Hojo, N. Matsumoto, K. Yamamoto.: Regulation of Mac-2BP secretion is mediated by its N-glycan binding to ERGIC-53. Glycobiology 23, 904-916 (2013).

6. Zamri, N., Masuda, N., Oura, F., Kabayama, K., Yamaji, Y., Nakada, H., Yamamoto, K., Yamaguchi, Y.: Characterization of anti-Tn-antigen MLS128 binding proteins involved in inhibiting the growth of human colorectal cancer cells. Biosci. Trends, 7, 221-229 (2013).

２０１２年

1. J. Park, A. Kanayama, K. Yamamoto, Y. Miyamoto: ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation. Biochem. Biophys. Res. Commun. 422, 291-297 (2012).

2. S. Qin, N. Kawasaki, D. Hu, H. Tozawa, N. Matsumoto, K. Yamamoto.: Subcellular Localization of ERGIC-53 under endoplasmic reticulum-stress condition. Glycobiology 22, 1709-1720 (2012).

3. S. Qin, D. Hu, K. Matsumoto, K. Takeda, N Matsumoto, Y. Yamaguchi, K. Yamamoto.: Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins. J. Biol. Chem. 287, 38080-38089 (2012).

２０１１年

1. N. Suzuki, D. Nawa, K. Yamamoto.: Distinct expression profiles of UDP-galactose:β-D-galactoside α1,4-galactosyltransferase and UDP-galactose:β-D-galactoside β1,4-galactosyltransferase in pigeon, ostrich, and chicken. Glycobiology 21, 283-294 (2011).

2. S. Hata, S. Fujishige, Y. Araki, M. Taniguchi, K. Urakami, E. Peskind, H. Akatsu, M. Araseki, K. Yamamoto, R.N. Martins, M. Maeda, M. Nishimura, A. Levey, K.A. Chung, T. Montine, J. Leverenz, A. Fagan, A. Goate, R. Bateman, D.M. Holtzman, T. Yamamoto, T. Nakaya, S. Gandy, T. Suzuki.: Misprocessing of multiple γ-secretase substrates in sporadic Alzheimer's disease. Ann. Neurol.69, 1026-1031 (2011).

3. Y. Chen, D. Hu, R. Yabe, H. Tateno, S. Qin, N. Matsumoto, J. Hirabayashi, K. Yamamoto.: Role of Malectin in Glc2Man9GlcNAc2-dependent quality control of α1-antitrypsin. Mol. Biol. Cell 22, 3559-3570 (2011) selected in Highlighed Articles

4. K. Yamamoto, and T. Irimura: Toshiaki Osawa: Biochemistry of lectins and their applications in immunochemistry and cellular biology. J. Biochem. 150, 477-482 (2011).

5. N. Suzuki, D. Nawa, K. Yamamoto.: Distinct expression profiles of UDP-galactose:β-D-galactoside α1,4-galactosyltransferase and UDP-galactose:β-D-galactoside β1,4-galactosyltransferase in pigeon, ostrich, and chicken. Glycobiology 21, 283-294 (2011) .

6. S. Hata, S. Fujishige, Y. Araki, M. Taniguchi, K. Urakami, E. Peskind, H. Akatsu, M. Araseki, K. Yamamoto, R.N. Martins, M. Maeda, M. Nishimura, A. Levey, K.A. Chung, T. Montine, J. Leverenz, A. Fagan, A. Goate, R. Bateman, D.M. Holtzman, T. Yamamoto, T. Nakaya, S. Gandy, T. Suzuki.: Misprocessing of multiple γ-secretase substrates in sporadic Alzheimer’s disease. Ann. Neurol. 69, 1026-1031 (2011) .

２０１０年

1. N. Suzuki and K. Yamamoto.: Molecular cloning of pigeon UDP-galactose:b-galactoside a1,4-galactosyotransferase and UDP-galactose:b-galactoside b1,4-galactosyltransferase, two novel enzymes catalyzing the formation of Gala1-4Galb1-4Galb1-4GlcNAc sequence. J. Biol. Chem 285, 5178-5187 (2010).

2. K. Mikami, D. Yamaguchi, H. Tateno, D. Hu, S. Qin, N. Kawasaki, M. Yamada, N. Matsumoto, J. Hirabayashi, Y. Ito, K. Yamamoto.: The sugar-binding ability of human OS-9 and its involvement in ER-associated degradation. Glycobiology (2010) 20, 310-320

3. D. Yamaguchi, D. Hu, N. Matsumoto, K. Yamamoto.: Human XTP3-B binds to α-antitrypsin variant null Hong Kong via the C-terminal MRH domain in a glycan-dependent manner. Glycobiology 20, 348-355 (2010).

4. M. Nishino, Y. Kamiya, T. Mizushima, S. Wakatsuki, H. Sasakawa, K. Yamamoto, S. Uchiyama, M. Noda, K. Fukui, HP. Hauri, K. Kato.: Structural basis for the cooperateve interplay between the two causative gene products of combained factor V and factor VIII deficiency. Proc Natl Acad Sci USA. 107, 4034-4039 (2010).

5. K. Yamamoto.: Affinity chromatography of oligosacchairdes and glycopeptides with immobilized lectins. Protein Protocols Handbook.3rd Ed. J.M.Walker, Humana Press pp1347-1362 (2010).

6. A. Akatsuka, M. Ito, C. Yamauchi, A. Ochiai, K. Yamamoto, and N. Matsumoto.: Tumor cells of

7. non-haematopoietic and haematopoietic origins express activation-induced C-type

8. lectin, the ligand for killer cell lectin-like receptor F1. Int. Immunol. 22,783-790 (2010).

9. K. Yamamoto and N. Kawasaki.: Detection of weak-binding sugar activity using membrane-based

10. carbohydrates. Methods Enzymol. 478, 233-240 (2010).

11. T. Satoh, Y. Chen, D. Hu, S. Hanashima, K. Yamamoto, Y. Yamaguchi.: Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation. Mol. Cell 40, 905-916 (2010).

12. 山本一夫: 免疫学 -巧妙なしくみを解き明かす- p.1-326 (2011) 東京化学同人

２００９年

1. S. Nakamura, K. Kuroki, I. Ohki, K. Sasaki, M. Kajikawa, T. Maruyama, M. Ito, Y. Kameda, M. Ikura, K. Yamamoto, N. Matsumoto, K. Maenaka.: Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1). J. Biol. Chem. (2009) 284,27327-35.

2. S. Hata, S. Fujishige, Y. Araki, N. Kato, M. Araseki, M. Nishimura, D. Hartmann, P. Saftig, F.Fahrenholz, M. Taniguchi, K. Urakami, H. Akatsu, RN. Martins, K. Yamamoto, M. Maeda, T. Yamamoto, T. Nakaya, S. Gandy, T. Suzuki.: Alcadein cleavages by APP a-and b-secretases generate small peptides p3-Alcs indicating Alzheimer disease-related g-secretase dysfunction. J. Biol. Chem. (2009) 284, 36024-36033

3. D.Hu, Y. Kamiya, K. Totani, D. Kamiya, N. Kawasaki, D.Yamaguchi, I. Matsuo, N. Matsumoto, Y. Ito, K. Kato and K. Yamamoto.: Sugar-binding activity of the MRH domain in ER-glucosidase II subunit is important for efficient glucose trimming. Glycobiology (2009) 19,1127-1135

4. K. Yamamoto.: Intracellular lectins involved in folding and transport in the endoplasmic reticulum (review). Biol. Pharm. Bull. 32,767-773 (2009).

5. N. Suzuki, TH. Su, SW. Wu, K. Yamamoto, KH. Khoo, YC. Lee.: Structural analysis of N-glycans from gull egg white glycoproteins and egg yolk IgG. Glycobiology 19, 693-706 (2009).

２００８年

1. N. Kawasaki, Y. Ichikawa, I. Matsuo, K. Totani, N. Matsumoto, Y. Ito, K. Yamamoto.: The sugar-binding ability of ERGIC-53 is enhanced by its interaction with MCFD2 Blood 111, 1972-1979 (2008).

2. Y. Kamiya, D. Kamiya, K. Yamamoto, B. Nyfeler, H.-P. Hauri, and K. Kato.: Molecular basis of sugar recognition by the human L-type lectins ERGIC-53, VIPL and VIP36 J. Biol. Chem. 283, 1857-1861 (2008).

3. B. Nyfeler, Y. Kamiya, K. Yamamoto, K. Kato, F. Boehlen, P. Moerloose, H. P. Hauri, M. N. Arbez.: Deletion of three residues from the C-terminus of MCFD2 affects binding to ERGIC-53 and causes combined factor V and factor VIII deficiency Blood 111, 1299-1301 (2008).

２００７年

1. D. Yamaguchi, N. Kawasaki, I. Matsuo, K. Totani, H. Tozawa, N. Matsumoto, Y. Ito, K. Yamamoto.: VIPL has sugar-binding activity speccific for high-mannnose-type N-glycans, and glucosylation of the α1,2 mannotriosyl branch blocks its binding Glycobiology, 17, 1061-1069 (2007).

2. D. Nawa, O. Shimada, N. Kawasaki, N. Matsumoto, K. Yamamoto.: Stable interaction of the cargo receptor VIP36 with molecular chaperone BiP Glycobiology, 117, 913-921 (2007).

3. N. Kawasaki, I. Matsuo, K. Totani, D. Nawa, N. Suzuki, D. Yamaguchi, N. Matsumoto, Y. Ito, and K. Yamamoto.: Detection of weak sugar binding activity of VIP36 using VIP36-streptavidin complex and membrane-based sugar chains J. Biochem. 141, 221-229 (2007).

4. K. Yamamoto, F. Yasukawa, S. Ito.: Measurement of the sugar-binding specificity of lectins using multiplexed bead-based suspension arrays Methods Mol. Biol. 381, 401-409 (2007).

5. 山本一夫、小浪悠紀子: レクチン（第2版）-歴史,構造・機能から応用まで- p.1-388 (2007) 丸善出版