Genetics problems

ANSWERS

Anatomy & Physiology - Genetics of Blood Disorders

SHOW ALL WORK!

1. If a female is a carrier for hemophilia X H X h and is married to a man with hemophilia X h Y , what is the probability that she will have a daughter with hemophilia?

2. A normal female marries a man who has hemophilia . (You’ll need to figure out the genotypes). What percentage of their sons will have hemophilia?

3. If a female has hemophilia and is married to a normal man.....

What percentage of her sons will have hemophilia?

What percentage of her daughters will have hemophilia?

4. A woman with sickle cell anemia is married to a man who is a carrier for the trait.

( a a x A a). What is the chance of their children having sickle cell anemia?

5. What is the chance that two people (both being carriers for sickle cell anemia) will have a child with the disease?

6, What is the chance that a female who is a carrier for sickle cell anemia will have a child with sickle cell anemia if she marries a normal man?

7. Von Willebrand Disease is an autosomal dominant disorder (not located on the sex chromosomes) where blood will not clot properly.

What would be the two possible genotypes of a person who has the disorder?

If a person is heterozygous for the trait (having the disease) is married to a normal spouse (dd), what is the chance that their children will have the disorder.

Blood Type Problems

1. List all the possible genotypes for each of the 4 blood types:

Type O ____________

Type A ____________

Type B ____________

Type AB ____________

SHOW WORK!

2. A man with AB blood is married to a woman with AB blood. What blood types will their children be and in what proportion?

3. A man who has type B blood (genotype: BB) is married to a woman with type O blood. What blood type will their children have?

4. A woman with type A blood (genotype: AO) is married to a type B person (genotype: BO). What blood types will their children have?

5. A woman with type A blood is claiming that a man with type AB blood is the father of her child, who is also type AB. Could this man be the father? Show the possible crosses; remember the woman can have AO or AA genotypes.

6. A man with type AB blood is married to a woman with type O blood. They have two natural children, and one adopted child. The children's blood types are: A, B, and O. Which child was adopted?

7. A person with type A blood (unknown genotype) marries a person with type O blood. What blood types are possible among their children. (Show 2 crosses

8. Two people, both with AB blood have four children. What blood types should the children be?

9. A person with type B blood (genotype BO) has children with a type AB person. What blood types are possible among their children?

10. A person with type O blood is married to a person with type A blood (unknown genotype). They have 6 children, 3 of them have type A blood, three of them have type O blood. What is the genotype of the two parents?

11. A person has type B blood. What are ALL the possible blood types of his parents. Show the crosses to prove your answer.

12. A man of unknown genotype has type B blood, his wife has type A blood (also unknown genotype). List ALL the blood types possible for their children. (you may need to do multiple crosses to consider the different possible genotypes of the parents)

13. Two people with type O blood have three children. How many of those three children also have type O blood?

14. Why is a person with type O blood called a “universal donor”?

15. Why is a person with type AB blood called a “universal acceptor”?